Gss (glutathione synthetase) - Rat Genome Database

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Gene: Gss (glutathione synthetase) Rattus norvegicus
Symbol: Gss
Name: glutathione synthetase
RGD ID: 2752
Description: Enables several functions, including anion binding activity; glutathione synthase activity; and identical protein binding activity. Involved in several processes, including glutathione biosynthetic process; response to amino acid; and response to tumor necrosis factor. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; glutathione synthetase deficiency of erythrocytes; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
Previously known as: glutathione synthase; Glutathione synthetase gene; GSH synthetase; GSH-S
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83164,508,005 - 164,538,343 (-)NCBIGRCr8
mRatBN7.23144,047,849 - 144,078,197 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,047,850 - 144,078,198 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3147,914,375 - 147,944,469 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,531,652 - 156,561,750 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,271,186 - 154,301,288 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,076,254 - 151,106,557 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,076,254 - 151,106,557 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,443,738 - 157,474,042 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43146,057,517 - 146,087,820 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13145,963,138 - 145,993,442 (-)NCBI
Celera3142,772,407 - 142,802,700 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(-)-quinic acid  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-benzoquinone  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-nitrofluorene  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
7,12-dimethyltetraphene  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
ammonium chloride  (EXP)
Anetholtrithion  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
celecoxib  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diethyl malate  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (EXP)
enilconazole  (ISO)
erdosteine  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galactose  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glutathione  (ISO)
Glutathione ethyl ester  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
indometacin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lipoic acid  (EXP)
lithocholic acid  (ISO)
LY294002  (ISO)
lycopene  (ISO)
mercaptopurine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
misonidazole  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrogen dioxide  (EXP)
ochratoxin A  (EXP)
oligopeptide  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenobarbital  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
purine-6-thiol  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (EXP)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)

Molecular Function


References - curated
# Reference Title Reference Citation
1. Glutathione synthesis in normal liver and in Yoshida AH-130 hepatoma. Biocca ME, etal., Toxicol Pathol. 1986;14(4):415-6.
2. Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction. Dahl N, etal., Hum Mol Genet 1997 Jul;6(7):1147-52.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Effects of chondroitin sulfate on alteration of actin cytoskeleton in rats with acute necrotizing pancreatitis. He ZY and Guo RX, Hepatobiliary Pancreat Dis Int. 2007 Oct;6(5):537-43.
6. Amino acid sequence of rat kidney glutathione synthetase. Huang CS, etal., Proc Natl Acad Sci U S A 1995 Feb 14;92(4):1232-6.
7. High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue. Jobgen W, etal., Amino Acids. 2009 May;37(1):187-98. Epub 2009 Feb 12.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Coordinated changes in xenobiotic metabolizing enzyme gene expression in aging male rats. Lee JS, etal., Toxicol Sci. 2008 Nov;106(1):263-83. Epub 2008 Jul 24.
10. Gender differences in glutathione metabolism in Alzheimer's disease. Liu H, etal., J Neurosci Res. 2005 Mar 15;79(6):861-7.
11. Novel kinetics of mammalian glutathione synthetase: characterization of gamma-glutamyl substrate cooperative binding. Luo JL, etal., Biochem Biophys Res Commun. 2000 Aug 28;275(2):577-81.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Mutations in the glutathione synthetase gene cause 5-oxoprolinuria. Shi ZZ, etal., Nat Genet. 1996 Nov;14(3):361-5.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. A spectrophotometric assay of gamma-glutamylcysteine synthetase and glutathione synthetase in crude extracts from tissues and cultured mammalian cells. Volohonsky G, etal., Chem Biol Interact. 2002 Apr 20;140(1):49-65.
23. Tumour necrosis factor alpha induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor kappaB and activator protein-1. Yang H, etal., Biochem J. 2005 Oct 15;391(Pt 2):399-408.
24. Role of AP-1 in the coordinate induction of rat glutamate-cysteine ligase and glutathione synthetase by tert-butylhydroquinone. Yang H, etal., J Biol Chem 2002 Sep 20;277(38):35232-9.
Additional References at PubMed
PMID:8660701   PMID:10369661   PMID:15489334   PMID:19056867   PMID:21988832   PMID:23376485   PMID:23533145   PMID:25416956   PMID:26871637  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83164,508,005 - 164,538,343 (-)NCBIGRCr8
mRatBN7.23144,047,849 - 144,078,197 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,047,850 - 144,078,198 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3147,914,375 - 147,944,469 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,531,652 - 156,561,750 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,271,186 - 154,301,288 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,076,254 - 151,106,557 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,076,254 - 151,106,557 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,443,738 - 157,474,042 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43146,057,517 - 146,087,820 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13145,963,138 - 145,993,442 (-)NCBI
Celera3142,772,407 - 142,802,700 (-)NCBICelera
Cytogenetic Map3q42NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382034,928,432 - 34,956,027 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2034,928,432 - 34,956,027 (-)EnsemblGRCh38hg38GRCh38
GRCh372033,516,235 - 33,543,830 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,979,897 - 33,007,262 (-)NCBINCBI36Build 36hg18NCBI36
Build 342032,979,897 - 33,007,262NCBI
Celera2030,265,329 - 30,292,695 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2030,294,556 - 30,321,979 (-)NCBIHuRef
CHM1_12033,417,456 - 33,444,826 (-)NCBICHM1_1
T2T-CHM13v2.02036,649,086 - 36,676,682 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392155,405,101 - 155,434,730 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,405,101 - 155,434,730 (-)EnsemblGRCm39 Ensembl
GRCm382155,563,181 - 155,592,810 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,563,181 - 155,592,810 (-)EnsemblGRCm38mm10GRCm38
MGSCv372155,388,919 - 155,418,442 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362155,254,624 - 155,284,147 (-)NCBIMGSCv36mm8
Celera2161,495,432 - 161,524,969 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.26NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542226,427,581 - 26,463,781 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542226,427,581 - 26,483,380 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v22140,661,205 - 40,688,813 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12040,654,308 - 40,682,219 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02031,256,734 - 31,284,356 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12032,381,745 - 32,409,327 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2032,381,745 - 32,409,297 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12423,973,807 - 24,000,281 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2423,901,045 - 23,997,286 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2423,619,971 - 23,646,466 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02424,665,657 - 24,692,375 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2424,665,043 - 24,692,288 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12423,952,937 - 23,979,420 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02424,048,251 - 24,074,736 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02424,487,171 - 24,513,688 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640172,955,595 - 172,983,992 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365615,765,610 - 5,793,567 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365615,765,637 - 5,793,951 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1738,312,720 - 38,342,298 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11738,316,199 - 38,342,253 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21743,511,098 - 43,539,281 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1239,230,629 - 39,258,511 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl239,230,487 - 39,254,648 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605087,554,278 - 87,582,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248424,446,721 - 4,478,450 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248424,445,015 - 4,470,124 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Gss
137 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:69
Interacting mature miRNAs:78
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,050,848 - 144,051,023 (+)MAPPERmRatBN7.2
Rnor_6.03151,079,253 - 151,079,427NCBIRnor6.0
Rnor_5.03157,446,738 - 157,446,912UniSTSRnor5.0
RGSC_v3.43146,060,515 - 146,060,690RGDRGSC3.4
RGSC_v3.43146,060,516 - 146,060,690UniSTSRGSC3.4
RGSC_v3.13145,966,138 - 145,966,312RGD
Celera3142,775,406 - 142,775,580UniSTS
RH 3.4 Map31298.6RGD
RH 3.4 Map31298.6UniSTS
Cytogenetic Map3q42UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23144,048,021 - 144,048,222 (+)MAPPERmRatBN7.2
Rnor_6.03151,076,426 - 151,076,626NCBIRnor6.0
Rnor_5.03157,443,911 - 157,444,111UniSTSRnor5.0
RGSC_v3.43146,057,689 - 146,057,889UniSTSRGSC3.4
Celera3142,772,579 - 142,772,779UniSTS
RH 3.4 Map31305.9UniSTS
Cytogenetic Map3q42UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 27 57 41 12 41 59 35 38 11
Low 16 7 8 11 15 3 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000025657   ⟹   ENSRNOP00000025657
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3144,047,852 - 144,078,198 (-)Ensembl
Rnor_6.0 Ensembl3151,076,254 - 151,106,557 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115033   ⟹   ENSRNOP00000094043
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3144,047,850 - 144,078,028 (-)Ensembl
RefSeq Acc Id: NM_012962   ⟹   NP_037094
Rat AssemblyChrPosition (strand)Source
GRCr83164,508,005 - 164,538,306 (-)NCBI
mRatBN7.23144,047,850 - 144,078,154 (-)NCBI
Rnor_6.03151,076,254 - 151,106,557 (-)NCBI
Rnor_5.03157,443,738 - 157,474,042 (-)NCBI
RGSC_v3.43146,057,517 - 146,087,820 (-)RGD
Celera3142,772,407 - 142,802,700 (-)RGD
RefSeq Acc Id: XM_039104373   ⟹   XP_038960301
Rat AssemblyChrPosition (strand)Source
GRCr83164,508,007 - 164,538,343 (-)NCBI
mRatBN7.23144,047,849 - 144,078,197 (-)NCBI
RefSeq Acc Id: NP_037094   ⟸   NM_012962
- UniProtKB: P46413 (UniProtKB/Swiss-Prot),   A6KI44 (UniProtKB/TrEMBL),   A0A8I6AYD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025657   ⟸   ENSRNOT00000025657
RefSeq Acc Id: XP_038960301   ⟸   XM_039104373
- Peptide Label: isoform X1
- UniProtKB: A6KI45 (UniProtKB/TrEMBL),   A0A8I6AYD3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000094043   ⟸   ENSRNOT00000115033
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46413-F1-model_v2 AlphaFold P46413 1-474 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692585
Promoter ID:EPDNEW_R3110
Type:initiation region
Description:glutathione synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.03151,106,540 - 151,106,600EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2752 AgrOrtholog
BioCyc Gene G2FUF-47127 BioCyc
BioCyc Pathway GLUTATHIONESYN-PWY [glutathione biosynthesis] BioCyc
  PWY-8043 [ophthalmate biosynthesis] BioCyc
BioCyc Pathway Image GLUTATHIONESYN-PWY BioCyc
  PWY-8043 BioCyc
Ensembl Genes ENSRNOG00000018964 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055024424 UniProtKB/Swiss-Prot
  ENSRNOG00060027817 UniProtKB/Swiss-Prot
  ENSRNOG00065028249 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025657 ENTREZGENE
  ENSRNOT00000025657.3 UniProtKB/Swiss-Prot
  ENSRNOT00000115033.1 UniProtKB/TrEMBL
  ENSRNOT00055041997 UniProtKB/Swiss-Prot
  ENSRNOT00060048298 UniProtKB/Swiss-Prot
  ENSRNOT00065048675 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1490.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1490.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glutathione_synthase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_synthase_a-hlx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_synthase_C_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_synthase_N_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GSH-S_sub-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GSH_synth_subst-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PreATP-grasp_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25458 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GSH_synth_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GSH_synthase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gss PhenoGen
PIRSF GSHase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018964 RatGTEx
  ENSRNOG00055024424 RatGTEx
  ENSRNOG00060027817 RatGTEx
  ENSRNOG00065028249 RatGTEx
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC230939

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gss  glutathione synthetase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA and enzyme are detected in kidney 69853