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Gene: Dhodh (dihydroorotate dehydrogenase) Mus musculus
Symbol: Dhodh
Name: dihydroorotate dehydrogenase
Description: Predicted to have several functions, including FMN binding activity; dihydroorotate dehydrogenase activity; and ubiquinone binding activity. Predicted to be involved in positive regulation of apoptotic process; pyrimidine-containing compound biosynthetic process; and regulation of mitochondrial fission. Localizes to mitochondrion. Is expressed in several structures, including alimentary system; branchial arch; limb bud; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)); PARTICIPATES IN beta-ureidopropionase deficiency pathway; de novo pyrimidine biosynthetic pathway; dihydropyrimidinase deficiency pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2810417D19Rik; AI834883; DHOdehase; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate dehydrogenase, mitochondrial; dihydroorotate oxidase
Homo sapiens (human) : DHODH (dihydroorotate dehydrogenase (quinone))  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dhodh (dihydroorotate dehydrogenase (quinone))  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dhodh (dihydroorotate dehydrogenase (quinone))
Pan paniscus (bonobo/pygmy chimpanzee) : DHODH (dihydroorotate dehydrogenase (quinone))
Canis lupus familiaris (dog) : DHODH (dihydroorotate dehydrogenase (quinone))
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dhodh (dihydroorotate dehydrogenase (quinone))
Sus scrofa (pig) : DHODH (dihydroorotate dehydrogenase (quinone))
Chlorocebus sabaeus (African green monkey) : DHODH (dihydroorotate dehydrogenase (quinone))
Heterocephalus glaber (naked mole-rat) : Dhodh (dihydroorotate dehydrogenase (quinone))
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl8109,591,343 - 109,608,673 (-)EnsemblGRCm38mm10GRCm38
GRCm388109,593,244 - 109,608,699 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv378112,117,148 - 112,132,573 (-)NCBIGRCm37mm9NCBIm37
MGSCv368112,482,377 - 112,497,802 (-)NCBImm8
Celera8113,818,789 - 113,834,192 (-)NCBICelera
Cytogenetic Map8D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dhodh
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68498
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.