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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor
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Accession:CHEBI:77103 term browser browse the term
Definition:An EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor that interferes with the action of dihydroorotate dehydrogenase (quinone), EC 1.3.5.2.
Synonyms:related_synonym: (S)-dihydroorotate:acceptor oxidoreductase inhibitor;   (S)-dihydroorotate:acceptor oxidoreductase inhibitors;   (S)-dihydroorotate:quinone oxidoreductase inhibitor;   (S)-dihydroorotate:quinone oxidoreductase inhibitors;   DHOD inhibitor;   DHOD inhibitors;   DHODH inhibitor;   DHODH inhibitors;   DHOdehase inhibitor;   DHOdehase inhibitors;   EC 1.3.5.2 (dihydroorotate dehydrogenase (quinone)) inhibitors;   EC 1.3.5.2 inhibitor;   EC 1.3.5.2 inhibitors;   dihydroorotate:ubiquinone oxidoreductase inhibitor;   dihydroorotate:ubiquinone oxidoreductase inhibitors
 xref: Wikipedia:Dihydroorotate_dehydrogenase_(quinone)



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atovaquone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity ISO Atovaquone results in increased activity of CYP1A2 protein CTD PMID:11124226 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity
affects binding
ISO
EXP
Atovaquone results in decreased activity of DHODH protein
Atovaquone binds to Dhodh protein
CTD
RGD
PMID:10658902 PMID:15044733 RGD:2316233 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Atovaquone inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
brequinar term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhodh dihydroorotate dehydrogenase (quinone) multiple interactions
decreases activity
EXP
ISO
brequinar inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; brequinar inhibits the reaction [DHODH protein results in increased metabolism of Quinones]; brequinar inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]
brequinar results in decreased activity of DHODH protein
CTD PMID:9776318 PMID:9802339 PMID:10658902 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        biochemical role 19630
          enzyme inhibitor 18576
            EC 1.* (oxidoreductase) inhibitor 17105
              EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor 6501
                EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor 295
                  EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor 3
                    (E)-2-[[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]benzoic acid 0
                    atovaquone 3
                    brequinar 1
                    brequinar sodium 0
paths to the root