Dhodh (dihydroorotate dehydrogenase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Dhodh (dihydroorotate dehydrogenase) Mus musculus
Analyze
Symbol: Dhodh
Name: dihydroorotate dehydrogenase
RGD ID: 68498
MGI Page MGI
Description: Enables dihydroorotase activity and dihydroorotate dehydrogenase activity. Involved in 'de novo' UMP biosynthetic process and UDP biosynthetic process. Located in mitochondrion. Is expressed in several structures, including branchial arch; embryo ectoderm; limb bud; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2810417D19Rik; AI834883; DHOdehase; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate dehydrogenase, mitochondrial; dihydroorotate oxidase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,319,876 - 110,335,330 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,317,975 - 110,335,305 (-)EnsemblGRCm39 Ensembl
GRCm388109,593,244 - 109,608,699 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,591,343 - 109,608,673 (-)EnsemblGRCm38mm10GRCm38
MGSCv378112,117,148 - 112,132,573 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368112,482,377 - 112,497,802 (-)NCBIMGSCv36mm8
Celera8113,818,789 - 113,834,192 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1,4-naphthoquinone  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
6-decylubiquinone  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atovaquone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bisphenol A  (ISO)
brequinar  (ISO)
caffeine  (ISO)
celastrol  (ISO)
ciprofloxacin  (ISO)
clofibric acid  (ISO)
copper(II) sulfate  (ISO)
DDE  (ISO)
dextran sulfate  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dihydroorotic acid  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
epoxiconazole  (EXP)
Evodiamine  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
glafenine  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
juglone  (ISO)
ketamine  (ISO)
lapachol  (ISO)
lawsone  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
Muraglitazar  (ISO)
N-nitrosodiethylamine  (ISO)
naphthazarin  (ISO)
nickel dichloride  (ISO)
okadaic acid  (ISO)
oxybenzone  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
plumbagin  (ISO)
Polyporic acid  (ISO)
resveratrol  (EXP,ISO)
sodium arsenite  (ISO)
Soman  (ISO)
sulfadimethoxine  (ISO)
teriflunomide  (EXP,ISO)
Tesaglitazar  (ISO)
thiram  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
ubiquinones  (EXP,ISO)
urethane  (ISO)
valproic acid  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
mitochondrial inner membrane  (IBA,IEA,ISO)
mitochondrion  (HDA,ISO)
neuronal cell body  (ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inhibition of the pyrimidine biosynthetic pathway with S-8660, an analogue of brequinar sodium, prolongs cardiac allograft survival in rats. Cramer DV, etal., J Heart Lung Transplant. 1993 Jan-Feb;12(1 Pt 1):140-6.
2. Cyclic modulation of enzymes of pyrimidine nucleotide biosynthesis precedes sialoglycoconjugate changes during 2-acetylaminofluorene-induced hepatocarcinogenesis in the rat. Elliott WL, etal., Biochim Biophys Acta. 1984 Jul 30;800(2):194-201.
3. Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway. Evans DR and Guy HI, J Biol Chem. 2004 Aug 6;279(32):33035-8. Epub 2004 Apr 19.
4. Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. Hansen M, etal., Protein Sci. 2004 Apr;13(4):1031-42.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Protective and anti-arthritic effects of deer antler aqua-acupuncture (DAA), inhibiting dihydroorotate dehydrogenase, on phosphate ions-mediated chondrocyte apoptosis and rat collagen-induced arthritis. Kim KS, etal., Int Immunopharmacol. 2004 Jul;4(7):963-73.
7. Suppression of experimental autoimmune neuritis by leflunomide. Korn T, etal., Brain. 2001 Sep;124(Pt 9):1791-802.
8. Pyrimidine nucleotide synthesis in the rat kidney in early diabetes. Kunjara S, etal., Biochem Med Metab Biol. 1991 Oct;46(2):215-25.
9. Pyrimidine nucleotide synthesis in the rat mammary gland: changes in the lactation cycle and effects of diabetes. Kunjara S, etal., Biochem Med Metab Biol. 1992 Dec;48(3):263-74.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. Oral administration of leflunomide (HWA486) results in prominent suppression of immunoglobulin E formation in a rat type 1 allergy model. Mizushima Y, etal., J Pharmacol Exp Ther. 1999 Feb;288(2):849-57.
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:6249586   PMID:8889548   PMID:10349636   PMID:10658902   PMID:11042159   PMID:11076861   PMID:11248707   PMID:12100469   PMID:12477932   PMID:14610273   PMID:14651853   PMID:14681479  
PMID:15489334   PMID:15571246   PMID:16141072   PMID:16141073   PMID:18614015   PMID:18799693   PMID:20413687   PMID:21430780   PMID:21565611   PMID:21677750   PMID:21873635   PMID:22692683  
PMID:27626380   PMID:29539633   PMID:30449682   PMID:30951662   PMID:30973865   PMID:31047779   PMID:31097699   PMID:32325033   PMID:33771897   PMID:37579695   PMID:38355793  


Genomics

Comparative Map Data
Dhodh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,319,876 - 110,335,330 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,317,975 - 110,335,305 (-)EnsemblGRCm39 Ensembl
GRCm388109,593,244 - 109,608,699 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,591,343 - 109,608,673 (-)EnsemblGRCm38mm10GRCm38
MGSCv378112,117,148 - 112,132,573 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368112,482,377 - 112,497,802 (-)NCBIMGSCv36mm8
Celera8113,818,789 - 113,834,192 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.12NCBI
DHODH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381672,008,744 - 72,027,659 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1672,008,588 - 72,027,664 (+)EnsemblGRCh38hg38GRCh38
GRCh371672,042,643 - 72,061,558 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,600,144 - 70,616,456 (+)NCBINCBI36Build 36hg18NCBI36
Build 341670,600,163 - 70,616,456NCBI
Celera1656,356,753 - 56,373,075 (+)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,809,449 - 57,826,108 (+)NCBIHuRef
CHM1_11673,455,964 - 73,472,648 (+)NCBICHM1_1
T2T-CHM13v2.01677,826,803 - 77,845,694 (+)NCBIT2T-CHM13v2.0
Dhodh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,460,636 - 54,483,049 (-)NCBIGRCr8
mRatBN7.21937,551,858 - 37,573,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,558,177 - 37,591,654 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1944,372,421 - 44,386,399 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,025,749 - 45,039,726 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,335,351 - 47,349,222 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01942,066,103 - 42,087,906 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,066,351 - 42,082,012 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01952,891,853 - 52,913,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,463,111 - 39,477,184 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11939,467,991 - 39,482,059 (-)NCBI
Celera1936,964,203 - 36,978,276 (-)NCBICelera
Cytogenetic Map19q12NCBI
Dhodh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554844,699,722 - 4,713,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554844,699,743 - 4,713,466 (+)NCBIChiLan1.0ChiLan1.0
DHODH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21882,126,469 - 82,142,783 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11688,054,928 - 88,070,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01652,977,879 - 52,994,496 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11671,854,238 - 71,870,673 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1671,854,238 - 71,870,673 (+)Ensemblpanpan1.1panPan2
DHODH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1577,756,411 - 77,766,207 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl577,756,407 - 77,774,090 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha577,718,144 - 77,727,932 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0578,195,768 - 78,205,557 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl578,195,854 - 78,239,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1578,015,829 - 78,025,617 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0577,838,711 - 77,848,499 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0578,337,853 - 78,347,642 (+)NCBIUU_Cfam_GSD_1.0
Dhodh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,711,350 - 37,725,488 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647521,862,166 - 21,877,711 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647521,863,627 - 21,877,660 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHODH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,942,933 - 14,955,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1614,942,898 - 14,956,000 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,563,531 - 14,574,102 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHODH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1555,161,788 - 55,177,383 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl555,161,916 - 55,180,896 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604717,957,062 - 17,973,450 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhodh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474614,254,193 - 14,268,034 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474614,254,811 - 14,268,034 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dhodh
1197 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:3017
Count of miRNA genes:764
Interacting mature miRNAs:1031
Transcripts:ENSMUST00000069058, ENSMUST00000123605, ENSMUST00000124138, ENSMUST00000125222, ENSMUST00000125779, ENSMUST00000128350, ENSMUST00000131107, ENSMUST00000133353, ENSMUST00000142106, ENSMUST00000143900, ENSMUST00000146064, ENSMUST00000150804
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300560Tgl1_mtriglyceride level 1 (mouse)Not determined8102486208111650036Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
35673316Ari3_mantibody response to influenza 3, day 15, IgM (mouse)8109426632113826632Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
36049782Arc2_mantibody response to CHIKV 2, day 7, IgM (mouse)8109426632113826632Mouse
36049783Arc3_mantibody response to CHIKV 3, day 7, FRNT50 (mouse)8109426632113826632Mouse
36049780Ars12_mantibody response to SARS-CoV 12, 4 days post-rechallenge, IgM (mouse)8109426632113826632Mouse
14746994Manh65_mmandible shape 65 (mouse)8106489629130127694Mouse
36049781Arc1_mantibody response to CHIKV 1, day 7, IgG (mouse)8109426632113826632Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8103443553127781786Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
1300681Pgia22_mproteoglycan induced arthritis 22 (mouse)Not determined8102486208116025457Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)897626632130127694Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined898563635130127694Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8105033977130127694Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8105033977130127694Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse

Markers in Region
AF029667  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388109,593,669 - 109,593,785UniSTSGRCm38
MGSCv378112,117,569 - 112,117,685UniSTSGRCm37
Celera8113,819,210 - 113,819,326UniSTS
Cytogenetic Map8D3UniSTS
Whitehead/MRC_RH81287.08UniSTS
Whitehead/MRC_RH81289.0UniSTS
Dhodh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8D3UniSTS
cM Map857.12UniSTS
Dhodh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8D3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000123605   ⟹   ENSMUSP00000115934
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,320,109 - 110,335,255 (-)Ensembl
GRCm38.p6 Ensembl8109,593,477 - 109,608,623 (-)Ensembl
Ensembl Acc Id: ENSMUST00000124138
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,320,605 - 110,321,582 (-)Ensembl
GRCm38.p6 Ensembl8109,593,973 - 109,594,950 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125222
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,319,879 - 110,320,683 (-)Ensembl
GRCm38.p6 Ensembl8109,593,247 - 109,594,051 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125779
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,320,678 - 110,328,143 (-)Ensembl
GRCm38.p6 Ensembl8109,594,046 - 109,601,511 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128350   ⟹   ENSMUSP00000118612
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,329,935 - 110,335,305 (-)Ensembl
GRCm38.p6 Ensembl8109,603,303 - 109,608,673 (-)Ensembl
Ensembl Acc Id: ENSMUST00000131107
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,327,963 - 110,335,052 (-)Ensembl
GRCm38.p6 Ensembl8109,601,331 - 109,608,420 (-)Ensembl
Ensembl Acc Id: ENSMUST00000133353   ⟹   ENSMUSP00000114190
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,317,975 - 110,332,864 (-)Ensembl
GRCm38.p6 Ensembl8109,591,343 - 109,606,232 (-)Ensembl
Ensembl Acc Id: ENSMUST00000142106
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,320,533 - 110,322,914 (-)Ensembl
GRCm38.p6 Ensembl8109,593,901 - 109,596,282 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143900   ⟹   ENSMUSP00000117980
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,320,379 - 110,335,255 (-)Ensembl
GRCm38.p6 Ensembl8109,593,747 - 109,608,623 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146064
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,327,950 - 110,335,052 (-)Ensembl
GRCm38.p6 Ensembl8109,601,318 - 109,608,420 (-)Ensembl
Ensembl Acc Id: ENSMUST00000150804   ⟹   ENSMUSP00000115549
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,322,662 - 110,334,998 (-)Ensembl
GRCm38.p6 Ensembl8109,596,030 - 109,608,366 (-)Ensembl
RefSeq Acc Id: NM_020046   ⟹   NP_064430
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398110,319,880 - 110,335,305 (-)NCBI
GRCm388109,593,248 - 109,608,673 (-)NCBI
MGSCv378112,117,148 - 112,132,573 (-)RGD
Celera8113,818,789 - 113,834,192 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036154200   ⟹   XP_036010093
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398110,319,876 - 110,335,327 (-)NCBI
Sequence:
RefSeq Acc Id: XR_387762
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398110,319,876 - 110,335,330 (-)NCBI
GRCm388109,593,244 - 109,608,699 (-)NCBI
Sequence:
RefSeq Acc Id: NP_064430   ⟸   NM_020046
- Peptide Label: precursor
- UniProtKB: O35435 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000115549   ⟸   ENSMUST00000150804
Ensembl Acc Id: ENSMUSP00000117980   ⟸   ENSMUST00000143900
Ensembl Acc Id: ENSMUSP00000114190   ⟸   ENSMUST00000133353
Ensembl Acc Id: ENSMUSP00000118612   ⟸   ENSMUST00000128350
Ensembl Acc Id: ENSMUSP00000115934   ⟸   ENSMUST00000123605
RefSeq Acc Id: XP_036010093   ⟸   XM_036154200
- Peptide Label: isoform X1
Protein Domains
Dihydroorotate dehydrogenase catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35435-F1-model_v2 AlphaFold O35435 1-395 view protein structure

Promoters
RGD ID:8668235
Promoter ID:EPDNEW_M12149
Type:initiation region
Name:Dhodh_1
Description:Mus musculus dihydroorotate dehydrogenase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388109,608,666 - 109,608,726EPDNEW
RGD ID:6843028
Promoter ID:MM_KWN:55691
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000081917
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368112,119,666 - 112,120,166 (-)MPROMDB
RGD ID:6843026
Promoter ID:MM_KWN:55694
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000034166,   NM_020046,   OTTMUST00000081909,   OTTMUST00000081910,   OTTMUST00000081914,   OTTMUST00000081915,   UC009NIQ.1,   UC009NIR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368112,132,166 - 112,133,242 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1928378 AgrOrtholog
Ensembl Genes ENSMUSG00000031730 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000123605 ENTREZGENE
  ENSMUST00000123605.9 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot
InterPro Aldolase_TIM UniProtKB/Swiss-Prot
  DHO_dehydrogenase UniProtKB/Swiss-Prot
  Dihydroorotate_DH UniProtKB/Swiss-Prot
  Dihydroorotate_DH_2 UniProtKB/Swiss-Prot
  Dihydroorotate_DH_CS UniProtKB/Swiss-Prot
KEGG Report mmu:56749 UniProtKB/Swiss-Prot
MGD MGI:1928378 ENTREZGENE
NCBI Gene 56749 ENTREZGENE
PANTHER DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL UniProtKB/Swiss-Prot
  DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot
Pfam DHO_dh UniProtKB/Swiss-Prot
PharmGKB DHODH RGD
PhenoGen Dhodh PhenoGen
PROSITE DHODEHASE_1 UniProtKB/Swiss-Prot
  DHODEHASE_2 UniProtKB/Swiss-Prot
Superfamily-SCOP FMN-linked oxidoreductases UniProtKB/Swiss-Prot
UniProt D3YZY5_MOUSE UniProtKB/TrEMBL
  E9Q1V3_MOUSE UniProtKB/TrEMBL
  F6TCT7_MOUSE UniProtKB/TrEMBL
  F6ZQJ5_MOUSE UniProtKB/TrEMBL
  O35435 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3UET5_MOUSE UniProtKB/TrEMBL
  Q8BMJ0_MOUSE UniProtKB/TrEMBL