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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-gamma-glutamyl-L-cysteine
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Accession:CHEBI:17515 term browser browse the term
Definition:A molecular entity formed when L-cysteine amino group binds to the gamma-carbonyl of L-glutamic acid.
Synonyms:related_synonym: 5-L-Glutamyl-L-cysteine;   Formula=C8H14N2O5S;   Glu(-Cys);   InChI=1S/C8H14N2O5S/c9-4(7(12)13)1-2-6(11)10-5(3-16)8(14)15/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1;   InChIKey=RITKHVBHSGLULN-WHFBIAKZSA-N;   L-gamma-Glutamylcysteine;   SMILES=N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O;   gamma-Glu-Cys;   gamma-Glutamylcysteine;   gammaGluCys
 alt_id: CHEBI:10566;   CHEBI:10570;   CHEBI:12400;   CHEBI:12404;   CHEBI:24185;   CHEBI:24194;   CHEBI:39975
 xref: CAS:636-58-8;   DrugBank:DB03408;   HMDB:HMDB0001049;   KEGG:C00669;   KNApSAcK:C00007507
 xref_mesh: MESH:C017341
 xref: MetaCyc:L-GAMMA-GLUTAMYLCYSTEINE;   PMID:11409324;   Reaxys:1729154;   Wikipedia:Gamma-Glutamylcysteine
 cyclic_relationship: is_conjugate_acid_of CHEBI:58173


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L-gamma-glutamyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases chemical synthesis
EXP Buthionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]; Cysteine promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]; Excitatory Amino Acid Agents promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine] CTD PMID:15115889 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        molecular messenger 18301
          neurotransmitter 10807
            L-glutamic acid 10205
              L-gamma-glutamyl-L-cysteine 1
                DON-10-gamma-glutamylcysteine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        carboacyl group 17416
                                          univalent carboacyl group 17416
                                            carbamoyl group 17213
                                              carboxamide 17213
                                                peptide 9420
                                                  oligopeptide 1250
                                                    dipeptide 373
                                                      glutamyl-L-amino acid 1
                                                        gamma-glutamylcysteine 1
                                                          L-gamma-glutamyl-L-cysteine 1
                                                            DON-10-gamma-glutamylcysteine 0
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