Bfar (bifunctional apoptosis regulator) - Rat Genome Database

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Gene: Bfar (bifunctional apoptosis regulator) Rattus norvegicus
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Symbol: Bfar
Name: bifunctional apoptosis regulator
RGD ID: 1304791
Description: Predicted to enable caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and membrane. Orthologous to human BFAR (bifunctional apoptosis regulator); INTERACTS WITH 2,5-hexanedione; arsenous acid; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC304709; RGD1305537; similar to RIKEN cDNA 3110001I22
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8102,059,189 - 2,092,207 (+)NCBIGRCr8
mRatBN7.2101,552,019 - 1,585,040 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl101,552,072 - 1,585,038 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx106,248,898 - 6,281,870 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01034,283,970 - 34,316,927 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0101,565,910 - 1,599,270 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0101,464,783 - 1,497,653 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl101,464,765 - 1,497,653 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010361,895 - 394,582 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41049 - 13,315 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera10613,130 - 645,931 (+)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10716992   PMID:15489334   PMID:15632090   PMID:21068390  


Genomics

Comparative Map Data
Bfar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8102,059,189 - 2,092,207 (+)NCBIGRCr8
mRatBN7.2101,552,019 - 1,585,040 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl101,552,072 - 1,585,038 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx106,248,898 - 6,281,870 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01034,283,970 - 34,316,927 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0101,565,910 - 1,599,270 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0101,464,783 - 1,497,653 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl101,464,765 - 1,497,653 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010361,895 - 394,582 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41049 - 13,315 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera10613,130 - 645,931 (+)NCBICelera
Cytogenetic Map10q11NCBI
BFAR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381614,632,951 - 14,669,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1614,632,931 - 14,669,236 (+)EnsemblGRCh38hg38GRCh38
GRCh371614,726,808 - 14,763,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361614,634,297 - 14,670,209 (+)NCBINCBI36Build 36hg18NCBI36
Build 341614,634,296 - 14,670,193NCBI
Celera1614,903,443 - 14,939,870 (+)NCBICelera
Cytogenetic Map16p13.12NCBI
HuRef1614,645,522 - 14,682,385 (+)NCBIHuRef
CHM1_11614,726,496 - 14,762,923 (+)NCBICHM1_1
T2T-CHM13v2.01614,670,491 - 14,706,771 (+)NCBIT2T-CHM13v2.0
Bfar
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391613,489,722 - 13,521,476 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1613,489,722 - 13,521,476 (+)EnsemblGRCm39 Ensembl
GRCm381613,671,858 - 13,703,612 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,671,858 - 13,703,612 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,671,929 - 13,678,388 (+)EnsemblGRCm38mm10GRCm38
MGSCv371613,671,951 - 13,703,705 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361613,585,572 - 13,616,279 (+)NCBIMGSCv36mm8
Celera1614,276,844 - 14,308,053 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.45NCBI
Bfar
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554424,226,756 - 4,255,623 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554424,229,236 - 4,255,623 (-)NCBIChiLan1.0ChiLan1.0
BFAR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21815,167,173 - 15,205,284 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11618,950,045 - 18,988,139 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01613,558,912 - 13,597,023 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11614,980,618 - 15,018,310 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1614,980,615 - 15,018,310 (+)Ensemblpanpan1.1panPan2
BFAR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,593,931 - 28,624,867 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,594,709 - 28,624,759 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,957,043 - 29,987,994 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0628,757,093 - 28,788,057 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl628,757,095 - 28,787,932 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1628,560,108 - 28,591,059 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0628,448,363 - 28,479,322 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0628,855,713 - 28,886,664 (-)NCBIUU_Cfam_GSD_1.0
Bfar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344114,714,164 - 114,741,497 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365012,811,907 - 2,841,258 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365012,811,967 - 2,839,357 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BFAR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl328,573,393 - 28,612,217 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1328,572,789 - 28,612,659 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2329,685,082 - 29,696,890 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BFAR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1514,092,049 - 14,132,270 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl514,092,097 - 14,133,132 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606815,918,502 - 15,961,414 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bfar
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247823,887,129 - 3,916,858 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247823,890,818 - 3,916,920 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bfar
159 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:99
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000004217
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat

Markers in Region
D10Got229  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8102,057,347 - 2,057,573 (+)Marker Load Pipeline
mRatBN7.2101,550,172 - 1,550,398 (+)MAPPERmRatBN7.2
Rnor_6.0101,462,872 - 1,463,097NCBIRnor6.0
Rnor_5.010359,984 - 360,209UniSTSRnor5.0
RGSC_v3.4101,786,780 - 1,787,005UniSTSRGSC3.4
Celera10611,219 - 611,444UniSTS
Cytogenetic Map10q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004217   ⟹   ENSRNOP00000004217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl101,552,072 - 1,585,038 (+)Ensembl
Rnor_6.0 Ensembl101,464,765 - 1,497,653 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099882   ⟹   ENSRNOP00000078143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl101,567,664 - 1,585,038 (+)Ensembl
RefSeq Acc Id: NM_001013125   ⟹   NP_001013143
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8102,059,241 - 2,092,207 (+)NCBI
mRatBN7.2101,552,066 - 1,585,040 (+)NCBI
Rnor_6.0101,464,783 - 1,497,653 (+)NCBI
Rnor_5.010361,895 - 394,582 (+)NCBI
RGSC_v3.41049 - 13,315 (+)RGD
Celera10613,130 - 645,931 (+)RGD
Sequence:
RefSeq Acc Id: NR_138253
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8102,059,241 - 2,065,665 (+)NCBI
mRatBN7.2101,552,066 - 1,558,490 (+)NCBI
RefSeq Acc Id: XM_039086234   ⟹   XP_038942162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8102,059,189 - 2,092,207 (+)NCBI
mRatBN7.2101,552,019 - 1,585,040 (+)NCBI
RefSeq Acc Id: XM_063269266   ⟹   XP_063125336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8102,059,301 - 2,092,207 (+)NCBI
RefSeq Acc Id: NP_001013143   ⟸   NM_001013125
- UniProtKB: Q5PQN2 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004217   ⟸   ENSRNOT00000004217
RefSeq Acc Id: XP_038942162   ⟸   XM_039086234
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y9Y1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078143   ⟸   ENSRNOT00000099882
RefSeq Acc Id: XP_063125336   ⟸   XM_063269266
- Peptide Label: isoform X1
- UniProtKB: Q5PQN2 (UniProtKB/Swiss-Prot)
Protein Domains
RING-type   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PQN2-F1-model_v2 AlphaFold Q5PQN2 1-450 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696925
Promoter ID:EPDNEW_R7450
Type:multiple initiation site
Name:Bfar_1
Description:bifunctional apoptosis regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0101,464,791 - 1,464,851EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304791 AgrOrtholog
BioCyc Gene G2FUF-26224 BioCyc
Ensembl Genes ENSRNOG00000003151 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055005086 UniProtKB/Swiss-Prot
  ENSRNOG00060012751 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004217.9 UniProtKB/Swiss-Prot
  ENSRNOT00000099882.1 UniProtKB/TrEMBL
  ENSRNOT00055008150 UniProtKB/Swiss-Prot
  ENSRNOT00060021662 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192877 IMAGE-MGC_LOAD
InterPro SAM UniProtKB/Swiss-Prot
  SAM/pointed_sf UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:304709 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94697 IMAGE-MGC_LOAD
NCBI Gene 304709 ENTREZGENE
PANTHER BIFUNCTIONAL APOPTOSIS REGULATOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SAM_1 UniProtKB/Swiss-Prot
  zf-C3HC4_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bfar PhenoGen
PROSITE SAM_DOMAIN UniProtKB/Swiss-Prot
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003151 RatGTEx
  ENSRNOG00055005086 RatGTEx
  ENSRNOG00060012751 RatGTEx
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47769 UniProtKB/Swiss-Prot
UniProt A0A8I5Y9Y1 ENTREZGENE, UniProtKB/TrEMBL
  BFAR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-09 Bfar  bifunctional apoptosis regulator  RGD1305537  similar to RIKEN cDNA 3110001I22  Data merged from RGD:1305537 737654 PROVISIONAL
2008-04-30 RGD1305537  similar to RIKEN cDNA 3110001I22   RGD1305537_predicted  similar to RIKEN cDNA 3110001I22 (predicted)  'predicted' is removed 2292626 APPROVED
2005-12-06 Bfar  bifunctional apoptosis regulator  Bfar_predicted  bifunctional apoptosis regulator (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1305537_predicted  similar to RIKEN cDNA 3110001I22 (predicted)  LOC363528_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 Bfar_predicted  bifunctional apoptosis regulator (predicted)      Symbol and Name status set to approved 70820 APPROVED
2005-01-12 LOC363528_predicted  similar to RIKEN cDNA 3110001I22 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL