Dhodh (dihydroorotate dehydrogenase (quinone))

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Gene: Dhodh (dihydroorotate dehydrogenase (quinone)) Ictidomys tridecemlineatus

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Symbol:

Dhodh

Name:

dihydroorotate dehydrogenase (quinone)

RGD ID:

12686730

Description:

ENCODES a protein that exhibits dihydroorotate dehydrogenase activity (ortholog); FMN binding (ortholog); quinone binding (ortholog); INVOLVED IN 'de novo' pyrimidine nucleobase biosynthetic process (ortholog); female pregnancy (ortholog); lactation (ortholog); PARTICIPATES IN beta-ureidopropionase deficiency pathway; de novo pyrimidine biosynthetic pathway; dihydropyrimidinase deficiency pathway; ASSOCIATED WITH autosomal dominant dyskeratosis congenita 6 (ortholog); beta thalassemia (ortholog); erythroleukemia (ortholog); FOUND IN mitochondrial inner membrane (ortholog); neuronal cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

dihydroorotate dehydrogenase (quinone), mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	37,711,350 - 37,725,488 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	21,862,166 - 21,877,711 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	21,863,627 - 21,877,660 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant dyskeratosis congenita 6 (ISO)

beta thalassemia (ISO)

erythroleukemia (ISO)

Experimental Arthritis (ISO)

Experimental Autoimmune Neuritis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Neoplasms (ISO)

genetic disease (ISO)

hereditary spherocytosis (ISO)

Immediate Hypersensitivity (ISO)

postaxial acrofacial dysostosis (ISO)

sickle cell anemia (ISO)

Transplant Rejection (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

'de novo' pyrimidine nucleobase biosynthetic process (IEA,ISO)

'de novo' UMP biosynthetic process (IEA)

female pregnancy (ISO)

lactation (ISO)

positive regulation of apoptotic process (ISO)

pyrimidine ribonucleotide biosynthetic process (IEA)

regulation of mitochondrial fission (ISO)

response to caffeine (ISO)

response to L-arginine (ISO)

response to starvation (ISO)

response to xenobiotic stimulus (ISO)

UDP biosynthetic process (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

membrane (IEA)

mitochondrial inner membrane (IEA,ISO)

mitochondrion (IEA)

neuronal cell body (ISO)

nucleoplasm (IEA)

Molecular Function

dihydroorotase activity (IEA)

dihydroorotate dehydrogenase (quinone) activity (IEA)

dihydroorotate dehydrogenase activity (IEA,ISO)

FMN binding (ISO)

oxidoreductase activity (IEA)

protein binding (ISO)

quinone binding (ISO)

ubiquinone binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

beta-ureidopropionase deficiency pathway (ISO)

de novo pyrimidine biosynthetic pathway (ISO)

dihydropyrimidinase deficiency pathway (ISO)

mitochondrial neurogastrointestinal encephalopathy syndrome pathway (ISO)

orotic aciduria 1 pathway (ISO)

pyrimidine metabolic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Dhodh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	37,711,350 - 37,725,488 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	21,862,166 - 21,877,711 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	21,863,627 - 21,877,660 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DHODH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	72,008,744 - 72,027,659 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	72,008,588 - 72,027,664 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	72,042,643 - 72,061,558 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	70,600,144 - 70,616,456 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	70,600,163 - 70,616,456	NCBI
Celera	16	56,356,753 - 56,373,075 (+)	NCBI		Celera
Cytogenetic Map	16	q22.2	NCBI
HuRef	16	57,809,449 - 57,826,108 (+)	NCBI		HuRef
CHM1_1	16	73,455,964 - 73,472,648 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	77,826,803 - 77,845,694 (+)	NCBI		T2T-CHM13v2.0

Dhodh
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	110,319,876 - 110,335,330 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	110,317,975 - 110,335,305 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	109,593,244 - 109,608,699 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	109,591,343 - 109,608,673 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	112,117,148 - 112,132,573 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	112,482,377 - 112,497,802 (-)	NCBI		MGSCv36	mm8
Celera	8	113,818,789 - 113,834,192 (-)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	57.12	NCBI

Dhodh
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	54,460,636 - 54,483,049 (-)	NCBI		GRCr8
mRatBN7.2	19	37,551,858 - 37,573,327 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	37,558,177 - 37,591,654 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	44,372,421 - 44,386,399 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	45,025,749 - 45,039,726 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	47,335,351 - 47,349,222 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	42,066,103 - 42,087,906 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	42,066,351 - 42,082,012 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	52,891,853 - 52,913,708 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	39,463,111 - 39,477,184 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	39,467,991 - 39,482,059 (-)	NCBI
Celera	19	36,964,203 - 36,978,276 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

Dhodh
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	4,699,722 - 4,713,466 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	4,699,743 - 4,713,466 (+)	NCBI	ChiLan1.0	ChiLan1.0

DHODH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	82,126,469 - 82,142,783 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	88,054,928 - 88,070,448 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	52,977,879 - 52,994,496 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	71,854,238 - 71,870,673 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	71,854,238 - 71,870,673 (+)	Ensembl	panpan1.1		panPan2

DHODH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	77,756,411 - 77,766,207 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	77,756,407 - 77,774,090 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	77,718,144 - 77,727,932 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	78,195,768 - 78,205,557 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	78,195,854 - 78,239,419 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	78,015,829 - 78,025,617 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	77,838,711 - 77,848,499 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	78,337,853 - 78,347,642 (+)	NCBI		UU_Cfam_GSD_1.0

DHODH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	14,942,933 - 14,955,997 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	14,942,898 - 14,956,000 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	14,563,531 - 14,574,102 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DHODH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	55,161,788 - 55,177,383 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	55,161,916 - 55,180,896 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	17,957,062 - 17,973,450 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dhodh
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	14,254,193 - 14,268,034 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	14,254,811 - 14,268,034 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005318387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000023203 ⟹ ENSSTOP00000016337

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936475	21,863,927 - 21,877,636 (-)	Ensembl

Ensembl Acc Id:

ENSSTOT00000038635 ⟹ ENSSTOP00000028109

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936475	21,862,166 - 21,877,711 (-)	Ensembl

RefSeq Acc Id:

XM_005318387 ⟹ XP_005318444

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	37,711,350 - 37,725,488 (+)	NCBI
SpeTri2.0	NW_004936475	21,863,627 - 21,877,660 (-)	NCBI

Sequence:

show sequence

GGCCGGCCCAATGGTAGAAGGAGCATGGCGTGGAGACAACTGAAAAAGCGAGCTCTGGATGCTG
TAGTCATCCTGGGGGGTGGAGGACTTCTCTGTGCCTCCTACCTGACAGCCACAGGGGATGAGCA
TTTCTATGCTGAATACTTGATGCCAGCTCTGCAGAGGCTGCTGGACCCAGAGTTAGCCCACAGG
CTGGCTGTTCGCTTCATCTCCCTGGGGCTCCTTCCTCCAGCCACATTTCAAGACTCTGACATGC
TGGAAGTGAAAGTCCTGGGCCATAAATTCCGAAATCCAGTAGGCATTGCTGCAGGATTTGACAA
GCATGGGGAAGCTGTGGATGGCTTATATAAGCTGGGCTTTGGCTTTGTTGAGGTAGGAAGTGTG
ACTCCCAAGCCTCAGGAAGGAAACCCCAGGCCCAGAGTCTTCCGCCTGCCTGAGGACCAAGCTG
TCATTAACAGGTATGGATTTAACAGCCACGGACTCTCAGTGGTGGAACACAGGTTGCGGGCCAG
ACGGCAGAAGCAGACCAAGCTCACAGAAGATGGGCTGCCACTGGGAATAAACCTGGGGAAGAAT
AAAATGTCGGTGGATGCTGCTGCAGACTATGCAGAGGGGGTTCAGGTCCTGGGCCCTTTGGCCG
ACTACCTGGTAGTGAACGTGTCCAGTCCCAACACAGCTGGGCTGCGGAGCCTTCAGGGAAAGGC
CGAGCTGCGCTGCCTGCTGACCAAGGTGCTGCAGGAGAGGGATGCTTTGAAGGGAGTGCAGAAG
CCGGCAGTACTGCTGAAGATTGCCCCTGACCTCACGGCTCAGGACAAGGAGGACATTGCCAGTG
TGGCGAGAGAGTTGGGCATCGATGGGTTGATTGTCACGAACACCACAGTGAGTCGCCCTGCTGG
TCTCCAAGGTGCTCTGCGCTCTGAGACAGGAGGGCTGAGTGGGAAGCCCCTCCGTGATTTATCA
ACTCAGACCATCCGGGAGATGTATGCGCTCACTCAAGGCAGAATTCCCATAATTGGGGTTGGCG
GTGTCAGCAGTGGGCAGGATGCGCTGGAGAAGATCCAGGCTGGTGCCTCCCTGGTGCAGCTGTA
CACGGCCCTCATCTACCAGGGGCCACCTGTGGTGGGCAAAGTTAAGCGGGAGCTGGAGGCCCTT
TTGAAAGAACAGGGTTTTAGCCGAGTCACAGATGCCATTGGAGCAGATCATCGGAGATGAGGAT
GCTTGACAGAAATCCATGACTGGATCATGTGAAGAAGGACTCTAAAGCCATGTCTCCCAAACCA
TGGCTTAGCAGGACTATAACAGCCAATCATAAGGGGGTCACCAGAGTCAATGGAGACTTTTTTC
AATTGGTTGCTCAAACATAAACTTAGTTGTGCTTCTTTCTGGATCCAAATCCCAGGATCCTTCA
ATTTGTAAGGATATTGAATATTTTGGGGGGAAATCATGGAAAAGATAAAGTCATTTAAATCCTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005318444	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000016337.2
	ENSSTOP00000028109.1
GenBank Protein	KAG3256922	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005318444 ⟸ XM_005318387

- UniProtKB:

A0A287D3K5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAWRQLKKRALDAVVILGGGGLLCASYLTATGDEHFYAEYLMPALQRLLDPELAHRLAVRFISL
GLLPPATFQDSDMLEVKVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPKPQEGN
PRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARRQKQTKLTEDGLPLGINLGKNKMSVDAAA
DYAEGVQVLGPLADYLVVNVSSPNTAGLRSLQGKAELRCLLTKVLQERDALKGVQKPAVLLKIA
PDLTAQDKEDIASVARELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMY
ALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIYQGPPVVGKVKRELEALLKEQGFSR
VTDAIGADHRR

hide sequence

Ensembl Acc Id:

ENSSTOP00000016337 ⟸ ENSSTOT00000023203

Ensembl Acc Id:

ENSSTOP00000028109 ⟸ ENSSTOT00000038635

Protein Domains

Dihydroorotate dehydrogenase catalytic

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000025792	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000023203.2	UniProtKB/TrEMBL
	ENSSTOT00000038635.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.70	UniProtKB/TrEMBL
InterPro	Aldolase_TIM	UniProtKB/TrEMBL
	DHO_dehydrogenase	UniProtKB/TrEMBL
	Dihydroorotate_DH	UniProtKB/TrEMBL
	Dihydroorotate_DH_2	UniProtKB/TrEMBL
	Dihydroorotate_DH_CS	UniProtKB/TrEMBL
NCBI Gene	Dhodh	ENTREZGENE
PANTHER	DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL	UniProtKB/TrEMBL
	DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED	UniProtKB/TrEMBL
Pfam	DHO_dh	UniProtKB/TrEMBL
PROSITE	DHODEHASE_1	UniProtKB/TrEMBL
	DHODEHASE_2	UniProtKB/TrEMBL
Superfamily-SCOP	FMN-linked oxidoreductases	UniProtKB/TrEMBL
UniProt	A0A287D3K5	ENTREZGENE, UniProtKB/TrEMBL
	I3MW42_ICTTR	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB