Prkx (protein kinase cAMP-dependent X-linked catalytic subunit) - Rat Genome Database

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Gene: Prkx (protein kinase cAMP-dependent X-linked catalytic subunit) Rattus norvegicus
Analyze
Symbol: Prkx
Name: protein kinase cAMP-dependent X-linked catalytic subunit
RGD ID: 1564076
Description: Predicted to enable cAMP-dependent protein kinase activity. Predicted to be involved in several processes, including endothelial cell migration; endothelial cell proliferation; and tube morphogenesis. Predicted to be located in cytoplasm and nucleoplasm. Orthologous to several human genes including PRKX (protein kinase cAMP-dependent X-linked catalytic subunit); PARTICIPATES IN apoptotic cell death pathway; bile acid transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cAMP-dependent protein kinase catalytic subunit PRKX; protein kinase, X-linked; serine/threonine-protein kinase PRKX
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X45,701,747 - 45,745,210 (-)NCBIGRCr8
mRatBN7.2X41,823,349 - 41,866,844 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX41,823,355 - 41,866,669 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX43,124,049 - 43,167,386 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X46,591,399 - 46,634,728 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X44,256,128 - 44,299,460 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X45,080,963 - 45,125,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX45,080,963 - 45,124,270 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X45,378,196 - 45,420,133 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X63,484,553 - 63,533,858 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX42,479,703 - 42,521,299 (-)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9860982   PMID:10026146   PMID:16491121   PMID:17980165   PMID:21684272  


Genomics

Comparative Map Data
Prkx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X45,701,747 - 45,745,210 (-)NCBIGRCr8
mRatBN7.2X41,823,349 - 41,866,844 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX41,823,355 - 41,866,669 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX43,124,049 - 43,167,386 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X46,591,399 - 46,634,728 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X44,256,128 - 44,299,460 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X45,080,963 - 45,125,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX45,080,963 - 45,124,270 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X45,378,196 - 45,420,133 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X63,484,553 - 63,533,858 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX42,479,703 - 42,521,299 (-)NCBICelera
Cytogenetic MapXq21NCBI
PRKX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X3,604,340 - 3,713,649 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX3,604,340 - 3,713,649 (-)EnsemblGRCh38hg38GRCh38
GRCh37X3,522,381 - 3,631,690 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X3,532,411 - 3,641,661 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X3,515,771 - 3,625,010NCBI
CeleraX7,803,269 - 7,912,726 (-)NCBICelera
Cytogenetic MapXp22.33NCBI
HuRefX1,474,445 - 1,580,609 (-)NCBIHuRef
CHM1_1X3,552,929 - 3,661,974 (-)NCBICHM1_1
T2T-CHM13v2.0X3,218,669 - 3,333,048 (-)NCBIT2T-CHM13v2.0
Prkx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X76,804,578 - 76,839,545 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX76,805,017 - 76,839,884 (-)EnsemblGRCm39 Ensembl
GRCm38X77,760,972 - 77,796,235 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX77,761,411 - 77,796,278 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X75,007,362 - 75,041,299 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X74,014,742 - 74,048,679 (-)NCBIMGSCv36mm8
CeleraX69,092,716 - 69,127,190 (-)NCBICelera
Cytogenetic MapXBNCBI
cM MapX38.32NCBI
Prkx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554992,167,252 - 2,211,911 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554992,167,252 - 2,227,510 (-)NCBIChiLan1.0ChiLan1.0
PRKX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X5,247,944 - 5,352,705 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X5,246,143 - 5,356,363 (-)NCBINHGRI_mPanPan1
PanPan1.1X3,548,503 - 3,654,289 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX3,547,985 - 3,654,322 (-)Ensemblpanpan1.1panPan2
PRKX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X1,938,205 - 2,007,948 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX1,945,379 - 2,014,661 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX1,888,783 - 1,962,819 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X1,864,516 - 1,938,512 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X1,856,007 - 1,929,869 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X1,871,602 - 1,945,594 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X1,899,988 - 1,973,995 (-)NCBIUU_Cfam_GSD_1.0
Prkx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049531,946,323 - 2,053,408 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366442,406,926 - 2,430,815 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366442,407,142 - 2,430,788 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX657,621 - 753,680 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X657,421 - 753,739 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X144,027,915 - 144,169,591 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X1,849,302 - 2,005,033 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660563,709,688 - 3,823,000 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248341,691,765 - 1,745,938 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkx
64 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1189
Count of miRNA genes:333
Interacting mature miRNAs:454
Transcripts:ENSRNOT00000004920
Prediction methods:Microtar, Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat

Markers in Region
RH127732  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X41,823,499 - 41,823,701 (+)MAPPERmRatBN7.2
Rnor_6.0X45,081,114 - 45,081,315NCBIRnor6.0
Rnor_5.0X45,378,347 - 45,378,548UniSTSRnor5.0
RGSC_v3.4X63,484,704 - 63,484,905UniSTSRGSC3.4
CeleraX42,479,854 - 42,480,055UniSTS
RH 3.4 MapX568.8UniSTS
Cytogenetic MapXq22UniSTS
BQ195742  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X41,850,044 - 41,850,254 (+)MAPPERmRatBN7.2
Rnor_6.0X45,107,646 - 45,107,855NCBIRnor6.0
Rnor_5.0X45,403,024 - 45,403,233UniSTSRnor5.0
RGSC_v3.4X63,517,094 - 63,517,303UniSTSRGSC3.4
CeleraX42,504,669 - 42,504,878UniSTS
RH 3.4 MapX583.9UniSTS
Cytogenetic MapXq22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 6 7 18 51 22 27 11
Low 2 37 50 41 1 41 8 11 23 13 14 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000090932   ⟹   ENSRNOP00000072103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX41,823,355 - 41,866,669 (-)Ensembl
Rnor_6.0 EnsemblX45,080,963 - 45,124,270 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX45,083,110 - 45,084,103 (-)Ensembl
RefSeq Acc Id: NM_001033963   ⟹   NP_001029135
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X45,701,747 - 45,745,066 (-)NCBI
mRatBN7.2X41,823,349 - 41,866,669 (-)NCBI
Rnor_6.0X45,080,963 - 45,124,270 (-)NCBI
Rnor_5.0X45,378,196 - 45,420,133 (-)NCBI
RGSC_v3.4X63,484,553 - 63,533,858 (-)RGD
CeleraX42,479,703 - 42,521,299 (-)RGD
Sequence:
RefSeq Acc Id: XM_017602134   ⟹   XP_017457623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X45,701,747 - 45,745,210 (-)NCBI
mRatBN7.2X41,823,349 - 41,866,844 (-)NCBI
Rnor_6.0X45,080,963 - 45,125,095 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001029135 (Get FASTA)   NCBI Sequence Viewer  
  XP_017457623 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91203 (Get FASTA)   NCBI Sequence Viewer  
  EDL96084 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072103
  ENSRNOP00000072103.1
RefSeq Acc Id: NP_001029135   ⟸   NM_001033963
- UniProtKB: Q5BK52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457623   ⟸   XM_017602134
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000072103   ⟸   ENSRNOT00000090932
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK52-F1-model_v2 AlphaFold Q5BK52 1-358 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701821
Promoter ID:EPDNEW_R12345
Type:initiation region
Name:Prkx_1
Description:protein kinase, X-linked
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X45,124,251 - 45,124,311EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564076 AgrOrtholog
BioCyc Gene G2FUF-2411 BioCyc
Ensembl Genes ENSRNOG00000060168 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090932 ENTREZGENE
  ENSRNOT00000090932.3 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7380393 IMAGE-MGC_LOAD
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:501563 UniProtKB/TrEMBL
MGC_CLONE MGC:108904 IMAGE-MGC_LOAD
NCBI Gene 501563 ENTREZGENE
PANTHER CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Prkx PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060168 RatGTEx
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A6IPS9_RAT UniProtKB/TrEMBL
  Q5BK52 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-15 Prkx  protein kinase cAMP-dependent X-linked catalytic subunit  Prkx  protein kinase, X-linked  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 Prkx  protein kinase, X-linked      Symbol and Name status set to provisional 70820 PROVISIONAL