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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68352
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dhodh
Name: dihydroorotate dehydrogenase
Acc ID: CHEBI:575568
Term: atovaquone
Definition: A naphthoquinone compound having a 4-(4-chlorophenyl)cyclohexyl group at the 2-position and a hydroxy substituent at the 3-position.
Chemical ID: MESH:D053626
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhodhaffects bindingEXP 2316233RGDAtovaquone binds to Dhodh protein 
Dhodhdecreases activityEXP 6480464CTDAtovaquone results in decreased activity of DHODH proteinPMID:10658902
Dhodhdecreases activityISODHODH (Homo sapiens)6480464CTDAtovaquone results in decreased activity of DHODH proteinPMID:10658902
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