Chia (chitinase, acidic) - Rat Genome Database

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Pathways
Gene: Chia (chitinase, acidic) Rattus norvegicus
Analyze
Symbol: Chia
Name: chitinase, acidic
RGD ID: 1303058
Description: Enables chitinase activity. Involved in chitin catabolic process. Located in extracellular region. Biomarker of cryptococcosis and silicosis. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic); PARTICIPATES IN amino sugar metabolic pathway; nucleotide sugar metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acidic mammalian chitinase; AMCase; eosinophil chemotactic cytokine; MGC112572; small acid mammalian chitinase
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82196,302,687 - 196,344,849 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2196,302,545 - 196,344,850 (+)EnsemblGRCr8
mRatBN7.22193,614,374 - 193,656,532 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2193,614,114 - 193,656,533 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2201,208,839 - 201,251,864 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02199,099,942 - 199,127,223 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02193,916,914 - 193,944,195 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02208,750,348 - 208,797,388 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,749,996 - 208,797,402 (+)Ensemblrn6Rnor6.0
Rnor_5.02228,203,126 - 228,221,354 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02228,174,304 - 228,176,046 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42201,385,584 - 201,431,777 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2186,305,695 - 186,342,272 (+)NCBICelera
RGSC_v3.12201,348,343 - 201,394,531 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
extracellular region  (IBA,IDA,IEA)
extracellular space  (ISO,ISS)
membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Polymorphisms and haplotypes of acid mammalian chitinase are associated with bronchial asthma. Bierbaum S, etal., Am J Respir Crit Care Med. 2005 Dec 15;172(12):1505-9. Epub 2005 Sep 22.
2. Identification of a novel acidic mammalian chitinase distinct from chitotriosidase. Boot RG, etal., J Biol Chem. 2001 Mar 2;276(9):6770-8. Epub 2000 Nov 20.
3. Cloning of a rat lung fibrogenic factor. Chen XH, etal., Gene. 2006 Dec 15;384:9-17. Epub 2006 Jul 29.
4. Increased expression of acidic mammalian chitinase and chitotriosidase in the nasal mucosa of patients with allergic rhinitis. Cho WS, etal., Laryngoscope. 2010 May;120(5):870-5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Identification of differentially expressed genes in rat silicosis model by suppression subtractive hybridization analysis. Jin Z, etal., Acta Biochim Biophys Sin (Shanghai). 2008 Aug;40(8):740-6.
7. Chitin stimulates expression of acidic mammalian chitinase and eotaxin-3 by human sinonasal epithelial cells in vitro. Lalaker A, etal., Am J Rhinol Allergy. 2009 Jan-Feb;23(1):8-14.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Increased expression of acidic mammalian chitinase in chronic rhinosinusitis with nasal polyps. Ramanathan M Jr, etal., Am J Rhinol. 2006 May-Jun;20(3):330-5.
11. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Reese TA, etal., Nature. 2007 May 3;447(7140):92-6. Epub 2007 Apr 22.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Pulmonary cryptococcosis induces chitinase in the rat. Vicencio AG, etal., Respir Res. 2008 May 15;9:40.
15. Polymorphisms of chitinases are not associated with asthma. Wu AC, etal., J Allergy Clin Immunol. 2010 Mar;125(3):754-7, 757.e1-757.e2.
16. Inhibition of acidic mammalian chitinase by RNA interference suppresses ovalbumin-sensitized allergic asthma. Yang CJ, etal., Hum Gene Ther. 2009 Dec;20(12):1597-606.
17. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Zhu Z, etal., Science. 2004 Jun 11;304(5677):1678-82.
18. Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways. Zimmermann N, etal., J Immunol. 2004 Feb 1;172(3):1815-24.
Additional References at PubMed
PMID:12477932   PMID:18824549   PMID:19435888   PMID:24155872  


Genomics

Comparative Map Data
Chia
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82196,302,687 - 196,344,849 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2196,302,545 - 196,344,850 (+)EnsemblGRCr8
mRatBN7.22193,614,374 - 193,656,532 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2193,614,114 - 193,656,533 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2201,208,839 - 201,251,864 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02199,099,942 - 199,127,223 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02193,916,914 - 193,944,195 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02208,750,348 - 208,797,388 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,749,996 - 208,797,402 (+)Ensemblrn6Rnor6.0
Rnor_5.02228,203,126 - 228,221,354 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02228,174,304 - 228,176,046 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42201,385,584 - 201,431,777 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2186,305,695 - 186,342,272 (+)NCBICelera
RGSC_v3.12201,348,343 - 201,394,531 (+)NCBI
Cytogenetic Map2q34NCBI
CHIA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,290,851 - 111,320,563 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1111,290,851 - 111,320,566 (+)Ensemblhg38GRCh38
GRCh371111,833,473 - 111,863,185 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,635,007 - 111,664,708 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1110,080,467 - 110,110,137 (+)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1109,704,997 - 109,734,617 (+)NCBIHuRef
CHM1_11111,948,560 - 111,978,245 (+)NCBICHM1_1
T2T-CHM13v2.01111,305,627 - 111,335,252 (+)NCBIT2T-CHM13v2.0
Chia1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393106,020,698 - 106,039,434 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3106,020,545 - 106,039,436 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383106,113,382 - 106,132,118 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3106,113,229 - 106,132,120 (+)Ensemblmm10GRCm38
MGSCv373105,916,300 - 105,935,036 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363106,241,438 - 106,260,174 (+)NCBIMGSCv36mm8
Celera3108,305,877 - 108,324,340 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map346.49NCBI
CHIA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,723,718 - 115,731,970 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11114,872,554 - 114,880,806 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01113,935,888 - 113,965,541 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11126,381,724 - 126,411,365 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1126,381,724 - 126,391,909 (-)EnsemblpanPan2panpan1.1
CHIA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,754,906 - 40,766,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl640,754,993 - 40,766,891 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha643,532,998 - 43,544,872 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0641,086,947 - 41,098,823 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl641,087,036 - 41,098,641 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1640,808,020 - 40,819,890 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,778,134 - 40,789,997 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0641,213,439 - 41,225,313 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Chia
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505817,495,274 - 17,507,271 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049390911,190 - 12,272 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049390911,194 - 12,273 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHIA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4109,035,326 - 109,046,499 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14109,035,323 - 109,046,499 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24119,410,881 - 119,422,056 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHIA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12022,273,628 - 22,282,097 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603836,195,130 - 36,204,450 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Chia
197 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:15
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000041562
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
BI288346  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,656,272 - 193,656,484 (+)MAPPERmRatBN7.2
Rnor_6.02208,797,129 - 208,797,340NCBIRnor6.0
Rnor_5.02228,221,095 - 228,221,306UniSTSRnor5.0
RGSC_v3.42201,431,519 - 201,431,730UniSTSRGSC3.4
Celera2186,342,013 - 186,342,224UniSTS
RH 3.4 Map21369.2UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 5 87 22 32 4 19 4 2 39 28 82 2 62 28

Sequence


Ensembl Acc Id: ENSRNOT00000041562   ⟹   ENSRNOP00000044947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2193,614,374 - 193,656,533 (+)Ensembl
Rnor_6.0 Ensembl2208,750,356 - 208,797,388 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086321   ⟹   ENSRNOP00000073705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2196,302,545 - 196,344,850 (+)Ensembl
mRatBN7.2 Ensembl2193,614,114 - 193,656,533 (+)Ensembl
Rnor_6.0 Ensembl2208,749,996 - 208,797,402 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100196   ⟹   ENSRNOP00000077248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2193,615,370 - 193,656,533 (+)Ensembl
RefSeq Acc Id: NM_207586   ⟹   NP_997469
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82196,302,687 - 196,344,849 (+)NCBI
mRatBN7.22193,614,374 - 193,656,532 (+)NCBI
Rnor_6.02208,750,348 - 208,797,388 (+)NCBI
Rnor_5.02228,174,304 - 228,176,046 (+)NCBI
Rnor_5.02228,203,126 - 228,221,354 (+)NCBI
RGSC_v3.42201,385,584 - 201,431,777 (+)RGD
Celera2186,305,695 - 186,342,272 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_997469 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98642 (Get FASTA)   NCBI Sequence Viewer  
  AAR28968 (Get FASTA)   NCBI Sequence Viewer  
  AGK24663 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073705
GenBank Protein Q6RY07 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_997469   ⟸   NM_207586
- Peptide Label: precursor
- UniProtKB: Q6RY07 (UniProtKB/Swiss-Prot),   A0A0G2K676 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044947   ⟸   ENSRNOT00000041562
Ensembl Acc Id: ENSRNOP00000073705   ⟸   ENSRNOT00000086321
Ensembl Acc Id: ENSRNOP00000077248   ⟸   ENSRNOT00000100196
Protein Domains
Chitin-binding type-2   GH18

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6RY07-F1-model_v2 AlphaFold Q6RY07 1-473 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691661
Promoter ID:EPDNEW_R2176
Type:single initiation site
Name:Chia_1
Description:chitinase, acidic
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02208,750,356 - 208,750,416EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303058 AgrOrtholog
BioCyc Gene G2FUF-51711 BioCyc
Ensembl Genes ENSRNOG00000033162 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000086321 ENTREZGENE
Gene3D-CATH 3.10.50.10 UniProtKB/Swiss-Prot
  Chitin binding domain UniProtKB/Swiss-Prot
  Glycosidases UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100637 IMAGE-MGC_LOAD
InterPro Chitin-bd_dom UniProtKB/Swiss-Prot
  Chitin-bd_dom_sf UniProtKB/Swiss-Prot
  Chitinase_II UniProtKB/Swiss-Prot
  Chitinase_insertion_sf UniProtKB/Swiss-Prot
  Glyco_hydro18_cat UniProtKB/Swiss-Prot
  Glyco_hydro_18_chit_AS UniProtKB/Swiss-Prot
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot
  Glycosyl_Hydrlase_18 UniProtKB/Swiss-Prot
KEGG Report rno:113901 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112572 IMAGE-MGC_LOAD
NCBI Gene 113901 ENTREZGENE
PANTHER ACIDIC MAMMALIAN CHITINASE UniProtKB/Swiss-Prot
  CHITINASE UniProtKB/Swiss-Prot
Pfam CBM_14 UniProtKB/Swiss-Prot
  Glyco_hydro_18 UniProtKB/Swiss-Prot
PhenoGen Chia PhenoGen
PROSITE CHIT_BIND_II UniProtKB/Swiss-Prot
  CHITINASE_18 UniProtKB/Swiss-Prot
  GH18_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033162 RatGTEx
SMART ChtBD2 UniProtKB/Swiss-Prot
  Glyco_18 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot
  SSF54556 UniProtKB/Swiss-Prot
  SSF57625 UniProtKB/Swiss-Prot
UniProt A0A0G2K676 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y1C5_RAT UniProtKB/TrEMBL
  CHIA_RAT UniProtKB/Swiss-Prot
  F1LPK5_RAT UniProtKB/TrEMBL
  Q4G094_RAT UniProtKB/TrEMBL
  Q6RY07 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Chia  chitinase, acidic      Symbol and Name status set to approved 1299863 APPROVED
2005-09-30 Chia        Symbol and Name status set to provisional 70820 PROVISIONAL