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Gene: Dhodh (dihydroorotate dehydrogenase) Mus musculus
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Symbol: Dhodh
Name: dihydroorotate dehydrogenase
Description: Predicted to have several functions, including FMN binding activity; dihydroorotate dehydrogenase activity; and ubiquinone binding activity. Predicted to be involved in positive regulation of apoptotic process; pyrimidine-containing compound biosynthetic process; and regulation of mitochondrial fission. Localizes to mitochondrion. Is expressed in several structures, including alimentary system; branchial arch; limb bud; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)); PARTICIPATES IN beta-ureidopropionase deficiency pathway; de novo pyrimidine biosynthetic pathway; dihydropyrimidinase deficiency pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2810417D19Rik; AI834883; DHOdehase; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate dehydrogenase, mitochondrial; dihydroorotate oxidase
Orthologs:
Homo sapiens (human) : DHODH (dihydroorotate dehydrogenase (quinone))  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dhodh (dihydroorotate dehydrogenase (quinone))  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dhodh (dihydroorotate dehydrogenase (quinone))
Pan paniscus (bonobo/pygmy chimpanzee) : DHODH (dihydroorotate dehydrogenase (quinone))
Canis lupus familiaris (dog) : DHODH (dihydroorotate dehydrogenase (quinone))
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dhodh (dihydroorotate dehydrogenase (quinone))
Sus scrofa (pig) : DHODH (dihydroorotate dehydrogenase (quinone))
Chlorocebus sabaeus (African green monkey) : DHODH (dihydroorotate dehydrogenase (quinone))
Heterocephalus glaber (naked mole-rat) : Dhodh (dihydroorotate dehydrogenase (quinone))
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl8109,591,343 - 109,608,673 (-)EnsemblGRCm38mm10GRCm38
GRCm388109,593,244 - 109,608,699 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv378112,117,148 - 112,132,573 (-)NCBIGRCm37mm9NCBIm37
MGSCv368112,482,377 - 112,497,802 (-)NCBImm8
Celera8113,818,789 - 113,834,192 (-)NCBICelera
Cytogenetic Map8D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dhodh
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68498
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.