DHODH (dihydroorotate dehydrogenase (quinone)) - Rat Genome Database
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Gene: DHODH (dihydroorotate dehydrogenase (quinone)) Sus scrofa
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Symbol: DHODH
Name: dihydroorotate dehydrogenase (quinone)
RGD ID: 14114673
Description: ENCODES a protein that exhibits dihydroorotate dehydrogenase activity (ortholog); FMN binding (ortholog); quinone binding (ortholog); INVOLVED IN 'de novo' pyrimidine nucleobase biosynthetic process (ortholog); female pregnancy (ortholog); lactation (ortholog); PARTICIPATES IN beta-ureidopropionase deficiency pathway; de novo pyrimidine biosynthetic pathway; dihydropyrimidinase deficiency pathway; ASSOCIATED WITH Acute Erythroblastic Leukemia (ortholog); beta thalassemia (ortholog); Experimental Arthritis (ortholog); FOUND IN mitochondrial inner membrane (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: dihydroorotate dehydrogenase (quinone), mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,942,933 - 14,956,000 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1614,942,898 - 14,956,000 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,563,531 - 14,574,102 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:26180101  


Genomics

Comparative Map Data
DHODH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,942,933 - 14,956,000 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1614,942,898 - 14,956,000 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,563,531 - 14,574,102 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHODH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1672,008,588 - 72,027,664 (+)EnsemblGRCh38hg38GRCh38
GRCh381672,008,744 - 72,027,659 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371672,042,643 - 72,061,558 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh371672,042,643 - 72,059,316 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,600,144 - 70,616,456 (+)NCBINCBI36hg18NCBI36
Build 341670,600,163 - 70,616,456NCBI
Celera1656,356,753 - 56,373,075 (+)NCBI
Cytogenetic Map16q22.2NCBI
HuRef1657,809,449 - 57,826,108 (+)NCBIHuRef
CHM1_11673,455,964 - 73,472,648 (+)NCBICHM1_1
Dhodh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,319,876 - 110,335,330 (-)NCBIGRCm39mm39
GRCm388109,593,244 - 109,608,699 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,591,343 - 109,608,673 (-)EnsemblGRCm38mm10GRCm38
MGSCv378112,117,148 - 112,132,573 (-)NCBIGRCm37mm9NCBIm37
MGSCv368112,482,377 - 112,497,802 (-)NCBImm8
Celera8113,818,789 - 113,834,192 (-)NCBICelera
Cytogenetic Map8D3NCBI
Dhodh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21937,551,858 - 37,573,327 (-)NCBI
Rnor_6.0 Ensembl1942,066,351 - 42,082,012 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01942,066,103 - 42,087,906 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01952,891,853 - 52,913,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,463,111 - 39,477,184 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11939,467,991 - 39,482,059 (-)NCBI
Celera1936,964,203 - 36,978,276 (-)NCBICelera
Cytogenetic Map19q12NCBI
Dhodh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554844,699,722 - 4,713,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554844,699,743 - 4,713,466 (+)NCBIChiLan1.0ChiLan1.0
DHODH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11671,854,238 - 71,870,673 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1671,854,238 - 71,870,673 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01652,977,879 - 52,994,496 (-)NCBIMhudiblu_PPA_v0panPan3
DHODH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl577,756,407 - 77,774,090 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1577,756,411 - 77,766,207 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dhodh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647521,863,627 - 21,877,660 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHODH
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1555,161,788 - 55,177,383 (+)NCBI
ChlSab1.1 Ensembl555,161,916 - 55,180,896 (+)Ensembl
Dhodh
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474614,254,811 - 14,268,034 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003043   ⟹   ENSSSCP00000002964
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl614,942,935 - 14,956,000 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000071452   ⟹   ENSSSCP00000066486
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl614,942,933 - 14,955,998 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000086301   ⟹   ENSSSCP00000065957
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl614,945,050 - 14,956,000 (+)Ensembl
RefSeq Acc Id: XM_021093828   ⟹   XP_020949487
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1614,942,898 - 14,956,000 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021093829   ⟹   XP_020949488
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1614,942,898 - 14,956,000 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020949487 (Get FASTA)   NCBI Sequence Viewer  
  XP_020949488 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ALI95909 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020949487   ⟸   XM_021093828
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020949488   ⟸   XM_021093829
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000002964   ⟸   ENSSSCT00000003043
RefSeq Acc Id: ENSSSCP00000065957   ⟸   ENSSSCT00000086301
RefSeq Acc Id: ENSSSCP00000066486   ⟸   ENSSSCT00000071452
Protein Domains
DHO_dh


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002746 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070001832 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000002964 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000065957 UniProtKB/TrEMBL
  ENSSSCP00000066486 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070002826 UniProtKB/TrEMBL
  ENSSSCP00070002839 UniProtKB/TrEMBL
  ENSSSCP00070002848 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003043 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000071452 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000086301 UniProtKB/TrEMBL
  ENSSSCT00070003415 UniProtKB/TrEMBL
  ENSSSCT00070003430 UniProtKB/TrEMBL
  ENSSSCT00070003441 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  Dihydroorotate_DH UniProtKB/TrEMBL
  Dihydroorotate_DH_2 UniProtKB/TrEMBL
  Dihydroorotate_DH_CS UniProtKB/TrEMBL
NCBI Gene DHODH ENTREZGENE
Pfam DHO_dh UniProtKB/TrEMBL
PROSITE DHODEHASE_1 UniProtKB/TrEMBL
  DHODEHASE_2 UniProtKB/TrEMBL
TIGRFAMs pyrD_sub2 UniProtKB/TrEMBL
UniProt A0A4X1SKD2_PIG UniProtKB/TrEMBL
  A0A4X1SLD6_PIG UniProtKB/TrEMBL
  A0A4X1SLF9_PIG UniProtKB/TrEMBL
  A0A5G2QM53_PIG UniProtKB/TrEMBL
  A0A5G2R7A7_PIG UniProtKB/TrEMBL
  F1S3B0_PIG UniProtKB/TrEMBL
VGNC ID VGNC:96780 ENTREZGENE