Cyp51 (cytochrome P450, family 51) - Rat Genome Database

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Gene: Cyp51 (cytochrome P450, family 51) Rattus norvegicus
Symbol: Cyp51
Name: cytochrome P450, family 51
RGD ID: 2481
Description: Enables sterol 14-demethylase activity. Involved in several processes, including cholesterol biosynthetic process via 24,25-dihydrolanosterol; positive regulation of oocyte development; and response to human chorionic gonadotropin. Located in acrosomal vesicle. Biomarker of diabetes mellitus. Orthologous to human CYP51A1 (cytochrome P450 family 51 subfamily A member 1); PARTICIPATES IN cholesterol biosynthetic pathway; alendronate pharmacodynamics pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
Previously known as: Cyp51a1; CYPLI; Cytochrom P450 Lanosterol 14 alpha-demethylase; cytochrome P450 51A1; cytochrome P450 Lanosterol 14 alpha-demethylase; cytochrome P450, subfamily 51; cytochrome P450-14DM; cytochrome P45014DM; cytochrome P450LI; lanosterol 14-alpha demethylase; LDM; MGC93630; P450-14DM; P45014DM; P450LI; RATCP14DM; sterol 14-alpha demethylase; sterol 14-alpha demethylase P450
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2430,036,956 - 30,055,410 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl430,036,865 - 30,055,410 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx435,009,705 - 35,028,159 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0430,935,797 - 30,954,251 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,331,773 - 29,350,227 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,175,564 - 27,194,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,175,243 - 27,194,018 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0427,078,790 - 27,097,244 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4426,752,677 - 26,771,131 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1426,758,233 - 26,776,686 (+)NCBI
Celera425,462,810 - 25,481,264 (+)NCBICelera
Cytogenetic Map4q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-hydroxypropanoic acid  (ISO)
22-Hydroxycholesterol  (ISO)
24,25-dihydrolanosterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acetohydrazide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-phellandrene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP)
bifonazole  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bitertanol  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
cerium trichloride  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
Dicyclohexyl phthalate  (EXP)
difenoconazole  (EXP,ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
diuron  (EXP)
econazole  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
epoxiconazole  (ISO)
ergosterol  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenarimol  (EXP,ISO)
fipronil  (ISO)
fluconazole  (ISO)
fluoranthene  (ISO)
flusilazole  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
hexaconazole  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
itraconazole  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
lanosterol  (EXP,ISO)
lead nitrate  (EXP,ISO)
leflunomide  (EXP,ISO)
letrozole  (ISO)
levofloxacin  (EXP)
limonene  (EXP)
lithocholic acid  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N(6)-butyryl-cAMP  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
obeticholic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
penconazole  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylpropanolamine  (ISO)
phosgene  (ISO)
phytosterols  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
prochloraz  (ISO)
progesterone  (ISO)
propiconazole  (EXP,ISO)
prothioconazole  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
Rebamipide  (EXP)
resveratrol  (ISO)
ritodrine  (ISO)
ritonavir  (EXP)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
toluene  (EXP)
tremolite asbestos  (ISO)
triadimefon  (EXP,ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
voriconazole  (ISO)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)


References - curated
# Reference Title Reference Citation
1. Occurrence of a P450 showing high homology to yeast lanosterol 14-demethylase (P450(14DM)) in the rat liver. Aoyama Y, etal., Biochem Biophys Res Commun 1994 Jun 30;201(3):1320-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Herman GE Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
4. Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome. Keber R, etal., J Biol Chem. 2011 Aug 19;286(33):29086-97. doi: 10.1074/jbc.M111.253245. Epub 2011 Jun 25.
5. Altered gene expression of hepatic lanosterol 14alpha-demethylase (CYP51) in lead nitrate-treated rats. Kojima M, etal., Arch Toxicol. 2002 Jul;76(7):398-403. doi: 10.1007/s00204-002-0365-3. Epub 2002 Jun 18.
6. Lanosterol 14alpha-demethylase (CYP51), NADPH-cytochrome P450 reductase and squalene synthase in spermatogenesis: late spermatids of the rat express proteins needed to synthesize follicular fluid meiosis activating sterol. Majdic G, etal., J Endocrinol. 2000 Aug;166(2):463-74. doi: 10.1677/joe.0.1660463.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Cloning and functional expression of the cDNA encoding rat lanosterol 14-alpha demethylase. Sloane DL, etal., Gene 1995 Aug 19;161(2):243-8.
15. Lanosterol 14 alpha-demethylase (cytochrome P-45014DM): modulation of its enzyme activity by cholesterol feeding. Sonoda Y, etal., Biol Pharm Bull. 1995 Jul;18(7):1009-11.
16. Elevated expression of lanosterol 14alpha-demethylase (CYP51) and the synthesis of oocyte meiosis-activating sterols in postmeiotic germ cells of male rats. Strömstedt M, etal., Endocrinology. 1998 May;139(5):2314-21. doi: 10.1210/endo.139.5.5984.
17. Role of meiosis-activating sterols in rat oocyte maturation: effects of specific inhibitors and changes in the expression of lanosterol 14alpha-demethylase during the preovulatory period. Vaknin KM, etal., Biol Reprod. 2001 Jan;64(1):299-309. doi: 10.1095/biolreprod64.1.299.
18. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
19. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
20. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
21. Insulin is the essential factor maintaining the constitutive expression of hepatic sterol 14-demethylase P450 (CYP51). Yamashita C, etal., J Biochem. 2000 Jul;128(1):93-9. doi: 10.1093/oxfordjournals.jbchem.a022734.
22. Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. Yan LP, etal., Life Sci. 2006 Jun 20;79(4):324-30. doi: 10.1016/j.lfs.2006.01.016. Epub 2006 Feb 10.
Additional References at PubMed
PMID:9498553   PMID:12477932   PMID:15269103   PMID:15489334   PMID:19946888   PMID:20149798   PMID:20876579   PMID:22871113   PMID:31352176  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2430,036,956 - 30,055,410 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl430,036,865 - 30,055,410 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx435,009,705 - 35,028,159 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0430,935,797 - 30,954,251 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,331,773 - 29,350,227 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,175,564 - 27,194,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,175,243 - 27,194,018 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0427,078,790 - 27,097,244 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4426,752,677 - 26,771,131 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1426,758,233 - 26,776,686 (+)NCBI
Celera425,462,810 - 25,481,264 (+)NCBICelera
Cytogenetic Map4q13NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38792,112,153 - 92,134,803 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl792,084,987 - 92,134,803 (-)EnsemblGRCh38hg38GRCh38
GRCh37791,741,467 - 91,764,117 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36791,579,402 - 91,601,946 (-)NCBINCBI36Build 36hg18NCBI36
Build 34791,386,116 - 91,408,661NCBI
Celera786,446,011 - 86,468,618 (-)NCBICelera
Cytogenetic Map7q21.2NCBI
HuRef786,348,902 - 86,371,499 (-)NCBIHuRef
CHM1_1791,671,533 - 91,694,128 (-)NCBICHM1_1
T2T-CHM13v2.0793,353,434 - 93,376,082 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2791,070,701 - 91,093,297 (-)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3954,130,674 - 4,154,697 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl54,131,145 - 4,154,746 (-)EnsemblGRCm39 Ensembl
GRCm3854,080,674 - 4,104,697 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl54,081,145 - 4,104,746 (-)EnsemblGRCm38mm10GRCm38
MGSCv3754,080,674 - 4,104,697 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3654,086,680 - 4,110,703 (-)NCBIMGSCv36mm8
Celera54,010,747 - 4,034,762 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.3NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554329,092,933 - 9,112,615 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554329,092,923 - 9,112,615 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan17158,262,334 - 158,287,365 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0784,110,130 - 84,132,870 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1797,708,806 - 97,730,486 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl797,708,806 - 97,729,824 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11417,746,654 - 17,767,019 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1417,746,656 - 17,766,658 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1417,307,241 - 17,328,397 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01417,552,569 - 17,573,808 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1417,550,375 - 17,573,565 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11417,710,915 - 17,732,068 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01417,425,396 - 17,446,546 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01417,699,282 - 17,720,469 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440511831,136,259 - 31,159,424 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366212,209,199 - 2,232,531 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366212,209,255 - 2,232,404 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl972,057,511 - 72,079,444 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1972,057,506 - 72,079,587 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2978,792,905 - 78,814,951 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12156,865,498 - 56,888,196 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2156,865,312 - 56,886,698 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604247,377,473 - 47,400,184 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248091,080,656 - 1,100,254 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248091,080,427 - 1,110,802 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cyp51
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:46
Interacting mature miRNAs:48
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2430,055,191 - 30,055,378 (+)MAPPERmRatBN7.2
Rnor_6.0427,193,800 - 27,193,986NCBIRnor6.0
Rnor_5.0427,097,026 - 27,097,212UniSTSRnor5.0
RGSC_v3.4426,770,913 - 26,771,099UniSTSRGSC3.4
Celera425,481,046 - 25,481,232UniSTS
RH 3.4 Map4168.4UniSTS
Cytogenetic Map4q13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2430,055,200 - 30,055,383 (+)MAPPERmRatBN7.2
Rnor_6.0427,193,809 - 27,193,991NCBIRnor6.0
Rnor_5.0427,097,035 - 27,097,217UniSTSRnor5.0
RGSC_v3.4426,770,922 - 26,771,104UniSTSRGSC3.4
Celera425,481,055 - 25,481,237UniSTS
RH 3.4 Map4168.4UniSTS
Cytogenetic Map4q13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2430,054,687 - 30,054,868 (+)MAPPERmRatBN7.2
Rnor_6.0427,193,296 - 27,193,476NCBIRnor6.0
Rnor_5.0427,096,522 - 27,096,702UniSTSRnor5.0
RGSC_v3.4426,770,409 - 26,770,589UniSTSRGSC3.4
Celera425,480,542 - 25,480,722UniSTS
RH 3.4 Map9723.0UniSTS
Cytogenetic Map4q13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2430,054,313 - 30,054,493 (+)MAPPERmRatBN7.2
Rnor_6.0427,192,922 - 27,193,101NCBIRnor6.0
Rnor_5.0427,096,148 - 27,096,327UniSTSRnor5.0
RGSC_v3.4426,770,035 - 26,770,214UniSTSRGSC3.4
Celera425,480,168 - 25,480,347UniSTS
RH 3.4 Map6547.8UniSTS
Cytogenetic Map4q13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2676,726,278 - 76,726,909 (+)MAPPERmRatBN7.2
Rnor_6.0680,127,507 - 80,128,137NCBIRnor6.0
Rnor_5.0689,653,379 - 89,654,009UniSTSRnor5.0
RGSC_v3.4679,727,169 - 79,727,799UniSTSRGSC3.4
Celera675,486,561 - 75,487,191UniSTS
Cytogenetic Map6q23UniSTS
Cytogenetic Map4q13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2676,727,021 - 76,727,338 (+)MAPPERmRatBN7.2
Rnor_6.0680,128,250 - 80,128,566NCBIRnor6.0
Rnor_5.0689,654,122 - 89,654,438UniSTSRnor5.0
RGSC_v3.4679,727,912 - 79,728,228UniSTSRGSC3.4
Celera675,487,304 - 75,487,620UniSTS
Cytogenetic Map6q23UniSTS
Cytogenetic Map4q13UniSTS

Related Rat Strains
The following Strains have been annotated to Cyp51


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 40 57 41 19 41 3 3 74 35 41 11 3
Low 3 5 8 5
Below cutoff


RefSeq Acc Id: ENSRNOT00000009985   ⟹   ENSRNOP00000009985
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl430,036,865 - 30,055,410 (+)Ensembl
Rnor_6.0 Ensembl427,175,243 - 27,194,018 (+)Ensembl
RefSeq Acc Id: NM_012941   ⟹   NP_037073
Rat AssemblyChrPosition (strand)Source
mRatBN7.2430,036,956 - 30,055,410 (+)NCBI
Rnor_6.0427,175,564 - 27,194,018 (+)NCBI
Rnor_5.0427,078,790 - 27,097,244 (+)NCBI
RGSC_v3.4426,752,677 - 26,771,131 (+)RGD
Celera425,462,810 - 25,481,264 (+)RGD
RefSeq Acc Id: NP_037073   ⟸   NM_012941
- UniProtKB: Q64549 (UniProtKB/Swiss-Prot),   Q64654 (UniProtKB/Swiss-Prot),   A6K271 (UniProtKB/TrEMBL),   A0A8I6AJ77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009985   ⟸   ENSRNOT00000009985

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64654-F1-model_v2 AlphaFold Q64654 1-503 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692842
Promoter ID:EPDNEW_R3366
Type:initiation region
Description:cytochrome P450, family 51
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0427,175,501 - 27,175,561EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2481 AgrOrtholog
BioCyc Gene G2FUF-45773 BioCyc
Ensembl Genes ENSRNOG00000007234 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000065555 UniProtKB/TrEMBL
  ENSRNOG00055001760 UniProtKB/Swiss-Prot
  ENSRNOG00060016934 UniProtKB/Swiss-Prot
  ENSRNOG00065018261 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009985 ENTREZGENE
  ENSRNOT00000009985.6 UniProtKB/Swiss-Prot
  ENSRNOT00000103698.1 UniProtKB/TrEMBL
  ENSRNOT00055002837 UniProtKB/Swiss-Prot
  ENSRNOT00060028958 UniProtKB/Swiss-Prot
  ENSRNOT00065030601 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25427 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp51 PhenoGen
PRINTS EP450IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007234 RatGTEx
  ENSRNOG00000065555 RatGTEx
  ENSRNOG00055001760 RatGTEx
  ENSRNOG00060016934 RatGTEx
  ENSRNOG00065018261 RatGTEx
Superfamily-SCOP Cytochrome P450 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  CP51A_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q64549 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp51  cytochrome P450, family 51  Cyp51  cytochrome P450, subfamily 51  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cyp51  cytochrome P450, subfamily 51     Cytochrom P450 Lanosterol 14 alpha-demethylase  Name updated 625702 APPROVED
2002-06-10 Cyp51  Cytochrom P450 Lanosterol 14 alpha-demethylase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in uterine tumors 70348
gene_disease upregulated in uterine tumors 70557
gene_expression expressed in uterus 70557