RGD Reference Report - Pyrimidine nucleotide synthesis in the rat mammary gland: changes in the lactation cycle and effects of diabetes. - Rat Genome Database

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Pyrimidine nucleotide synthesis in the rat mammary gland: changes in the lactation cycle and effects of diabetes.

Authors: Kunjara, S  Sochor, M  Bennett, M  Greenbaum, AL  McLean, P 
Citation: Kunjara S, etal., Biochem Med Metab Biol. 1992 Dec;48(3):263-74.
RGD ID: 5132591
Pubmed: (View Article at PubMed) PMID:1476792

Measurements have been made of the activities of the enzymes of the de novo and salvage pathways of pyrimidine synthesis (carbamoyl phosphate synthetase II (glutamine) (EC 6.3.5.5); dihydroorotate dehydrogenase (EC 1.3.99.11); the overall activity of Complex II (orotate phosphoribosyl pyrophosphate transferase (EC 2.4.2.10) and orotidine 5-phosphate decarboxylase (EC 4.1.1.23); uracil phosphoribosyltransferase (EC 2.4.2.9)) in the mammary gland of rats at different stages of the lactation cycle and the effects of diabetes on the activity of these enzymes in lactation have been studied. From a consideration of the changes in enzyme activities and the changes in the tissue concentration of phosphoribosyl pyrophosphate, an activator of the de novo pathway and substrate for both the de novo and salvage routes, it is concluded that the de novo pathway is the major route of pyrimidine synthesis in mammary tissue. Diabetes decreases the activity of the enzymes of the de novo pathway; the effects are particularly marked for Complex II. The present results on pyrimidine synthesis are compared to the pattern for purine synthesis previously published.

Annotation

Disease Annotations    

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Cad  (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase)
Dhodh  (dihydroorotate dehydrogenase (quinone))
Umps  (uridine monophosphate synthetase)
Uprt  (uracil phosphoribosyltransferase homolog)

Genes (Mus musculus)
Cad  (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase)
Dhodh  (dihydroorotate dehydrogenase)
Umps  (uridine monophosphate synthetase)
Uprt  (uracil phosphoribosyltransferase)

Genes (Homo sapiens)
CAD  (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase)
DHODH  (dihydroorotate dehydrogenase (quinone))
UMPS  (uridine monophosphate synthetase)
UPRT  (uracil phosphoribosyltransferase homolog)


Additional Information