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Gene: Pkd1 (polycystin 1, transient receptor poteintial channel interacting) Mus musculus
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Symbol: Pkd1
Name: polycystin 1, transient receptor poteintial channel interacting
Description: Exhibits calcium channel activity. Involved in several processes, including animal organ development; cytoplasmic sequestering of transcription factor; and receptor signaling pathway via JAK-STAT. Localizes to several cellular components, including the Golgi apparatus; motile cilium; and polycystin complex. Used to study autosomal recessive polycystic kidney disease; hypertrophic cardiomyopathy; and polycystic kidney disease 1. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; and polycystic kidney disease 1. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; metanephros; and respiratory system. Orthologous to human PKD1 (polycystin 1, transient receptor potential channel interacting); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; acetylcholine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: autosomal dominant polycystic kidney disease 1 protein homolog; FLJ00285; mFLJ00285; MGC118471; PC1; polycystic kidney disease 1 homolog; polycystin 1; polycystin-1
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1724,549,834 - 24,596,508 (+)Ensembl
GRCm381724,548,689 - 24,596,514 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371724,686,895 - 24,733,459 (+)NCBIGRCm37mm9NCBIm37
MGSCv361724,277,550 - 24,324,083 (+)NCBImm8
Celera1725,067,435 - 25,114,509 (+)NCBICelera
Cytogenetic Map17 A3.3NCBI
cM Map1712.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Pkd1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11105
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.