DHODH (dihydroorotate dehydrogenase (quinone)) - Rat Genome Database
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Gene: DHODH (dihydroorotate dehydrogenase (quinone)) Canis lupus familiaris
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Symbol: DHODH
Name: dihydroorotate dehydrogenase (quinone)
RGD ID: 12380714
Description: ENCODES a protein that exhibits dihydroorotate dehydrogenase activity (ortholog); FMN binding (ortholog); quinone binding (ortholog); INVOLVED IN 'de novo' pyrimidine nucleobase biosynthetic process (ortholog); female pregnancy (ortholog); lactation (ortholog); PARTICIPATES IN beta-ureidopropionase deficiency pathway; de novo pyrimidine biosynthetic pathway; dihydropyrimidinase deficiency pathway; ASSOCIATED WITH Acute Erythroblastic Leukemia (ortholog); beta thalassemia (ortholog); Experimental Arthritis (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrion (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate dehydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl577,756,407 - 77,774,090 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1577,756,411 - 77,766,207 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
DHODH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl577,756,407 - 77,774,090 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1577,756,411 - 77,766,207 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
DHODH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1672,008,588 - 72,027,664 (+)EnsemblGRCh38hg38GRCh38
GRCh381672,008,744 - 72,027,659 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371672,042,643 - 72,061,558 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,600,144 - 70,616,456 (+)NCBINCBI36hg18NCBI36
Build 341670,600,163 - 70,616,456NCBI
Celera1656,356,753 - 56,373,075 (+)NCBI
Cytogenetic Map16q22.2NCBI
HuRef1657,809,449 - 57,826,108 (+)NCBIHuRef
CHM1_11673,455,964 - 73,472,648 (+)NCBICHM1_1
Dhodh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,319,876 - 110,335,330 (-)NCBIGRCm39mm39
GRCm39 Ensembl8110,317,975 - 110,335,305 (-)Ensembl
GRCm388109,593,244 - 109,608,699 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,591,343 - 109,608,673 (-)EnsemblGRCm38mm10GRCm38
MGSCv378112,117,148 - 112,132,573 (-)NCBIGRCm37mm9NCBIm37
MGSCv368112,482,377 - 112,497,802 (-)NCBImm8
Celera8113,818,789 - 113,834,192 (-)NCBICelera
Cytogenetic Map8D3NCBI
Dhodh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21937,551,858 - 37,573,327 (-)NCBI
Rnor_6.0 Ensembl1942,066,351 - 42,082,012 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01942,066,103 - 42,087,906 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01952,891,853 - 52,913,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,463,111 - 39,477,184 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11939,467,991 - 39,482,059 (-)NCBI
Celera1936,964,203 - 36,978,276 (-)NCBICelera
Cytogenetic Map19q12NCBI
Dhodh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554844,699,722 - 4,713,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554844,699,743 - 4,713,466 (+)NCBIChiLan1.0ChiLan1.0
DHODH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11671,854,238 - 71,870,673 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1671,854,238 - 71,870,673 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01652,977,879 - 52,994,496 (-)NCBIMhudiblu_PPA_v0panPan3
Dhodh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647521,863,627 - 21,877,660 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHODH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,942,933 - 14,956,000 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1614,942,898 - 14,956,000 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,563,531 - 14,574,102 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHODH
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1555,161,788 - 55,177,383 (+)NCBI
ChlSab1.1 Ensembl555,161,916 - 55,180,896 (+)Ensembl
Dhodh
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474614,254,811 - 14,268,034 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8
Low 5 5 22 6 6 6 6 6 12 10 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005620754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022419266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038477249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038477250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038477251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038538452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038538453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038538454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038602570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038602571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038602572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038667177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038667178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038667179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_848306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000032204   ⟹   ENSCAFP00000029990
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl577,756,407 - 77,774,090 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000071575   ⟹   ENSCAFP00000044282
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl577,756,407 - 77,774,090 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000084723   ⟹   ENSCAFP00000059706
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl577,756,407 - 77,774,090 (+)Ensembl
RefSeq Acc Id: XM_005620754   ⟹   XP_005620811
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1577,756,411 - 77,766,207 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022419266   ⟹   XP_022274974
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1577,756,674 - 77,766,207 (+)NCBI
Sequence:
RefSeq Acc Id: XM_848306   ⟹   XP_853399
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1577,756,411 - 77,766,207 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_853399   ⟸   XM_848306
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005620811   ⟸   XM_005620754
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_022274974   ⟸   XM_022419266
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000059706   ⟸   ENSCAFT00000084723
RefSeq Acc Id: ENSCAFP00000044282   ⟸   ENSCAFT00000071575
RefSeq Acc Id: ENSCAFP00000029990   ⟸   ENSCAFT00000032204
Protein Domains
DHO_dh


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020218 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000029990 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000044282 UniProtKB/TrEMBL
  ENSCAFP00000059706 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000032204 UniProtKB/TrEMBL
  ENSCAFT00000071575 UniProtKB/TrEMBL
  ENSCAFT00000084723 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  Dihydroorotate_DH UniProtKB/TrEMBL
  Dihydroorotate_DH_2 UniProtKB/TrEMBL
  Dihydroorotate_DH_CS UniProtKB/TrEMBL
NCBI Gene DHODH ENTREZGENE
Pfam DHO_dh UniProtKB/TrEMBL
PROSITE DHODEHASE_1 UniProtKB/TrEMBL
  DHODEHASE_2 UniProtKB/TrEMBL
TIGRFAMs pyrD_sub2 UniProtKB/TrEMBL
UniProt A0A5F4BTM5_CANLF UniProtKB/TrEMBL
  A0A5F4D1U7_CANLF UniProtKB/TrEMBL
  E2RPD0_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:53333 ENTREZGENE