Pkd1 (polycystin 1, transient receptor potential channel interacting) - Rat Genome Database

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Gene: Pkd1 (polycystin 1, transient receptor potential channel interacting) Rattus norvegicus
Analyze
Symbol: Pkd1
Name: polycystin 1, transient receptor potential channel interacting
RGD ID: 3333
Description: Predicted to enable several functions, including Wnt receptor activity; transcription regulator inhibitor activity; and transmembrane transporter binding activity. Predicted to contribute to calcium channel activity. Involved in positive regulation of cytosolic calcium ion concentration. Located in lateral plasma membrane. Used to study polycystic kidney disease. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; and polycystic kidney disease 1. Orthologous to human PKD1 (polycystin 1, transient receptor potential channel interacting); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: polycystic kidney disease 1; polycystic kidney disease 1 homolog; polycystic kidney disease 1 homolog (human); polycystin 1; polycystin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Pkd1em2Mcwi ; Pkd1em3Mcwi ; Pkd1em1Mcwi ; Pkd1em6Mcwi
Genetic Models: LEW-Pkd1em2Mcwi ; LEW-Pkd1em6Mcwi ; LEW-Pkd1em1Mcwi ; LEW-Pkd1em3Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,077,733 - 14,125,682 (+)NCBIGRCr8
mRatBN7.21013,573,779 - 13,621,138 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,573,021 - 13,621,128 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,320,767 - 18,367,923 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,809,613 - 17,856,769 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,308,806 - 13,355,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,914,057 - 13,962,008 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,915,214 - 13,962,008 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,731,035 - 13,778,993 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,801,445 - 13,848,212 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,801,471 - 13,848,236 (+)NCBI
Celera1013,254,601 - 13,301,131 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Pkd1Ratautosomal dominant polycystic kidney disease  ISORGD:7367067175279DNA:mutations:multipleRGD 
Pkd1Ratautosomal dominant polycystic kidney disease severityISORGD:111057175280DNA:missense mutation:cds:p.R3277C (mouse)RGD 
Pkd1Ratautosomal dominant polycystic kidney disease  ISORGD:7367061601399DNA:mutations:exons, intron:multipleRGD 
Pkd1Ratintracranial aneurysm susceptibilityISORGD:7367061580867DNA:mutations:multiple (human)RGD 
Pkd1Ratpolycystic kidney disease  IAGP 633540 RGD 
Pkd1Ratpolycystic liver disease  ISORGD:1110514402035 RGD 
Pkd1Ratpolycystic liver disease severityISORGD:1110514402033 RGD 
1 to 20 of 47 rows
Object Symbol
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Original Reference(s)
Pkd1Rat46, XY Disorders of Sex Development  ISORGD:7367068554872ClinVar Annotator: match by term: 46,XY disorder of sex developmentClinVar 
Pkd1RatAbnormal Cortical Gyration  ISORGD:7367068554872ClinVar Annotator: match by term: Abnormal cortical gyrationClinVarPMID:25741868
Pkd1Ratatrial heart septal defect 1  ISORGD:7367068554872ClinVar Annotator: match by term: ASD IIClinVarPMID:25741868
Pkd1Ratautosomal dominant polycystic kidney disease  ISORGD:7367068554872ClinVar Annotator: match by term: Autosomal dominant polycystic kidney disease | ClinVar Annotator: match by more ...ClinVarPMID:10200984|PMID:10364515|PMID:10854095|PMID:10923038|PMID:10987650|PMID:11012875|PMID:11058904|PMID:11115377|PMID:11216660|PMID:11840199|PMID:11857740|PMID:11967008|PMID:12070253|PMID:12482949|PMID:12842373|PMID:15772804|PMID:16430766|PMID:17574468|PMID:17582161|PMID:18077784|PMID:18640754|PMID:18791038|PMID:18837007|PMID:19158373|PMID:19165178|PMID:19515475|PMID:19686598|PMID:20301424|PMID:20558538|PMID:20950398|PMID:20981092|PMID:21115670|PMID:21551026|PMID:21706482|PMID:22008521|PMID:22090377|PMID:22185115|PMID:22333914|PMID:22383692|PMID:22508176|PMID:22608885|PMID:23064367|PMID:23266634|PMID:23300259|PMID:23383103|PMID:23431072|PMID:23760289|PMID:23985799|PMID:24033266|PMID:24374109|PMID:24575920|PMID:24611717|PMID:24694054|PMID:25029430|PMID:25333066|PMID:25475747|PMID:25491204|PMID:25525159|PMID:25574838|PMID:25646624|PMID:25741868|PMID:26139440|PMID:26150605|PMID:26453610|PMID:26467025|PMID:26632257|PMID:26661679|PMID:26823553|PMID:26950445|PMID:27165007|PMID:27499327|PMID:27567292|PMID:27782177|PMID:27835667|PMID:27884173|PMID:27894351|PMID:28378423|PMID:28522688|PMID:28815929|PMID:29038287|PMID:29270497|PMID:29520754|PMID:29529603|PMID:29633482|PMID:29650765|PMID:29801666|PMID:30333007|PMID:30369598|PMID:30413633|PMID:30586318|PMID:30816285|PMID:30858458|PMID:31027891|PMID:31056860|PMID:31157564|PMID:31488014|PMID:31738409|PMID:31740684|PMID:32203225|PMID:32381729|PMID:32398770|PMID:32457805|PMID:32816041|PMID:32939031|PMID:33102977|PMID:33168999|PMID:33226606|PMID:33315352|PMID:33437033|PMID:33437386|PMID:33454723|PMID:33532864|PMID:33555573|PMID:33939064|PMID:34890546|PMID:34974531|PMID:35778421|PMID:36646975|PMID:36755831|PMID:37152951|PMID:37372416|PMID:37419908|PMID:38177409|PMID:38541974|PMID:8845849|PMID:9192675|PMID:9199561|PMID:9285784|PMID:9521593
Pkd1Ratautosomal dominant polycystic kidney disease  ISORGD:7367068554872ClinVar Annotator: match by term: Autosomal dominant polycystic kidney diseaseClinVarPMID:10200984|PMID:10364515|PMID:10854095|PMID:10923038|PMID:10987650|PMID:11012875|PMID:11058904|PMID:11115377|PMID:11216660|PMID:11840199|PMID:11857740|PMID:11967008|PMID:12070253|PMID:12482949|PMID:15772804|PMID:16430766|PMID:17574468|PMID:17582161|PMID:18077784|PMID:18640754|PMID:18791038|PMID:18837007|PMID:19165178|PMID:19515475|PMID:20301424|PMID:20558538|PMID:20950398|PMID:20981092|PMID:21115670|PMID:21551026|PMID:21706482|PMID:22008521|PMID:22090377|PMID:22185115|PMID:22333914|PMID:22383692|PMID:22508176|PMID:22608885|PMID:23064367|PMID:23266634|PMID:23300259|PMID:23383103|PMID:23431072|PMID:23760289|PMID:23985799|PMID:24033266|PMID:24374109|PMID:24611717|PMID:24694054|PMID:25029430|PMID:25333066|PMID:25475747|PMID:25646624|PMID:25741868|PMID:26139440|PMID:26453610|PMID:26467025|PMID:26632257|PMID:26661679|PMID:26823553|PMID:26950445|PMID:27165007|PMID:27499327|PMID:27567292|PMID:27782177|PMID:27835667|PMID:27884173|PMID:27894351|PMID:28378423|PMID:28522688|PMID:28815929|PMID:29038287|PMID:29270497|PMID:29520754|PMID:29529603|PMID:29633482|PMID:29650765|PMID:29801666|PMID:30333007|PMID:30369598|PMID:30413633|PMID:30586318|PMID:30816285|PMID:30858458|PMID:31027891|PMID:31056860|PMID:31157564|PMID:31488014|PMID:31738409|PMID:31740684|PMID:32203225|PMID:32381729|PMID:32398770|PMID:32457805|PMID:32816041|PMID:33102977|PMID:33168999|PMID:33226606|PMID:33315352|PMID:33437033|PMID:33437386|PMID:33454723|PMID:33532864|PMID:33555573|PMID:33939064|PMID:34974531|PMID:35778421|PMID:36646975|PMID:36755831|PMID:37152951|PMID:37419908|PMID:38177409|PMID:8845849|PMID:9199561|PMID:9285784|PMID:9521593
Pkd1Ratautosomal dominant polycystic kidney disease  ISORGD:7367068554872ClinVar Annotator: match by term: Autosomal dominant polycystic kidney diseaseClinVarPMID:10200984|PMID:10364515|PMID:10854095|PMID:10923038|PMID:10987650|PMID:11058904|PMID:11115377|PMID:11216660|PMID:11840199|PMID:11857740|PMID:11967008|PMID:12070253|PMID:12482949|PMID:15772804|PMID:16430766|PMID:17574468|PMID:17582161|PMID:18077784|PMID:18640754|PMID:18791038|PMID:18837007|PMID:19165178|PMID:19515475|PMID:20301424|PMID:20558538|PMID:20950398|PMID:20981092|PMID:21115670|PMID:22008521|PMID:22090377|PMID:22333914|PMID:22383692|PMID:22508176|PMID:22608885|PMID:23064367|PMID:23266634|PMID:23300259|PMID:23383103|PMID:23431072|PMID:23760289|PMID:23985799|PMID:24033266|PMID:24374109|PMID:24611717|PMID:24694054|PMID:25029430|PMID:25333066|PMID:25475747|PMID:25646624|PMID:25741868|PMID:26139440|PMID:26453610|PMID:26467025|PMID:26632257|PMID:26661679|PMID:26823553|PMID:26950445|PMID:27165007|PMID:27499327|PMID:27567292|PMID:27782177|PMID:27835667|PMID:27884173|PMID:27894351|PMID:28378423|PMID:28522688|PMID:28815929|PMID:29038287|PMID:29270497|PMID:29520754|PMID:29529603|PMID:29633482|PMID:29650765|PMID:29801666|PMID:30333007|PMID:30369598|PMID:30413633|PMID:30586318|PMID:30816285|PMID:31027891|PMID:31056860|PMID:31157564|PMID:31738409|PMID:31740684|PMID:32203225|PMID:32381729|PMID:32457805|PMID:32816041|PMID:33102977|PMID:33168999|PMID:33226606|PMID:33315352|PMID:33437033|PMID:33532864|PMID:33555573|PMID:33939064|PMID:34974531|PMID:35778421|PMID:37419908|PMID:38177409|PMID:8845849|PMID:9199561|PMID:9285784|PMID:9521593
Pkd1Ratautosomal dominant polycystic kidney disease  ISORGD:7367068554872ClinVar Annotator: match by term: Autosomal dominant polycystic kidney disease | ClinVar Annotator: match by more ...ClinVarPMID:10200984|PMID:10364515|PMID:10854095|PMID:10923038|PMID:10987650|PMID:11058904|PMID:11115377|PMID:11216660|PMID:11840199|PMID:11857740|PMID:11941481|PMID:11967008|PMID:12070253|PMID:12482949|PMID:15772804|PMID:16430766|PMID:17574468|PMID:17582161|PMID:18077784|PMID:18640754|PMID:18791038|PMID:18837007|PMID:19165178|PMID:19515475|PMID:20301424|PMID:20558538|PMID:20950398|PMID:20981092|PMID:21115670|PMID:22008521|PMID:22090377|PMID:22333914|PMID:22383692|PMID:22508176|PMID:22608885|PMID:23064367|PMID:23266634|PMID:23300259|PMID:23431072|PMID:23760289|PMID:23985799|PMID:24033266|PMID:24374109|PMID:24611717|PMID:24694054|PMID:25029430|PMID:25333066|PMID:25646624|PMID:25741868|PMID:26139440|PMID:26453610|PMID:26467025|PMID:26632257|PMID:26661679|PMID:26823553|PMID:26950445|PMID:27165007|PMID:27499327|PMID:27567292|PMID:27782177|PMID:27835667|PMID:27884173|PMID:27894351|PMID:28378423|PMID:28522688|PMID:28815929|PMID:29038287|PMID:29270497|PMID:29520754|PMID:29633482|PMID:29650765|PMID:29801666|PMID:30333007|PMID:30369598|PMID:30586318|PMID:30816285|PMID:31027891|PMID:31056860|PMID:31157564|PMID:31738409|PMID:31740684|PMID:32165824|PMID:32203225|PMID:32381729|PMID:32457805|PMID:32816041|PMID:33168999|PMID:33226606|PMID:33315352|PMID:33437033|PMID:33532864|PMID:33939064|PMID:34974531|PMID:35778421|PMID:37419908|PMID:38177409|PMID:8845849|PMID:9199561|PMID:9285784|PMID:9521593
Pkd1Ratautosomal dominant polycystic kidney disease  ISORGD:7367068554872ClinVar Annotator: match by term: Autosomal dominant polycystic kidney disease | ClinVar Annotator: match by more ...ClinVarPMID:10200984|PMID:10364515|PMID:10854095|PMID:10987650|PMID:11058904|PMID:11115377|PMID:11216660|PMID:11840199|PMID:11857740|PMID:11967008|PMID:12070253|PMID:12482949|PMID:15772804|PMID:16430766|PMID:17574468|PMID:17582161|PMID:18077784|PMID:18640754|PMID:18837007|PMID:19165178|PMID:19515475|PMID:20301424|PMID:20558538|PMID:20981092|PMID:21115670|PMID:22008521|PMID:22090377|PMID:22383692|PMID:22508176|PMID:22608885|PMID:23064367|PMID:23266634|PMID:23300259|PMID:23431072|PMID:23760289|PMID:24033266|PMID:24374109|PMID:24694054|PMID:25029430|PMID:25333066|PMID:25646624|PMID:25741868|PMID:26139440|PMID:26453610|PMID:26467025|PMID:26632257|PMID:26661679|PMID:26950445|PMID:27499327|PMID:27567292|PMID:27835667|PMID:27884173|PMID:27894351|PMID:29650765|PMID:29801666|PMID:30333007|PMID:31056860|PMID:31157564|PMID:31738409|PMID:32203225|PMID:32457805|PMID:33168999|PMID:33532864|PMID:9521593
Pkd1Ratautosomal recessive polycystic kidney disease  ISORGD:7367068554872ClinVar Annotator: match by term: Autosomal recessive polycystic kidney diseaseClinVarPMID:25741868|PMID:26467025|PMID:29100090|PMID:32775833|PMID:33639313
Pkd1Ratbile duct cancer  ISORGD:7367068554872ClinVar Annotator: match by term: Bile duct cancerClinVarPMID:12007219|PMID:16430766|PMID:17574468|PMID:25741868|PMID:26467025|PMID:27782177
Pkd1Ratbladder exstrophy-epispadias-cloacal exstrophy complex  ISORGD:7367068554872ClinVar Annotator: match by term: Bladder exstrophy-epispadias-cloacal exstrophy complexClinVarPMID:25741868|PMID:26467025
Pkd1Ratchronic kidney disease  ISORGD:7367068554872ClinVar Annotator: match by term: Chronic kidney diseaseClinVarPMID:23431072|PMID:25741868|PMID:31589614
Pkd1Ratclubfoot  ISORGD:7367068554872ClinVar Annotator: match by term: ClubfootClinVarPMID:17582161|PMID:25741868|PMID:26139440|PMID:26467025
Pkd1Ratcystic kidney disease  ISORGD:7367068554872ClinVar Annotator: match by term: Renal cystClinVarPMID:11115377|PMID:11967008|PMID:19515475|PMID:22508176|PMID:24694054|PMID:25491204|PMID:25741868|PMID:26467025|PMID:29529603|PMID:31488014|PMID:36755831
Pkd1Ratdevelopmental and epileptic encephalopathy 1  ISORGD:7367068554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy, 1ClinVarPMID:28492532|PMID:30866059
Pkd1Ratend stage renal disease  ISORGD:7367068554872ClinVar Annotator: match by term: Stage 5 chronic kidney diseaseClinVarPMID:25741868
Pkd1Ratendometrial carcinoma  ISORGD:7367068554872ClinVar Annotator: match by term: Endometrial carcinomaClinVar 
Pkd1Ratepilepsy  ISORGD:7367068554872ClinVar Annotator: match by term: Epilepsy | ClinVar Annotator: match by term: SeizureClinVarPMID:25741868|PMID:28492532
Pkd1Ratextrahepatic bile duct carcinoma  ISORGD:7367068554872ClinVar Annotator: match by term: Extrahepatic bile duct cancerClinVarPMID:25741868
Pkd1RatFamilial Thoracic Aortic Aneurysm 1  ISORGD:7367068554872ClinVar Annotator: match by term: Familial thoracic aortic aneurysmClinVarPMID:25741868
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Pkd1RatAnimal Disease Models  ISORGD:73670611554173CTD Direct Evidence: marker/mechanismCTDPMID:25877301
Pkd1Ratautosomal dominant polycystic kidney disease  ISORGD:73670611554173CTD Direct Evidence: marker/mechanismCTDPMID:7581371|PMID:8004675|PMID:12089381|PMID:19401297|PMID:25877301|PMID:28887310
Pkd1RatCysts  ISORGD:73670611554173CTD Direct Evidence: marker/mechanismCTDPMID:21685914
Pkd1Ratpolycystic kidney disease  ISORGD:73670611554173CTD Direct Evidence: marker/mechanismCTDPMID:17932118|PMID:25877301|PMID:28887310
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Original Reference(s)
Pkd1Ratautosomal recessive polycystic kidney disease  ISSRGD:1110513592920OMIM:263200MouseDO 
Pkd1Rathypertrophic cardiomyopathy  ISSRGD:1110513592920 MouseDO 
Pkd1Ratpolycystic kidney disease 1  ISSRGD:1110513592920OMIM:173900MouseDO 
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Original Reference(s)
Pkd1Ratpolycystic kidney disease 1  ISORGD:7367067240710 OMIM 

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Original Reference(s)
Pkd1Rat(1->4)-beta-D-glucan multiple interactionsISORGD:111056480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PKD1 mRNACTDPMID:36331819
Pkd1Rat17alpha-ethynylestradiol affects expressionISORGD:111056480464Ethinyl Estradiol affects the expression of PKD1 mRNACTDPMID:17555576
Pkd1Rat17beta-estradiol affects expressionISORGD:7367066480464Estradiol affects the expression of PKD1 mRNACTDPMID:22574217
Pkd1Rat17beta-estradiol multiple interactionsISORGD:111056480464[Estradiol co-treated with Progesterone] results in increased expression of PKD1 mRNACTDPMID:19693291
Pkd1Rat17beta-estradiol increases expressionISORGD:111056480464Estradiol results in increased expression of PKD1 mRNACTDPMID:19693291|PMID:39298647
Pkd1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PKD1 mRNACTDPMID:33387578
Pkd1Rat2-acetamidofluorene decreases expressionEXP 64804642-Acetylaminofluorene results in decreased expression of PKD1 mRNACTDPMID:22584684
Pkd1Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISORGD:7367066480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...CTDPMID:28628672
Pkd1Rat4,4'-sulfonyldiphenol multiple interactionsISORGD:7367066480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ...CTDPMID:28628672
Pkd1Rat4,4'-sulfonyldiphenol decreases methylationISORGD:111056480464bisphenol S results in decreased methylation of PKD1 exonCTDPMID:33297965
Pkd1Rat4,4'-sulfonyldiphenol decreases expressionISORGD:111056480464bisphenol S results in decreased expression of PKD1 mRNACTDPMID:39298647
Pkd1Ratacetylcholine affects response to substanceISORGD:111056480464PKD1 protein affects the susceptibility to AcetylcholineCTDPMID:18679710
Pkd1Ratacrylamide increases expressionISORGD:111056480464Acrylamide results in increased expression of PKD1 mRNACTDPMID:30807115
Pkd1Rataflatoxin B1 increases expressionISORGD:111056480464Aflatoxin B1 results in increased expression of PKD1 mRNACTDPMID:19770486
Pkd1Rataflatoxin B1 decreases expressionEXP 6480464Aflatoxin B1 results in decreased expression of PKD1 mRNACTDPMID:33354967
Pkd1Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of PKD1 mRNACTDPMID:16483693
Pkd1Ratantirheumatic drug increases expressionISORGD:7367066480464Antirheumatic Agents results in increased expression of PKD1 mRNACTDPMID:24449571
Pkd1Rataristolochic acid A increases expressionISORGD:7367066480464aristolochic acid I results in increased expression of PKD1 mRNACTDPMID:33212167
Pkd1Ratarsane affects methylationISORGD:7367066480464Arsenic affects the methylation of PKD1 geneCTDPMID:25304211
Pkd1Ratarsenic atom affects methylationISORGD:7367066480464Arsenic affects the methylation of PKD1 geneCTDPMID:25304211

1 to 20 of 91 rows

Biological Process
1 to 20 of 98 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pkd1Ratblood vessel development acts_upstream_of_or_withinIEAUniProtKB:O08852|ensembl:ENSMUSP000000492961600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratblood vessel development acts_upstream_of_or_withinISORGD:111051624291MGI:2183523 PMID:10677526RGDPMID:10677526
Pkd1Ratbranching morphogenesis of an epithelial tube involved_inISORGD:111051624291 PMID:24939912RGDPMID:24939912
Pkd1Ratbranching morphogenesis of an epithelial tube involved_inIEAUniProtKB:P98161|ensembl:ENSP000002623041600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratbranching morphogenesis of an epithelial tube involved_inIEAUniProtKB:O08852|ensembl:ENSMUSP000000492961600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratbranching morphogenesis of an epithelial tube involved_inISORGD:7367061624291 PMID:12482949RGDPMID:12482949
Pkd1Ratcalcium ion transmembrane transport involved_inIEAUniProtKB:O08852|ensembl:ENSMUSP000000492961600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratcalcium ion transmembrane transport involved_inISORGD:111051624291 PMID:12514735RGDPMID:12514735
Pkd1Ratcalcium ion transport involved_inISORGD:7367061624291 PMID:27214281RGDPMID:27214281
Pkd1Ratcalcium ion transport involved_inIEAUniProtKB:O08852|ensembl:ENSMUSP000000492961600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratcalcium ion transport involved_inISORGD:111051624291 PMID:12514735RGDPMID:12514735
Pkd1Ratcalcium ion transport acts_upstream_of_or_withinISORGD:111051624291MGI:1857562 PMID:12514735RGDPMID:12514735
Pkd1Ratcalcium ion transport involved_inIBAMGI:97603|PANTHER:PTN005318024|UniProtKB:P981611600115GO_REF:0000033GO_CentralGO_REF:0000033
Pkd1Ratcalcium ion transport involved_inIEAUniProtKB:P98161|ensembl:ENSP000002623041600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratcartilage condensation acts_upstream_of_or_withinIEAUniProtKB:O08852|ensembl:ENSMUSP000000492961600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratcartilage condensation acts_upstream_of_or_withinISORGD:111051624291MGI:2152589 PMID:11593033RGDPMID:11593033
Pkd1Ratcartilage development involved_inISORGD:7367061624291 PMID:11891195RGDPMID:11891195
Pkd1Ratcartilage development involved_inIEAUniProtKB:P98161|ensembl:ENSP000002623041600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratcell surface receptor signaling pathway involved_inISORGD:7367061624291 PMID:27214281RGDPMID:27214281
Pkd1Ratcell surface receptor signaling pathway involved_inIEAUniProtKB:P98161|ensembl:ENSP000002623041600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
1 to 20 of 46 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pkd1Ratbasolateral plasma membrane located_inISORGD:7367061624291 PMID:10770959RGDPMID:10770959
Pkd1Ratbasolateral plasma membrane located_inIEAUniProtKB:P98161|ensembl:ENSP000002623041600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratcalcium channel complex part_ofISORGD:7367061624291 PMID:27214281RGDPMID:27214281
Pkd1Ratcalcium channel complex part_ofIEAUniProtKB:P98161|ensembl:ENSP000002623041600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratcation channel complex part_ofISORGD:7367061624291 PMID:30093605RGDPMID:30093605
Pkd1Ratcation channel complex part_ofIEAUniProtKB:P98161|ensembl:ENSP000002623041600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Pkd1Ratcell surface located_inISORGD:111051624291 PMID:24939912RGDPMID:24939912
Pkd1Ratcell surface located_inIEAUniProtKB:O08852|ensembl:ENSMUSP000000492961600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratcilium located_inIEAARBA:ARBA000283531600115GO_REF:0000117UniProtGO_REF:0000117
Pkd1Ratcilium located_inIEAUniProtKB:P98161|ensembl:ENSP000002623041600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratcilium located_inIEAUniProtKB-KW:KW-09691600115GO_REF:0000043UniProtGO_REF:0000043
Pkd1Ratcilium located_inIEAUniProtKB-SubCell:SL-00661600115GO_REF:0000044UniProtGO_REF:0000044
Pkd1Ratcilium located_inISORGD:7367061624291 PMID:28154160RGDPMID:28154160
Pkd1Ratcilium located_inISORGD:111051624291 PMID:12514735, PMID:18285569, PMID:24939912, PMID:25405894RGDPMID:12514735|PMID:18285569|PMID:24939912|PMID:25405894
Pkd1Ratcilium located_inIEAUniProtKB:O08852|ensembl:ENSMUSP000000492961600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratcytoplasm located_inIEAUniProtKB:O08852|ensembl:ENSMUSP000000492961600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratcytoplasm located_inISORGD:111051624291 PMID:16311606RGDPMID:16311606
Pkd1Ratendoplasmic reticulum located_inISORGD:111051624291 PMID:25405894RGDPMID:25405894
Pkd1Ratendoplasmic reticulum located_inIEAUniProtKB:O08852|ensembl:ENSMUSP000000492961600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pkd1Ratcalcium channel activity contributes_toISORGD:7367061624291 PMID:27214281RGDPMID:27214281
Pkd1Ratcalcium channel activity enablesIEAUniProtKB:O08852|ensembl:ENSMUSP000000492961600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratcalcium channel activity enablesISORGD:111051624291 PMID:12514735RGDPMID:12514735
Pkd1Ratcalcium channel activity contributes_toIEAUniProtKB:P98161|ensembl:ENSP000002623041600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratmonoatomic cation channel activity contributes_toIBAPANTHER:PTN005318024|UniProtKB:P981611600115GO_REF:0000033GO_CentralGO_REF:0000033
Pkd1Ratmonoatomic cation channel activity enablesISORGD:111051624291PR:A2A259 PMID:15548533RGDPMID:15548533
Pkd1Ratmonoatomic cation channel activity enablesIEAUniProtKB:O08852|ensembl:ENSMUSP000000492961600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratprotein binding enablesISORGD:111051624291PR:A2A259|PR:O35245|UniProtKB:O35245|UniProtKB:O35551|UniProtKB:Q13563-1|UniProtKB:Q8BHC7 PMID:11901144, PMID:12007403, PMID:15548533, PMID:21642537, PMID:22795130, PMID:25405894RGDPMID:11901144|PMID:12007403|PMID:15548533|PMID:21642537|PMID:22795130|PMID:25405894
Pkd1Ratprotein binding enablesISORGD:736706|UniProtKB:P98161-11624291UniProtKB:Q13563 PMID:30093605RGDPMID:30093605
Pkd1Ratprotein binding enablesISORGD:7367061624291UniProtKB:O15259|UniProtKB:P46561|UniProtKB:Q13563|UniProtKB:Q13563-1|UniProtKB:Q8TAM2|UniProtKB:Q9NYP8 PMID:10097141, PMID:15563610, PMID:19556541, PMID:20168298, PMID:20856870, PMID:24939912, PMID:37681898RGDPMID:10097141|PMID:15563610|PMID:19556541|PMID:20168298|PMID:20856870|PMID:24939912|PMID:37681898
Pkd1Ratprotein binding enablesISORGD:736706,UniProtKB:P98161-31624291UniProtKB:Q13563-1 PMID:21642537RGDPMID:21642537
Pkd1Ratprotein domain specific binding enablesISORGD:7367061624291UniProtKB:Q13563 PMID:9171830RGDPMID:9171830
Pkd1Ratprotein domain specific binding enablesIEAUniProtKB:P98161|ensembl:ENSP000002623041600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Ratprotein kinase binding enablesISORGD:7367061624291UniProtKB:P51817 PMID:17980165RGDPMID:17980165
Pkd1Ratprotein kinase binding enablesIEAUniProtKB:P98161|ensembl:ENSP000002623041600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Rattranscription regulator inhibitor activity enablesISORGD:111051624291 PMID:16311606RGDPMID:16311606
Pkd1Rattranscription regulator inhibitor activity enablesIEAUniProtKB:O08852|ensembl:ENSMUSP000000492961600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1Rattransmembrane transporter binding enablesISORGD:7367061624291UniProtKB:Q13563 PMID:9192675RGDPMID:9192675
Pkd1Rattransmembrane transporter binding enablesIEAUniProtKB:P98161|ensembl:ENSP000002623041600115GO_REF:0000107EnsemblGO_REF:0000107
Pkd1RatWnt receptor activity enablesISORGD:7367061624291 PMID:27214281RGDPMID:27214281
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1 to 18 of 18 rows
#
Reference Title
Reference Citation
1. A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Fedeles SV, etal., Nat Genet. 2011 Jun 19;43(7):639-47. doi: 10.1038/ng.860.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Novel PKD1 and PKD2 mutations in autosomal dominant polycystic kidney disease (ADPKD). Hoefele J, etal., Nephrol Dial Transplant. 2011 Jul;26(7):2181-8. Epub 2010 Nov 29.
5. Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity. Hopp K, etal., J Clin Invest. 2012 Nov 1;122(11):4257-73. doi: 10.1172/JCI64313. Epub 2012 Oct 15.
6. Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene. Kleymenova E, etal., Mol Cell 2001 Apr;7(4):823-32.
7. Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes. Lu W, etal., Nat Genet. 1999 Feb;21(2):160-1. doi: 10.1038/5944.
8. Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling. Masyuk AI, etal., Gastroenterology. 2006 Sep;131(3):911-20.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Screening the 3' region of the polycystic kidney disease 1 (PKD1) gene reveals six novel mutations. Peral B, etal., Am J Hum Genet. 1996 Jan;58(1):86-96.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Association of mutation position in polycystic kidney disease 1 (PKD1) gene and development of a vascular phenotype. Rossetti S, etal., Lancet. 2003 Jun 28;361(9376):2196-201.
18. Tissue-specific expression and splicing of the rat polycystic kidney disease 1 gene. Xu H, etal., DNA Seq 2001 Dec;12(5-6):361-6.
1 to 18 of 18 rows
PMID:9171830   PMID:9192675   PMID:10677526   PMID:10770959   PMID:11593033   PMID:11891195   PMID:11901144   PMID:12007403   PMID:12482949   PMID:12514735   PMID:15326289   PMID:15545994  
PMID:15548533   PMID:15632090   PMID:15858826   PMID:16282979   PMID:16311606   PMID:17980165   PMID:18285569   PMID:19056867   PMID:19135240   PMID:19158352   PMID:19897428   PMID:20181743  
PMID:20862291   PMID:21518438   PMID:23001567   PMID:24039875   PMID:24740233   PMID:24767999   PMID:24939912   PMID:25367197   PMID:25405894   PMID:25807483   PMID:25888683   PMID:25889640  
PMID:26739494   PMID:27214281   PMID:28154160   PMID:28408623   PMID:29126879   PMID:29133434   PMID:29949809   PMID:30093605   PMID:33065236   PMID:34407229  



Pkd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,077,733 - 14,125,682 (+)NCBIGRCr8
mRatBN7.21013,573,779 - 13,621,138 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,573,021 - 13,621,128 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,320,767 - 18,367,923 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,809,613 - 17,856,769 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,308,806 - 13,355,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,914,057 - 13,962,008 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,915,214 - 13,962,008 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,731,035 - 13,778,993 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,801,445 - 13,848,212 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,801,471 - 13,848,236 (+)NCBI
Celera1013,254,601 - 13,301,131 (+)NCBICelera
Cytogenetic Map10q12NCBI
PKD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,088,708 - 2,135,898 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,088,708 - 2,135,898 (-)EnsemblGRCh38hg38GRCh38
GRCh37162,138,709 - 2,185,899 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,078,712 - 2,125,900 (-)NCBINCBI36Build 36hg18NCBI36
Build 34162,078,711 - 2,125,900NCBI
Celera162,350,824 - 2,400,282 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,063,439 - 2,112,133 (-)NCBIHuRef
CHM1_1162,138,626 - 2,185,837 (-)NCBICHM1_1
T2T-CHM13v2.0162,108,809 - 2,158,372 (-)NCBIT2T-CHM13v2.0
Pkd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,767,657 - 24,815,457 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,768,808 - 24,815,482 (+)EnsemblGRCm39 Ensembl
GRCm381724,548,689 - 24,596,514 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,549,834 - 24,596,508 (+)EnsemblGRCm38mm10GRCm38
MGSCv371724,686,895 - 24,733,459 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,277,550 - 24,324,083 (+)NCBIMGSCv36mm8
Celera1725,067,435 - 25,114,509 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.4NCBI
Pkd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,145,640 - 15,178,377 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,132,555 - 15,178,377 (+)NCBIChiLan1.0ChiLan1.0
LOC100972297
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21832,327,012 - 32,348,526 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11637,144,981 - 37,166,519 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016604,927 - 1,697,831 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,176,778 - 2,185,337 (-)NCBIpanpan1.1PanPan1.1panPan2
PKD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,811,051 - 38,865,503 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,837,964 - 38,865,503 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,062,677 - 40,104,408 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,132,038 - 39,173,761 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,132,038 - 39,173,760 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,816,853 - 38,858,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,789,176 - 38,830,884 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,267,946 - 39,309,679 (+)NCBIUU_Cfam_GSD_1.0
Pkd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,751,303 - 104,783,237 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,930,621 - 1,957,179 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,923,383 - 1,958,160 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PKD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,849,609 - 39,899,455 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,849,579 - 39,899,455 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,282,099 - 42,331,966 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PKD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,985,165 - 2,031,518 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,983,632 - 2,015,551 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606829,031,552 - 29,079,001 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pkd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913118,733 - 165,859 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913118,520 - 166,939 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Pkd1
77 total Variants

Predicted Target Of
Summary Value
Count of predictions:566
Count of miRNA genes:240
Interacting mature miRNAs:288
Transcripts:ENSRNOT00000015092
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat

1 to 10 of 25 rows
RH143904  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,620,574 - 13,620,692 (+)MAPPERmRatBN7.2
Rnor_6.01013,961,445 - 13,961,562NCBIRnor6.0
Rnor_5.01013,778,430 - 13,778,547UniSTSRnor5.0
RGSC_v3.41013,847,649 - 13,847,766UniSTSRGSC3.4
Celera1013,300,568 - 13,300,685UniSTS
RH 3.4 Map10191.5UniSTS
Cytogenetic Map10q12UniSTS
RH94522  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,621,172 - 13,621,274 (+)MAPPERmRatBN7.2
Rnor_6.01013,962,043 - 13,962,144NCBIRnor6.0
Rnor_5.01013,779,028 - 13,779,129UniSTSRnor5.0
RGSC_v3.41013,848,247 - 13,848,348UniSTSRGSC3.4
Celera1013,301,166 - 13,301,267UniSTS
Cytogenetic Map10q12UniSTS
RH138827  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,621,139 - 13,621,352 (+)MAPPERmRatBN7.2
Rnor_6.01013,962,010 - 13,962,222NCBIRnor6.0
Rnor_5.01013,778,995 - 13,779,207UniSTSRnor5.0
RGSC_v3.41013,848,214 - 13,848,426UniSTSRGSC3.4
Celera1013,301,133 - 13,301,345UniSTS
Cytogenetic Map10q12UniSTS
Pkd1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,617,394 - 13,617,955 (+)MAPPERmRatBN7.2
Rnor_6.01013,958,265 - 13,958,825NCBIRnor6.0
Rnor_5.01013,775,250 - 13,775,810UniSTSRnor5.0
RGSC_v3.41013,844,496 - 13,845,056UniSTSRGSC3.4
Celera1013,297,465 - 13,298,025UniSTS
Cytogenetic Map10q12UniSTS


This gene Pkd1 is modified in the following models/strains:
LEW-Pkd1em2Mcwi     LEW-Pkd1em6Mcwi     LEW-Pkd1em1Mcwi     LEW-Pkd1em3Mcwi    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000015092   ⟹   ENSRNOP00000015092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,573,021 - 13,621,128 (+)Ensembl
Rnor_6.0 Ensembl1013,915,214 - 13,962,008 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116450   ⟹   ENSRNOP00000089569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,573,021 - 13,621,128 (+)Ensembl
RefSeq Acc Id: NM_001414013   ⟹   NP_001400942
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,078,679 - 14,125,682 (+)NCBI
mRatBN7.21013,574,133 - 13,621,138 (+)NCBI
RefSeq Acc Id: XM_008767539   ⟹   XP_008765761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,077,744 - 14,125,681 (+)NCBI
mRatBN7.21013,573,783 - 13,621,137 (+)NCBI
Rnor_6.01013,914,057 - 13,962,004 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767540   ⟹   XP_008765762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,077,744 - 14,125,681 (+)NCBI
mRatBN7.21013,573,783 - 13,621,137 (+)NCBI
Rnor_6.01013,914,057 - 13,962,004 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767541   ⟹   XP_008765763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,077,738 - 14,120,353 (+)NCBI
mRatBN7.21013,573,779 - 13,615,811 (+)NCBI
Rnor_6.01013,914,057 - 13,956,650 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085207   ⟹   XP_038941135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,101,996 - 14,125,681 (+)NCBI
mRatBN7.21013,597,450 - 13,621,138 (+)NCBI
RefSeq Acc Id: XM_063268414   ⟹   XP_063124484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,077,733 - 14,125,681 (+)NCBI
RefSeq Acc Id: XM_063268415   ⟹   XP_063124485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,077,744 - 14,125,681 (+)NCBI
RefSeq Acc Id: XM_063268416   ⟹   XP_063124486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,097,841 - 14,125,681 (+)NCBI
1 to 5 of 10 rows
1 to 5 of 10 rows
RefSeq Acc Id: XP_008765761   ⟸   XM_008767539
- Peptide Label: isoform X2
- UniProtKB: Q9ERV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765762   ⟸   XM_008767540
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AC84 (UniProtKB/TrEMBL),   Q9ERV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765763   ⟸   XM_008767541
- Peptide Label: isoform X6
- UniProtKB: A6HCU0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015092   ⟸   ENSRNOT00000015092
RefSeq Acc Id: XP_038941135   ⟸   XM_039085207
- Peptide Label: isoform X7
C-type lectin   PKD   PLAT   REJ   WSC


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 70 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-25846 BioCyc
Ensembl Genes ENSRNOG00000010771 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015092 ENTREZGENE
  ENSRNOT00000015092.8 UniProtKB/TrEMBL
  ENSRNOT00000116450 ENTREZGENE
  ENSRNOT00000116450.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.10.100.10 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/TrEMBL
InterPro C-type_lectin UniProtKB/TrEMBL
  C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin_fold UniProtKB/TrEMBL
  Cys-rich_flank_reg_C UniProtKB/TrEMBL
  GPS_dom UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LipOase_LH2 UniProtKB/TrEMBL
  LRR-contain_N UniProtKB/TrEMBL
  PKD/Chitinase_dom UniProtKB/TrEMBL
  PKD/REJ-like UniProtKB/TrEMBL
  PKD1_2_channel UniProtKB/TrEMBL
  PKD_1 UniProtKB/TrEMBL
  PKD_dom UniProtKB/TrEMBL
  PKD_dom_sf UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/TrEMBL
  PLAT_polycystin1 UniProtKB/TrEMBL
  Polycystin_cat UniProtKB/TrEMBL
  Polycystin_dom UniProtKB/TrEMBL
  REJ-like UniProtKB/TrEMBL
  WSC_carb-bd UniProtKB/TrEMBL
NCBI Gene 24650 ENTREZGENE
PANTHER POLYCYSTIN-1 UniProtKB/TrEMBL
  POLYCYSTIN-1 UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  PKD UniProtKB/TrEMBL
  PKD_channel UniProtKB/TrEMBL
1 to 40 of 70 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-19 Pkd1  polycystic kidney disease 1  Pkd1  polycystic kidney disease 1 homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Pkd1  polycystic kidney disease 1 homolog (human)  Pkd1  polycystic kidney disease 1 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Pkd1  polycystic kidney disease 1 homolog    Polycystic kidney disease 1  Name updated 625702 APPROVED
2002-06-10 Pkd1  Polycystic kidney disease 1      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_cellular_localization found localized to the Golgi and lateral cell membrane 633539
gene_expression displays ubiquitous expression 633540
gene_regulation requires the Tsc2 tumor suprressor gene for correct transport from the Golgi to the lateral cell membrane 633539