Cyp51 (cytochrome P450, family 51)

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Gene: Cyp51 (cytochrome P450, family 51) Rattus norvegicus

Analyze

Symbol:

Cyp51

Name:

cytochrome P450, family 51

RGD ID:

2481

Description:

Exhibits sterol 14-demethylase activity. Involved in cholesterol biosynthetic process via 24,25-dihydrolanosterol. Localizes to intracellular membrane-bounded organelle. Orthologous to human CYP51A1 (cytochrome P450 family 51 subfamily A member 1); PARTICIPATES IN cholesterol biosynthetic pathway; alendronate pharmacodynamics pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

Cyp51a1; CYPLI; Cytochrom P450 Lanosterol 14 alpha-demethylase; cytochrome P450 51A1; cytochrome P450 Lanosterol 14 alpha-demethylase; cytochrome P450, subfamily 51; cytochrome P450-14DM; cytochrome P45014DM; cytochrome P450LI; lanosterol 14-alpha demethylase; LDM; MGC93630; P450-14DM; P45014DM; P450LI; RATCP14DM; sterol 14-alpha demethylase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Is Marker For:

Strains: BB/OK

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	30,036,956 - 30,055,410 (+)	NCBI
Rnor_6.0 Ensembl	4	27,175,243 - 27,194,018 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	4	27,175,564 - 27,194,018 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	4	27,078,790 - 27,097,244 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	26,752,677 - 26,771,131 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	4	26,758,233 - 26,776,686 (+)	NCBI
Celera	4	25,462,810 - 25,481,264 (+)	NCBI		Celera
Cytogenetic Map	4	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Antley-Bixler syndrome (ISO)

diabetes mellitus (IEP)

Hypercholesterolemia (IEP)

long QT syndrome (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-(3-(trifluoromethyl)phenyl)piperazine (EXP)

1-benzylpiperazine (EXP)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

1H-pyrazole (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-amino-2-deoxy-D-glucopyranose (ISO)

2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one (ISO)

2-hydroxypropanoic acid (ISO)

22-Hydroxycholesterol (ISO)

24,25-dihydrolanosterol (ISO)

3',5'-cyclic AMP (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

acetamide (EXP)

acetohydrazide (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (ISO)

alpha-hexachlorocyclohexane (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

benzalkonium chloride (ISO)

benzo[a]pyrene (ISO)

beta-D-glucosamine (ISO)

beta-naphthoflavone (EXP,ISO)

bezafibrate (EXP)

bifonazole (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bitertanol (ISO)

bromobenzene (EXP)

Butylbenzyl phthalate (EXP)

carbon nanotube (ISO)

cerium trichloride (ISO)

chloroprene (ISO)

chromium(6+) (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

clobetasol (ISO)

clotrimazole (ISO)

cobalt dichloride (ISO)

cocaine (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) sulfate (ISO)

coumarin (EXP)

coumestrol (ISO)

cyclosporin A (EXP,ISO)

cyproconazole (ISO)

dexamethasone (EXP,ISO)

dibutyl phthalate (EXP,ISO)

dichloromethane (ISO)

diclofenac (ISO)

difenoconazole (EXP,ISO)

dioxygen (ISO)

dipentyl phthalate (EXP)

diuron (EXP)

econazole (ISO)

endosulfan (EXP)

enilconazole (ISO)

epoxiconazole (ISO)

ergosterol (ISO)

erlotinib hydrochloride (ISO)

ethanol (EXP,ISO)

ethyl methanesulfonate (ISO)

fenarimol (EXP,ISO)

fipronil (ISO)

fluconazole (ISO)

fluoranthene (ISO)

flusilazole (EXP,ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

furan (ISO)

gamma-hexachlorocyclohexane (EXP)

genistein (ISO)

glycidol (EXP)

hexaconazole (ISO)

hydrazine (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

isotretinoin (ISO)

itraconazole (ISO)

ketoconazole (EXP,ISO)

lanosterol (EXP,ISO)

lead nitrate (EXP,ISO)

leflunomide (EXP,ISO)

letrozole (ISO)

levofloxacin (EXP)

limonene (EXP)

lithocholic acid (ISO)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

miconazole (ISO)

mono(2-ethylhexyl) phthalate (EXP)

N(6)-butyryl-cAMP (ISO)

N-nitrosodiethylamine (EXP,ISO)

obeticholic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

penconazole (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (EXP,ISO)

phenylephrine (EXP)

phenylpropanolamine (ISO)

phosgene (ISO)

phytosterols (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

pravastatin (EXP,ISO)

prochloraz (ISO)

progesterone (ISO)

propiconazole (EXP,ISO)

prothioconazole (ISO)

pyrazinecarboxamide (EXP)

quercetin (ISO)

quercetin 3-O-beta-D-glucofuranoside (ISO)

quercetin 3-O-beta-D-glucopyranoside (ISO)

quinolin-8-ol (ISO)

rac-lactic acid (ISO)

Rebamipide (EXP)

resveratrol (ISO)

ritodrine (ISO)

ritonavir (EXP)

rotenone (EXP)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

simvastatin (EXP)

sodium dodecyl sulfate (EXP)

sodium fluoride (ISO)

succimer (ISO)

sunitinib (ISO)

tamoxifen (ISO)

tebuconazole (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tolcapone (EXP)

toluene (EXP)

tremolite asbestos (ISO)

triadimefon (EXP,ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP)

valdecoxib (EXP)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

voriconazole (ISO)

Yessotoxin (ISO)

zaragozic acid A (EXP,ISO)

zearalenone (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cholesterol biosynthetic process via 24,25-dihydrolanosterol (IDA)

demethylation (IEA)

negative regulation of amyloid-beta clearance (ISO)

negative regulation of protein catabolic process (ISO)

negative regulation of protein secretion (ISO)

positive regulation of oocyte development (IMP)

regulation of cholesterol biosynthetic process (TAS)

response to human chorionic gonadotropin (IEP)

response to insulin (IEP)

response to lead ion (IEP)

spermatogenesis (IEP)

steroid biosynthetic process (ISO)

sterol metabolic process (IBA)

Cellular Component

acrosomal vesicle (IDA)

cytoplasm (IDA)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (IEA)

integral component of membrane (IEA)

intracellular membrane-bounded organelle (IDA)

Molecular Function

heme binding (ISO)

iron ion binding (IEA)

monooxygenase activity (IBA)

oxidoreductase activity (IBA)

sterol 14-demethylase activity (IDA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

alendronate pharmacodynamics pathway (ISO)

cholesterol biosynthetic pathway (IDA,ISO)

cholesterol ester storage disease pathway (ISO)

congenital hemidysplasia with ichthyosiform erythroderma and limb defects pathway (ISO)

desmosterolosis pathway (ISO)

hypercholesterolemia pathway (ISO)

ibandronate pharmacodynamics pathway (ISO)

mevalonic aciduria pathway (ISO)

nitrogenous bisphosphonate pharmacodynamics pathway (ISO)

pamidronate pharmacodynamics pathway (ISO)

risedronate pharmacodynamics pathway (ISO)

Smith-Lemli-Opitz Syndrome pathway (ISO)

statin pharmacodynamics pathway (ISO)

steroid biosynthetic pathway (IEA)

Wolman disease pathway (ISO)

X-linked dominant chondrodysplasia punctata 2 pathway (ISO)

zoledronate pharmacodynamics pathway (ISO)

References

References - curated


1.	Aoyama Y, etal., Biochem Biophys Res Commun 1994 Jun 30;201(3):1320-6.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Herman GE Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
4.	Keber R, etal., J Biol Chem. 2011 Aug 19;286(33):29086-97. doi: 10.1074/jbc.M111.253245. Epub 2011 Jun 25.
5.	Kojima M, etal., Arch Toxicol. 2002 Jul;76(7):398-403. doi: 10.1007/s00204-002-0365-3. Epub 2002 Jun 18.
6.	Majdic G, etal., J Endocrinol. 2000 Aug;166(2):463-74. doi: 10.1677/joe.0.1660463.
7.	MGD data from the GO Consortium
8.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	Pipeline to import KEGG annotations from KEGG into RGD
10.	Pipeline to import SMPDB annotations from SMPDB into RGD
11.	RGD automated data pipeline
12.	RGD automated import pipeline for gene-chemical interactions
13.	RGD comprehensive gene curation
14.	Sloane DL, etal., Gene 1995 Aug 19;161(2):243-8.
15.	Sonoda Y, etal., Biol Pharm Bull. 1995 Jul;18(7):1009-11.
16.	Strömstedt M, etal., Endocrinology. 1998 May;139(5):2314-21. doi: 10.1210/endo.139.5.5984.
17.	Vaknin KM, etal., Biol Reprod. 2001 Jan;64(1):299-309. doi: 10.1095/biolreprod64.1.299.
18.	Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
19.	Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
20.	Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
21.	Yamashita C, etal., J Biochem. 2000 Jul;128(1):93-9. doi: 10.1093/oxfordjournals.jbchem.a022734.
22.	Yan LP, etal., Life Sci. 2006 Jun 20;79(4):324-30. doi: 10.1016/j.lfs.2006.01.016. Epub 2006 Feb 10.

Additional References at PubMed

PMID:9498553	PMID:12477932	PMID:15269103	PMID:15489334	PMID:19946888	PMID:20149798	PMID:20876579	PMID:22871113	PMID:31352176

Genomics

Comparative Map Data

Cyp51
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	30,036,956 - 30,055,410 (+)	NCBI
Rnor_6.0 Ensembl	4	27,175,243 - 27,194,018 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	4	27,175,564 - 27,194,018 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	4	27,078,790 - 27,097,244 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	26,752,677 - 26,771,131 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	4	26,758,233 - 26,776,686 (+)	NCBI
Celera	4	25,462,810 - 25,481,264 (+)	NCBI		Celera
Cytogenetic Map	4	q13	NCBI

CYP51A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	7	92,112,153 - 92,134,803 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	7	92,112,153 - 92,134,803 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	7	91,741,467 - 91,764,117 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	91,579,402 - 91,601,946 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	7	91,386,116 - 91,408,661	NCBI
Celera	7	86,446,011 - 86,468,618 (-)	NCBI
Cytogenetic Map	7	q21.2	NCBI
HuRef	7	86,348,902 - 86,371,499 (-)	NCBI		HuRef
CHM1_1	7	91,671,533 - 91,694,128 (-)	NCBI		CHM1_1
CRA_TCAGchr7v2	7	91,070,701 - 91,093,297 (-)	NCBI

Cyp51
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	4,130,674 - 4,154,697 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	5	4,131,145 - 4,154,746 (-)	Ensembl
GRCm38	5	4,080,674 - 4,104,697 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	4,081,145 - 4,104,746 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	4,080,674 - 4,104,697 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	5	4,086,680 - 4,110,703 (-)	NCBI			mm8
Celera	5	4,010,747 - 4,034,762 (-)	NCBI		Celera
Cytogenetic Map	5	A1	NCBI
cM Map	5	2.3	NCBI

LOC102027002
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	9,092,933 - 9,112,615 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955432	9,092,923 - 9,112,615 (-)	NCBI	ChiLan1.0	ChiLan1.0

CYP51A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	7	97,708,806 - 97,730,486 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	97,708,806 - 97,729,824 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	7	84,110,130 - 84,132,870 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

CYP51A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	17,746,654 - 17,767,019 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	17,746,656 - 17,766,658 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	17,307,241 - 17,328,397 (-)	NCBI
ROS_Cfam_1.0	14	17,552,569 - 17,573,808 (-)	NCBI
UMICH_Zoey_3.1	14	17,710,915 - 17,732,068 (-)	NCBI
UNSW_CanFamBas_1.0	14	17,425,396 - 17,446,546 (-)	NCBI
UU_Cfam_GSD_1.0	14	17,699,282 - 17,720,469 (-)	NCBI

LOC101955024
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	31,136,259 - 31,159,424 (-)	NCBI
SpeTri2.0	NW_004936621	2,209,255 - 2,232,404 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYP51A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	72,057,511 - 72,079,444 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	72,057,506 - 72,079,587 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	78,792,905 - 78,814,951 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CYP51A1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	56,865,498 - 56,888,196 (+)	NCBI
ChlSab1.1 Ensembl	21	56,865,312 - 56,886,698 (+)	Ensembl

LOC101724157
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624809	1,080,427 - 1,110,802 (+)	NCBI

Position Markers

RH128867

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	4	27,193,800 - 27,193,986	NCBI	Rnor6.0
Rnor_5.0	4	27,097,026 - 27,097,212	UniSTS	Rnor5.0
RGSC_v3.4	4	26,770,913 - 26,771,099	UniSTS	RGSC3.4
Celera	4	25,481,046 - 25,481,232	UniSTS
RH 3.4 Map	4	168.4	UniSTS
Cytogenetic Map	4	q13	UniSTS

RH129291

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	4	27,193,809 - 27,193,991	NCBI	Rnor6.0
Rnor_5.0	4	27,097,035 - 27,097,217	UniSTS	Rnor5.0
RGSC_v3.4	4	26,770,922 - 26,771,104	UniSTS	RGSC3.4
Celera	4	25,481,055 - 25,481,237	UniSTS
RH 3.4 Map	4	168.4	UniSTS
Cytogenetic Map	4	q13	UniSTS

RH137266

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	4	27,193,296 - 27,193,476	NCBI	Rnor6.0
Rnor_5.0	4	27,096,522 - 27,096,702	UniSTS	Rnor5.0
RGSC_v3.4	4	26,770,409 - 26,770,589	UniSTS	RGSC3.4
Celera	4	25,480,542 - 25,480,722	UniSTS
RH 3.4 Map	9	723.0	UniSTS
Cytogenetic Map	4	q13	UniSTS

RH141214

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	4	27,192,922 - 27,193,101	NCBI	Rnor6.0
Rnor_5.0	4	27,096,148 - 27,096,327	UniSTS	Rnor5.0
RGSC_v3.4	4	26,770,035 - 26,770,214	UniSTS	RGSC3.4
Celera	4	25,480,168 - 25,480,347	UniSTS
RH 3.4 Map	6	547.8	UniSTS
Cytogenetic Map	4	q13	UniSTS

UniSTS:256608

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	6	80,127,507 - 80,128,137	NCBI	Rnor6.0
Rnor_5.0	6	89,653,379 - 89,654,009	UniSTS	Rnor5.0
RGSC_v3.4	6	79,727,169 - 79,727,799	UniSTS	RGSC3.4
Celera	6	75,486,561 - 75,487,191	UniSTS
Cytogenetic Map	6	q23	UniSTS
Cytogenetic Map	4	q13	UniSTS

Cyp51

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	6	80,128,250 - 80,128,566	NCBI	Rnor6.0
Rnor_5.0	6	89,654,122 - 89,654,438	UniSTS	Rnor5.0
RGSC_v3.4	6	79,727,912 - 79,728,228	UniSTS	RGSC3.4
Celera	6	75,487,304 - 75,487,620	UniSTS
Cytogenetic Map	6	q23	UniSTS
Cytogenetic Map	4	q13	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589046	Scfw2	Subcutaneous fat weight QTL 2	5.54	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	4	1	28352196	Rat
9589097	Slep11	Serum leptin concentration QTL 11	5.09	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	4	1	28352196	Rat
9590100	Sffal4	Serum free fatty acids level QTL 4	7.36	0.05	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	4	1	28352196	Rat
8552903	Pigfal2	Plasma insulin-like growth factor 1 level QTL 2	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	1	28352196	Rat
1357343	Gluco4	Glucose level QTL 4		0.00002	adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	4	1	29778604	Rat
1357341	Gluco5	Glucose level QTL 5	6.4		adipocyte free fatty acid secretion trait (VT:0010465)	absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)	4	1	29778604	Rat
738021	Hcar13	Hepatocarcinoma resistance QTL 13	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	4	1	31554484	Rat
634323	Hc2	Hypercalciuria QTL 2	2.15		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	4	1	42118977	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	3043231	79575658	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	3043231	145254791	Rat
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	3044017	55791834	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	3044017	64915903	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	3047807	55324857	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	6467693	43414792	Rat
1300141	Bp178	Blood pressure QTL 178			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	6572939	37703537	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	7342404	92484039	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	7850904	182171018	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	8052189	53052189	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	8052189	53052189	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	8052189	53052189	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	8052189	53052189	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	8052189	53052189	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	8052189	53052189	Rat
2303585	Bw86	Body weight QTL 86	4		body mass (VT:0001259)	body weight (CMO:0000012)	4	12638974	57638974	Rat
7387227	Uae40	Urinary albumin excretion QTL 40	2.9	0.0052	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	16149941	61149941	Rat
70222	Eae2	Experimental allergic encephalomyelitis QTL 2	4.3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	4	18222187	37685319	Rat
1354665	Stl10	Serum triglyceride level QTL 10	3.57		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	18222187	43414792	Rat
61412	Pia2	Pristane induced arthritis QTL 2	3.9		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	4	18222187	61039065	Rat
8552803	Bw144	Body weight QTL 144	16		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	19618866	31825560	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	23850384	169318094	Rat
6909122	Insul22	Insulin level QTL 22	4.63		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	4	23991721	76238799	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	23991721	76238799	Rat
1578655	Bmd11	Bone mineral density QTL 11	11		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	4	24631874	69631874	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	26654749	81874227	Rat

Related Rat Strains

The following Strains have been annotated to Cyp51

BB/OK

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	51
Count of miRNA genes:	46
Interacting mature miRNAs:	48
Transcripts:	ENSRNOT00000009985
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	40	57	41	19	41	3	3	74	35	41	11	3
Low		3					5	8					5
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB004096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC079436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY724494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D55681	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229545	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U17697	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000009985 ⟹ ENSRNOP00000009985

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	4	27,175,243 - 27,194,018 (+)	Ensembl

RefSeq Acc Id:

NM_012941 ⟹ NP_037073

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	30,036,956 - 30,055,410 (+)	NCBI
Rnor_6.0	4	27,175,564 - 27,194,018 (+)	NCBI
Rnor_5.0	4	27,078,790 - 27,097,244 (+)	NCBI
RGSC_v3.4	4	26,752,677 - 26,771,131 (+)	RGD
Celera	4	25,462,810 - 25,481,264 (+)	RGD

Sequence:

show sequence

TTTCCCGAGAAGCGGCAGGGACCTCGGCCTCCAGCTTACCGGGCGGATCGAAGCAGCGGTCGGG
ATGGTACTGCTGGGCTTGCTGCAGTCAGGCGGCTCGGTGCTCGGGCAGGCGATGGAGCAGGTGA
CAGGAGGCAACCTGCTTTCCACGCTGCTCATCGCCTGCGCCTTCACGCTTAGCCTTGTCTACCT
GTTCCGCCTCGCAGTGGGCCACATGGTCCAGCTGCCCGCTGGAGCGAAAAGTCCGCCATATATT
TACTCTCCAATTCCGTTCCTTGGCCACGCGATAGCATTTGGGAAAAGTCCAATTGAGTTCCTGG
AAAATGCATATGAGAAGTACGGACCTGTGTTTAGCTTTACCATGGTGGGCAAGACTTTCACTTA
CCTTTTGGGGAGTGACGCAGCCGCCCTGCTCTTCAACAGTAAGAACGAAGACCTGAATGCGGAA
GAGGTCTACGGTCGGCTGACAACGCCCGTGTTTGGGAAGGGAGTTGCATACGACGTGCCAAATG
CAGTTTTCCTGGAACAGAAGAAAATACTAAAAAGCGGCCTTAACATAGCCCACTTCAAGCAGTA
TGTTTCTATCATTGAAAAAGAAGCGAAGGAGTACTTTAAAAGTTGGGGAGAAAGCGGAGAAAGA
AATGTGTTTGAAGCGCTGTCTGAGCTCATAATTTTAACAGCTAGCCATTGCTTACATGGAAAGG
AAATTAGAAGTCAGCTCAACGAGAAGGTGGCTCAGCTGTACGCAGACCTGGATGGAGGCTTTAG
CCATGCCGCCTGGCTGTTGCCAGGCTGGCTGCCCCTGCCGAGTTTCAGGCGCAGGGACAGAGCC
CATCGAGAGATCAAGAATATTTTCTACAAGGCCATCCAGAAACGTAGGCTGTCAAAAGAACCAG
CCGAGGACATTCTTCAAACTTTACTGGATTCTACATACAAGGATGGGCGTCCTCTGACGGACGA
CGAGATCGCAGGGATGCTCATCGGACTGCTGCTGGCCGGACAGCACACATCCTCCACCACCAGT
GCCTGGATGGGCTTCTTTCTGGCCAGAGATAAACCACTTCAAGACAAATGCTACTTAGAACAGA
AAACGGTGTGCGGGGAGGATCTGCCTCCCTTAACTTATGAGCAGTTGAAGGATCTGAATTTACT
TGATAGATGCATAAAAGAAACACTAAGACTGAGGCCTCCTATAATGACCATGATGAGAATGGCC
AAGACCCCTCAGACTGTGGCTGGGTACACCATTCCTCCAGGACATCAGGTGTGTGTTTCTCCAA
CTGTCAATCAAAGACTGAAAGACTCCTGGGTAGAACGCTTGGACTTCAATCCTGACCGCTACCT
ACAGGACAACCCAGCGTCGGGAGAGAAGTTTGCCTATGTGCCGTTTGGAGCCGGGCGCCATCGT
TGTATTGGAGAAAATTTTGCCTATGTTCAAATTAAGACAATTTGGTCCACTATGCTTCGTTTAT
ATGAATTTGACCTCATCAATGGATATTTTCCCAGTGTGAATTATACAACAATGATTCATACCCC
AGAAAACCCAGTAATCCGTTACAAACGAAGATCAAAATGAAGAAAGGAACAAGGAGCCAGTGTG
GAGACGGGACTGCAAGCTGCAGCTTGGCAGAGAATGAAGCTTTGACACAGCTTTCATACTGTAC
TGTTTTTTAAGTGTGTGGTTCTGAAAGCCAGTTTGATTTTAATGTTTTATTAACTCGGTGATTT
TTGTCAGACCTAATGGCATTTGAAACAGTTATAATAGTTCTGATAGGATTTCAGGGAAGCCAAG
TTTATGTTAGAAATCGTTTAGGGGAGCCTCGGTATTCAGAGATGATACAGAATATAGCATCCAG
GTAACTAACTTCAGAAGCACACGTTGCCGTAGGGAGATTCCGGCTTGGAACTAGTTTGGGAAGT
TTTAAGCCTGGTCAGATGCTACAGAGGCAATGGGTCATTGGTGTGGTTGGGCCACTTCTGTGCG
TAAAGATGTGAGAGGGTGAAGGATAAGTTTTCTGCGAAGCTCTAGATGGTGTGAGTGCCCTTTG
TAGTGTTAACTGAGAGCACCACTCCAGCGAGATGGCAGCAATCTTGGACCTTATCTTGATAACC
TTATTTCCTAAAAATAATAAATACTAAAGAGTACTTATGTTATTGGTTCCAGAAAAATCCAAAA
TCAAATCCTTGTGGAATTTTTAATTTTAATTAAAAAAAAAAAAACAAGTACCATGATTTTAAAA
GTGTATGATTCTGAGCTTAGTGAATTCTGGCCTTGAGATTGAGGAATGGGGACATGGTATCATT
GCCCGTGTTCTTTGGAGGCTGTGCTCAGGAGCCAACCTAACAGATTGTTACCATGGGCCTAATT
CTGACCTGCCCATAATCTGTATTAGGAATCAAGAGATCTGTTGCTGGGTGTGGTGCTGCACACC
TGTAATACTAGTGCTCGGGCTGAGGCAGGAGGATTGAGAGTTTGAGGCCAACCTAGGCTACATA
GCAAGACTTAACACCCTCCCCAAAATAAAACCTTTTTTCTCTAAAGTATGTGTACTGGCTGGTC
TTAGGTGACAACCTGACACACGCTAGGGTCATCAGAGAAAAGGGAACCTCAGTTGAGGAAATGC
TGTAAGGATGCTTAGTGGTCAATGAGAGAGGGCCCAGCCCACTGTGGGTGGTTCCACCCCTAGG
CTGGTCATCCTGGGTCCTAAGAAAGCAGGCTGACTAAGACACCAGGAGCAAGACAGTAAGCAGC
ATCCTTCATGGCCTCTGCATCAGCTCCTGCCTTAGGTTCCTGACCCGCTTGAGTTCCCGTCCTG
ACTTTCTTTGATAATGAACAGTAGTATGGAAGTGTAAGCCAAATAACCCACCCCCACCCTCCCA
ACTTGCTTTTTGCTCATGGTGTTTTGTAGCAATAGAAACCCTAACTGTTACAGCTGTAAGAGGC
TTTTGAAGACTCTTCAAATGAAGGCCCAAATCTCTGCTGTTAAAGGTTTCAGATTAAAATTCTC
TATGAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_037073	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA87074	(Get FASTA)	NCBI Sequence Viewer
	AAH87033	(Get FASTA)	NCBI Sequence Viewer
	BAA09529	(Get FASTA)	NCBI Sequence Viewer
	BAA20354	(Get FASTA)	NCBI Sequence Viewer
	EDL84353	(Get FASTA)	NCBI Sequence Viewer
	Q64654	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_037073 ⟸ NM_012941

- UniProtKB:

Q64654 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MVLLGLLQSGGSVLGQAMEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKSPPYI
YSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAE
EVYGRLTTPVFGKGVAYDVPNAVFLEQKKILKSGLNIAHFKQYVSIIEKEAKEYFKSWGESGER
NVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRA
HREIKNIFYKAIQKRRLSKEPAEDILQTLLDSTYKDGRPLTDDEIAGMLIGLLLAGQHTSSTTS
AWMGFFLARDKPLQDKCYLEQKTVCGEDLPPLTYEQLKDLNLLDRCIKETLRLRPPIMTMMRMA
KTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHR
CIGENFAYVQIKTIWSTMLRLYEFDLINGYFPSVNYTTMIHTPENPVIRYKRRSK

hide sequence

RefSeq Acc Id:

ENSRNOP00000009985 ⟸ ENSRNOT00000009985

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692842

Promoter ID:

EPDNEW_R3366

Type:

initiation region

Name:

Cyp51_1

Description:

cytochrome P450, family 51

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	27,175,501 - 27,175,561	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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CSV

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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CSV

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2481	AgrOrtholog
Ensembl Genes	ENSRNOG00000007234	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000009985	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000009985	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.630.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7130609	IMAGE-MGC_LOAD
InterPro	Cyt_P450	UniProtKB/Swiss-Prot
	Cyt_P450_CS	UniProtKB/Swiss-Prot
	Cyt_P450_E_grp-IV	UniProtKB/Swiss-Prot
	Cyt_P450_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:25427	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93630	IMAGE-MGC_LOAD
NCBI Gene	25427	ENTREZGENE
Pfam	p450	UniProtKB/Swiss-Prot
PhenoGen	Cyp51	PhenoGen
PRINTS	EP450IV	UniProtKB/Swiss-Prot
	P450	UniProtKB/Swiss-Prot
PROSITE	CYTOCHROME_P450	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48264	UniProtKB/Swiss-Prot
UniProt	CP51A_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q64549	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-04-19	Cyp51	cytochrome P450, family 51	Cyp51	cytochrome P450, subfamily 51	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-11-06	Cyp51	cytochrome P450, subfamily 51		Cytochrom P450 Lanosterol 14 alpha-demethylase	Name updated	625702	APPROVED
2002-06-10	Cyp51	Cytochrom P450 Lanosterol 14 alpha-demethylase			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	upregulated in uterine tumors	70348
gene_disease	upregulated in uterine tumors	70557
gene_expression	expressed in uterus	70557

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)