(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of FMO2 mRNA] CTD PMID:31150632 (2,4,5-trichlorophenoxy)acetic acid decreases expression ISO RGD:733628 6480464 2 more ... CTD PMID:18579281 1,1-dichloroethene decreases expression ISO RGD:733628 6480464 vinylidene chloride results in decreased expression of FMO2 mRNA CTD PMID:26682919 1,2-dimethylhydrazine decreases expression EXP 6480464 1, 2-Dimethylhydrazine results in decreased expression of FMO2 mRNA CTD PMID:27840820 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:733628 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:733628 6480464 [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of FMO2 mRNA more ... CTD PMID:16214954 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:733628 6480464 Tetrachlorodibenzodioxin affects the expression of FMO2 mRNA CTD PMID:21570461 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:733628 6480464 Tetrachlorodibenzodioxin results in increased expression of FMO2 mRNA CTD PMID:18765683 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of FMO2 mRNA CTD PMID:21724226 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:733627 6480464 Tetrachlorodibenzodioxin results in decreased expression of FMO2 mRNA CTD PMID:20106945 2-hydroxypropanoic acid decreases expression ISO RGD:733627 6480464 Lactic Acid results in decreased expression of FMO2 mRNA CTD PMID:30851411 3-methylcholanthrene increases expression ISO RGD:733628 6480464 Methylcholanthrene results in increased expression of FMO2 mRNA CTD PMID:20570689 4-(ethoxymethylene)-2-phenyloxazol-5-one decreases expression EXP 6480464 Oxazolone results in decreased expression of FMO2 mRNA CTD PMID:21893156 4-hydroxyphenyl retinamide increases expression ISO RGD:733628 6480464 Fenretinide results in increased expression of FMO2 mRNA CTD PMID:28973697 aldrin decreases expression ISO RGD:733628 6480464 Aldrin results in decreased expression of FMO2 mRNA CTD PMID:18579281 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of FMO2 mRNA CTD PMID:16483693 arsane decreases expression ISO RGD:733628 6480464 Arsenic results in decreased expression of FMO2 mRNA CTD PMID:19654921 arsenic atom decreases expression ISO RGD:733628 6480464 Arsenic results in decreased expression of FMO2 mRNA CTD PMID:19654921 azathioprine increases expression ISO RGD:733628 6480464 Azathioprine results in increased expression of FMO2 mRNA CTD PMID:21621594 benzo[a]pyrene increases expression ISO RGD:733628 6480464 Benzo(a)pyrene results in increased expression of FMO2 mRNA CTD PMID:19770486 more ... benzydamine increases oxidation ISO RGD:733627 6480464 FMO2 protein results in increased oxidation of Benzydamine CTD PMID:26062974 benzydamine multiple interactions ISO RGD:733627 6480464 [FMO2 protein results in increased oxidation of Benzydamine] which results in increased chemical synthesis of benzydamine N-oxide CTD PMID:26062974 beta-D-glucan increases expression ISO RGD:733628 6480464 beta-Glucans results in increased expression of FMO2 mRNA CTD PMID:27910771 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FMO2 mRNA CTD PMID:18164116 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:733628 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of FMO2 mRNA CTD PMID:24988533 bisphenol A increases methylation ISO RGD:733628 6480464 bisphenol A results in increased methylation of FMO2 promoter CTD PMID:27312807 bisphenol A multiple interactions ISO RGD:733628 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A increases expression ISO RGD:733628 6480464 bisphenol A results in increased expression of FMO2 mRNA CTD PMID:25594700 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of FMO2 mRNA CTD PMID:25181051 , PMID:27178563 buta-1,3-diene increases expression ISO RGD:733628 6480464 1, 3-butadiene results in increased expression of FMO2 mRNA CTD PMID:29038090 calcitriol decreases expression ISO RGD:733627 6480464 Calcitriol results in decreased expression of FMO2 mRNA CTD PMID:26485663 chloroprene increases expression ISO RGD:733628 6480464 Chloroprene results in increased expression of FMO2 mRNA CTD PMID:23125180 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of FMO2 mRNA CTD PMID:23125180 choline multiple interactions ISO RGD:733628 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FMO2 mRNA CTD PMID:20938992 ciguatoxin CTX1B affects expression ISO RGD:733628 6480464 Ciguatoxins affects the expression of FMO2 mRNA CTD PMID:18353800 clofibrate decreases expression ISO RGD:733628 6480464 Clofibrate results in decreased expression of FMO2 mRNA CTD PMID:23811191 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of FMO2 mRNA CTD PMID:24386269 copper(II) sulfate decreases expression ISO RGD:733628 6480464 Copper Sulfate results in decreased expression of FMO2 mRNA CTD PMID:18579281 cyclosporin A decreases expression ISO RGD:733627 6480464 Cyclosporine results in decreased expression of FMO2 mRNA CTD PMID:20106945 cyclosporin A increases expression ISO RGD:733628 6480464 Cyclosporine results in increased expression of FMO2 mRNA CTD PMID:21621594 cypermethrin increases expression ISO RGD:733628 6480464 cypermethrin results in increased expression of FMO2 mRNA CTD PMID:21142847 dibenz[a,h]anthracene increases expression ISO RGD:733628 6480464 1 more ... CTD PMID:26377693 dioxygen decreases expression ISO RGD:733628 6480464 Oxygen deficiency results in decreased expression of FMO2 mRNA CTD PMID:24205000 dioxygen multiple interactions ISO RGD:733628 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of FMO2 mRNA CTD PMID:30529165 diuron decreases expression EXP 6480464 Diuron results in decreased expression of FMO2 mRNA CTD PMID:25152437 doxorubicin decreases expression ISO RGD:733627 6480464 Doxorubicin results in decreased expression of FMO2 mRNA CTD PMID:29803840 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of FMO2 mRNA CTD PMID:29391264 ethanol increases expression ISO RGD:733628 6480464 Ethanol results in increased expression of FMO2 mRNA CTD PMID:19167417 , PMID:30319688 ethanol affects expression ISO RGD:733628 6480464 Ethanol affects the expression of FMO2 mRNA CTD PMID:30319688 ethionamide increases oxidation ISO RGD:733627 6480464 FMO2 protein results in increased oxidation of Ethionamide CTD PMID:26062974 Ethylenethiourea decreases oxidation ISO RGD:733627 6480464 FMO2 gene polymorphism results in decreased oxidation of Ethylenethiourea CTD PMID:15864117 Ethylenethiourea increases oxidation ISO RGD:733627 6480464 FMO2 protein results in increased oxidation of Ethylenethiourea CTD PMID:15864117 folic acid multiple interactions ISO RGD:733628 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FMO2 mRNA CTD PMID:20938992 furan increases expression EXP 6480464 furan results in increased expression of FMO2 mRNA CTD PMID:26194646 , PMID:27387713 isoprenaline increases expression ISO RGD:733628 6480464 Isoproterenol results in increased expression of FMO2 mRNA CTD PMID:20003209 L-methionine multiple interactions ISO RGD:733628 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FMO2 mRNA CTD PMID:20938992 lead diacetate decreases expression ISO RGD:733628 6480464 lead acetate results in decreased expression of FMO2 mRNA CTD PMID:29746905 lutein decreases expression ISO RGD:733628 6480464 Lutein results in decreased expression of FMO2 mRNA CTD PMID:24865317 manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of FMO2 mRNA CTD PMID:28801915 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of FMO2 mRNA CTD PMID:19564919 methamphetamine multiple interactions EXP 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of FMO2 mRNA CTD PMID:19564919 methimazole decreases oxidation ISO RGD:733627 6480464 FMO2 gene polymorphism results in decreased oxidation of Methimazole CTD PMID:15864117 methimazole increases oxidation ISO RGD:733627 6480464 FMO2 protein results in increased oxidation of Methimazole CTD PMID:15864117 methotrexate affects expression ISO RGD:733628 6480464 Methotrexate affects the expression of FMO2 mRNA CTD PMID:18502557 methotrexate increases expression ISO RGD:733628 6480464 Methotrexate results in increased expression of FMO2 mRNA CTD PMID:21621594 mono(2-ethylhexyl) phthalate increases expression EXP 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of FMO2 mRNA CTD PMID:16809437 N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of FMO2 mRNA CTD PMID:28659758 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FMO2 mRNA, [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FMO2 mRNA CTD PMID:18164116 , PMID:20360939 nickel atom decreases expression ISO RGD:733627 6480464 Nickel results in decreased expression of FMO2 mRNA CTD PMID:24768652 , PMID:25583101 paracetamol affects expression ISO RGD:733628 6480464 Acetaminophen affects the expression of FMO2 mRNA CTD PMID:17562736 pentachlorophenol increases expression ISO RGD:733628 6480464 Pentachlorophenol results in increased expression of FMO2 mRNA CTD PMID:23892564 pentane-2,3-dione decreases expression EXP 6480464 2, 3-pentanedione results in decreased expression of FMO2 mRNA CTD PMID:25710175 permethrin multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of FMO2 mRNA CTD PMID:28659758 phenethyl caffeate multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FMO2 mRNA CTD PMID:20360939 phenobarbital multiple interactions ISO RGD:733628 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of FMO2 mRNA] CTD PMID:19482888 phenobarbital affects expression ISO RGD:733628 6480464 Phenobarbital affects the expression of FMO2 mRNA CTD PMID:23091169 phenobarbital increases expression ISO RGD:733628 6480464 Phenobarbital results in increased expression of FMO2 mRNA CTD PMID:19482888 pirinixic acid multiple interactions ISO RGD:733628 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FMO2 mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO RGD:733628 6480464 pirinixic acid results in decreased expression of FMO2 mRNA CTD PMID:23811191 potassium dichromate decreases expression ISO RGD:733628 6480464 Potassium Dichromate results in decreased expression of FMO2 mRNA CTD PMID:23608068 prednisolone increases expression ISO RGD:733628 6480464 Prednisolone results in increased expression of FMO2 mRNA CTD PMID:21621594 propranolol increases oxidation ISO RGD:733627 6480464 FMO2 protein results in increased oxidation of Propranolol CTD PMID:26062974 Pyridostigmine bromide multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of FMO2 mRNA CTD PMID:28659758 rac-lactic acid decreases expression ISO RGD:733627 6480464 Lactic Acid results in decreased expression of FMO2 mRNA CTD PMID:30851411 rotenone increases expression EXP 6480464 Rotenone results in increased expression of FMO2 mRNA CTD PMID:28374803 SCH 23390 multiple interactions EXP 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of FMO2 mRNA CTD PMID:19564919 SCH 23390 increases expression EXP 6480464 SCH 23390 results in increased expression of FMO2 mRNA CTD PMID:19564919 sevoflurane affects expression EXP 6480464 sevoflurane affects the expression of FMO2 mRNA CTD PMID:15967596 silicon dioxide decreases expression ISO RGD:733627 6480464 Silicon Dioxide analog results in decreased expression of FMO2 mRNA CTD PMID:23806026 silicon dioxide decreases expression ISO RGD:733628 6480464 Silicon Dioxide results in decreased expression of FMO2 mRNA CTD PMID:23221170 silver atom increases expression ISO RGD:733628 6480464 Silver results in increased expression of FMO2 mRNA CTD PMID:19429238 silver(0) increases expression ISO RGD:733628 6480464 Silver results in increased expression of FMO2 mRNA CTD PMID:19429238 sodium arsenate increases expression ISO RGD:733628 6480464 sodium arsenate results in increased expression of FMO2 mRNA CTD PMID:21795629 sodium arsenite decreases expression ISO RGD:733627 6480464 sodium arsenite results in decreased expression of FMO2 mRNA CTD PMID:29301061 sodium arsenite decreases expression ISO RGD:733628 6480464 sodium arsenite results in decreased expression of FMO2 protein CTD PMID:29044176 sodium fluoride decreases expression ISO RGD:733628 6480464 Sodium Fluoride results in decreased expression of FMO2 protein CTD PMID:28918527 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of FMO2 mRNA CTD PMID:25905778 tacrolimus hydrate increases expression ISO RGD:733628 6480464 Tacrolimus results in increased expression of FMO2 mRNA CTD PMID:21621594 testosterone decreases expression ISO RGD:733628 6480464 Testosterone results in decreased expression of FMO2 mRNA CTD PMID:20844152 , PMID:21669218 testosterone enanthate affects expression ISO RGD:733627 6480464 testosterone enanthate affects the expression of FMO2 mRNA CTD PMID:17440010 tetrachloroethene increases expression ISO RGD:733628 6480464 Tetrachloroethylene results in increased expression of FMO2 mRNA CTD PMID:28973375 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of FMO2 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of FMO2 mRNA] CTD PMID:31150632 thiourea increases metabolic processing ISO RGD:733627 6480464 FMO2 protein results in increased metabolism of Thiourea CTD PMID:12214664 titanium dioxide decreases expression ISO RGD:733628 6480464 titanium dioxide results in decreased expression of FMO2 mRNA CTD PMID:23557971 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of FMO2 mRNA CTD PMID:30012374 trifluoperazine increases oxidation ISO RGD:733627 6480464 FMO2 protein results in increased oxidation of Trifluoperazine CTD PMID:26062974 trimellitic anhydride decreases expression ISO RGD:733628 6480464 trimellitic anhydride results in decreased expression of FMO2 mRNA CTD PMID:19042947 trimellitic anhydride decreases expression EXP 6480464 trimellitic anhydride results in decreased expression of FMO2 mRNA CTD PMID:21893156 valproic acid affects expression ISO RGD:733628 6480464 Valproic Acid affects the expression of FMO2 mRNA CTD PMID:17963808 valproic acid decreases methylation ISO RGD:733627 6480464 Valproic Acid results in decreased methylation of FMO2 gene CTD PMID:29154799 vancomycin increases expression ISO RGD:733628 6480464 Vancomycin results in increased expression of FMO2 mRNA CTD PMID:18930951 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of FMO2 mRNA CTD PMID:19015723 zinc atom decreases expression ISO RGD:733628 6480464 Zinc deficiency results in decreased expression of FMO2 mRNA CTD PMID:20857495 zinc(0) decreases expression ISO RGD:733628 6480464 Zinc deficiency results in decreased expression of FMO2 mRNA CTD PMID:20857495
Biological Process drug metabolic process ISO RGD:733627 1624291 (PMID:11744609) RGD PMID:11744609 NADP metabolic process ISO RGD:733627 1624291 (PMID:11744609) RGD PMID:11744609 NADPH oxidation ISO RGD:733627 1624291 (PMID:15144220), (PMID:9804831) RGD PMID:15144220 , PMID:9804831 NADPH oxidation ISS UniProtKB:Q99518 1600115 GO_REF:0000024 UniProt GO_REF:0000024 NADPH oxidation IEA UniProtKB:Q99518 , ensembl:ENSP000002099291600115 GO_REF:0000107 Ensembl GO_REF:0000107 organic acid metabolic process ISO RGD:733627 1624291 (PMID:11744609) RGD PMID:11744609 organic acid metabolic process IEA UniProtKB:Q99518 , ensembl:ENSP000002099291600115 GO_REF:0000107 Ensembl GO_REF:0000107 oxidation-reduction process IEA UniProtKB-KW:KW-0560 1600115 GO_REF:0000038 UniProt GO_REF:0000038 oxygen metabolic process ISO RGD:733628 1624291 (MGI:MGI:2652626, PMID:11835629) RGD MGI:MGI:2652626 , PMID:11835629 oxygen metabolic process IEA UniProtKB:Q8K2I3 , ensembl:ENSMUSP000000444051600115 GO_REF:0000107 Ensembl GO_REF:0000107 toxin metabolic process ISO RGD:733627 1624291 (PMID:11744609) RGD PMID:11744609 toxin metabolic process IEA UniProtKB:Q99518 , ensembl:ENSP000002099291600115 GO_REF:0000107 Ensembl GO_REF:0000107 xenobiotic metabolic process ISO RGD:733627 1624291 (PMID:11744609) RGD PMID:11744609 xenobiotic metabolic process IEA UniProtKB:Q99518 , ensembl:ENSP000002099291600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component endoplasmic reticulum membrane IEA UniProtKB-SubCell:SL-0097 1600115 GO_REF:0000039 UniProt GO_REF:0000039 endoplasmic reticulum membrane IEA UniProtKB-SubCell:SL-0097 1600115 GO_REF:0000040 UniProt GO_REF:0000040 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000037 UniProt GO_REF:0000037 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000038 UniProt GO_REF:0000038 membrane ISO RGD:733627 1624291 (PMID:9804831) RGD PMID:9804831 membrane ISS UniProtKB:Q99518 1600115 GO_REF:0000024 UniProt GO_REF:0000024 Molecular Function flavin adenine dinucleotide binding IEA InterPro:IPR000960 , InterPro:IPR020946 1600115 GO_REF:0000002 InterPro GO_REF:0000002 monooxygenase activity ISO RGD:733628 1624291 (MGI:MGI:2652626, PMID:11835629) RGD MGI:MGI:2652626 , PMID:11835629 monooxygenase activity IBA MGI:MGI:1310002 more ... 13792537 PMID:21873635 GO_Central N,N-dimethylaniline monooxygenase activity ISO RGD:733627 1624291 (PMID:11744609) RGD PMID:11744609 N,N-dimethylaniline monooxygenase activity IEA EC:1.14.13.8 1600115 GO_REF:0000003 UniProt GO_REF:0000003 N,N-dimethylaniline monooxygenase activity IEA InterPro:IPR000960 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 NADP binding IEA InterPro:IPR000960 , InterPro:IPR020946 1600115 GO_REF:0000002 InterPro GO_REF:0000002
Gene-Chemical Interaction Annotations
