Plin4 (perilipin 4) - Rat Genome Database

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Gene: Plin4 (perilipin 4) Rattus norvegicus
Analyze
Symbol: Plin4
Name: perilipin 4
RGD ID: 1590867
Description: Predicted to be located in cytosol; lipid droplet; and plasma membrane. Orthologous to human PLIN4 (perilipin 4); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; aconitine.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC363331; perilipin-4; similar to plasma membrane associated protein, S3-12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,016,334 - 1,025,249 (-)NCBIGRCr8
mRatBN7.29929,168 - 938,062 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9929,176 - 938,056 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0910,963,494 - 10,972,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,963,723 - 10,971,277 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,950,449 - 9,959,307 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,569,598 - 7,577,672 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aconitine  (EXP)
Aflatoxin B2 alpha  (ISO)
aldrin  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
difenoconazole  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
fenofibrate  (ISO)
genistein  (ISO)
glyphosate  (ISO)
graphene oxide  (ISO)
graphite  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
ketoconazole  (EXP)
Licarin A  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (ISO)
nickel atom  (ISO)
oleic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (ISO)
Theaflavin 3,3'-digallate  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
lipid droplet  (ISO)
plasma membrane  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9624692   PMID:21498505   PMID:31505169  


Genomics

Comparative Map Data
Plin4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,016,334 - 1,025,249 (-)NCBIGRCr8
mRatBN7.29929,168 - 938,062 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9929,176 - 938,056 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0910,963,494 - 10,972,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,963,723 - 10,971,277 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,950,449 - 9,959,307 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,569,598 - 7,577,672 (+)NCBICelera
Cytogenetic Map9q11NCBI
PLIN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,502,192 - 4,518,486 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,502,192 - 4,518,486 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,502,204 - 4,518,498 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,453,192 - 4,468,716 (-)NCBINCBI36Build 36hg18NCBI36
Celera194,440,384 - 4,456,502 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef194,263,728 - 4,279,514 (-)NCBIHuRef
CHM1_1194,502,353 - 4,517,894 (-)NCBICHM1_1
T2T-CHM13v2.0194,485,651 - 4,503,969 (-)NCBIT2T-CHM13v2.0
Plin4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,407,587 - 56,416,947 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,407,591 - 56,416,803 (-)EnsemblGRCm39 Ensembl
GRCm381756,100,587 - 56,109,948 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,100,591 - 56,109,803 (-)EnsemblGRCm38mm10GRCm38
MGSCv371756,240,014 - 56,249,225 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361755,693,887 - 55,703,096 (-)NCBIMGSCv36mm8
Celera1759,519,252 - 59,528,463 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.16NCBI
Plin4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554954,417,672 - 4,426,945 (+)NCBIChiLan1.0ChiLan1.0
PLIN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,896,360 - 8,912,729 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,126,185 - 8,142,539 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,522,090 - 3,542,567 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,471,393 - 4,487,696 (-)NCBIpanpan1.1PanPan1.1panPan2
PLIN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,192,340 - 55,204,878 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,192,559 - 55,203,039 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2054,920,436 - 54,933,201 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02055,850,367 - 55,863,134 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2055,850,424 - 55,863,134 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12054,912,331 - 54,925,082 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,392,870 - 55,405,630 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,591,145 - 55,604,603 (+)NCBIUU_Cfam_GSD_1.0
Plin4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,207,749 - 215,219,532 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365882,615,251 - 2,626,991 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLIN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,318,628 - 74,331,909 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,318,624 - 74,331,920 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2274,811,668 - 74,824,921 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLIN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.164,232,908 - 4,247,248 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl64,229,480 - 4,246,905 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660813,945,448 - 3,960,594 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Plin4
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:110
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000075424
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat

Markers in Region
RH132982  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29929,247 - 929,442 (-)MAPPERmRatBN7.2
Rnor_6.0910,972,086 - 10,972,280NCBIRnor6.0
Rnor_5.099,959,033 - 9,959,227UniSTSRnor5.0
Celera97,577,398 - 7,577,592UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 19 8 3 7 10 3 1 7
Low 3 10 11 3 12 3 1 1 16 14 10 9 1
Below cutoff 4 13 13 3 13 19 6 14 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_006244372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008757920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008757921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008757922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008757923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008757924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008757929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008757934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008757941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000075424   ⟹   ENSRNOP00000065507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9929,176 - 938,056 (-)Ensembl
Rnor_6.0 Ensembl910,963,723 - 10,971,277 (+)Ensembl
RefSeq Acc Id: XM_006244372   ⟹   XP_006244434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,016,334 - 1,025,229 (-)NCBI
mRatBN7.29929,168 - 938,061 (-)NCBI
Rnor_6.0910,963,503 - 10,972,360 (+)NCBI
Rnor_5.099,950,449 - 9,959,307 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244374   ⟹   XP_006244436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,016,334 - 1,025,229 (-)NCBI
mRatBN7.29929,168 - 938,061 (-)NCBI
Rnor_6.0910,963,503 - 10,972,360 (+)NCBI
Rnor_5.099,950,449 - 9,959,307 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244375   ⟹   XP_006244437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,016,334 - 1,025,229 (-)NCBI
mRatBN7.29929,168 - 938,061 (-)NCBI
Rnor_6.0910,963,503 - 10,972,360 (+)NCBI
Rnor_5.099,950,449 - 9,959,307 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063267952   ⟹   XP_063124022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,016,334 - 1,025,249 (-)NCBI
RefSeq Acc Id: XM_063267953   ⟹   XP_063124023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,016,334 - 1,025,248 (-)NCBI
RefSeq Acc Id: XM_063267954   ⟹   XP_063124024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,016,334 - 1,025,247 (-)NCBI
RefSeq Acc Id: XM_063267955   ⟹   XP_063124025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,016,334 - 1,024,776 (-)NCBI
RefSeq Acc Id: XM_063267956   ⟹   XP_063124026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,017,744 - 1,025,229 (-)NCBI
RefSeq Acc Id: XM_063267957   ⟹   XP_063124027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,017,745 - 1,025,229 (-)NCBI
RefSeq Acc Id: XP_006244434   ⟸   XM_006244372
- Peptide Label: isoform X1
- UniProtKB: M0R7S5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244436   ⟸   XM_006244374
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006244437   ⟸   XM_006244375
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000065507   ⟸   ENSRNOT00000075424
RefSeq Acc Id: XP_063124022   ⟸   XM_063267952
- Peptide Label: isoform X1
- UniProtKB: M0R7S5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124023   ⟸   XM_063267953
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063124024   ⟸   XM_063267954
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063124025   ⟸   XM_063267955
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063124026   ⟸   XM_063267956
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063124027   ⟸   XM_063267957
- Peptide Label: isoform X6

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7S5-F1-model_v2 AlphaFold M0R7S5 1-1395 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590867 AgrOrtholog
BioCyc Gene G2FUF-28563 BioCyc
Ensembl Genes ENSRNOG00000047046 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075424.3 UniProtKB/TrEMBL
Gene3D-CATH Flagellar protein FliS UniProtKB/TrEMBL
InterPro Perilipin UniProtKB/TrEMBL
KEGG Report rno:363331 UniProtKB/TrEMBL
NCBI Gene 363331 ENTREZGENE
PANTHER PERILIPIN 4 UniProtKB/TrEMBL
  PERILIPIN-4 UniProtKB/TrEMBL
Pfam Perilipin UniProtKB/TrEMBL
PhenoGen Plin4 PhenoGen
RatGTEx ENSRNOG00000047046 RatGTEx
Superfamily-SCOP Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain UniProtKB/TrEMBL
UniProt M0R7S5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-18 Plin4  perilipin 4  LOC363331  similar to plasma membrane associated protein, S3-12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC363331  similar to plasma membrane associated protein, S3-12      Symbol and Name status set to provisional 70820 PROVISIONAL