Gene: Dhodh (dihydroorotate dehydrogenase (quinone)) Rattus norvegicus
Analyze
Symbol:
Dhodh
Name:
dihydroorotate dehydrogenase (quinone)
Description:
Exhibits several functions, including FMN binding activity; dihydroorotate dehydrogenase activity; and ubiquinone binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; lactation; and response to L-arginine. Localizes to mitochondrial inner membrane and neuronal cell body. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)); PARTICIPATES IN beta-ureidopropionase deficiency pathway; de novo pyrimidine biosynthetic pathway; dihydropyrimidinase deficiency pathway; INTERACTS WITH 1,4-naphthoquinone; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
DHOdehase; dihydroorotate dehydrogenase; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate dehydrogenase, mitochondrial; dihydroorotate oxidase
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
DHODH (dihydroorotate dehydrogenase (quinone)) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Dhodh (dihydroorotate dehydrogenase) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Dhodh (dihydroorotate dehydrogenase (quinone)) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
DHODH (dihydroorotate dehydrogenase (quinone)) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
DHODH (dihydroorotate dehydrogenase (quinone)) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Dhodh (dihydroorotate dehydrogenase (quinone)) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
DHODH (dihydroorotate dehydrogenase (quinone)) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
DHODH (dihydroorotate dehydrogenase (quinone)) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Dhodh (dihydroorotate dehydrogenase (quinone)) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
DHODH (dihydroorotate dehydrogenase (quinone))
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Mus musculus (house mouse):
Dhodh (dihydroorotate dehydrogenase)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Danio rerio (zebrafish):
dhodh (dihydroorotate dehydrogenase)
Alliance
DIOPT (TreeFam|PhylomeDB)
Drosophila melanogaster (fruit fly):
Dhod
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Saccharomyces cerevisiae (baker's yeast):
URA1
Alliance
DIOPT (OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Caenorhabditis elegans (roundworm):
dhod-1
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 19 42,066,103 - 42,087,906 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 19 42,066,351 - 42,082,012 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 19 52,891,853 - 52,913,708 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 19 39,463,111 - 39,477,184 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 19 39,467,991 - 39,482,059 (-) NCBI Celera 19 36,964,203 - 36,978,276 (-) NCBI Celera Cytogenetic Map 19 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
postaxial acrofacial dysostosis ISO RGD:68497 8554872 ClinVar Annotator: match by OMIM:263750 ClinVar PMID:19915526 postaxial acrofacial dysostosis ISO RGD:68497 8554872 ClinVar Annotator: match by term: Miller syndrome ClinVar PMID:19915526 more ... postaxial acrofacial dysostosis ISO RGD:68497 8554872 ClinVar Annotator: match by term: Miller syndrome ClinVar PMID:19915526 more ... postaxial acrofacial dysostosis ISO RGD:68497 8554872 ClinVar Annotator: match by term: Miller syndrome ClinVar PMID:28492532 postaxial acrofacial dysostosis ISO RGD:68497 8554872 ClinVar Annotator: match by term: Miller syndrome ClinVar PMID:25741868 , PMID:28492532 postaxial acrofacial dysostosis ISO RGD:68497 8554872 ClinVar Annotator: match by term: Miller syndrome ClinVar PMID:24033266 , PMID:25741868 postaxial acrofacial dysostosis ISO RGD:68497 8554872 ClinVar Annotator: match by term: Miller syndrome ClinVar PMID:25741868 postaxial acrofacial dysostosis ISO RGD:68497 8554872 ClinVar Annotator: match by OMIM:263750 ClinVar
Imported Annotations - CTD
Acute Erythroblastic Leukemia ISO RGD:68497 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:38827 beta thalassemia ISO RGD:68497 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:38827 hereditary spherocytosis ISO RGD:68497 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:38827 sickle cell anemia ISO RGD:68497 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:38827 Imported Annotations - OMIM
postaxial acrofacial dysostosis ISO RGD:68497 7240710 OMIM
1,4-naphthoquinone decreases activity ISO RGD:68497 6480464 1, 4-naphthoquinone results in decreased activity of DHODH protein CTD PMID:10658902 1,4-naphthoquinone decreases activity EXP 6480464 1, 4-naphthoquinone results in decreased activity of DHODH protein CTD PMID:10658902 17alpha-ethynylestradiol decreases expression ISO RGD:68498 6480464 Ethinyl Estradiol results in decreased expression of DHODH mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO RGD:68498 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of DHODH mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:68498 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of DHODH mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:68498 6480464 Tetrachlorodibenzodioxin affects the expression of DHODH mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of DHODH mRNA CTD PMID:21215274 , PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of DHODH mRNA] CTD PMID:21215274 2,4,6-trinitrotoluene affects expression EXP 6480464 Trinitrotoluene affects the expression of DHODH mRNA CTD PMID:21346803 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of DHODH mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of DHODH mRNA CTD PMID:21346803 2-acetamidofluorene decreases activity EXP 6480464 2-Acetylaminofluorene results in decreased activity of DHODH protein CTD PMID:6331524 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of DHODH mRNA CTD PMID:21346803 6-decylubiquinone increases metabolic processing EXP 6480464 DHODH protein results in increased metabolism of 2 more ... CTD PMID:9802339 6-decylubiquinone multiple interactions EXP 6480464 A 771726 inhibits the reaction [DHODH protein results in increased metabolism of 2 more ... CTD PMID:9802339 aflatoxin B1 increases methylation ISO RGD:68497 6480464 Aflatoxin B1 results in increased methylation of DHODH gene CTD PMID:27153756 all-trans-retinoic acid decreases expression ISO RGD:68497 6480464 Tretinoin results in decreased expression of DHODH mRNA CTD PMID:23724009 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of DHODH mRNA CTD PMID:16483693 arsane affects methylation ISO RGD:68497 6480464 Arsenic affects the methylation of DHODH gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:68497 6480464 Arsenic affects the methylation of DHODH gene CTD PMID:25304211 atovaquone decreases activity ISO RGD:68497 6480464 Atovaquone results in decreased activity of DHODH protein CTD PMID:10658902 atovaquone decreases activity EXP 6480464 Atovaquone results in decreased activity of DHODH protein CTD PMID:10658902 benzo[a]pyrene decreases expression ISO RGD:68497 6480464 Benzo(a)pyrene results in decreased expression of DHODH mRNA CTD PMID:20064835 benzo[a]pyrene increases expression ISO RGD:68498 6480464 Benzo(a)pyrene results in increased expression of DHODH mRNA CTD PMID:22228805 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of DHODH gene CTD PMID:28505145 caffeine increases expression EXP 6480464 Caffeine results in increased expression of DHODH protein CTD PMID:6149265 celastrol decreases expression ISO RGD:68497 6480464 tripterine results in decreased expression of DHODH mRNA, tripterine results in decreased expression of DHODH protein CTD PMID:27374097 ciprofloxacin multiple interactions EXP 6480464 Ciprofloxacin inhibits the reaction [DHODH protein results in increased oxidation of 4, 5-dihydroorotic acid] CTD PMID:9776318 ciprofloxacin decreases activity EXP 6480464 Ciprofloxacin results in decreased activity of DHODH protein CTD PMID:9776318 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DHODH mRNA CTD PMID:17602206 copper(II) sulfate decreases expression ISO RGD:68497 6480464 Copper Sulfate results in decreased expression of DHODH mRNA CTD PMID:19549813 dibutyl phthalate decreases expression ISO RGD:68498 6480464 Dibutyl Phthalate results in decreased expression of DHODH mRNA CTD PMID:17361019 , PMID:21266533 dihydroorotic acid multiple interactions ISO RGD:68497 6480464 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4 more ... CTD PMID:11248707 dihydroorotic acid increases metabolic processing EXP 6480464 DHODH protein results in increased metabolism of 4, 5-dihydroorotic acid CTD PMID:9802339 dihydroorotic acid increases oxidation EXP 6480464 DHODH protein results in increased oxidation of 4, 5-dihydroorotic acid CTD PMID:9776318 dihydroorotic acid multiple interactions EXP 6480464 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [DHODH protein results in increased oxidation of 4 more ... CTD PMID:11248707 more ... dihydroorotic acid multiple interactions ISO RGD:68498 6480464 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4 more ... CTD PMID:11248707 dioxygen decreases expression ISO RGD:68497 6480464 Oxygen deficiency results in decreased expression of DHODH mRNA CTD PMID:26516004 doxorubicin decreases expression ISO RGD:68498 6480464 Doxorubicin results in decreased expression of DHODH mRNA CTD PMID:26873546 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of DHODH mRNA CTD PMID:29391264 formaldehyde decreases expression ISO RGD:68497 6480464 Formaldehyde results in decreased expression of DHODH mRNA CTD PMID:23649840 glafenine increases expression EXP 6480464 Glafenine results in increased expression of DHODH mRNA CTD PMID:24136188 juglone decreases activity ISO RGD:68497 6480464 juglone results in decreased activity of DHODH protein CTD PMID:10658902 juglone decreases activity EXP 6480464 juglone results in decreased activity of DHODH protein CTD PMID:10658902 ketamine decreases expression EXP 6480464 Ketamine results in decreased expression of DHODH mRNA CTD PMID:20080153 Lapachol decreases activity ISO RGD:68497 6480464 lapachol results in decreased activity of DHODH protein CTD PMID:10658902 Lapachol decreases activity EXP 6480464 lapachol results in decreased activity of DHODH protein CTD PMID:10658902 lawsone decreases activity EXP 6480464 lawsone results in decreased activity of DHODH protein CTD PMID:10658902 lawsone decreases activity ISO RGD:68497 6480464 lawsone results in decreased activity of DHODH protein CTD PMID:10658902 lead(0) affects expression ISO RGD:68497 6480464 Lead affects the expression of DHODH mRNA CTD PMID:22313790 lead(2+) affects expression ISO RGD:68497 6480464 Lead affects the expression of DHODH mRNA CTD PMID:22313790 leflunomide decreases activity EXP 6480464 leflunomide results in decreased activity of DHODH protein CTD PMID:9802339 leflunomide decreases activity ISO RGD:68497 6480464 leflunomide results in decreased activity of DHODH protein CTD PMID:9802339 methyl methanesulfonate decreases expression ISO RGD:68497 6480464 Methyl Methanesulfonate results in decreased expression of DHODH mRNA CTD PMID:23649840 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DHODH mRNA CTD PMID:17602206 naphthazarin decreases activity ISO RGD:68497 6480464 naphthazarin results in decreased activity of DHODH protein CTD PMID:10658902 naphthazarin decreases activity EXP 6480464 naphthazarin results in decreased activity of DHODH protein CTD PMID:10658902 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of DHODH mRNA CTD PMID:22110744 oxybenzone increases expression EXP 6480464 oxybenzone results in increased expression of DHODH mRNA CTD PMID:30316929 paracetamol affects expression ISO RGD:68498 6480464 Acetaminophen affects the expression of DHODH mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:68497 6480464 Acetaminophen results in decreased expression of DHODH mRNA CTD PMID:21420995 more ... plumbagin decreases activity ISO RGD:68497 6480464 plumbagin results in decreased activity of DHODH protein CTD PMID:10658902 plumbagin decreases activity EXP 6480464 plumbagin results in decreased activity of DHODH protein CTD PMID:10658902 Polyporic acid decreases activity ISO RGD:68497 6480464 polyporic acid results in decreased activity of DHODH protein CTD PMID:10658902 Polyporic acid decreases activity EXP 6480464 polyporic acid results in decreased activity of DHODH protein CTD PMID:10658902 resveratrol increases expression ISO RGD:68498 6480464 resveratrol results in increased expression of DHODH mRNA CTD PMID:22610192 Soman decreases expression EXP 6480464 Soman results in decreased expression of DHODH mRNA CTD PMID:19281266 teriflunomide decreases activity EXP 6480464 A 771726 results in decreased activity of DHODH protein CTD PMID:9776318 , PMID:9802339 teriflunomide decreases activity ISO RGD:68497 6480464 A 771726 results in decreased activity of DHODH protein CTD PMID:9802339 teriflunomide decreases expression ISO RGD:68497 6480464 A 771726 results in decreased expression of DHODH mRNA CTD PMID:29427785 teriflunomide multiple interactions ISO RGD:68498 6480464 A 771726 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4, 5-dihydroorotic acid]] CTD PMID:11248707 teriflunomide multiple interactions ISO RGD:68497 6480464 A 771726 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4, 5-dihydroorotic acid]] CTD PMID:11248707 teriflunomide multiple interactions EXP 6480464 A 771726 inhibits the reaction [DHODH protein results in increased metabolism of 2 more ... CTD PMID:11248707 more ... Tesaglitazar increases expression EXP 6480464 tesaglitazar results in increased expression of DHODH mRNA CTD PMID:21515302 ubiquinones multiple interactions ISO RGD:68497 6480464 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4 more ... CTD PMID:11248707 ubiquinones increases metabolic processing EXP 6480464 DHODH protein results in increased metabolism of Ubiquinone CTD PMID:9802339 ubiquinones multiple interactions EXP 6480464 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4 more ... CTD PMID:11248707 , PMID:9802339 ubiquinones multiple interactions ISO RGD:68498 6480464 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4 more ... CTD PMID:11248707 urethane decreases expression ISO RGD:68497 6480464 Urethane results in decreased expression of DHODH mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:68498 6480464 Valproic Acid affects the expression of DHODH mRNA CTD PMID:17292431 valproic acid decreases expression ISO RGD:68498 6480464 Valproic Acid results in decreased expression of DHODH mRNA CTD PMID:21427059 vitamin E decreases expression ISO RGD:68497 6480464 Vitamin E results in decreased expression of DHODH mRNA CTD PMID:19244175
Gene-Chemical Interaction Annotations
