Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PRKX mRNA] | CTD | PMID:31150632 | (1->4)-beta-D-glucan | multiple interactions | ISO | Prkx (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PRKX mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | multiple interactions | ISO | Prkx (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PRKX mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | ISO | Prkx (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of PRKX mRNA | CTD | PMID:17555576 | 17beta-estradiol | multiple interactions | ISO | PRKX (Homo sapiens) | 6480464 | [Progesterone co-treated with Estradiol] results in increased expression of PRKX mRNA | CTD | PMID:17404688 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of PRKX mRNA | CTD | PMID:26496021 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Prkx (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PRKX mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PRKX mRNA | CTD | PMID:34747641 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of PRKX mRNA | CTD | PMID:21346803 | 2-hydroxypropanoic acid | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of PRKX mRNA | CTD | PMID:30851411 | 3,3',5,5'-tetrabromobisphenol A | increases expression | EXP | | 6480464 | tetrabromobisphenol A results in increased expression of PRKX mRNA | CTD | PMID:27914987 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | PRKX (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of PRKX gene | CTD | PMID:31601247 | 4-hydroxyphenyl retinamide | increases expression | ISO | Prkx (Mus musculus) | 6480464 | Fenretinide results in increased expression of PRKX mRNA | CTD | PMID:28973697 | acrylamide | decreases expression | ISO | PRKX (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of PRKX mRNA | CTD | PMID:32763439 | aflatoxin B1 | affects expression | ISO | PRKX (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of PRKX protein | CTD | PMID:20106945 | aflatoxin B1 | affects methylation | ISO | PRKX (Homo sapiens) | 6480464 | Aflatoxin B1 affects the methylation of PRKX intron | CTD | PMID:30157460 | aflatoxin B1 | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of PRKX mRNA | CTD | PMID:27153756 | aflatoxin B1 | increases expression | ISO | Prkx (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of PRKX mRNA | CTD | PMID:19770486 | Aflatoxin B2 alpha | decreases methylation | ISO | PRKX (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of PRKX intron | CTD | PMID:30157460 | antirheumatic drug | decreases expression | ISO | PRKX (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of PRKX mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | PRKX (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PRKX mRNA | CTD | PMID:33212167 | Aroclor 1254 | decreases expression | ISO | Prkx (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of PRKX mRNA | CTD | PMID:23650126 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of PRKX gene | CTD | PMID:35440735 | benzene | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Benzene results in increased expression of PRKX mRNA | CTD | PMID:19162166 | benzo[a]pyrene | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of PRKX mRNA | CTD | PMID:20106945 and PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | PRKX (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of PRKX exon | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Prkx (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PRKX mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases methylation | ISO | PRKX (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PRKX promoter | CTD | PMID:27901495 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of PRKX mRNA | CTD | PMID:26496021 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PRKX mRNA | CTD | PMID:25181051 | cisplatin | multiple interactions | ISO | PRKX (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of PRKX mRNA | CTD | PMID:27392435 | cisplatin | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Cisplatin results in increased expression of PRKX mRNA | CTD | PMID:27392435 | copper atom | multiple interactions | ISO | PRKX (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of PRKX mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | PRKX (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of PRKX mRNA | CTD | PMID:20971185 | cyclosporin A | decreases expression | ISO | PRKX (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of PRKX mRNA | CTD | PMID:20106945 | cyclosporin A | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PRKX mRNA | CTD | PMID:27989131 | daunorubicin | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Daunorubicin results in increased expression of PRKX mRNA | CTD | PMID:26537877 and PMID:28940058 | dexamethasone | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Dexamethasone results in increased expression of PRKX mRNA | CTD | PMID:16144937 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of PRKX mRNA | CTD | PMID:21266533 | dorsomorphin | multiple interactions | ISO | PRKX (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKX mRNA | CTD | PMID:27188386 | doxorubicin | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of PRKX mRNA | CTD | PMID:26537877 more ... | doxorubicin | decreases expression | ISO | PRKX (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PRKX mRNA | CTD | PMID:29803840 | ethanol | affects splicing | ISO | Prkx (Mus musculus) | 6480464 | Ethanol affects the splicing of PRKX mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of PRKX mRNA | CTD | PMID:23649840 | etoposide | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Etoposide results in increased expression of PRKX mRNA | CTD | PMID:29397400 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of PRKX mRNA | CTD | PMID:30307764 | folic acid | multiple interactions | ISO | Prkx (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PRKX mRNA | CTD | PMID:22206623 | formaldehyde | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of PRKX mRNA | CTD | PMID:23649840 | fulvestrant | multiple interactions | ISO | PRKX (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of PRKX gene | CTD | PMID:31601247 | graphite | affects expression | EXP | | 6480464 | Graphite affects the expression of PRKX mRNA | CTD | PMID:29933104 | hydroquinone O-beta-D-glucopyranoside | decreases expression | ISO | PRKX (Homo sapiens) | 6480464 | Arbutin results in decreased expression of PRKX mRNA | CTD | PMID:17103032 | levetiracetam | increases expression | EXP | | 6480464 | Levetiracetam results in increased expression of PRKX mRNA | CTD | PMID:20345932 | mercury dibromide | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of PRKX mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | PRKX (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKX mRNA | CTD | PMID:27188386 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of PRKX mRNA | CTD | PMID:19564919 | methyl methanesulfonate | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of PRKX mRNA | CTD | PMID:23649840 | mitoxantrone | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Mitoxantrone results in increased expression of PRKX mRNA | CTD | PMID:26537877 and PMID:28940058 | nickel atom | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Nickel results in increased expression of PRKX mRNA | CTD | PMID:24768652 and PMID:25583101 | nickel sulfate | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of PRKX mRNA | CTD | PMID:22714537 | paracetamol | affects expression | ISO | Prkx (Mus musculus) | 6480464 | Acetaminophen affects the expression of PRKX mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PRKX mRNA | CTD | PMID:26690555 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Prkx (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PRKX mRNA | CTD | PMID:36331819 | pirinixic acid | decreases expression | ISO | Prkx (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of PRKX mRNA | CTD | PMID:17426115 | potassium chromate | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of PRKX mRNA | CTD | PMID:22714537 | progesterone | multiple interactions | ISO | PRKX (Homo sapiens) | 6480464 | [Progesterone co-treated with Estradiol] results in increased expression of PRKX mRNA | CTD | PMID:17404688 | progesterone | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Progesterone results in increased expression of PRKX mRNA | CTD | PMID:17404688 | rac-lactic acid | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of PRKX mRNA | CTD | PMID:30851411 | resveratrol | decreases expression | ISO | Prkx (Mus musculus) | 6480464 | resveratrol results in decreased expression of PRKX mRNA | CTD | PMID:22610192 | SB 431542 | multiple interactions | ISO | PRKX (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKX mRNA | CTD | PMID:27188386 | SCH 23390 | increases expression | EXP | | 6480464 | SCH 23390 results in increased expression of PRKX mRNA | CTD | PMID:19564919 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of PRKX mRNA | CTD | PMID:19281266 | sunitinib | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PRKX mRNA | CTD | PMID:31533062 | testosterone | decreases expression | ISO | PRKX (Homo sapiens) | 6480464 | Testosterone results in decreased expression of PRKX mRNA | CTD | PMID:33359661 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of PRKX mRNA | CTD | PMID:31150632 | tetrachloromethane | increases expression | ISO | Prkx (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of PRKX mRNA | CTD | PMID:31919559 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PRKX mRNA] | CTD | PMID:31150632 | tunicamycin | increases expression | ISO | Prkx (Mus musculus) | 6480464 | Tunicamycin results in increased expression of PRKX mRNA | CTD | PMID:17127020 | valproic acid | increases expression | ISO | PRKX (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PRKX mRNA | CTD | PMID:23179753 and PMID:27188386 | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of PRKX mRNA | CTD | PMID:23034163 | zinc atom | increases expression | EXP | | 6480464 | Zinc deficiency results in increased expression of PRKX mRNA | CTD | PMID:19111725 | zinc(0) | increases expression | EXP | | 6480464 | Zinc deficiency results in increased expression of PRKX mRNA | CTD | PMID:19111725 | |