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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:anthracenes
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Accession:CHEBI:46955 term browser browse the term
Definition:Compounds containing an anthracene skeleton.
Synonyms:xref_mesh: MESH:D000873


show annotations for term's descendants           Sort by:
anthracenes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions EXP Anthracenes analog inhibits the reaction [Metribolone binds to AR protein] CTD PMID:3695475 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
decreases response to substance		 EXP Anthracenes analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
GABRA1 protein mutant form results in decreased susceptibility to Anthracenes analog		 CTD PMID:18275132 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP Anthracenes analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:18275132 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP Anthracenes analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:18275132 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO Anthracenes results in decreased activity of TOP1 protein CTD PMID:7598737 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO Anthracenes results in decreased activity of TOP2A protein CTD PMID:20561793 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
1-Amino-2,4-dibromoanthraquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO 1-amino-2,4-dibromoanthraquinone binds to and results in increased activity of ESR1 protein CTD PMID:20707409 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases mutagenesis ISO 1-amino-2,4-dibromoanthraquinone results in increased mutagenesis of HRAS gene CTD PMID:11560247 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO 1-amino-2,4-dibromoanthraquinone results in increased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 1-amino-2,4-dibromoanthraquinone results in increased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
1-hydroxyanthraquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO 1-hydroxyanthraquinone results in decreased activity of CYP1A2 protein CTD PMID:33438235 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
2-Aminoanthraquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO 2-aminoanthraquinone binds to and results in increased activity of ESR1 protein CTD PMID:20707409 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
2-hydroxychrysophanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases chemical synthesis
multiple interactions		 ISO CYP1A2 protein results in increased chemical synthesis of 2-hydroxychrysophanol
[CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol		 CTD PMID:29698620 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases chemical synthesis		 ISO [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol
CYP3A4 protein results in increased chemical synthesis of 2-hydroxychrysophanol		 CTD PMID:29698620 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Alizarin Red S binds to ALB protein CTD PMID:18968587 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
9,10-anthraquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 9,10-anthraquinone analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:26915975 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO 9,10-anthraquinone analog results in increased expression of BAD protein CTD PMID:26915975 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 9,10-anthraquinone analog results in increased expression of BAX mRNA; 9,10-anthraquinone analog results in increased expression of BAX protein CTD PMID:26915975 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 9,10-anthraquinone analog results in decreased expression of BCL2 mRNA; 9,10-anthraquinone analog results in decreased expression of BCL2 protein CTD PMID:26915975 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO 9,10-anthraquinone analog results in decreased expression of BCL2L1 protein CTD PMID:26915975 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO 9,10-anthraquinone analog results in increased expression of BCL2L11 protein CTD PMID:26915975 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression		 ISO 9,10-anthraquinone analog results in increased activity of CASP3 protein
9,10-anthraquinone analog results in increased expression of CASP3 mRNA		 CTD PMID:26915975 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO 9,10-anthraquinone analog results in increased activity of CASP9 protein CTD PMID:26915975 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO 9,10-anthraquinone results in increased expression of CCL5 mRNA CTD PMID:23333790 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO 9,10-anthraquinone analog results in decreased expression of CCND1 protein CTD PMID:26915975 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO 9,10-anthraquinone analog results in decreased expression of CCND2 protein CTD PMID:26915975 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO 9,10-anthraquinone analog results in decreased expression of PTGS2 mRNA; 9,10-anthraquinone analog results in decreased expression of PTGS2 protein CTD PMID:26915975 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
9-anthroic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO 9-anthroic acid binds to ALB protein CTD PMID:16404478 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity
increases activity		 ISO 9-anthroic acid results in decreased activity of CFTR protein
9-anthroic acid results in increased activity of CFTR protein mutant form		 CTD PMID:15290302 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
9-Nitroanthracene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 9-nitroanthracene binds to and results in increased activity of AHR protein CTD PMID:28186253 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
alizarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions		 ISO alizarin results in decreased activity of CYP1A1 protein
alizarin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein]		 CTD PMID:12379470 PMID:37515497 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO alizarin results in decreased activity of CYP1A2 protein CTD PMID:12379470 PMID:33438235 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP1B1 protein CTD PMID:12379470 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP2E1 protein CTD PMID:12379470 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO alizarin binds to and results in increased activity of ESR1 protein CTD PMID:20707409 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein] CTD PMID:37515497 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP		 alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; alizarin inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein] CTD PMID:33421718 PMID:38670245 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein] CTD PMID:33421718 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]; alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC protein] CTD PMID:33421718 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nat1 N-acetyltransferase 1 decreases activity ISO alizarin results in decreased activity of NAT1 protein CTD PMID:34783865 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of alizarin CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
Aloe emodin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in decreased expression of ADIPOQ mRNA] CTD PMID:22645054 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases activity ISO aloe emodin results in decreased activity of AKR1B10 protein CTD PMID:35065925 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO aloe emodin results in decreased activity of AKR1C3 protein CTD PMID:35065925 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO aloe emodin results in increased expression of ATF3 mRNA CTD PMID:22210228 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO aloe emodin results in increased expression of BAX protein CTD PMID:19928967 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO aloe emodin results in decreased expression of BCL2 mRNA; aloe emodin results in decreased expression of BCL2 protein CTD PMID:19928967 PMID:22210228 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
increases expression		 ISO aloe emodin results in increased activity of CASP3 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP3; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP3 protein modified form]
aloe emodin results in increased cleavage of CASP3 protein		 CTD PMID:19928967 PMID:22210228 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
increases expression		 ISO aloe emodin results in increased activity of CASP8 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP8; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP8 protein modified form]		 CTD PMID:19928967 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
increases expression
multiple interactions		 ISO aloe emodin results in increased activity of CASP9 protein
aloe emodin results in increased expression of CASP9 protein modified form
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP9; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP9 protein modified form]		 CTD PMID:19928967 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cbr1 carbonyl reductase 1 decreases activity ISO aloe emodin results in decreased activity of CBR1 protein CTD PMID:35065925 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO aloe emodin results in increased expression of CYCS protein CTD PMID:19928967 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO aloe emodin results in decreased activity of CYP1A1 protein CTD PMID:27633141 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO aloe emodin results in decreased activity of CYP1A2 protein CTD PMID:27633141 PMID:33438235 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO aloe emodin results in decreased activity of CYP1B1 protein CTD PMID:27633141 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases chemical synthesis		 ISO [CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CYP2B6 protein results in increased chemical synthesis of aloe emodin		 CTD PMID:29698620 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO aloe emodin results in decreased activity of CYP2C19 protein CTD PMID:33438235 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis
multiple interactions		 ISO CYP3A4 protein results in increased chemical synthesis of aloe emodin
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin		 CTD PMID:29698620 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO aloe emodin results in increased expression of DDIT3 mRNA; aloe emodin results in increased expression of DDIT3 protein CTD PMID:22210228 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO aloe emodin results in increased phosphorylation of EIF2S1 protein CTD PMID:22210228 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of FABP4 mRNA] CTD PMID:22645054 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO aloe emodin results in increased expression of and affects the localization of FADD protein CTD PMID:19928967 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO aloe emodin results in increased expression of FAS protein CTD PMID:19928967 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO aloe emodin results in increased expression of FASLG protein CTD PMID:19928967 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO aloe emodin results in increased expression of HSPA5 mRNA; aloe emodin results in increased expression of HSPA5 protein CTD PMID:22210228 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of LPL mRNA] CTD PMID:22645054 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
decreases expression		 ISO aloe emodin results in decreased expression of and results in decreased activity of NAT1 protein
aloe emodin results in decreased expression of NAT1 mRNA		 CTD PMID:16314733 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] CTD PMID:19352036 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of PPARG mRNA] CTD PMID:22645054 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA] CTD PMID:19352036 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Retn resistin multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of RETN mRNA] CTD PMID:22645054 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO aloe emodin results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO aloe emodin results in decreased activity of SULT1E1 protein CTD PMID:27633141 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of TNF mRNA]
aloe emodin results in increased expression of TNF protein		 CTD PMID:19928967 PMID:22645054 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO aloe emodin results in increased expression of TNFRSF1A protein CTD PMID:19928967 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO aloe emodin results in increased expression of TNFRSF1B protein CTD PMID:19928967 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO aloe emodin results in increased expression of TP53 protein CTD PMID:19928967 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO aloe emodin results in increased expression of and affects the localization of TRADD protein CTD PMID:19928967 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of aloe emodin CTD PMID:24854283 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO aloe emodin results in increased splicing of XBP1 mRNA CTD PMID:22210228 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
anthracen-2-amine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam8 ADAM metallopeptidase domain 8 increases expression EXP 2-anthramine results in increased expression of ADAM8 mRNA CTD PMID:23038007 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801 		JBrowse link
G Aen apoptosis enhancing nuclease increases expression EXP 2-anthramine results in increased expression of AEN mRNA CTD PMID:23038007 NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523 		JBrowse link
G Alb albumin decreases expression EXP 2-anthramine results in decreased expression of ALB protein CTD PMID:31714650 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP 2-anthramine results in increased expression of ALDH1A1 mRNA CTD PMID:23038007 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Anxa1 annexin A1 increases expression EXP 2-anthramine results in increased expression of ANXA1 mRNA CTD PMID:23038007 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Ar androgen receptor multiple interactions ISO 2-anthramine inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D increases expression EXP 2-anthramine results in increased expression of ATP6V1D mRNA CTD PMID:23038007 NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303 		JBrowse link
G Car2 carbonic anhydrase 2 increases expression EXP 2-anthramine results in increased expression of CAR2 mRNA CTD PMID:23038007 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP 2-anthramine results in increased expression of CCNG1 mRNA CTD PMID:23038007 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Cd46 CD46 molecule increases expression EXP 2-anthramine results in increased expression of CD46 mRNA CTD PMID:23038007 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cd93 CD93 molecule increases expression EXP 2-anthramine results in increased expression of CD93 mRNA CTD PMID:23038007 NCBI chr 3:135,891,859...135,898,378
Ensembl chr 3:135,891,859...135,898,378 		JBrowse link
G Cdh13 cadherin 13 increases expression EXP 2-anthramine results in increased expression of CDH13 mRNA CTD PMID:23038007 NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP 2-anthramine results in increased expression of CDKN1A mRNA CTD PMID:23038007 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression EXP 2-anthramine results in increased expression of CDKN1C mRNA CTD PMID:23038007 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions ISO CYB5A protein promotes the reaction [CYP1A2 protein results in increased activity of 2-anthramine] CTD PMID:15728263 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
increases activity		 ISO CYB5A protein promotes the reaction [CYP1A2 protein results in increased activity of 2-anthramine]
CYP1A2 protein affects the metabolism of 2-anthramine		 CTD PMID:2655891 PMID:15728263 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 decreases expression EXP 2-anthramine results in decreased expression of CYP4A8 mRNA CTD PMID:23038007 NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476 		JBrowse link
G Dcn decorin increases expression EXP 2-anthramine results in increased expression of DCN mRNA CTD PMID:23038007 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression EXP 2-anthramine results in increased expression of DDIT4 mRNA CTD PMID:23038007 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 increases expression EXP 2-anthramine results in increased expression of DMBT1 mRNA CTD PMID:23038007 NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478 		JBrowse link
G Dph3 diphthamide biosynthesis 3 increases expression EXP 2-anthramine results in increased expression of DPH3 mRNA CTD PMID:23038007 NCBI chr16:7,288,295...7,293,734
Ensembl chr16:7,282,705...7,291,265 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression EXP 2-anthramine results in increased expression of FABP1 mRNA CTD PMID:31714650 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression EXP 2-anthramine results in increased expression of FABP4 mRNA CTD PMID:23038007 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fas Fas cell surface death receptor increases expression EXP 2-anthramine results in increased expression of FAS mRNA CTD PMID:23038007 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases expression EXP 2-anthramine results in increased expression of G6PC1 mRNA CTD PMID:23038007 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gck glucokinase increases expression EXP 2-anthramine results in increased expression of GCK mRNA CTD PMID:23038007 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP 2-anthramine results in increased expression of GRIA3 mRNA CTD PMID:23038007 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP 2-anthramine results in increased expression of GSTA5 mRNA CTD PMID:23038007 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP 2-anthramine results in increased expression of HAVCR1 mRNA CTD PMID:31714650 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO 2-anthramine results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [2-anthramine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP 2-anthramine results in increased expression of IGFBP2 mRNA CTD PMID:23038007 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937 		JBrowse link
G Il1b interleukin 1 beta decreases expression
increases expression		 ISO
EXP		 2-anthramine results in decreased expression of IL1B mRNA
2-anthramine results in increased expression of IL1B mRNA		 CTD PMID:29594315 PMID:31714650 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [2-anthramine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il7 interleukin 7 increases expression EXP 2-anthramine results in increased expression of IL7 mRNA CTD PMID:31714650 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075 		JBrowse link
G Jam3 junctional adhesion molecule 3 increases expression EXP 2-anthramine results in increased expression of JAM3 mRNA CTD PMID:23038007 NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355 		JBrowse link
G Lama5 laminin subunit alpha 5 increases expression EXP 2-anthramine results in increased expression of LAMA5 mRNA CTD PMID:23038007 NCBI chr 3:167,270,296...167,318,370
Ensembl chr 3:167,270,296...167,318,451 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP 2-anthramine results in increased expression of MGMT mRNA CTD PMID:23038007 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mmd2 monocyte to macrophage differentiation-associated 2 decreases expression EXP 2-anthramine results in decreased expression of MMD2 mRNA CTD PMID:23038007 NCBI chr12:11,962,733...12,009,776
Ensembl chr12:11,962,757...12,009,773 		JBrowse link
G Nhej1 nonhomologous end-joining factor 1 increases expression EXP 2-anthramine results in increased expression of NHEJ1 mRNA CTD PMID:23038007 NCBI chr 9:76,526,322...76,622,488
Ensembl chr 9:76,526,324...76,622,444 		JBrowse link
G Nrcam neuronal cell adhesion molecule increases expression EXP 2-anthramine results in increased expression of NRCAM mRNA CTD PMID:23038007 NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992 		JBrowse link
G Pln phospholamban increases expression EXP 2-anthramine results in increased expression of PLN mRNA CTD PMID:23038007 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Rbp7 retinol binding protein 7 increases expression EXP 2-anthramine results in increased expression of RBP7 mRNA CTD PMID:23038007 NCBI chr 5:159,889,723...159,894,338
Ensembl chr 5:159,889,723...159,894,339 		JBrowse link
G Sgcb sarcoglycan, beta increases expression EXP 2-anthramine results in increased expression of SGCB mRNA CTD PMID:23038007 NCBI chr14:34,563,614...34,578,614
Ensembl chr14:34,563,608...34,578,583 		JBrowse link
G Slc25a37 solute carrier family 25 member 37 increases expression EXP 2-anthramine results in increased expression of SLC25A37 mRNA CTD PMID:23038007 NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199 		JBrowse link
G Sox4 SRY-box transcription factor 4 increases expression EXP 2-anthramine results in increased expression of SOX4 mRNA CTD PMID:23038007 NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP 2-anthramine results in increased expression of SPP1 mRNA CTD PMID:31714650 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Thyn1 thymocyte nuclear protein 1 increases expression EXP 2-anthramine results in increased expression of THYN1 mRNA CTD PMID:23038007 NCBI chr 8:25,406,563...25,415,445
Ensembl chr 8:25,406,500...25,415,445 		JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression EXP 2-anthramine results in increased expression of TNFRSF9 mRNA CTD PMID:23038007 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000 		JBrowse link
G Vxn vexin increases expression EXP 2-anthramine results in increased expression of VXN mRNA CTD PMID:23038007 NCBI chr 5:9,659,213...9,684,684
Ensembl chr 5:9,659,213...9,684,684 		JBrowse link
anthracene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp2 acid phosphatase 2, lysosomal multiple interactions
affects expression		 ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of ACP2 protein
anthracene affects the expression of ACP2 protein		 CTD PMID:28803881 NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects binding
increases activity
affects localization		 ISO
EXP		 2-oxohexyl isothiocyanate inhibits the reaction [anthracene affects the localization of AHR protein]; [acenaphthene co-treated with anthracene co-treated with 1,12-benzoperylene co-treated with 1,2,5,6-dibenzanthracene co-treated with fluorene co-treated with naphthalene co-treated with phenanthrene] results in increased activity of AHR protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; alyssin inhibits the reaction [anthracene affects the localization of AHR protein]; sulforaphane affects the reaction [anthracene affects the localization of AHR protein]
anthracene binds to AHR protein
anthracene results in increased activity of AHR protein		 CTD PMID:3024361 PMID:17665671 PMID:19362136 PMID:28710019 PMID:30980910 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHRR protein; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein] CTD PMID:28710019 PMID:30980910 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Ar androgen receptor multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; anthracene inhibits the reaction [Androgens results in increased activity of AR protein]; anthracene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 PMID:28377212 PMID:30980910 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of ARNT protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of ARNT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ARNT mRNA CTD PMID:28710019 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression		 ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of BAX protein
anthracene affects the expression of BAX protein		 CTD PMID:28803881 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 ISO anthracene results in increased expression of CASP3 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CASP3 protein		 CTD PMID:28803881 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccna2 cyclin A2 decreases expression
multiple interactions		 ISO anthracene results in decreased expression of CCNA2 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in decreased expression of CCNA2 protein		 CTD PMID:28803881 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions		 ISO anthracene results in increased expression of CCND1 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CCND1 protein		 CTD PMID:28803881 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression
multiple interactions		 ISO anthracene results in increased expression of CDK2 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CDK2 protein		 CTD PMID:28803881 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO anthracene results in increased expression of CYP19A1 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of CYP19A1 protein		 CTD PMID:28803881 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity		 EXP
ISO		 anthracene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
anthracene results in increased expression of CYP1A1 mRNA
[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein]; alyssin inhibits the reaction [anthracene results in increased activity of CYP1A1 protein]; sulforaphane inhibits the reaction [anthracene results in increased activity of CYP1A1 protein]		 CTD PMID:15315710 PMID:19362136 PMID:21668866 PMID:28710019 PMID:30980910 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
affects binding
multiple interactions		 ISO anthracene results in increased activity of CYP1A2 protein
anthracene binds to CYP1A2 protein
[acenaphthylene co-treated with acenaphthene co-treated with dibenzofuran co-treated with fluorene co-treated with phenanthrene co-treated with anthracene] results in increased expression of CYP1A2 mRNA
alyssin inhibits the reaction [anthracene results in increased activity of CYP1A2 protein]; sulforaphane inhibits the reaction [anthracene results in increased activity of CYP1A2 protein]		 CTD PMID:7750161 PMID:8001243 PMID:19362136 PMID:32278787 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO anthracene results in increased expression of CYP1B1 mRNA CTD PMID:21668866 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein] CTD PMID:30980910 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of NFKB2 protein CTD PMID:30980910 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO anthracene results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein promotes the reaction [anthracene results in increased expression of CXCL8 mRNA] CTD PMID:18434080 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
anthracene-1,8,9-triol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Anthralin results in increased expression of CXCL8 mRNA] CTD PMID:9628260 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Anthralin results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Anthralin results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Anthralin results in increased expression of CSF2 mRNA CTD PMID:9628260 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Anthralin results in decreased activity of CYP1A2 protein CTD PMID:33438235 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Anthralin results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Anthralin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Anthralin results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844 		JBrowse link
G Il1a interleukin 1 alpha increases expression
multiple interactions		 ISO Anthralin results in increased expression of IL1A mRNA; Anthralin results in increased expression of IL1A protein
Plant Extracts inhibits the reaction [Anthralin results in increased expression of IL1A mRNA]; Plant Extracts inhibits the reaction [Anthralin results in increased expression of IL1A protein]		 CTD PMID:7665919 PMID:8435107 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Anthralin results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Il6 interleukin 6 increases expression ISO Anthralin results in increased expression of IL6 mRNA CTD PMID:9628260 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Anthralin results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Nup54 nucleoporin 54 increases expression ISO Anthralin results in increased expression of NUP54 protein CTD PMID:20025956 NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression ISO Anthralin results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO Anthralin results in increased expression of PIK3R5 protein CTD PMID:20025956 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Anthralin results in increased expression of PTGS2 mRNA CTD PMID:8989914 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Anthralin results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524 		JBrowse link
G Rif1 replication timing regulatory factor 1 increases expression ISO Anthralin results in increased expression of RIF1 protein CTD PMID:20025956 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Anthralin results in increased expression of SLC2A1 protein CTD PMID:20025956 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Stmn1 stathmin 1 increases expression ISO Anthralin results in increased expression of STMN1 protein CTD PMID:20025956 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Tfrc transferrin receptor increases expression ISO Anthralin results in increased expression of TFRC protein CTD PMID:20025956 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Anthralin results in increased expression of TGFB1 mRNA CTD PMID:8148055 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Anthralin results in increased expression of TNF mRNA; Anthralin results in increased expression of TNF protein CTD PMID:9628260 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Anthralin CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Anthralin results in increased expression of VEGFA protein CTD PMID:20025956 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
anthraflavic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 2,6-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Alb albumin affects binding ISO 2,6-dihydroxyanthraquinone binds to ALB protein CTD PMID:16404478 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 2,6-dihydroxyanthraquinone results in increased expression of CYP1A1 mRNA CTD PMID:11502733 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO 2,6-dihydroxyanthraquinone results in increased expression of CYP1B1 mRNA CTD PMID:11502733 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone CTD PMID:12756209 PMID:14557274 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
anthrarobin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of anthrarobin CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of anthrarobin CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
aurantio-obtusin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO aurantio-obtusin inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid] CTD PMID:35101544 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 increases expression ISO aurantio-obtusin results in increased expression of ACSL4 protein CTD PMID:35995123 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO aurantio-obtusin results in increased expression of BAX protein CTD PMID:35995123 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO aurantio-obtusin results in decreased expression of BCL2 protein CTD PMID:35995123 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp1 caspase 1 increases expression ISO aurantio-obtusin results in increased expression of CASP1 mRNA CTD PMID:34718095 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO aurantio-obtusin results in increased cleavage of CASP3 protein
aurantio-obtusin results in increased expression of and results in increased cleavage of CASP3 protein		 CTD PMID:34718095 PMID:35995123 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO aurantio-obtusin results in increased expression of CCL2 mRNA CTD PMID:34718095 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Crebbp CREB binding protein increases phosphorylation ISO aurantio-obtusin results in increased phosphorylation of CREBBP protein CTD PMID:35995123 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO aurantio-obtusin results in increased expression of GPT protein CTD PMID:34718095 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO aurantio-obtusin results in decreased expression of HAMP mRNA CTD PMID:34718095 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Il18 interleukin 18 increases expression ISO aurantio-obtusin results in increased expression of IL18 mRNA; aurantio-obtusin results in increased expression of IL18 protein CTD PMID:34718095 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO aurantio-obtusin results in increased expression of IL1B mRNA; aurantio-obtusin results in increased expression of IL1B protein CTD PMID:34718095 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO aurantio-obtusin results in increased expression of IL6 mRNA
aurantio-obtusin inhibits the reaction [Bleomycin results in increased secretion of IL6 protein]		 CTD PMID:28299617 PMID:34718095 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 increases expression ISO aurantio-obtusin results in increased expression of KCNN4 mRNA; aurantio-obtusin results in increased expression of KCNN4 protein CTD PMID:34718095 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO aurantio-obtusin results in decreased expression of NFKB1 mRNA CTD PMID:34718095 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO aurantio-obtusin results in increased expression of NLRP3 mRNA; aurantio-obtusin results in increased expression of NLRP3 protein CTD PMID:34718095 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO aurantio-obtusin results in decreased expression of RELA protein CTD PMID:34718095 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO aurantio-obtusin results in decreased activity of SLC22A6 protein CTD PMID:29045746 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO aurantio-obtusin results in decreased activity of SLC22A8 protein CTD PMID:29045746 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Spn sialophorin increases expression ISO aurantio-obtusin results in increased expression of SPN mRNA CTD PMID:34718095 NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO aurantio-obtusin results in increased expression of TNF mRNA CTD PMID:34718095 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Xpo1 exportin 1 decreases expression ISO aurantio-obtusin results in decreased expression of XPO1 mRNA CTD PMID:34718095 NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498 		JBrowse link
Capoamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity EXP capoamycin results in increased activity of AHR protein CTD PMID:25500124 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
chrysazin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO danthron inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
increases expression		 ISO danthron affects the localization of and results in increased expression of AIFM1 protein
danthron results in increased expression of AIFM1 mRNA		 CTD PMID:21126053 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Alb albumin affects binding ISO danthron binds to ALB protein CTD PMID:16404478 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO danthron results in increased expression of ATF6 protein CTD PMID:21126053 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO danthron results in increased expression of BAX protein CTD PMID:21126053 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO danthron results in decreased expression of BCL2 protein CTD PMID:21126053 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
decreases expression		 ISO danthron results in increased expression of BCL2L1 protein
danthron results in decreased expression of BCL2L1 protein		 CTD PMID:21126053 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO danthron results in increased expression of BID protein CTD PMID:21126053 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO danthron results in decreased expression of BIRC2 protein CTD PMID:21126053 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO danthron results in increased expression of BIRC3 protein CTD PMID:21126053 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO danthron results in decreased expression of BIRC5 protein CTD PMID:21126053 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 ISO benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP3 protein]; danthron results in increased activity of and results in increased expression of CASP3 protein
danthron results in increased expression of CASP3 mRNA		 CTD PMID:21126053 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression		 ISO benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP8 protein]; danthron results in increased activity of and results in increased expression of CASP8 protein
danthron results in increased expression of CASP8 mRNA		 CTD PMID:21126053 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression		 ISO benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP9 protein]; danthron results in increased activity of and results in increased expression of CASP9 protein
danthron results in increased expression of CASP9 mRNA		 CTD PMID:21126053 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO danthron affects the localization of and results in increased expression of CYCS protein CTD PMID:21126053 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO danthron results in decreased activity of CYP1A2 protein CTD PMID:33438235 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO danthron results in increased expression of DDIT3 protein CTD PMID:21126053 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression ISO danthron results in increased expression of DIABLO protein CTD PMID:21126053 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Endog endonuclease G increases expression
multiple interactions		 ISO danthron results in increased expression of ENDOG mRNA
danthron affects the localization of and results in increased expression of ENDOG protein		 CTD PMID:21126053 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO danthron results in increased expression of FAS protein CTD PMID:21126053 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO danthron results in increased expression of FASLG protein CTD PMID:21126053 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO danthron results in increased expression of HSPA5 protein CTD PMID:21126053 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO danthron results in decreased expression of SOD1 protein CTD PMID:21126053 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO danthron results in decreased expression of SOD2 protein CTD PMID:21126053 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO danthron results in increased expression of TNFSF10 protein CTD PMID:21126053 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO danthron results in decreased expression of XIAP protein CTD PMID:21126053 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
chrysophanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP chrysophanic acid results in decreased expression of ABCB11 mRNA; chrysophanic acid results in decreased expression of ABCB11 protein CTD PMID:28161596 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP chrysophanic acid results in increased expression of ABCC2 mRNA; chrysophanic acid results in increased expression of ABCC2 protein CTD PMID:28161596 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression EXP chrysophanic acid results in increased expression of ABCC4 mRNA; chrysophanic acid results in increased expression of ABCC4 protein CTD PMID:28161596 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO chrysophanic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO chrysophanic acid results in decreased phosphorylation of AKT1 protein CTD PMID:30300626 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO chrysophanic acid results in increased expression of BAK1 protein CTD PMID:30300626 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO chrysophanic acid results in increased expression of BAX protein CTD PMID:30300626 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO chrysophanic acid results in decreased activity of CYP1A1 protein CTD PMID:27633141 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
multiple interactions
increases metabolic processing		 ISO chrysophanic acid results in decreased activity of CYP1A2 protein
[CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol		 CTD PMID:27633141 PMID:29698620 PMID:33438235 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO chrysophanic acid results in decreased activity of CYP1B1 protein CTD PMID:27633141 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases metabolic processing		 ISO [CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin CTD PMID:29698620 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
increases chemical synthesis
multiple interactions		 ISO CYP3A4 protein results in increased metabolism of chrysophanic acid
CYP3A4 protein results in increased chemical synthesis of chrysophanic acid metabolite
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol; [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin		 CTD PMID:29698620 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP chrysophanic acid results in increased expression of CYP7A1 mRNA; chrysophanic acid results in increased expression of CYP7A1 protein CTD PMID:28161596 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP chrysophanic acid results in decreased expression of CYP8B1 mRNA; chrysophanic acid results in decreased expression of CYP8B1 protein CTD PMID:28161596 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO chrysophanic acid results in increased expression of DDIT3 protein CTD PMID:30300626 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
multiple interactions		 ISO chrysophanic acid results in increased phosphorylation of EIF2AK3 protein
Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2AK3 protein]		 CTD PMID:30300626 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions		 ISO chrysophanic acid results in increased phosphorylation of EIF2S1 protein
Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2S1 protein]		 CTD PMID:30300626 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO chrysophanic acid results in increased expression of ERN1 protein CTD PMID:30300626 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO chrysophanic acid results in decreased phosphorylation of MAPK1 protein CTD PMID:30300626 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects phosphorylation ISO chrysophanic acid affects the phosphorylation of MAPK14 protein CTD PMID:30300626 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO chrysophanic acid results in decreased phosphorylation of MAPK3 protein CTD PMID:30300626 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 affects phosphorylation ISO chrysophanic acid affects the phosphorylation of MAPK8 protein CTD PMID:30300626 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO chrysophanic acid results in decreased expression of PCNA protein CTD PMID:30300626 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO chrysophanic acid results in decreased phosphorylation of RPS6 protein CTD PMID:30300626 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO chrysophanic acid results in decreased phosphorylation of RPS6KB1 protein CTD PMID:30300626 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP chrysophanic acid results in decreased expression of SLC10A1 mRNA; chrysophanic acid results in decreased expression of SLC10A1 protein CTD PMID:28161596 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO chrysophanic acid results in decreased activity of SLC22A6 protein CTD PMID:29045746 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO chrysophanic acid results in decreased activity of SLC22A8 protein CTD PMID:29045746 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO chrysophanic acid results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of chrysophanic acid CTD PMID:24854283 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Citreorosein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases chemical synthesis ISO CYP2C19 protein results in increased chemical synthesis of 1,3,8-trihydroxy-6-hydroxymethylanthraquinone CTD PMID:27989148 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis ISO CYP3A4 protein results in increased chemical synthesis of 1,3,8-trihydroxy-6-hydroxymethylanthraquinone CTD PMID:27989148 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
Disperse Blue 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2ax H2A.X variant histone increases phosphorylation EXP Disperse Blue 1 results in increased phosphorylation of H2AX protein CTD PMID:33211169 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Krt14 keratin 14 increases expression EXP Disperse Blue 1 results in increased expression of KRT14 protein CTD PMID:33211169 NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
emodin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases expression
multiple interactions
affects activity
decreases expression		 EXP
ISO		 Emodin results in increased expression of ABCB11 mRNA; Emodin results in increased expression of ABCB11 protein
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside affects the reaction [[Emodin affects the activity of ABCB11 protein] which affects the export of Taurocholic Acid]; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCB11 protein; [Emodin affects the activity of ABCB11 protein] which affects the export of Taurocholic Acid
dorsomorphin inhibits the reaction [Emodin results in decreased expression of ABCB11 mRNA]; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA]
Emodin results in decreased expression of ABCB11 mRNA; Emodin results in decreased expression of ABCB11 protein		 CTD PMID:28161596 PMID:30517764 PMID:35753641 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression		 ISO
EXP		 Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
Emodin results in increased expression of ABCB1A mRNA
ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]		 CTD PMID:19549930 PMID:24380838 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression EXP Emodin results in increased expression of ABCB1B mRNA CTD PMID:19549930 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP Emodin results in decreased expression of ABCB4 mRNA CTD PMID:28161596 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions
decreases expression		 EXP
ISO		 Emodin results in increased expression of ABCC2 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of ABCC2 protein; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC2 protein
Emodin results in decreased expression of ABCC2 mRNA
Emodin results in decreased expression of ABCC2 mRNA; Emodin results in decreased expression of ABCC2 protein		 CTD PMID:19549930 PMID:28161596 PMID:30517764 PMID:35753641 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions
decreases expression		 EXP
ISO		 Emodin results in increased expression of ABCC3 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of ABCC3 protein; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC3 protein
Emodin results in decreased expression of ABCC3 mRNA
Emodin results in decreased expression of ABCC3 mRNA; Emodin results in decreased expression of ABCC3 protein		 CTD PMID:19549930 PMID:28161596 PMID:30517764 PMID:35753641 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression
multiple interactions		 EXP
ISO		 Emodin results in decreased expression of ABCC4 mRNA; Emodin results in decreased expression of ABCC4 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC4 protein
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC4 mRNA]		 CTD PMID:28161596 PMID:30517764 PMID:35753641 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 increases expression EXP Emodin results in increased expression of ABCC6 mRNA CTD PMID:19549930 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464 		JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression ISO Emodin results in decreased expression of ACTA1 mRNA CTD PMID:16045814 NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 EXP Emodin results in decreased expression of ACTA2 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]		 CTD PMID:15288473 PMID:27989784 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 protein] CTD PMID:37023836 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000 		JBrowse link
G Agt angiotensinogen multiple interactions EXP Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]; Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein] CTD PMID:17886230 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Emodin binds to and results in increased activity of AHR protein
Emodin binds to and results in increased activity of AHR protein; Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]		 CTD PMID:14644660 PMID:17869316 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases activity ISO Emodin results in decreased activity of AKR1B10 protein CTD PMID:35065925 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Emodin results in decreased activity of AKR1C3 protein CTD PMID:35065925 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 decreases activity ISO Emodin results in decreased activity of AKR7A3 protein CTD PMID:35065925 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
decreases expression		 ISO
EXP		 [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of AKT1 protein; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; SB 203580 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]; U 0126 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]
AKT activator SC79 inhibits the reaction [Emodin results in decreased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]
Emodin results in decreased expression of AKT1 mRNA		 CTD PMID:15288473 PMID:16045814 PMID:17077332 PMID:23848338 PMID:27032576 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases phosphorylation
multiple interactions		 ISO
EXP		 Emodin results in decreased phosphorylation of AKT2 protein
AKT activator SC79 inhibits the reaction [Emodin results in decreased phosphorylation of AKT2 protein]		 CTD PMID:37393915 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 decreases phosphorylation
multiple interactions		 ISO
EXP		 Emodin results in decreased phosphorylation of AKT3 protein
AKT activator SC79 inhibits the reaction [Emodin results in decreased phosphorylation of AKT3 protein]		 CTD PMID:37393915 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Ar androgen receptor multiple interactions ISO Emodin inhibits the reaction [cobaltous chloride results in increased expression of AR protein] CTD PMID:23212659 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arg2 arginase 2 decreases expression ISO Emodin results in decreased expression of ARG2 mRNA CTD PMID:21319176 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378 		JBrowse link
G Arid3a AT-rich interaction domain 3A increases expression ISO Emodin results in increased expression of ARID3A mRNA CTD PMID:15612046 NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599 		JBrowse link
G Atm ATM serine/threonine kinase increases expression
increases phosphorylation		 ISO Emodin results in increased expression of ATM mRNA
Emodin results in increased phosphorylation of ATM protein		 CTD PMID:16045814 PMID:20855424 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Bag5 BAG cochaperone 5 decreases expression ISO Emodin results in decreased expression of BAG5 mRNA CTD PMID:16045814 NCBI chr 6:130,768,467...130,772,122
Ensembl chr 6:130,768,141...130,772,970 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
increases expression
multiple interactions
decreases expression		 ISO
EXP		 Emodin affects the expression of BAX protein
Emodin results in increased expression of BAX protein
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside promotes the reaction [Emodin results in increased expression of BAX protein]
Emodin results in decreased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BAX protein]; SB 203580 affects the reaction [Emodin affects the expression of BAX protein]; U 0126 affects the reaction [Emodin affects the expression of BAX protein]		 CTD PMID:19549930 PMID:27032576 PMID:35753641 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
affects expression		 ISO
EXP		 Emodin results in decreased expression of BCL2 mRNA; Emodin results in decreased expression of BCL2 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of BCL2 protein
Emodin affects the expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BCL2 protein]; SB 203580 affects the reaction [Emodin affects the expression of BCL2 protein]; U 0126 affects the reaction [Emodin affects the expression of BCL2 protein]		 CTD PMID:19549930 PMID:23848338 PMID:27032576 PMID:35753641 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bfar bifunctional apoptosis regulator decreases expression ISO Emodin results in decreased expression of BFAR mRNA CTD PMID:16045814 NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038 		JBrowse link
G Bid BH3 interacting domain death agonist increases degradation
multiple interactions		 ISO Emodin results in increased degradation of BID protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased degradation of BID protein]; SB 203580 promotes the reaction [Emodin results in increased degradation of BID protein]		 CTD PMID:27032576 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Emodin results in decreased expression of BIRC5 mRNA; Emodin results in decreased expression of BIRC5 protein CTD PMID:23848338 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Canx calnexin decreases expression ISO Emodin results in decreased expression of CANX mRNA CTD PMID:16045814 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821 		JBrowse link
G Casp1 caspase 1 increases expression
multiple interactions		 ISO Emodin results in increased expression of CASP1 mRNA
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased cleavage of CASP1 protein]		 CTD PMID:15612046 PMID:37023836 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 decreases expression ISO Emodin results in decreased expression of CASP12 mRNA CTD PMID:21319176 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
affects expression
increases cleavage
increases activity		 ISO
EXP		 Emodin results in increased expression of CASP3 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased cleavage of CASP3 protein; Emodin inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in increased cleavage of CASP3 protein]; Emodin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Emodin inhibits the reaction [Oxidopamine results in decreased expression of and results in increased cleavage of CASP3 protein]; Emodin inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]
Emodin affects the expression of CASP3 protein modified form
Emodin results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of CASP3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Emodin results in increased activity of CASP3 protein]; Emodin results in increased cleavage of and results in increased activity of CASP3 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of CASP3 protein]; U 0126 promotes the reaction [Emodin results in increased cleavage of CASP3 protein]		 CTD PMID:19549930 PMID:23848338 PMID:25448808 PMID:27032576 PMID:34492313 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein]; SB 203580 promotes the reaction [Emodin results in increased activity of CASP8 protein]; U 0126 promotes the reaction [Emodin results in increased activity of CASP8 protein] CTD PMID:27032576 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases expression
multiple interactions		 ISO
EXP		 Emodin results in increased expression of CASP9 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased cleavage of CASP9 protein		 CTD PMID:21319176 PMID:35753641 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
affects expression		 ISO
EXP		 Emodin inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein]
Emodin promotes the reaction [Cisplatin results in decreased activity of CAT protein]
Emodin affects the expression of CAT protein		 CTD PMID:19549930 PMID:22271272 PMID:26139382 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbr1 carbonyl reductase 1 decreases activity ISO Emodin results in decreased activity of CBR1 protein CTD PMID:35065925 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Ccl26 C-C motif chemokine ligand 26 multiple interactions ISO Emodin inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein] CTD PMID:37788752 NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335 		JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO Emodin results in decreased expression of CCNB2 mRNA CTD PMID:16045814 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO Emodin inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein] CTD PMID:37788752 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990 		JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions		 EXP Emodin results in increased expression of CDH1 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]		 CTD PMID:27989784 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk13 cyclin-dependent kinase 13 decreases expression ISO Emodin results in decreased expression of CDK13 mRNA CTD PMID:16045814 NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Emodin results in decreased expression of CDK4 mRNA CTD PMID:16045814 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO Emodin results in increased expression of CDKN1C mRNA CTD PMID:21319176 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 decreases expression ISO Emodin results in decreased expression of CELSR3 mRNA CTD PMID:16045814 NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354 		JBrowse link
G Chia chitinase, acidic multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased expression of CHIA mRNA] CTD PMID:22484343 NCBI chr 2:193,614,374...193,656,532
Ensembl chr 2:193,614,114...193,656,533 		JBrowse link
G Cidec cell death-inducing DFFA-like effector c decreases expression ISO Emodin results in decreased expression of CIDEC mRNA CTD PMID:21319176 NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Emodin results in decreased expression of COL1A1 mRNA CTD PMID:15288473 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] CTD PMID:19474275 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression EXP Emodin results in decreased expression of COL3A1 mRNA CTD PMID:15288473 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cops5 COP9 signalosome subunit 5 multiple interactions ISO [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein CTD PMID:17077332 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 increases expression ISO Emodin results in increased expression of CSNK2A1 mRNA CTD PMID:21319176 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G Csnk2b casein kinase 2 beta increases expression ISO Emodin results in increased expression of CSNK2B mRNA CTD PMID:21319176 NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133 		JBrowse link
G Ctsd cathepsin D decreases expression ISO Emodin results in decreased expression of CTSD mRNA CTD PMID:16045814 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA] CTD PMID:18590720 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA] CTD PMID:18590720 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase increases expression ISO Emodin results in increased expression of CYLD mRNA CTD PMID:21319176 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression		 ISO Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Emodin results in decreased activity of CYP1A1 protein
Emodin results in increased expression of CYP1A1 mRNA; Emodin results in increased expression of CYP1A1 protein		 CTD PMID:11502733 PMID:14644660 PMID:17012224 PMID:27633141 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases hydroxylation
increases oxidation
decreases activity		 ISO [CYP1A2 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
CYP1A2 protein results in increased hydroxylation of Emodin
CYP1A2 protein results in increased oxidation of Emodin
Emodin results in decreased activity of CYP1A2 protein		 CTD PMID:27633141 PMID:27989148 PMID:30672276 PMID:33438235 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
decreases activity		 ISO Emodin results in increased expression of CYP1B1 mRNA; Emodin results in increased expression of CYP1B1 protein
Emodin results in decreased activity of CYP1B1 protein		 CTD PMID:11502733 PMID:14990334 PMID:27633141 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression
multiple interactions		 EXP
ISO		 Emodin results in decreased expression of CYP27A1 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of CYP27A1 protein		 CTD PMID:28161596 PMID:30517764 PMID:35753641 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases oxidation
decreases activity
multiple interactions		 ISO CYP2C19 protein results in increased oxidation of Emodin
Emodin results in decreased activity of CYP2C19 protein
[CYP2C19 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite		 CTD PMID:27989148 PMID:33438235 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Emodin results in decreased activity of CYP2D6 protein CTD PMID:33438235 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
affects response to substance
increases hydroxylation
increases oxidation		 ISO [CYP3A4 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
Emodin results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the susceptibility to Emodin
CYP3A4 protein results in increased hydroxylation of Emodin
CYP3A4 protein results in increased oxidation of Emodin		 CTD PMID:27989148 PMID:30672276 PMID:33438235 PMID:34875353 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Emodin CTD PMID:30672276 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions		 EXP Emodin results in decreased expression of CYP7A1 mRNA; Emodin results in decreased expression of CYP7A1 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of CYP7A1 protein		 CTD PMID:28161596 PMID:35753641 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Emodin results in decreased expression of CYP7B1 mRNA CTD PMID:30517764 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP Emodin results in decreased expression of CYP8B1 mRNA; Emodin results in decreased expression of CYP8B1 protein CTD PMID:28161596 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Dct dopachrome tautomerase decreases expression ISO Emodin results in decreased expression of DCT mRNA; Emodin results in decreased expression of DCT protein CTD PMID:26972667 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Emodin results in increased expression of DDIT3 protein CTD PMID:19549930 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dhfr dihydrofolate reductase decreases expression ISO Emodin results in decreased expression of DHFR mRNA CTD PMID:16045814 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO Emodin results in increased expression of DNAJB1 mRNA CTD PMID:16045814 NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458 		JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 increases expression ISO Emodin results in increased expression of DYNC1H1 mRNA CTD PMID:21319176 NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883 		JBrowse link
G E2f5 E2F transcription factor 5 increases expression ISO Emodin results in increased expression of E2F5 mRNA CTD PMID:16045814 NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of EGR1 mRNA] CTD PMID:18590720 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein increases expression ISO Emodin results in increased expression of EI24 mRNA CTD PMID:16045814 NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571 		JBrowse link
G Eif2b1 eukaryotic translation initiation factor 2B subunit alpha decreases expression ISO Emodin results in decreased expression of EIF2B1 mRNA CTD PMID:16045814 NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Emodin results in increased activity of ESR1 protein CTD PMID:19161236 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO Emodin results in increased activity of ESR2 protein CTD PMID:19161236 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fabp5 fatty acid binding protein 5 decreases expression ISO Emodin results in decreased expression of FABP5 mRNA CTD PMID:15612046 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO Emodin results in increased expression of FADD mRNA CTD PMID:21319176 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
decreases expression
increases expression		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FAS protein]; U 0126 promotes the reaction [Emodin results in increased expression of FAS protein]
Emodin results in decreased expression of FAS protein		 CTD PMID:19549930 PMID:27032576 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FASLG protein]; SB 203580 promotes the reaction [Emodin results in increased expression of FASLG protein]; U 0126 promotes the reaction [Emodin results in increased expression of FASLG protein] CTD PMID:27032576 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fn1 fibronectin 1 decreases expression EXP Emodin results in decreased expression of FN1 mRNA CTD PMID:15288473 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Foxo1 forkhead box O1 increases expression ISO Emodin results in increased expression of FOXO1 mRNA CTD PMID:16045814 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GADD45A mRNA] CTD PMID:30517764 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gas2 growth arrest-specific 2 increases expression ISO Emodin results in increased expression of GAS2 mRNA CTD PMID:16045814 NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP Emodin results in increased expression of GCLC mRNA CTD PMID:34971761 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP Emodin results in increased expression of GCLM mRNA CTD PMID:34971761 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 increases expression ISO Emodin results in increased expression of GCNT2 mRNA CTD PMID:15612046 NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Emodin inhibits the reaction [Oxaliplatin results in increased expression of GFAP protein]; Emodin inhibits the reaction [TNF protein results in increased expression of GFAP protein] CTD PMID:36184831 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Golga3 golgin A3 increases expression ISO Emodin results in increased expression of GOLGA3 mRNA CTD PMID:21319176 NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509
Ensembl chr 4:46,454,870...46,500,509 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Emodin co-treated with 1-aminobenzotriazole] results in increased expression of GPT protein; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein] CTD PMID:34492313 PMID:37023836 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Emodin results in increased expression of GPX1 mRNA CTD PMID:16045814 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPX2 mRNA] CTD PMID:30517764 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression
multiple interactions		 ISO
EXP		 Emodin results in decreased expression of GPX4 mRNA; Emodin results in decreased expression of GPX4 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of GPX4 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of GPX4 protein]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of GPX4 mRNA]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of GPX4 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of GPX4 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of GPX4 protein]		 CTD PMID:37393915 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Emodin promotes the reaction [Cisplatin results in decreased activity of GSR protein] CTD PMID:22271272 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression ISO Emodin results in decreased expression of GSTM3 mRNA CTD PMID:16045814 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Emodin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO Emodin results in increased expression of H2AX protein; Emodin results in increased expression of H2AX protein modified form
TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]		 CTD PMID:20855424 PMID:34492313 PMID:36893906 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 decreases expression ISO Emodin results in decreased expression of HACD3 mRNA CTD PMID:16045814 NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 decreases expression
multiple interactions		 ISO
EXP		 Emodin results in decreased expression of HES1 mRNA; Emodin results in decreased expression of HES1 protein
JAG1 protein inhibits the reaction [Emodin results in decreased expression of HES1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HES1 protein]		 CTD PMID:37393915 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA] CTD PMID:21382473 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hils1 histone linker H1 domain, spermatid-specific 1 increases expression ISO Emodin results in increased expression of H1F9 mRNA CTD PMID:21319176 NCBI chr10:79,913,525...79,914,321
Ensembl chr10:79,913,480...79,914,321 		JBrowse link
G Hk2 hexokinase 2 increases expression ISO Emodin results in increased expression of HK2 mRNA CTD PMID:21319176 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
increases expression		 ISO
EXP		 Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 protein]
Emodin results in decreased expression of HMOX1 mRNA; Emodin results in decreased expression of HMOX1 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of HMOX1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of HMOX1 protein]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of HMOX1 mRNA]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of HMOX1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HMOX1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HMOX1 protein]
Emodin results in increased expression of HMOX1 mRNA		 CTD PMID:26139382 PMID:30517764 PMID:34875353 PMID:37393915 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression
affects glucuronidation		 EXP
ISO		 Emodin results in decreased expression of HNF4A protein
Emodin results in decreased expression of HNF4A mRNA; Emodin results in decreased expression of HNF4A protein
HNF4A gene SNP affects the glucuronidation of Emodin		 CTD PMID:32538071 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Emodin results in increased expression of HSPA5 protein CTD PMID:19549930 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ICAM1 protein] CTD PMID:18590720 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igsf11 immunoglobulin superfamily, member 11 increases expression ISO Emodin results in increased expression of IGSF11 mRNA CTD PMID:21319176 NCBI chr11:61,733,139...61,884,059
Ensembl chr11:61,733,144...61,868,348 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL10 mRNA] CTD PMID:30517764 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein] CTD PMID:22484343 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il15 interleukin 15 increases expression ISO Emodin results in increased expression of IL15 mRNA CTD PMID:15612046 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL18 protein] CTD PMID:37023836 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL1B protein]
Emodin inhibits the reaction [Oxaliplatin results in increased expression of IL1B protein]; Emodin inhibits the reaction [TNF protein results in increased expression of IL1B protein]		 CTD PMID:26139382 PMID:30517764 PMID:36184831 PMID:37023836 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein] CTD PMID:22484343 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein] CTD PMID:22484343 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein]
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]		 CTD PMID:18590720 PMID:23848338 PMID:26139382 PMID:30517764 PMID:37023836 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO Emodin results in decreased expression of ITPR1 mRNA CTD PMID:16045814 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 multiple interactions
decreases expression		 EXP 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of and results in decreased cleavage of NOTCH1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of GPX4 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of GPX4 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HES1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HES1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HMOX1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HMOX1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NFE2L2 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NQO1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NQO1 protein]; JAG1 protein inhibits the reaction [Emodin results in increased expression of PTGS2 mRNA]; JAG1 protein inhibits the reaction [Emodin results in increased expression of TP53 protein]
Emodin results in decreased expression of JAG1 protein		 CTD PMID:27989784 PMID:37393915 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Jak1 Janus kinase 1 decreases phosphorylation
multiple interactions		 ISO Emodin results in decreased phosphorylation of JAK1 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]		 CTD PMID:23848338 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation
multiple interactions		 ISO Emodin results in decreased phosphorylation of JAK2 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]		 CTD PMID:23848338 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein CTD PMID:17077332 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Krt19 keratin 19 decreases expression ISO Emodin results in decreased expression of KRT19 mRNA CTD PMID:16045814 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 increases expression ISO Emodin results in increased expression of LAPTM5 mRNA CTD PMID:15612046 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Emodin results in decreased expression of LEF1 mRNA CTD PMID:15612046 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions ISO [Emodin co-treated with cobaltous chloride] results in increased expression of LRP1 protein CTD PMID:23212659 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 decreases expression ISO Emodin results in decreased expression of MACF1 mRNA CTD PMID:16045814 NCBI chr 5:135,623,734...135,949,097
Ensembl chr 5:135,623,742...135,945,905 		JBrowse link
G Maob monoamine oxidase B decreases activity EXP Emodin results in decreased activity of MAOB protein CTD PMID:15120460 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein] CTD PMID:15288473 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein] CTD PMID:15288473 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 EXP
ISO		 Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]
Emodin results in decreased phosphorylation of MAPK1 protein
Emodin results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK1 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with T0901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:15288473 PMID:26972667 PMID:27032576 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO Emodin results in increased expression of MAPK10 mRNA CTD PMID:15612046 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Acetylcysteine inhibits the reaction [Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]]; Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein] CTD PMID:14729614 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation		 EXP
ISO		 Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]
Emodin results in decreased phosphorylation of MAPK3 protein
Emodin results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with T0901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15288473 PMID:26972667 PMID:27032576 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Emodin results in decreased expression of MAPT mRNA CTD PMID:16045814 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
increases expression		 ISO Emodin results in decreased expression of MCL1 mRNA; Emodin results in decreased expression of MCL1 protein
Emodin results in increased expression of MCL1 mRNA		 CTD PMID:21319176 PMID:23848338 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Melk maternal embryonic leucine zipper kinase decreases expression ISO Emodin results in decreased expression of MELK mRNA; Emodin results in decreased expression of MELK protein CTD PMID:36893906 NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP Emodin results in increased expression of MGMT mRNA CTD PMID:19549930 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO Emodin results in decreased expression of MITF protein CTD PMID:26972667 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein] CTD PMID:18590720 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA] CTD PMID:22484343 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
affects expression		 EXP Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]
Emodin affects the expression of MYC protein		 CTD PMID:17886230 PMID:19549930 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Mylk myosin light chain kinase increases activity EXP Emodin results in increased activity of MYLK protein CTD PMID:15133857 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 increases expression ISO Emodin results in increased expression of NCOA2 mRNA CTD PMID:21319176 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression
affects localization		 ISO
EXP		 Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of NFE2L2 protein]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of NFE2L2 mRNA]; Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein
Emodin results in decreased expression of NFE2L2 mRNA
Emodin affects the localization of NFE2L2 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of NFE2L2 mRNA]; [[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which binds to NFE2L2 protein; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein]; Emodin affects the localization of [PKM protein binds to NFE2L2 protein]; Emodin promotes the reaction [PKM protein binds to NFE2L2 protein]; Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein; JAG1 protein inhibits the reaction [Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NFE2L2 mRNA]		 CTD PMID:26139382 PMID:34971761 PMID:37393915 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions		 EXP
ISO		 Emodin results in increased expression of NFKB1 protein
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NFKB1 mRNA]		 CTD PMID:19549930 PMID:37023836 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions		 ISO Emodin results in increased expression of NFKBIA mRNA
Emodin inhibits the reaction [Ovalbumin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]		 CTD PMID:16045814 PMID:22484343 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nkx6-2 NK6 homeobox 2 increases expression ISO Emodin results in increased expression of NKX6-2 mRNA CTD PMID:15612046 NCBI chr 1:194,380,149...194,383,533
Ensembl chr 1:194,381,975...194,383,515 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA] CTD PMID:37023836 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
affects expression		 EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NOS2 protein]
Emodin affects the expression of NOS2		 CTD PMID:18590720 PMID:23615023 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Notch1 notch receptor 1 decreases expression
multiple interactions
decreases response to substance		 EXP
ISO		 Emodin results in decreased expression of NOTCH1 protein
Emodin results in decreased expression of and results in decreased cleavage of NOTCH1 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; Emodin results in decreased expression of and results in decreased cleavage of NOTCH1 protein; JAG1 protein inhibits the reaction [Emodin results in decreased expression of and results in decreased cleavage of NOTCH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein]
NOTCH1 protein results in decreased susceptibility to Emodin		 CTD PMID:27989784 PMID:37393915 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
decreases expression
multiple interactions		 ISO
EXP		 Emodin results in increased expression of NQO1 mRNA
Emodin results in decreased expression of NQO1 mRNA; Emodin results in decreased expression of NQO1 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of NQO1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of NQO1 protein]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of NQO1 mRNA]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of NQO1 protein]; Emodin results in increased expression of and results in increased activity of NQO1 protein; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NQO1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NQO1 protein]		 CTD PMID:34875353 PMID:34971761 PMID:37393915 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Emodin results in increased expression of NR0B2 mRNA CTD PMID:30517764 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Emodin results in increased expression of NR1H3 mRNA; Emodin results in increased expression of NR1H3 protein CTD PMID:26972667 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Emodin results in decreased expression of NR1H4 mRNA; Emodin results in decreased expression of NR1H4 protein CTD PMID:30517764 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Oma1 OMA1 zinc metallopeptidase multiple interactions EXP Emodin inhibits the reaction [Hydrogen Peroxide results in increased expression of OMA1 protein]; Emodin inhibits the reaction [Oxidopamine results in increased expression of OMA1 protein] CTD PMID:34971761 NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity
increases cleavage
multiple interactions		 ISO Emodin results in increased activity of PARP1 protein
Emodin results in increased cleavage of PARP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of PARP1 protein]; [U 0126 co-treated with Emodin] results in increased cleavage of PARP1 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]		 CTD PMID:23848338 PMID:27032576 PMID:34492313 PMID:36893906 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein] CTD PMID:17886230 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdcl phosducin like decreases expression ISO Emodin results in decreased expression of PDCL mRNA CTD PMID:16045814 NCBI chr 3:21,110,165...21,119,763
Ensembl chr 3:21,110,167...21,119,715
Ensembl chr 3:21,110,167...21,119,715 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein] CTD PMID:15288473 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions
decreases expression		 EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]
Emodin results in decreased expression of PDGFRB protein		 CTD PMID:15288473 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Emodin results in decreased expression of PECAM1 protein CTD PMID:23848338 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 increases expression ISO Emodin results in increased expression of PIK3C3 mRNA CTD PMID:16045814 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 affects expression EXP Emodin affects the expression of PIK3R1 protein CTD PMID:19549930 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pkm pyruvate kinase M1/2 affects localization
decreases activity
multiple interactions		 EXP Emodin affects the localization of PKM protein
Emodin results in decreased activity of PKM protein
[[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which binds to NFE2L2 protein; [[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which results in decreased activity of PKM protein; [Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]; Emodin affects the localization of [PKM protein binds to NFE2L2 protein]; Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]; Emodin promotes the reaction [PKM protein binds to NFE2L2 protein]		 CTD PMID:34971761 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions		 ISO Emodin results in increased expression of PPARG protein
Emodin results in increased stability of and results in increased expression of PPARG mRNA		 CTD PMID:25448808 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D increases expression ISO Emodin results in increased expression of PPM1D mRNA CTD PMID:16045814 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607 		JBrowse link
G Ppp1r1c protein phosphatase 1, regulatory (inhibitor) subunit 1C decreases expression ISO Emodin results in decreased expression of PPP1R1C mRNA CTD PMID:15612046 NCBI chr 3:64,616,700...64,719,696
Ensembl chr 3:64,616,700...64,724,104 		JBrowse link
G Prdx6 peroxiredoxin 6 increases expression ISO Emodin results in increased expression of PRDX6 mRNA CTD PMID:16045814 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355 		JBrowse link
G Prkca protein kinase C, alpha affects localization EXP Emodin affects the localization of PRKCA protein CTD PMID:15133857 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcd protein kinase C, delta decreases expression
affects expression		 ISO
EXP		 Emodin results in decreased expression of PRKCD mRNA
Emodin affects the expression of PRKCD protein		 CTD PMID:16045814 PMID:19549930 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prm3 protamine 3 increases expression ISO Emodin results in increased expression of PRM3 mRNA CTD PMID:21319176 NCBI chr10:4,877,471...4,877,985
Ensembl chr10:4,877,471...4,877,985 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP
ISO		 2-tert-butylhydroquinone inhibits the reaction [Emodin results in increased expression of PTGS2 mRNA]; AKT activator SC79 inhibits the reaction [Emodin results in increased expression of PTGS2 mRNA]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of PTGS2 protein]; Emodin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; JAG1 protein inhibits the reaction [Emodin results in increased expression of PTGS2 mRNA]
Emodin results in increased expression of PTGS2 mRNA; Emodin results in increased expression of PTGS2 protein		 CTD PMID:36184831 PMID:37393915 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 affects expression EXP Emodin affects the expression of PTK2 protein CTD PMID:19549930 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 increases expression
multiple interactions		 ISO Emodin results in increased expression of PTPN6 protein
PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]		 CTD PMID:23848338 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression
multiple interactions		 ISO
EXP		 Emodin results in decreased expression of RAF1 mRNA
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]		 CTD PMID:15288473 PMID:16045814 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rag1 recombination activating 1 decreases expression ISO Emodin results in decreased expression of RAG1 mRNA CTD PMID:15612046 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rarb retinoic acid receptor, beta decreases expression ISO Emodin results in decreased expression of RARB mRNA CTD PMID:22609528 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Emodin results in decreased expression of RB1 mRNA CTD PMID:16045814 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rcn2 reticulocalbin 2 increases expression ISO Emodin results in increased expression of RCN2 mRNA CTD PMID:16045814 NCBI chr 8:56,449,206...56,466,253
Ensembl chr 8:56,449,206...56,466,251 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases localization		 EXP
ISO		 Emodin affects the expression of and affects the localization of RELA protein; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased localization of RELA protein]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of RELA protein]; Emodin inhibits the reaction [TNF protein results in increased expression of RELA protein]
Emodin results in decreased localization of RELA protein
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of RELA protein]; Emodin inhibits the reaction [Ovalbumin affects the localization of RELA protein]		 CTD PMID:18590720 PMID:19549930 PMID:22484343 PMID:30517764 PMID:36184831 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Emodin results in decreased expression of RHOA mRNA CTD PMID:16045814 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO Emodin results in decreased expression of ROCK1 mRNA CTD PMID:16045814 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases expression ISO Emodin results in decreased expression of ROCK2 mRNA CTD PMID:16045814 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression ISO Emodin results in decreased expression of SAE1 mRNA CTD PMID:16045814 NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]] CTD PMID:14534369 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression
multiple interactions		 EXP
ISO		 Emodin results in decreased expression of SLC10A1 mRNA; Emodin results in decreased expression of SLC10A1 protein
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]		 CTD PMID:28161596 PMID:30517764 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO Emodin results in decreased activity of SLC22A6 protein CTD PMID:29045746 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO Emodin results in decreased activity of SLC22A8 protein CTD PMID:29045746 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA] CTD PMID:30517764 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Smcp sperm mitochondria-associated cysteine-rich protein increases expression ISO Emodin results in increased expression of SMCP mRNA CTD PMID:21319176 NCBI chr 2:178,160,948...178,165,951
Ensembl chr 2:178,160,127...178,166,001 		JBrowse link
G Snu13 small nuclear ribonucleoprotein 13 decreases expression ISO Emodin results in decreased expression of SNU13 mRNA CTD PMID:15612046 NCBI chr 7:113,565,293...113,570,887
Ensembl chr 7:113,565,295...113,570,872
Ensembl chr 1:113,565,295...113,570,872 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA] CTD PMID:21382473 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects activity		 ISO
EXP		 Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA]
Emodin affects the activity of SOD2 protein		 CTD PMID:21382473 PMID:23615023 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation ISO Emodin results in decreased phosphorylation of SRC protein CTD PMID:23848338 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 increases expression ISO Emodin results in increased expression of ST8SIA1 mRNA CTD PMID:16045814 NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects localization
multiple interactions		 ISO Emodin affects the localization of STAT3 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein; pervanadate inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]		 CTD PMID:23848338 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Emodin results in decreased expression of STIP1 mRNA CTD PMID:16045814 NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO Emodin results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Supt20h SPT20 homolog, SAGA complex component increases expression ISO Emodin results in increased expression of SUPT20H mRNA CTD PMID:16045814 NCBI chr 2:138,897,316...138,930,493
Ensembl chr 2:138,897,416...138,930,495 		JBrowse link
G Taok3 TAO kinase 3 decreases expression ISO Emodin results in decreased expression of TAOK3 mRNA CTD PMID:16045814 NCBI chr12:39,312,354...39,473,656
Ensembl chr12:39,314,027...39,461,244 		JBrowse link
G Tbcc tubulin folding cofactor C decreases expression ISO Emodin results in decreased expression of TBCC mRNA CTD PMID:16045814 NCBI chr 9:14,098,855...14,100,043
Ensembl chr 9:14,098,868...14,100,042 		JBrowse link
G Tcfl5 transcription factor like 5 increases expression ISO Emodin results in increased expression of TCFL5 mRNA CTD PMID:15612046 NCBI chr 3:167,734,471...167,754,174
Ensembl chr 3:167,734,473...167,754,282 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases activity		 EXP 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin results in decreased activity of TGFB1 protein]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein] CTD PMID:15288473 PMID:19474275 PMID:27989784 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of TNF protein]; Emodin inhibits the reaction [TNF protein results in increased expression of GFAP protein]; Emodin inhibits the reaction [TNF protein results in increased expression of IL1B protein]; Emodin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Emodin inhibits the reaction [TNF protein results in increased expression of RELA protein]
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of TNF protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]		 CTD PMID:14534369 PMID:15313406 PMID:18590720 PMID:26139382 PMID:36184831 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions
increases activity		 ISO Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate]; TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]
Emodin results in increased activity of TOP2A protein		 CTD PMID:20855424 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tp53 tumor protein p53 affects expression
multiple interactions
increases expression		 EXP
ISO		 Emodin affects the expression of TP53 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in increased expression of TP53 protein]; AKT activator SC79 inhibits the reaction [Emodin results in increased expression of TP53 protein]; JAG1 protein inhibits the reaction [Emodin results in increased expression of TP53 protein]		 CTD PMID:19549930 PMID:37393915 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp63 tumor protein p63 increases expression ISO Emodin results in increased expression of TRP63 mRNA CTD PMID:15612046 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 increases expression
decreases expression		 ISO Emodin results in increased expression of TRAF2 mRNA
Emodin results in decreased expression of TRAF2 mRNA		 CTD PMID:16045814 PMID:21319176 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 increases expression ISO Emodin results in increased expression of TRPV2 mRNA CTD PMID:15612046 NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260 		JBrowse link
G Tsga13 testis specific, 13 increases expression ISO Emodin results in increased expression of TSGA13 mRNA CTD PMID:21319176 NCBI chr 4:59,501,773...59,522,925
Ensembl chr 4:59,501,774...59,522,818 		JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO Emodin results in decreased expression of TUBB3 mRNA CTD PMID:16045814 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP Emodin results in increased expression of and results in increased activity of TXN protein CTD PMID:34971761 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnl4b thioredoxin-like 4B decreases expression ISO Emodin results in decreased expression of TXNL4B mRNA CTD PMID:16045814 NCBI chr19:37,530,157...37,539,827
Ensembl chr19:37,530,152...37,538,521 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression
multiple interactions		 ISO
EXP		 Emodin results in decreased expression of TXNRD1 mRNA
Emodin results in increased expression of and results in increased activity of TXNRD1 protein		 CTD PMID:16045814 PMID:34971761 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Tyr tyrosinase decreases activity ISO Emodin results in decreased activity of TYR protein CTD PMID:26972667 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO Emodin results in decreased expression of TYRP1 mRNA; Emodin results in decreased expression of TYRP1 protein CTD PMID:26972667 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I increases expression ISO Emodin results in increased expression of UBE2I mRNA CTD PMID:21319176 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Emodin CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Emodin CTD PMID:14557274 PMID:24854283 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Emodin CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases expression ISO
EXP		 Emodin results in decreased expression of UGT2B7 mRNA; Emodin results in decreased expression of UGT2B7 protein CTD PMID:32538071 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression ISO Emodin results in decreased expression of VDAC1 mRNA CTD PMID:16045814 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Emodin results in decreased expression of VEGFA mRNA; Emodin results in decreased expression of VEGFA protein CTD PMID:23848338 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin decreases expression
multiple interactions		 EXP Emodin results in decreased expression of VIM protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]		 CTD PMID:27989784 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 affects expression EXP Emodin affects the expression of XRCC1 protein CTD PMID:19549930 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
G Zfp37 zinc finger protein 37 increases expression ISO Emodin results in increased expression of ZFP37 mRNA CTD PMID:21319176 NCBI chr 5:75,598,732...75,638,896
Ensembl chr 5:75,598,732...75,638,942 		JBrowse link
Frangulin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 decreases activity ISO frangulin A results in decreased activity of AKR1B10 protein CTD PMID:35065925 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO frangulin A results in decreased activity of AKR1C3 protein CTD PMID:35065925 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Cbr1 carbonyl reductase 1 decreases activity ISO frangulin A results in decreased activity of CBR1 protein CTD PMID:35065925 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [frangulin A co-treated with frangulin B] results in decreased activity of CYP1A2 protein CTD PMID:33438235 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
Frangulin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 decreases activity ISO frangulin B results in decreased activity of AKR1B10 protein CTD PMID:35065925 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO frangulin B results in decreased activity of AKR1C3 protein CTD PMID:35065925 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Cbr1 carbonyl reductase 1 decreases activity ISO frangulin B results in decreased activity of CBR1 protein CTD PMID:35065925 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [frangulin A co-treated with frangulin B] results in decreased activity of CYP1A2 protein CTD PMID:33438235 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
Macrosporin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Top2a DNA topoisomerase II alpha decreases activity ISO macrosporin results in decreased activity of TOP2A protein CTD PMID:27682608 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
Maprotiline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases expression EXP Maprotiline results in increased expression of ABCB11 mRNA CTD PMID:27765674 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP Maprotiline results in decreased expression of ABCC2 mRNA CTD PMID:27765674 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Becn1 beclin 1 increases expression ISO Maprotiline results in increased expression of BECN1 protein CTD PMID:20503272 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Maprotiline results in increased activity of CASP3 protein] CTD PMID:23219590 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Maprotiline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Maprotiline results in increased phosphorylation of MAPK1 protein] CTD PMID:23219590 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Maprotiline results in increased phosphorylation of MAPK3 protein] CTD PMID:23219590 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Maprotiline results in increased expression of NOS2 mRNA CTD PMID:12429386 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Maprotiline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
mitoxantrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 affects response to substance ISO ABCA1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Mitoxantrone results in increased expression of ABCB1 protein CTD PMID:15239124 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects export
affects response to substance
increases transport
multiple interactions
increases export
increases expression
decreases abundance
decreases response to substance
increases response to substance
affects transport
affects uptake		 ISO ABCG2 protein affects the export of Mitoxantrone
ABCG2 protein affects the susceptibility to Mitoxantrone
ABCG2 protein results in increased transport of Mitoxantrone
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] inhibits the reaction [Folic Acid deficiency results in decreased susceptibility to Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; [5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; [Folic Acid deficiency results in increased expression of ABCG2 protein] which results in decreased susceptibility to Mitoxantrone; [GSK 1363089 results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; [Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [MLN 8237 affects the activity of ABCG2 protein] which affects the export of Mitoxantrone; [Novobiocin results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone; Beclomethasone inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Cadmium Chloride inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Dactinomycin inhibits the reaction [Mitoxantrone results in increased expression of ABCG2 mRNA]; desisobutyrylciclesonide inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 gene mutant form results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; GSK 1363089 inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Haloperidol inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Novobiocin inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Olanzapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; oxfendazole inhibits the reaction [ABCG2 protein affects the transport of Mitoxantrone]; Paliperidone Palmitate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Protons promotes the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Quetiapine Fumarate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Risperidone inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein affects the uptake of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mitoxantrone results in increased expression of ABCG2 mRNA; Mitoxantrone results in increased expression of ABCG2 protein
ABCG2 protein results in decreased abundance of Mitoxantrone
ABCG2 protein results in increased susceptibility to Mitoxantrone		 CTD PMID:10606239 PMID:12869632 PMID:15239124 PMID:15640379 PMID:15695404 More... NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain decreases expression ISO Mitoxantrone results in decreased expression of ACADVL protein CTD PMID:34246718 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075 		JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 affects response to substance ISO ACSL3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627 		JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression ISO Mitoxantrone results in decreased expression of ACTA1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742 		JBrowse link
G Actg2 actin gamma 2, smooth muscle affects response to substance ISO ACTG2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465 		JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 affects response to substance ISO ADARB1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852 		JBrowse link
G Agpat5 1-acylglycerol-3-phosphate O-acyltransferase 5 affects response to substance ISO AGPAT5 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr16:70,939,480...70,985,745
Ensembl chr16:70,943,135...70,985,560 		JBrowse link
G Ahcyl1 adenosylhomocysteinase-like 1 affects response to substance ISO AHCYL1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member affects response to substance ISO ALDH2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Amotl1 angiomotin-like 1 affects response to substance ISO AMOTL1 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 8:11,348,651...11,467,564
Ensembl chr 8:11,353,674...11,467,573 		JBrowse link
G Ank2 ankyrin 2 decreases expression ISO Mitoxantrone results in decreased expression of ANK2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) affects response to substance ISO ASNS protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Ass1 argininosuccinate synthase 1 affects response to substance ISO ASS1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Atg5 autophagy related 5 decreases expression ISO Mitoxantrone results in decreased expression of ATG5 protein CTD PMID:36216988 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atm ATM serine/threonine kinase decreases expression
increases phosphorylation
multiple interactions		 ISO
EXP		 Mitoxantrone results in decreased expression of ATM mRNA
Mitoxantrone results in increased phosphorylation of ATM protein
[Poly(ADP-ribose) Polymerase Inhibitors co-treated with Mitoxantrone] results in increased phosphorylation of ATM protein		 CTD PMID:22832221 PMID:29913208 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression ISO Mitoxantrone results in decreased expression of ATP1A2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression ISO Mitoxantrone results in decreased expression of ATP5F1A protein CTD PMID:34246718 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO Mitoxantrone results in decreased expression of ATP5F1B protein CTD PMID:34246718 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273 		JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma decreases expression ISO Mitoxantrone results in decreased expression of ATP5F1C protein CTD PMID:34246718 NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367 		JBrowse link
G Atp7a ATPase copper transporting alpha decreases response to substance ISO ATP7A protein results in decreased susceptibility to Mitoxantrone CTD PMID:17510416 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Bace2 beta-secretase 2 affects response to substance ISO BACE2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr11:36,707,447...36,789,550
Ensembl chr11:36,707,458...36,789,546 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Mitoxantrone results in increased expression of BAX mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbx BBX high mobility group box domain containing affects response to substance ISO BBX protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr11:50,381,249...50,628,934
Ensembl chr11:50,381,247...50,623,251 		JBrowse link
G Bcam basal cell adhesion molecule (Lutheran blood group) affects response to substance ISO BCAM protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:79,415,016...79,429,403
Ensembl chr 1:79,415,017...79,429,403 		JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Mitoxantrone results in increased expression of BCAT1 mRNA CTD PMID:23558518 NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]
Mitoxantrone results in decreased expression of BCL2 mRNA		 CTD PMID:8219202 PMID:8840993 PMID:15582267 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein] CTD PMID:8840993 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 decreases expression ISO Mitoxantrone results in decreased expression of BECN1 protein CTD PMID:36216988 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO Mitoxantrone results in decreased expression of BIRC2 protein CTD PMID:15359644 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects expression
increases expression		 ISO Mitoxantrone affects the expression of BIRC5 mRNA
Mitoxantrone results in increased expression of BIRC5 protein		 CTD PMID:16638212 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp7 bone morphogenetic protein 7 affects response to substance ISO BMP7 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788 		JBrowse link
G Bst2 bone marrow stromal cell antigen 2 affects response to substance ISO BST2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979 		JBrowse link
G Btbd3 BTB domain containing 3 affects response to substance ISO BTBD3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:125,591,427...125,621,660
Ensembl chr 3:125,591,490...125,619,038 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G decreases expression ISO Mitoxantrone results in decreased expression of CACNA1G mRNA CTD PMID:26537877 PMID:28940058 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752 		JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 decreases expression ISO Mitoxantrone results in decreased expression of CACNA2D2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173 		JBrowse link
G Calr calreticulin affects localization ISO Mitoxantrone affects the localization of CALR protein CTD PMID:20003823 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 affects response to substance ISO CAMK2N1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600 		JBrowse link
G Casc3 CASC3 exon junction complex subunit affects response to substance ISO CASC3 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr10:83,769,014...83,788,966
Ensembl chr10:83,769,001...83,788,966 		JBrowse link
G Casp2 caspase 2 increases expression
increases splicing		 ISO Mitoxantrone results in increased expression of CASP2 mRNA alternative form
Mitoxantrone results in increased splicing of CASP2 mRNA		 CTD PMID:14757846 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP3 protein]
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]		 CTD PMID:8840993 PMID:12948851 PMID:16215684 PMID:22700542 PMID:32894303 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 increases activity ISO Mitoxantrone results in increased activity of CASP6 protein CTD PMID:12948851 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Mitoxantrone results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP7 protein]		 CTD PMID:12948851 PMID:22700542 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity ISO Mitoxantrone results in increased activity of CASP8 protein CTD PMID:12948851 PMID:32894303 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Mitoxantrone results in increased activity of CASP9 protein CTD PMID:12948851 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity EXP Mitoxantrone results in decreased activity of CAT protein CTD PMID:29913208 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cavin3 caveolae associated protein 3 affects response to substance ISO CAVIN3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161 		JBrowse link
G Cavin4 caveolae associated protein 4 decreases expression ISO Mitoxantrone results in decreased expression of CAVIN4 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 5:62,996,906...63,007,677
Ensembl chr 5:62,996,865...63,007,678 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) affects response to substance ISO CD55 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Celf2 CUGBP, Elav-like family member 2 affects response to substance ISO CELF2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333 		JBrowse link
G Cep15 centrosomal protein 15 affects response to substance ISO CEP15 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838 		JBrowse link
G Ces2h carboxylesterase 2H affects response to substance ISO CES2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Chrdl1 chordin-like 1 affects response to substance ISO CHRDL1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr  X:106,889,125...106,992,937
Ensembl chr  X:106,889,125...106,992,921 		JBrowse link
G Cklf chemokine-like factor affects response to substance ISO CKLF protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr19:698,097...706,570
Ensembl chr19:698,033...706,570 		JBrowse link
G Ckm creatine kinase, M-type decreases expression ISO Mitoxantrone results in decreased expression of CKM mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Clns1a chloride nucleotide-sensitive channel 1A affects response to substance ISO CLNS1A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:152,019,369...152,039,670
Ensembl chr 1:152,019,378...152,039,661 		JBrowse link
G Clu clusterin affects response to substance ISO CLU protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Coch cochlin affects response to substance ISO COCH protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109 		JBrowse link
G Col11a1 collagen type XI alpha 1 chain affects response to substance ISO COL11A1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853 		JBrowse link
G Corin corin, serine peptidase decreases expression ISO Mitoxantrone results in decreased expression of CORIN mRNA CTD PMID:26537877 PMID:28940058 NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503 		JBrowse link
G Cpvl carboxypeptidase, vitellogenic-like affects response to substance ISO CPVL protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:82,981,421...83,091,730
Ensembl chr 4:82,981,422...83,085,655 		JBrowse link
G Crebl2 cAMP responsive element binding protein-like 2 affects response to substance ISO CREBL2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:167,673,359...167,699,299
Ensembl chr 4:167,673,315...167,699,292 		JBrowse link
G Cs citrate synthase decreases activity ISO Mitoxantrone results in decreased activity of CS protein CTD PMID:34246718 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Csrnp2 cysteine and serine rich nuclear protein 2 affects response to substance ISO CSRNP2 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 7:131,594,232...131,610,075
Ensembl chr 7:131,594,232...131,610,075 		JBrowse link
G Cth cystathionine gamma-lyase affects response to substance ISO CTH protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule affects response to substance ISO CXADR protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Mitoxantrone results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Mitoxantrone results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Dapk1 death associated protein kinase 1 affects response to substance ISO DAPK1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 affects response to substance ISO DDIT4 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Dhrs2 dehydrogenase/reductase 2 affects response to substance ISO DHRS2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644 		JBrowse link
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease affects response to substance ISO DIS3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642 		JBrowse link
G Dmd dystrophin decreases expression ISO Mitoxantrone results in decreased expression of DMD mRNA CTD PMID:26537877 PMID:28940058 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207 		JBrowse link
G Dusp4 dual specificity phosphatase 4 affects response to substance
increases expression		 ISO DUSP4 protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in increased expression of DUSP4 mRNA		 CTD PMID:16217747 PMID:26537877 PMID:28940058 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138 		JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 affects response to substance ISO DYRK2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106 		JBrowse link
G Egr1 early growth response 1 affects response to substance ISO EGR1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha affects response to substance ISO EIF2S1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eif5a eukaryotic translation initiation factor 5A affects response to substance ISO EIF5A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656 		JBrowse link
G Elavl4 ELAV like RNA binding protein 4 affects response to substance ISO ELAVL4 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 5:125,056,848...125,200,543
Ensembl chr 5:125,056,848...125,200,446 		JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 affects response to substance ISO ELOVL5 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284 		JBrowse link
G En2 engrailed homeobox 2 affects response to substance ISO EN2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:7,221,096...7,226,943
Ensembl chr 4:7,221,096...7,226,943 		JBrowse link
G Enc1 ectodermal-neural cortex 1 affects response to substance ISO ENC1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713 		JBrowse link
G Epb41l2 erythrocyte membrane protein band 4.1-like 2 affects response to substance ISO EPB41L2 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 1:19,863,010...20,037,795
Ensembl chr 1:19,863,009...20,037,721 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases response to substance		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone] CTD PMID:21712253 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression ISO Mitoxantrone results in decreased expression of ERBB3 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Etfdh electron transfer flavoprotein dehydrogenase decreases expression ISO Mitoxantrone results in decreased expression of ETFDH protein CTD PMID:34246718 NCBI chr 2:164,740,547...164,762,754
Ensembl chr 2:164,729,749...164,762,745 		JBrowse link
G Evi5 ecotropic viral integration site 5 affects response to substance ISO EVI5 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678 		JBrowse link
G Extl2 exostosin-like glycosyltransferase 2 affects response to substance ISO EXTL2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:203,922,217...203,946,940
Ensembl chr 2:203,922,187...203,943,653 		JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP Mitoxantrone results in increased expression of FABP3 protein CTD PMID:22878004 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Fam117a family with sequence similarity 117, member A affects response to substance ISO FAM117A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr10:80,281,411...80,325,345
Ensembl chr10:80,281,408...80,325,343 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO Hydrocortisone promotes the reaction [Mitoxantrone results in increased expression of FAS]
Mitoxantrone results in increased expression of FAS mRNA; Mitoxantrone results in increased expression of FAS protein		 CTD PMID:9676859 PMID:26537877 PMID:28940058 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fasn fatty acid synthase decreases response to substance
multiple interactions		 ISO FASN protein results in decreased susceptibility to Mitoxantrone
orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]		 CTD PMID:18281512 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 affects response to substance ISO FDFT1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Mitoxantrone results in increased expression of FHL1 mRNA CTD PMID:23558518 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928 		JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 affects response to substance ISO FLRT3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841 		JBrowse link
G Fndc3a fibronectin type III domain containing 3a affects response to substance ISO FNDC3A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:47,689,909...47,867,354
Ensembl chr15:47,689,919...47,866,784 		JBrowse link
G Foxf2 forkhead box F2 affects response to substance ISO FOXF2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase affects response to substance ISO FYN protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Fzd2 frizzled class receptor 2 affects response to substance ISO FZD2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334 		JBrowse link
G Gch1 GTP cyclohydrolase 1 affects response to substance ISO GCH1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Mitoxantrone results in increased expression of GDF15 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Glul glutamate-ammonia ligase affects response to substance ISO GLUL protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Mitoxantrone results in increased expression of GPX1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx3 glutathione peroxidase 3 affects response to substance ISO GPX3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 affects response to substance ISO GUCY1B1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916 		JBrowse link
G H2ax H2A.X variant histone increases expression
increases phosphorylation
multiple interactions		 ISO
EXP		 Mitoxantrone results in increased expression of H2AX protein
Mitoxantrone results in increased phosphorylation of H2AX protein
Poly(ADP-ribose) Polymerase Inhibitors affects the reaction [Mitoxantrone results in increased expression of H2AX protein]		 CTD PMID:19738048 PMID:24994473 PMID:29913208 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression ISO Mitoxantrone results in decreased expression of HADHB protein CTD PMID:34246718 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869 		JBrowse link
G Hdac4 histone deacetylase 4 affects response to substance ISO HDAC4 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hmg20b high mobility group 20 B affects response to substance ISO HMG20B protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:8,368,934...8,373,650
Ensembl chr 7:8,368,990...8,373,640 		JBrowse link
G Hoxa5 homeo box A5 affects response to substance ISO HOXA5 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234 		JBrowse link
G Hrc histidine rich calcium binding protein decreases expression ISO Mitoxantrone results in decreased expression of HRC mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 affects response to substance ISO HSPA2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha affects response to substance
decreases expression		 ISO IDH3A protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in decreased expression of IDH3A protein		 CTD PMID:16217747 PMID:34246718 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084 		JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 affects response to substance ISO IFITM1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects response to substance ISO IGF1R protein affects the susceptibility to Mitoxantrone CTD PMID:15499378 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 affects response to substance ISO IGF2BP3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects response to substance ISO IGFBP3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 affects response to substance ISO IGFBP7 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 affects response to substance ISO IL13RA2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381 		JBrowse link
G Immt inner membrane mitochondrial protein decreases expression ISO Mitoxantrone results in decreased expression of IMMT protein CTD PMID:34246718 NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109 		JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 affects response to substance ISO IQGAP1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755 		JBrowse link
G Irf7 interferon regulatory factor 7 affects response to substance ISO IRF7 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Irx1 iroquois homeobox 1 affects response to substance ISO IRX1 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 1:31,294,615...31,300,444
Ensembl chr 1:31,294,615...31,300,444 		JBrowse link
G Irx4 iroquois homeobox 4 decreases expression ISO Mitoxantrone results in decreased expression of IRX4 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier affects response to substance ISO ISG15 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 affects response to substance ISO ISG20 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027 		JBrowse link
G Jak2 Janus kinase 2 decreases expression ISO Mitoxantrone results in decreased expression of JAK2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in increased expression of JUN mRNA] CTD PMID:8219202 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 affects response to substance ISO KCNAB2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:162,899,511...162,988,057
Ensembl chr 5:162,901,896...162,988,243 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases expression ISO Mitoxantrone results in decreased expression of KCNH2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 increases expression ISO Mitoxantrone results in increased expression of KCNJ2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 decreases expression ISO Mitoxantrone results in decreased expression of KCNQ1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Krr1 KRR1, small subunit processome component homolog affects response to substance ISO KRR1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:47,475,557...47,486,996
Ensembl chr 7:47,475,557...47,486,985 		JBrowse link
G Lama2 laminin subunit alpha 2 affects r