Cyp4f5 (cytochrome P450, family 4, subfamily f, polypeptide 5) - Rat Genome Database

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Gene: Cyp4f5 (cytochrome P450, family 4, subfamily f, polypeptide 5) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp4f5
Name: cytochrome P450, family 4, subfamily f, polypeptide 5
RGD ID: 708364
Description: Predicted to enable aromatase activity; heme binding activity; and iron ion binding activity. Involved in leukotriene metabolic process and response to 3-methylcholanthrene. Predicted to be located in endoplasmic reticulum membrane. Biomarker of congestive heart failure and hypertrophic cardiomyopathy; PARTICIPATES IN arachidonic acid metabolic pathway; INTERACTS WITH 1-nitropropane; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYPIVF5; cytochrome P450 4F5; cytochrome P450 4F5-like; LOC691320; similar to cytochrome P450 4F1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8712,194,567 - 12,209,495 (+)NCBIGRCr8
mRatBN7.2711,544,040 - 11,558,982 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl711,544,082 - 11,558,978 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx714,361,994 - 14,377,041 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0716,239,423 - 16,254,470 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0714,111,496 - 14,126,355 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0714,559,806 - 14,574,345 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,529,482 - 14,574,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0714,712,613 - 14,727,091 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4713,119,551 - 13,134,015 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1713,119,550 - 13,134,014 (+)NCBI
Celera79,652,973 - 9,667,356 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
2. Regulation of neuronal type genes in congestive heart failure rats. Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
3. Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6. Bylund J, etal., Arch Biochem Biophys 2003 Apr 1;412(1):34-41.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily. Kawashima H and Strobel HW, Biochem Biophys Res Commun 1995 Dec 26;217(3):1137-44.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16182239  


Genomics

Variants

.
Variants in Cyp4f5
81 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:76
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000007428
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 1 1
Low 43 57 41 17 41 8 11 62 35 36 10 8
Below cutoff 12 4

Sequence


RefSeq Acc Id: ENSRNOT00000007428   ⟹   ENSRNOP00000007428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,544,120 - 11,558,978 (+)Ensembl
Rnor_6.0 Ensembl714,559,878 - 14,574,342 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000065282   ⟹   ENSRNOP00000062471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl713,881,583 - 13,887,854 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090844   ⟹   ENSRNOP00000072675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl714,529,482 - 14,574,361 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093545   ⟹   ENSRNOP00000076271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,544,082 - 11,558,838 (+)Ensembl
RefSeq Acc Id: NM_173124   ⟹   NP_775147
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,194,637 - 12,209,492 (+)NCBI
mRatBN7.2711,544,120 - 11,558,979 (+)NCBI
Rnor_6.0714,559,878 - 14,574,342 (+)NCBI
Rnor_5.0714,712,613 - 14,727,091 (+)NCBI
RGSC_v3.4713,119,551 - 13,134,015 (+)RGD
Celera79,652,973 - 9,667,356 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078523   ⟹   XP_038934451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,194,567 - 12,209,495 (+)NCBI
mRatBN7.2711,544,049 - 11,558,982 (+)NCBI
RefSeq Acc Id: XM_039078525   ⟹   XP_038934453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,195,092 - 12,209,495 (+)NCBI
mRatBN7.2711,544,568 - 11,558,982 (+)NCBI
RefSeq Acc Id: XM_039078527   ⟹   XP_038934455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,203,008 - 12,209,495 (+)NCBI
mRatBN7.2711,552,491 - 11,558,982 (+)NCBI
RefSeq Acc Id: XM_063263077   ⟹   XP_063119147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,194,567 - 12,209,495 (+)NCBI
RefSeq Acc Id: XM_063263078   ⟹   XP_063119148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,195,084 - 12,209,495 (+)NCBI
RefSeq Acc Id: NP_775147   ⟸   NM_173124
- UniProtKB: P51870 (UniProtKB/Swiss-Prot),   Q9EQ70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072675   ⟸   ENSRNOT00000090844
RefSeq Acc Id: ENSRNOP00000007428   ⟸   ENSRNOT00000007428
RefSeq Acc Id: XP_038934451   ⟸   XM_039078523
- Peptide Label: isoform X1
- UniProtKB: A2VD07 (UniProtKB/TrEMBL),   A6K954 (UniProtKB/TrEMBL),   Q9EQ70 (UniProtKB/TrEMBL),   F7FNW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934453   ⟸   XM_039078525
- Peptide Label: isoform X3
- UniProtKB: A0A1W2Q6H4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934455   ⟸   XM_039078527
- Peptide Label: isoform X4
- UniProtKB: A0A1W2Q6H4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000062471   ⟸   ENSRNOT00000065282
RefSeq Acc Id: ENSRNOP00000076271   ⟸   ENSRNOT00000093545
RefSeq Acc Id: XP_063119147   ⟸   XM_063263077
- Peptide Label: isoform X2
- UniProtKB: Q9EQ70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119148   ⟸   XM_063263078
- Peptide Label: isoform X3
- UniProtKB: A0A1W2Q6H4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZGC5-F1-model_v2 AlphaFold D3ZGC5 1-262 view protein structure
AF-P51870-F1-model_v2 AlphaFold P51870 1-526 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708364 AgrOrtholog
BioCyc Gene G2FUF-34822 BioCyc
Ensembl Genes ENSRNOG00000042496 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000050888 Ensembl
  ENSRNOG00055032633 UniProtKB/Swiss-Prot
  ENSRNOG00060031462 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007428 ENTREZGENE
  ENSRNOT00000007428.7 UniProtKB/TrEMBL
  ENSRNOT00000093545.2 UniProtKB/TrEMBL
  ENSRNOT00055056380 UniProtKB/Swiss-Prot
  ENSRNOT00060054532 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7375658 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:286905 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156578 IMAGE-MGC_LOAD
NCBI Gene 286905 ENTREZGENE
PANTHER CYTOCHROME P450 CYP4F16-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp4f5 PhenoGen
PRINTS EP450IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042496 RatGTEx
  ENSRNOG00000050888 RatGTEx
  ENSRNOG00055032633 RatGTEx
  ENSRNOG00060031462 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1W2Q6H4 ENTREZGENE, UniProtKB/TrEMBL
  A2VD07 ENTREZGENE
  A6K954 ENTREZGENE, UniProtKB/TrEMBL
  CP4F5_RAT UniProtKB/Swiss-Prot
  F7FNW8 ENTREZGENE, UniProtKB/TrEMBL
  P51870 ENTREZGENE
  Q9EQ70 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A2VD07 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cyp4f5  cytochrome P450, family 4, subfamily f, polypeptide 5  LOC691320  similar to cytochrome P450 4F1  Data merged from RGD:1585095 737654 PROVISIONAL
2010-04-19 Cyp4f5  cytochrome P450, family 4, subfamily f, polypeptide 5  Cyp4f5  cytochrome P450 4F5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC691320  similar to cytochrome P450 4F1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-09-30 Cyp4f5        Symbol and Name status set to provisional 70820 PROVISIONAL