Cyp51 (cytochrome P450, family 51) - Rat Genome Database

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Gene: Cyp51 (cytochrome P450, family 51) Rattus norvegicus
Analyze
Symbol: Cyp51
Name: cytochrome P450, family 51
RGD ID: 2481
Description: Exhibits sterol 14-demethylase activity. Involved in cholesterol biosynthetic process via 24,25-dihydrolanosterol. Localizes to intracellular membrane-bounded organelle. Orthologous to human CYP51A1 (cytochrome P450 family 51 subfamily A member 1); PARTICIPATES IN cholesterol biosynthetic pathway; alendronate pharmacodynamics pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cyp51a1; CYPLI; Cytochrom P450 Lanosterol 14 alpha-demethylase; cytochrome P450 51A1; cytochrome P450 Lanosterol 14 alpha-demethylase; cytochrome P450, subfamily 51; cytochrome P450-14DM; cytochrome P45014DM; cytochrome P450LI; lanosterol 14-alpha demethylase; LDM; MGC93630; P450-14DM; P45014DM; P450LI; RATCP14DM; sterol 14-alpha demethylase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2430,036,956 - 30,055,410 (+)NCBI
Rnor_6.0 Ensembl427,175,243 - 27,194,018 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0427,175,564 - 27,194,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0427,078,790 - 27,097,244 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4426,752,677 - 26,771,131 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1426,758,233 - 26,776,686 (+)NCBI
Celera425,462,810 - 25,481,264 (+)NCBICelera
Cytogenetic Map4q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-hydroxypropanoic acid  (ISO)
22-Hydroxycholesterol  (ISO)
24,25-dihydrolanosterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acetohydrazide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
alpha-hexachlorocyclohexane  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP)
bifonazole  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bitertanol  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (EXP)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
difenoconazole  (EXP,ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diuron  (EXP)
econazole  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
epoxiconazole  (ISO)
ergosterol  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenarimol  (EXP,ISO)
fipronil  (ISO)
fluconazole  (ISO)
fluoranthene  (ISO)
flusilazole  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
glycidol  (EXP)
hexaconazole  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
itraconazole  (ISO)
ketoconazole  (EXP,ISO)
lanosterol  (EXP,ISO)
lead nitrate  (EXP,ISO)
leflunomide  (EXP,ISO)
letrozole  (ISO)
levofloxacin  (EXP)
limonene  (EXP)
lithocholic acid  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N(6)-butyryl-cAMP  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
obeticholic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
penconazole  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylpropanolamine  (ISO)
phosgene  (ISO)
phytosterols  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
prochloraz  (ISO)
progesterone  (ISO)
propiconazole  (EXP,ISO)
prothioconazole  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
Rebamipide  (EXP)
resveratrol  (ISO)
ritodrine  (ISO)
ritonavir  (EXP)
rotenone  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
toluene  (EXP)
tremolite asbestos  (ISO)
triadimefon  (EXP,ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
voriconazole  (ISO)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

References

References - curated
1. Aoyama Y, etal., Biochem Biophys Res Commun 1994 Jun 30;201(3):1320-6.
2. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Herman GE Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
4. Keber R, etal., J Biol Chem. 2011 Aug 19;286(33):29086-97. doi: 10.1074/jbc.M111.253245. Epub 2011 Jun 25.
5. Kojima M, etal., Arch Toxicol. 2002 Jul;76(7):398-403. doi: 10.1007/s00204-002-0365-3. Epub 2002 Jun 18.
6. Majdic G, etal., J Endocrinol. 2000 Aug;166(2):463-74. doi: 10.1677/joe.0.1660463.
7. MGD data from the GO Consortium
8. NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Pipeline to import KEGG annotations from KEGG into RGD
10. Pipeline to import SMPDB annotations from SMPDB into RGD
11. RGD automated data pipeline
12. RGD automated import pipeline for gene-chemical interactions
13. RGD comprehensive gene curation
14. Sloane DL, etal., Gene 1995 Aug 19;161(2):243-8.
15. Sonoda Y, etal., Biol Pharm Bull. 1995 Jul;18(7):1009-11.
16. Strömstedt M, etal., Endocrinology. 1998 May;139(5):2314-21. doi: 10.1210/endo.139.5.5984.
17. Vaknin KM, etal., Biol Reprod. 2001 Jan;64(1):299-309. doi: 10.1095/biolreprod64.1.299.
18. Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
19. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
20. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
21. Yamashita C, etal., J Biochem. 2000 Jul;128(1):93-9. doi: 10.1093/oxfordjournals.jbchem.a022734.
22. Yan LP, etal., Life Sci. 2006 Jun 20;79(4):324-30. doi: 10.1016/j.lfs.2006.01.016. Epub 2006 Feb 10.
Additional References at PubMed
PMID:9498553   PMID:12477932   PMID:15269103   PMID:15489334   PMID:19946888   PMID:20149798   PMID:20876579   PMID:22871113   PMID:31352176  


Genomics

Comparative Map Data
Cyp51
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2430,036,956 - 30,055,410 (+)NCBI
Rnor_6.0 Ensembl427,175,243 - 27,194,018 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0427,175,564 - 27,194,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0427,078,790 - 27,097,244 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4426,752,677 - 26,771,131 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1426,758,233 - 26,776,686 (+)NCBI
Celera425,462,810 - 25,481,264 (+)NCBICelera
Cytogenetic Map4q13NCBI
CYP51A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl792,112,153 - 92,134,803 (-)EnsemblGRCh38hg38GRCh38
GRCh38792,112,153 - 92,134,803 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37791,741,467 - 91,764,117 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36791,579,402 - 91,601,946 (-)NCBINCBI36hg18NCBI36
Build 34791,386,116 - 91,408,661NCBI
Celera786,446,011 - 86,468,618 (-)NCBI
Cytogenetic Map7q21.2NCBI
HuRef786,348,902 - 86,371,499 (-)NCBIHuRef
CHM1_1791,671,533 - 91,694,128 (-)NCBICHM1_1
CRA_TCAGchr7v2791,070,701 - 91,093,297 (-)NCBI
Cyp51
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3954,130,674 - 4,154,697 (-)NCBIGRCm39mm39
GRCm39 Ensembl54,131,145 - 4,154,746 (-)Ensembl
GRCm3854,080,674 - 4,104,697 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl54,081,145 - 4,104,746 (-)EnsemblGRCm38mm10GRCm38
MGSCv3754,080,674 - 4,104,697 (-)NCBIGRCm37mm9NCBIm37
MGSCv3654,086,680 - 4,110,703 (-)NCBImm8
Celera54,010,747 - 4,034,762 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.3NCBI
LOC102027002
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554329,092,933 - 9,112,615 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554329,092,923 - 9,112,615 (-)NCBIChiLan1.0ChiLan1.0
CYP51A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1797,708,806 - 97,730,486 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl797,708,806 - 97,729,824 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0784,110,130 - 84,132,870 (-)NCBIMhudiblu_PPA_v0panPan3
CYP51A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11417,746,654 - 17,767,019 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1417,746,656 - 17,766,658 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1417,307,241 - 17,328,397 (-)NCBI
ROS_Cfam_1.01417,552,569 - 17,573,808 (-)NCBI
UMICH_Zoey_3.11417,710,915 - 17,732,068 (-)NCBI
UNSW_CanFamBas_1.01417,425,396 - 17,446,546 (-)NCBI
UU_Cfam_GSD_1.01417,699,282 - 17,720,469 (-)NCBI
LOC101955024
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511831,136,259 - 31,159,424 (-)NCBI
SpeTri2.0NW_0049366212,209,255 - 2,232,404 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP51A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl972,057,511 - 72,079,444 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1972,057,506 - 72,079,587 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2978,792,905 - 78,814,951 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP51A1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12156,865,498 - 56,888,196 (+)NCBI
ChlSab1.1 Ensembl2156,865,312 - 56,886,698 (+)Ensembl
LOC101724157
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248091,080,427 - 1,110,802 (+)NCBI

Position Markers
RH128867  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0427,193,800 - 27,193,986NCBIRnor6.0
Rnor_5.0427,097,026 - 27,097,212UniSTSRnor5.0
RGSC_v3.4426,770,913 - 26,771,099UniSTSRGSC3.4
Celera425,481,046 - 25,481,232UniSTS
RH 3.4 Map4168.4UniSTS
Cytogenetic Map4q13UniSTS
RH129291  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0427,193,809 - 27,193,991NCBIRnor6.0
Rnor_5.0427,097,035 - 27,097,217UniSTSRnor5.0
RGSC_v3.4426,770,922 - 26,771,104UniSTSRGSC3.4
Celera425,481,055 - 25,481,237UniSTS
RH 3.4 Map4168.4UniSTS
Cytogenetic Map4q13UniSTS
RH137266  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0427,193,296 - 27,193,476NCBIRnor6.0
Rnor_5.0427,096,522 - 27,096,702UniSTSRnor5.0
RGSC_v3.4426,770,409 - 26,770,589UniSTSRGSC3.4
Celera425,480,542 - 25,480,722UniSTS
RH 3.4 Map9723.0UniSTS
Cytogenetic Map4q13UniSTS
RH141214  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0427,192,922 - 27,193,101NCBIRnor6.0
Rnor_5.0427,096,148 - 27,096,327UniSTSRnor5.0
RGSC_v3.4426,770,035 - 26,770,214UniSTSRGSC3.4
Celera425,480,168 - 25,480,347UniSTS
RH 3.4 Map6547.8UniSTS
Cytogenetic Map4q13UniSTS
UniSTS:256608  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0680,127,507 - 80,128,137NCBIRnor6.0
Rnor_5.0689,653,379 - 89,654,009UniSTSRnor5.0
RGSC_v3.4679,727,169 - 79,727,799UniSTSRGSC3.4
Celera675,486,561 - 75,487,191UniSTS
Cytogenetic Map6q23UniSTS
Cytogenetic Map4q13UniSTS
Cyp51  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0680,128,250 - 80,128,566NCBIRnor6.0
Rnor_5.0689,654,122 - 89,654,438UniSTSRnor5.0
RGSC_v3.4679,727,912 - 79,728,228UniSTSRGSC3.4
Celera675,487,304 - 75,487,620UniSTS
Cytogenetic Map6q23UniSTS
Cytogenetic Map4q13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4128352196Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4128352196Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4128352196Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4128352196Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4129778604Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4129778604Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4131554484Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)4142118977Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4304323179575658Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)43043231145254791Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304401755791834Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304401764915903Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304780755324857Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4646769343414792Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4657293937703537Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)4734240492484039Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4805218953052189Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)4805218953052189Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)4805218953052189Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4805218953052189Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4805218953052189Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)4805218953052189Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41263897457638974Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41614994161149941Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)41822218737685319Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41822218743414792Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)41822218761039065Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)41961886631825560Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)423850384169318094Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42399172176238799Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42399172176238799Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)42463187469631874Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42665474981874227Rat


Related Rat Strains
The following Strains have been annotated to Cyp51

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:46
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000009985
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 57 41 19 41 3 3 74 35 41 11 3
Low 3 5 8 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009985   ⟹   ENSRNOP00000009985
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl427,175,243 - 27,194,018 (+)Ensembl
RefSeq Acc Id: NM_012941   ⟹   NP_037073
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2430,036,956 - 30,055,410 (+)NCBI
Rnor_6.0427,175,564 - 27,194,018 (+)NCBI
Rnor_5.0427,078,790 - 27,097,244 (+)NCBI
RGSC_v3.4426,752,677 - 26,771,131 (+)RGD
Celera425,462,810 - 25,481,264 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037073   ⟸   NM_012941
- UniProtKB: Q64654 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009985   ⟸   ENSRNOT00000009985

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692842
Promoter ID:EPDNEW_R3366
Type:initiation region
Name:Cyp51_1
Description:cytochrome P450, family 51
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0427,175,501 - 27,175,561EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2481 AgrOrtholog
Ensembl Genes ENSRNOG00000007234 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000009985 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009985 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7130609 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
KEGG Report rno:25427 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93630 IMAGE-MGC_LOAD
NCBI Gene 25427 ENTREZGENE
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp51 PhenoGen
PRINTS EP450IV UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt CP51A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q64549 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp51  cytochrome P450, family 51  Cyp51  cytochrome P450, subfamily 51  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cyp51  cytochrome P450, subfamily 51     Cytochrom P450 Lanosterol 14 alpha-demethylase  Name updated 625702 APPROVED
2002-06-10 Cyp51  Cytochrom P450 Lanosterol 14 alpha-demethylase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in uterine tumors 70348
gene_disease upregulated in uterine tumors 70557
gene_expression expressed in uterus 70557