Dhodh (dihydroorotate dehydrogenase (quinone)) - Rat Genome Database

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Gene: Dhodh (dihydroorotate dehydrogenase (quinone)) Rattus norvegicus
Analyze
Symbol: Dhodh
Name: dihydroorotate dehydrogenase (quinone)
RGD ID: 68352
Description: Exhibits FMN binding activity; dihydroorotate dehydrogenase activity; and ubiquinone binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; lactation; and response to L-arginine. Localizes to mitochondrial inner membrane and neuronal cell body. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)); PARTICIPATES IN beta-ureidopropionase deficiency pathway; de novo pyrimidine biosynthetic pathway; dihydropyrimidinase deficiency pathway; INTERACTS WITH 1,4-naphthoquinone; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DHOdehase; dihydroorotate dehydrogenase; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate dehydrogenase, mitochondrial; dihydroorotate oxidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21937,551,858 - 37,573,327 (-)NCBI
Rnor_6.0 Ensembl1942,066,351 - 42,082,012 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01942,066,103 - 42,087,906 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01952,891,853 - 52,913,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,463,111 - 39,477,184 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11939,467,991 - 39,482,059 (-)NCBI
Celera1936,964,203 - 36,978,276 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Bader B, etal., Protein Expr Purif. 1998 Aug;13(3):414-22.
2. Cramer DV, etal., J Heart Lung Transplant. 1993 Jan-Feb;12(1 Pt 1):140-6.
3. Elliott WL, etal., Biochim Biophys Acta. 1984 Jul 30;800(2):194-201.
4. Evans DR and Guy HI, J Biol Chem. 2004 Aug 6;279(32):33035-8. Epub 2004 Apr 19.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. GOA data from the GO Consortium
7. Hansen M, etal., Protein Sci. 2004 Apr;13(4):1031-42.
8. Hassan AS and Milner JA, Metabolism. 1981 Aug;30(8):739-44.
9. Kim KS, etal., Int Immunopharmacol. 2004 Jul;4(7):963-73.
10. Knecht W, etal., Protein Expr Purif. 1997 Jun;10(1):89-99.
11. Korn T, etal., Brain. 2001 Sep;124(Pt 9):1791-802.
12. Kraft J, etal., Arch Toxicol. 1998 Nov;72(11):711-21.
13. Kunjara S, etal., Biochem Med Metab Biol. 1991 Oct;46(2):215-25.
14. Kunjara S, etal., Biochem Med Metab Biol. 1992 Dec;48(3):263-74.
15. Lakaschus G and Loffler M, Biochem Pharmacol. 1992 Mar 3;43(5):1025-30.
16. Minana MD, etal., J Neurochem. 1984 Dec;43(6):1556-60.
17. Mizushima Y, etal., J Pharmacol Exp Ther. 1999 Feb;288(2):849-57.
18. NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline
20. Pipeline to import KEGG annotations from KEGG into RGD
21. Pipeline to import SMPDB annotations from SMPDB into RGD
22. Rawls J, etal., Eur J Biochem. 2000 Apr;267(7):2079-87.
23. RGD automated data pipeline
24. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. RGD automated import pipeline for gene-chemical interactions
26. Rotgeri A and Loffler M, Adv Exp Med Biol 1994;370:693-7.
27. Schaefer ChM, etal., Nucleosides Nucleotides Nucleic Acids. 2010 Jun;29(4-6):476-81.
28. Silva HT Jr, etal., Transplant Proc. 1997 Feb-Mar;29(1-2):1292-3.
29. Spodnik JH, etal., Mitochondrion. 2002 Dec;2(3):163-79.
Additional References at PubMed
PMID:14651853   PMID:15571246   PMID:18614015  


Genomics

Comparative Map Data
Dhodh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21937,551,858 - 37,573,327 (-)NCBI
Rnor_6.0 Ensembl1942,066,351 - 42,082,012 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01942,066,103 - 42,087,906 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01952,891,853 - 52,913,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,463,111 - 39,477,184 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11939,467,991 - 39,482,059 (-)NCBI
Celera1936,964,203 - 36,978,276 (-)NCBICelera
Cytogenetic Map19q12NCBI
DHODH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1672,008,588 - 72,027,664 (+)EnsemblGRCh38hg38GRCh38
GRCh381672,008,744 - 72,027,659 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371672,042,643 - 72,061,558 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,600,144 - 70,616,456 (+)NCBINCBI36hg18NCBI36
Build 341670,600,163 - 70,616,456NCBI
Celera1656,356,753 - 56,373,075 (+)NCBI
Cytogenetic Map16q22.2NCBI
HuRef1657,809,449 - 57,826,108 (+)NCBIHuRef
CHM1_11673,455,964 - 73,472,648 (+)NCBICHM1_1
Dhodh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,319,876 - 110,335,330 (-)NCBIGRCm39mm39
GRCm39 Ensembl8110,317,975 - 110,335,305 (-)Ensembl
GRCm388109,593,244 - 109,608,699 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,591,343 - 109,608,673 (-)EnsemblGRCm38mm10GRCm38
MGSCv378112,117,148 - 112,132,573 (-)NCBIGRCm37mm9NCBIm37
MGSCv368112,482,377 - 112,497,802 (-)NCBImm8
Celera8113,818,789 - 113,834,192 (-)NCBICelera
Cytogenetic Map8D3NCBI
Dhodh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554844,699,722 - 4,713,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554844,699,743 - 4,713,466 (+)NCBIChiLan1.0ChiLan1.0
DHODH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11671,854,238 - 71,870,673 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1671,854,238 - 71,870,673 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01652,977,879 - 52,994,496 (-)NCBIMhudiblu_PPA_v0panPan3
DHODH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1577,756,411 - 77,766,207 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl577,756,407 - 77,774,090 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha577,718,144 - 77,727,932 (+)NCBI
ROS_Cfam_1.0578,195,768 - 78,205,557 (+)NCBI
UMICH_Zoey_3.1578,015,829 - 78,025,617 (+)NCBI
UNSW_CanFamBas_1.0577,838,711 - 77,848,499 (+)NCBI
UU_Cfam_GSD_1.0578,337,853 - 78,347,642 (+)NCBI
Dhodh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,711,350 - 37,725,488 (+)NCBI
SpeTri2.0NW_00493647521,863,627 - 21,877,660 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHODH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,942,933 - 14,956,000 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1614,942,898 - 14,956,000 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,563,531 - 14,574,102 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHODH
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1555,161,788 - 55,177,383 (+)NCBI
ChlSab1.1 Ensembl555,161,916 - 55,180,896 (+)Ensembl
Dhodh
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474614,254,811 - 14,268,034 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19104464846044648Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19195770746957707Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19243296347217667Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19243296362275575Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)19370183548701835Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)19370183548701835Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19500757143907843Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19650676160220581Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19807254547318201Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191130392747879277Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191702800352538299Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191899398262275575Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191917749562275575Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)192140778762275575Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192445572643907843Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192481825762275575Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)193299439262275575Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193791679960220451Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193791679960220451Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:30
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000066733
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 14 19 9 9 9 22 12 29
Low 3 29 38 32 10 32 8 11 52 23 12 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066733   ⟹   ENSRNOP00000061315
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1942,066,351 - 42,082,012 (+)Ensembl
RefSeq Acc Id: NM_001008553   ⟹   NP_001008553
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21937,559,170 - 37,573,244 (-)NCBI
Rnor_6.01942,066,491 - 42,080,564 (+)NCBI
Rnor_5.01952,891,853 - 52,913,708 (+)NCBI
RGSC_v3.41939,463,111 - 39,477,184 (-)RGD
Celera1936,964,203 - 36,978,276 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255601   ⟹   XP_006255663
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21937,551,858 - 37,573,327 (-)NCBI
Rnor_6.01942,066,339 - 42,087,906 (+)NCBI
Rnor_5.01952,891,853 - 52,913,708 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772529   ⟹   XP_008770751
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21937,557,897 - 37,573,327 (-)NCBI
Rnor_6.01942,066,339 - 42,080,936 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601352   ⟹   XP_017456841
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01942,066,103 - 42,080,747 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005496685
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21937,551,858 - 37,573,327 (-)NCBI
RefSeq Acc Id: XR_361830
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21937,559,377 - 37,573,327 (-)NCBI
Rnor_6.01942,066,338 - 42,080,308 (+)NCBI
Rnor_5.01952,891,853 - 52,913,708 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001008553 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255663 (Get FASTA)   NCBI Sequence Viewer  
  XP_008770751 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA56765 (Get FASTA)   NCBI Sequence Viewer  
  Q63707 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001008553   ⟸   NM_001008553
- Peptide Label: precursor
- UniProtKB: Q63707 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255663   ⟸   XM_006255601
- Peptide Label: isoform X1
- UniProtKB: Q63707 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008770751   ⟸   XM_008772529
- Peptide Label: isoform X1
- UniProtKB: Q63707 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017456841   ⟸   XM_017601352
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000061315   ⟸   ENSRNOT00000066733

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68352 AgrOrtholog
Ensembl Genes ENSRNOG00000015063 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000061315 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000066733 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot
InterPro Aldolase_TIM UniProtKB/Swiss-Prot
  Dihydroorotate_DH UniProtKB/Swiss-Prot
  Dihydroorotate_DH_2 UniProtKB/Swiss-Prot
  Dihydroorotate_DH_CS UniProtKB/Swiss-Prot
KEGG Report rno:65156 UniProtKB/Swiss-Prot
NCBI Gene 65156 ENTREZGENE
Pfam DHO_dh UniProtKB/Swiss-Prot
PharmGKB DHODH RGD
PhenoGen Dhodh PhenoGen
PROSITE DHODEHASE_1 UniProtKB/Swiss-Prot
  DHODEHASE_2 UniProtKB/Swiss-Prot
TIGRFAMs pyrD_sub2 UniProtKB/Swiss-Prot
UniProt PYRD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-09-29 Dhodh  dihydroorotate dehydrogenase (quinone)  Dhodh  dihydroorotate dehydrogenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Dhodh  dihydroorotate dehydrogenase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference