Dhodh (dihydroorotate dehydrogenase) - Rat Genome Database

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Gene: Dhodh (dihydroorotate dehydrogenase) Rattus norvegicus
Analyze
Symbol: Dhodh
Name: dihydroorotate dehydrogenase (Ensembl:dihydroorotate dehydrogenase (quinone))
RGD ID: 68352
Description: Enables FMN binding activity; dihydroorotate dehydrogenase activity; and ubiquinone binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; lactation; and response to L-arginine. Located in mitochondrial inner membrane and neuronal cell body. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)); PARTICIPATES IN beta-ureidopropionase deficiency pathway; de novo pyrimidine biosynthetic pathway; dihydropyrimidinase deficiency pathway; INTERACTS WITH 1,4-naphthoquinone; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DHOdehase; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate dehydrogenase, mitochondrial; dihydroorotate oxidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,460,636 - 54,483,049 (-)NCBIGRCr8
mRatBN7.21937,551,858 - 37,573,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,558,177 - 37,591,654 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1944,372,421 - 44,386,399 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,025,749 - 45,039,726 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,335,351 - 47,349,222 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01942,066,103 - 42,087,906 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,066,351 - 42,082,012 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01952,891,853 - 52,913,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,463,111 - 39,477,184 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11939,467,991 - 39,482,059 (-)NCBI
Celera1936,964,203 - 36,978,276 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,4-naphthoquinone  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
6-decylubiquinone  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atovaquone  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
brequinar  (EXP,ISO)
caffeine  (EXP)
celastrol  (ISO)
ciprofloxacin  (EXP)
clofibric acid  (EXP)
copper(II) sulfate  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dihydroorotic acid  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
Evodiamine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
glafenine  (EXP)
indometacin  (EXP)
ivermectin  (ISO)
juglone  (EXP,ISO)
ketamine  (EXP)
lapachol  (EXP,ISO)
lawsone  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
naphthazarin  (EXP,ISO)
nickel dichloride  (EXP)
oxybenzone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
plumbagin  (EXP,ISO)
Polyporic acid  (EXP,ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
teriflunomide  (EXP,ISO)
Tesaglitazar  (EXP)
thiram  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
ubiquinones  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase. Bader B, etal., Protein Expr Purif. 1998 Aug;13(3):414-22.
2. Inhibition of the pyrimidine biosynthetic pathway with S-8660, an analogue of brequinar sodium, prolongs cardiac allograft survival in rats. Cramer DV, etal., J Heart Lung Transplant. 1993 Jan-Feb;12(1 Pt 1):140-6.
3. Cyclic modulation of enzymes of pyrimidine nucleotide biosynthesis precedes sialoglycoconjugate changes during 2-acetylaminofluorene-induced hepatocarcinogenesis in the rat. Elliott WL, etal., Biochim Biophys Acta. 1984 Jul 30;800(2):194-201.
4. Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway. Evans DR and Guy HI, J Biol Chem. 2004 Aug 6;279(32):33035-8. Epub 2004 Apr 19.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. Hansen M, etal., Protein Sci. 2004 Apr;13(4):1031-42.
8. Alterations in liver nucleic acids and nucleotides in arginine deficient rats. Hassan AS and Milner JA, Metabolism. 1981 Aug;30(8):739-44.
9. Protective and anti-arthritic effects of deer antler aqua-acupuncture (DAA), inhibiting dihydroorotate dehydrogenase, on phosphate ions-mediated chondrocyte apoptosis and rat collagen-induced arthritis. Kim KS, etal., Int Immunopharmacol. 2004 Jul;4(7):963-73.
10. Rat dihydroorotate dehydrogenase: isolation of the recombinant enzyme from mitochondria of insect cells. Knecht W, etal., Protein Expr Purif. 1997 Jun;10(1):89-99.
11. Suppression of experimental autoimmune neuritis by leflunomide. Korn T, etal., Brain. 2001 Sep;124(Pt 9):1791-802.
12. Biological effects of the dihydroorotate dehydrogenase inhibitor polyporic acid, a toxic constituent of the mushroom Hapalopilus rutilans, in rats and humans. Kraft J, etal., Arch Toxicol. 1998 Nov;72(11):711-21.
13. Pyrimidine nucleotide synthesis in the rat kidney in early diabetes. Kunjara S, etal., Biochem Med Metab Biol. 1991 Oct;46(2):215-25.
14. Pyrimidine nucleotide synthesis in the rat mammary gland: changes in the lactation cycle and effects of diabetes. Kunjara S, etal., Biochem Med Metab Biol. 1992 Dec;48(3):263-74.
15. Differential susceptibility of dihydroorotate dehydrogenase/oxidase to Brequinar Sodium (NSC 368 390) in vitro. Lakaschus G and Loffler M, Biochem Pharmacol. 1992 Mar 3;43(5):1025-30.
16. Lesch-Nyhan syndrome, caffeine model: increase of purine and pyrimidine enzymes in rat brain. Minana MD, etal., J Neurochem. 1984 Dec;43(6):1556-60.
17. Oral administration of leflunomide (HWA486) results in prominent suppression of immunoglobulin E formation in a rat type 1 allergy model. Mizushima Y, etal., J Pharmacol Exp Ther. 1999 Feb;288(2):849-57.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase. Rawls J, etal., Eur J Biochem. 2000 Apr;267(7):2079-87.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Molecular cloning and sequence analyses of rat liver dihydroorotate dehydrogenase. Rotgeri A and Loffler M, Adv Exp Med Biol 1994;370:693-7.
27. Region-specific distribution of dihydroorotate dehydrogenase in the rat central nervous system points to pyrimidine de novo synthesis in neurons. Schaefer ChM, etal., Nucleosides Nucleotides Nucleic Acids. 2010 Jun;29(4-6):476-81.
28. In vitro and in vivo effects of leflunomide, brequinar, and cyclosporine on pyrimidine biosynthesis. Silva HT Jr, etal., Transplant Proc. 1997 Feb-Mar;29(1-2):1292-3.
29. Mechanism of leflunomide-induced proliferation of mitochondria in mammalian cells. Spodnik JH, etal., Mitochondrion. 2002 Dec;2(3):163-79.
Additional References at PubMed
PMID:14651853   PMID:15571246   PMID:18614015  


Genomics

Comparative Map Data
Dhodh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,460,636 - 54,483,049 (-)NCBIGRCr8
mRatBN7.21937,551,858 - 37,573,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,558,177 - 37,591,654 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1944,372,421 - 44,386,399 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,025,749 - 45,039,726 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,335,351 - 47,349,222 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01942,066,103 - 42,087,906 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,066,351 - 42,082,012 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01952,891,853 - 52,913,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,463,111 - 39,477,184 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11939,467,991 - 39,482,059 (-)NCBI
Celera1936,964,203 - 36,978,276 (-)NCBICelera
Cytogenetic Map19q12NCBI
DHODH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381672,008,744 - 72,027,659 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1672,008,588 - 72,027,664 (+)EnsemblGRCh38hg38GRCh38
GRCh371672,042,643 - 72,061,558 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,600,144 - 70,616,456 (+)NCBINCBI36Build 36hg18NCBI36
Build 341670,600,163 - 70,616,456NCBI
Celera1656,356,753 - 56,373,075 (+)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,809,449 - 57,826,108 (+)NCBIHuRef
CHM1_11673,455,964 - 73,472,648 (+)NCBICHM1_1
T2T-CHM13v2.01677,826,803 - 77,845,694 (+)NCBIT2T-CHM13v2.0
Dhodh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,319,876 - 110,335,330 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,317,975 - 110,335,305 (-)EnsemblGRCm39 Ensembl
GRCm388109,593,244 - 109,608,699 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,591,343 - 109,608,673 (-)EnsemblGRCm38mm10GRCm38
MGSCv378112,117,148 - 112,132,573 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368112,482,377 - 112,497,802 (-)NCBIMGSCv36mm8
Celera8113,818,789 - 113,834,192 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.12NCBI
Dhodh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554844,699,722 - 4,713,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554844,699,743 - 4,713,466 (+)NCBIChiLan1.0ChiLan1.0
DHODH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21882,126,469 - 82,142,783 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11688,054,928 - 88,070,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01652,977,879 - 52,994,496 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11671,854,238 - 71,870,673 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1671,854,238 - 71,870,673 (+)Ensemblpanpan1.1panPan2
DHODH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1577,756,411 - 77,766,207 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl577,756,407 - 77,774,090 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha577,718,144 - 77,727,932 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0578,195,768 - 78,205,557 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl578,195,854 - 78,239,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1578,015,829 - 78,025,617 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0577,838,711 - 77,848,499 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0578,337,853 - 78,347,642 (+)NCBIUU_Cfam_GSD_1.0
Dhodh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,711,350 - 37,725,488 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647521,862,166 - 21,877,711 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647521,863,627 - 21,877,660 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHODH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,942,933 - 14,955,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1614,942,898 - 14,956,000 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,563,531 - 14,574,102 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHODH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1555,161,788 - 55,177,383 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl555,161,916 - 55,180,896 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604717,957,062 - 17,973,450 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhodh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474614,254,193 - 14,268,034 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474614,254,811 - 14,268,034 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dhodh
185 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:30
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000066733
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000066733   ⟹   ENSRNOP00000061315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1937,559,170 - 37,572,187 (-)Ensembl
Rnor_6.0 Ensembl1942,066,351 - 42,082,012 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102191   ⟹   ENSRNOP00000091052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1937,559,159 - 37,591,654 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102725   ⟹   ENSRNOP00000082215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1937,559,503 - 37,573,252 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104788   ⟹   ENSRNOP00000082848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1937,558,177 - 37,573,252 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106163   ⟹   ENSRNOP00000095764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1937,559,170 - 37,591,654 (-)Ensembl
RefSeq Acc Id: NM_001008553   ⟹   NP_001008553
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81954,468,690 - 54,482,763 (-)NCBI
mRatBN7.21937,559,170 - 37,573,244 (-)NCBI
Rnor_6.01942,066,491 - 42,080,564 (+)NCBI
Rnor_5.01952,891,853 - 52,913,708 (+)NCBI
RGSC_v3.41939,463,111 - 39,477,184 (-)RGD
Celera1936,964,203 - 36,978,276 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255601   ⟹   XP_006255663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81954,460,636 - 54,483,049 (-)NCBI
mRatBN7.21937,551,858 - 37,573,327 (-)NCBI
Rnor_6.01942,066,339 - 42,087,906 (+)NCBI
Rnor_5.01952,891,853 - 52,913,708 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772529   ⟹   XP_008770751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81954,467,676 - 54,483,049 (-)NCBI
mRatBN7.21937,557,897 - 37,573,327 (-)NCBI
Rnor_6.01942,066,339 - 42,080,936 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063278274   ⟹   XP_063134344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81954,463,601 - 54,483,049 (-)NCBI
RefSeq Acc Id: XR_005496685
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81954,460,636 - 54,483,049 (-)NCBI
mRatBN7.21937,551,858 - 37,573,327 (-)NCBI
RefSeq Acc Id: XR_010060026
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81954,460,636 - 54,483,049 (-)NCBI
RefSeq Acc Id: XR_361830
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81954,463,601 - 54,483,049 (-)NCBI
mRatBN7.21937,559,377 - 37,573,327 (-)NCBI
Rnor_6.01942,066,338 - 42,080,308 (+)NCBI
Rnor_5.01952,891,853 - 52,913,708 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001008553 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255663 (Get FASTA)   NCBI Sequence Viewer  
  XP_008770751 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134344 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA56765 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091052
GenBank Protein Q63707 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008553   ⟸   NM_001008553
- Peptide Label: precursor
- UniProtKB: Q63707 (UniProtKB/Swiss-Prot),   A0A8I6APC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255663   ⟸   XM_006255601
- Peptide Label: isoform X1
- UniProtKB: Q63707 (UniProtKB/Swiss-Prot),   A0A8I6APC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770751   ⟸   XM_008772529
- Peptide Label: isoform X1
- UniProtKB: Q63707 (UniProtKB/Swiss-Prot),   A0A8I6APC4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061315   ⟸   ENSRNOT00000066733
Ensembl Acc Id: ENSRNOP00000091052   ⟸   ENSRNOT00000102191
Ensembl Acc Id: ENSRNOP00000095764   ⟸   ENSRNOT00000106163
Ensembl Acc Id: ENSRNOP00000082848   ⟸   ENSRNOT00000104788
Ensembl Acc Id: ENSRNOP00000082215   ⟸   ENSRNOT00000102725
RefSeq Acc Id: XP_063134344   ⟸   XM_063278274
- Peptide Label: isoform X1
- UniProtKB: Q63707 (UniProtKB/Swiss-Prot),   A0A8I6APC4 (UniProtKB/TrEMBL)
Protein Domains
Dihydroorotate dehydrogenase catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63707-F1-model_v2 AlphaFold Q63707 1-395 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68352 AgrOrtholog
BioCyc Gene G2FUF-5729 BioCyc
BioCyc Pathway PWY-5686 [UMP biosynthesis I] BioCyc
BioCyc Pathway Image PWY-5686 BioCyc
Ensembl Genes ENSRNOG00000015063 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000102191 ENTREZGENE
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot
InterPro Aldolase_TIM UniProtKB/Swiss-Prot
  DHO_dehydrogenase UniProtKB/Swiss-Prot
  Dihydroorotate_DH UniProtKB/Swiss-Prot
  Dihydroorotate_DH_2 UniProtKB/Swiss-Prot
  Dihydroorotate_DH_CS UniProtKB/Swiss-Prot
KEGG Report rno:65156 UniProtKB/Swiss-Prot
NCBI Gene 65156 ENTREZGENE
PANTHER DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL UniProtKB/Swiss-Prot
  DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot
Pfam DHO_dh UniProtKB/Swiss-Prot
PharmGKB DHODH RGD
PhenoGen Dhodh PhenoGen
PROSITE DHODEHASE_1 UniProtKB/Swiss-Prot
  DHODEHASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015063 RatGTEx
Superfamily-SCOP FMN-linked oxidoreductases UniProtKB/Swiss-Prot
UniProt A0A8I5ZUQ4_RAT UniProtKB/TrEMBL
  A0A8I5ZW02_RAT UniProtKB/TrEMBL
  A0A8I6AD09_RAT UniProtKB/TrEMBL
  A0A8I6APC4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QVC7_RAT UniProtKB/TrEMBL
  PYRD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-11-14 Dhodh  dihydroorotate dehydrogenase  Dhodh  dihydroorotate dehydrogenase (quinone)  Name changed 629549 APPROVED
2011-09-29 Dhodh  dihydroorotate dehydrogenase (quinone)  Dhodh  dihydroorotate dehydrogenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Dhodh  dihydroorotate dehydrogenase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference