CYP51A1 (cytochrome P450 family 51 subfamily A member 1) - Rat Genome Database

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Gene: CYP51A1 (cytochrome P450 family 51 subfamily A member 1) Canis lupus familiaris
Analyze
Symbol: CYP51A1
Name: cytochrome P450 family 51 subfamily A member 1
RGD ID: 12346621
Description: ENCODES a protein that exhibits sterol 14-demethylase activity (ortholog); INVOLVED IN cholesterol biosynthetic process via 24,25-dihydrolanosterol (ortholog); negative regulation of amyloid-beta clearance (ortholog); negative regulation of protein catabolic process (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH Antley-Bixler syndrome (ortholog); cataract (ortholog); cerebral cavernous malformation (ortholog); FOUND IN acrosomal vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cytochrome P450, family 51, subfamily A, polypeptide 1; lanosterol 14-alpha demethylase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11417,746,654 - 17,767,019 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1417,746,656 - 17,766,658 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1417,307,241 - 17,328,397 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01417,552,569 - 17,573,808 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1417,550,375 - 17,573,565 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11417,710,915 - 17,732,068 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01417,425,396 - 17,446,546 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01417,699,282 - 17,720,469 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
CYP51A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11417,746,654 - 17,767,019 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1417,746,656 - 17,766,658 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1417,307,241 - 17,328,397 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01417,552,569 - 17,573,808 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1417,550,375 - 17,573,565 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11417,710,915 - 17,732,068 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01417,425,396 - 17,446,546 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01417,699,282 - 17,720,469 (-)NCBIUU_Cfam_GSD_1.0
CYP51A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38792,112,153 - 92,134,803 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl792,084,987 - 92,134,803 (-)EnsemblGRCh38hg38GRCh38
GRCh37791,741,467 - 91,764,117 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36791,579,402 - 91,601,946 (-)NCBINCBI36Build 36hg18NCBI36
Build 34791,386,116 - 91,408,661NCBI
Celera786,446,011 - 86,468,618 (-)NCBICelera
Cytogenetic Map7q21.2NCBI
HuRef786,348,902 - 86,371,499 (-)NCBIHuRef
CHM1_1791,671,533 - 91,694,128 (-)NCBICHM1_1
T2T-CHM13v2.0793,353,434 - 93,376,082 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2791,070,701 - 91,093,297 (-)NCBI
Cyp51
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3954,130,674 - 4,154,697 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl54,131,145 - 4,154,746 (-)EnsemblGRCm39 Ensembl
GRCm3854,080,674 - 4,104,697 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl54,081,145 - 4,104,746 (-)EnsemblGRCm38mm10GRCm38
MGSCv3754,080,674 - 4,104,697 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3654,086,680 - 4,110,703 (-)NCBIMGSCv36mm8
Celera54,010,747 - 4,034,762 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.3NCBI
Cyp51
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8430,991,693 - 31,010,147 (+)NCBIGRCr8
mRatBN7.2430,036,956 - 30,055,410 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl430,036,865 - 30,055,410 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx435,009,705 - 35,028,159 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0430,935,797 - 30,954,251 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,331,773 - 29,350,227 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,175,564 - 27,194,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,175,243 - 27,194,018 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0427,078,790 - 27,097,244 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4426,752,677 - 26,771,131 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1426,758,233 - 26,776,686 (+)NCBI
Celera425,462,810 - 25,481,264 (+)NCBICelera
Cytogenetic Map4q13NCBI
LOC102027002
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554329,092,933 - 9,112,615 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554329,092,923 - 9,112,615 (-)NCBIChiLan1.0ChiLan1.0
CYP51A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26109,998,616 - 110,022,815 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17158,262,334 - 158,287,365 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0784,110,130 - 84,132,870 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1797,708,806 - 97,730,486 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl797,708,806 - 97,729,824 (-)Ensemblpanpan1.1panPan2
LOC101955024
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511831,136,259 - 31,159,424 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366212,209,199 - 2,232,531 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366212,209,255 - 2,232,404 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP51A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl972,057,511 - 72,079,444 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1972,057,506 - 72,079,587 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2978,792,905 - 78,814,951 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP51A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12156,865,498 - 56,888,196 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2156,865,312 - 56,886,698 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604247,377,473 - 47,400,184 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101724157
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248091,080,656 - 1,100,254 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248091,080,427 - 1,110,802 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CYP51A1
183 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 1 22 6 6 6 12 8 9 5
Low 3 4 6 6 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005628499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038686396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038686397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038686398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_532457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000003074   ⟹   ENSCAFP00000002855
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1417,746,656 - 17,766,658 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845022260   ⟹   ENSCAFP00845017507
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1417,550,375 - 17,573,565 (-)Ensembl
RefSeq Acc Id: XM_005628499   ⟹   XP_005628556
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11417,746,654 - 17,767,011 (-)NCBI
Dog10K_Boxer_Tasha1417,307,241 - 17,328,397 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022427338   ⟹   XP_022283046
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11417,746,654 - 17,767,019 (-)NCBI
Dog10K_Boxer_Tasha1417,307,241 - 17,328,337 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038494482   ⟹   XP_038350410
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11417,710,915 - 17,731,857 (-)NCBI
RefSeq Acc Id: XM_038494483   ⟹   XP_038350411
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11417,710,915 - 17,732,068 (-)NCBI
RefSeq Acc Id: XM_038494484   ⟹   XP_038350412
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11417,710,915 - 17,732,008 (-)NCBI
RefSeq Acc Id: XM_038556776   ⟹   XP_038412704
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01417,699,282 - 17,720,258 (-)NCBI
RefSeq Acc Id: XM_038556777   ⟹   XP_038412705
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01417,699,282 - 17,720,469 (-)NCBI
RefSeq Acc Id: XM_038556778   ⟹   XP_038412706
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01417,699,282 - 17,720,409 (-)NCBI
RefSeq Acc Id: XM_038620711   ⟹   XP_038476639
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01417,425,396 - 17,446,335 (-)NCBI
RefSeq Acc Id: XM_038620712   ⟹   XP_038476640
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01417,425,396 - 17,446,546 (-)NCBI
RefSeq Acc Id: XM_038620713   ⟹   XP_038476641
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01417,425,396 - 17,446,486 (-)NCBI
RefSeq Acc Id: XM_038686396   ⟹   XP_038542324
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01417,552,569 - 17,573,597 (-)NCBI
RefSeq Acc Id: XM_038686397   ⟹   XP_038542325
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01417,552,569 - 17,573,808 (-)NCBI
RefSeq Acc Id: XM_038686398   ⟹   XP_038542326
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01417,552,569 - 17,573,748 (-)NCBI
RefSeq Acc Id: XM_532457   ⟹   XP_532457
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11417,746,654 - 17,766,782 (-)NCBI
Dog10K_Boxer_Tasha1417,307,241 - 17,328,186 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_532457   ⟸   XM_532457
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KHI8 (UniProtKB/TrEMBL),   A0A8P0N517 (UniProtKB/TrEMBL),   A0A8C0Z2B7 (UniProtKB/TrEMBL),   A0A8I3NH11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005628556   ⟸   XM_005628499
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_022283046   ⟸   XM_022427338
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000002855   ⟸   ENSCAFT00000003074
RefSeq Acc Id: XP_038350411   ⟸   XM_038494483
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038350412   ⟸   XM_038494484
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038350410   ⟸   XM_038494482
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038476640   ⟸   XM_038620712
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038476641   ⟸   XM_038620713
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038476639   ⟸   XM_038620711
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038542325   ⟸   XM_038686397
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038542326   ⟸   XM_038686398
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038542324   ⟸   XM_038686396
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KHI8 (UniProtKB/TrEMBL),   A0A8P0N517 (UniProtKB/TrEMBL),   A0A8C0Z2B7 (UniProtKB/TrEMBL),   A0A8I3NH11 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038412705   ⟸   XM_038556777
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038412706   ⟸   XM_038556778
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038412704   ⟸   XM_038556776
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KHI8 (UniProtKB/TrEMBL),   A0A8C0Z2B7 (UniProtKB/TrEMBL),   A0A8I3NH11 (UniProtKB/TrEMBL),   A0A8P0N517 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845017507   ⟸   ENSCAFT00845022260

Promoters
RGD ID:13685742
Promoter ID:EPDNEW_C3810
Type:initiation region
Name:CYP51A1_1
Description:cytochrome P450 family 51 subfamily A member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11417,766,728 - 17,766,788EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001945 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012291 UniProtKB/TrEMBL
  ENSCAFG00040019679 UniProtKB/TrEMBL
  ENSCAFG00845012499 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003074.5 UniProtKB/TrEMBL
  ENSCAFT00030022794.1 UniProtKB/TrEMBL
  ENSCAFT00040036414.1 UniProtKB/TrEMBL
  ENSCAFT00845022260 ENTREZGENE
  ENSCAFT00845022260.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
NCBI Gene CYP51A1 ENTREZGENE
PANTHER 24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 7 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A8C0KHI8 ENTREZGENE
  A0A8C0Z2B7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NH11 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N517 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:50376 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-09 CYP51A1  cytochrome P450 family 51 subfamily A member 1    cytochrome P450, family 51, subfamily A, polypeptide 1  Symbol and/or name change 5135510 APPROVED