Advanced Search (OLGA)

Gene: Jam3 (junctional adhesion molecule 3) Rattus norvegicus

Analyze

Symbol:

Jam3

Name:

junctional adhesion molecule 3

RGD ID:

1303248

Description:

Predicted to enable cell-cell adhesion mediator activity; identical protein binding activity; and integrin binding activity. Involved in axon regeneration. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; bicellular tight junction; and paranodal junction. Predicted to be part of filamentous actin and protein complex involved in cell adhesion. Predicted to be active in cell-cell contact zone and plasma membrane. Biomarker of sciatic neuropathy. Orthologous to human JAM3 (junctional adhesion molecule 3); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

JAM-3; JAM-C; junctional adhesion molecule C; MGC94974

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	JAM3 (junctional adhesion molecule 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Jam3 (junction adhesion molecule 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Jam3 (junctional adhesion molecule 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	JAM3 (junctional adhesion molecule 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	JAM3 (junctional adhesion molecule 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Jam3 (junctional adhesion molecule 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	JAM3 (junctional adhesion molecule 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	JAM3 (junctional adhesion molecule 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Jam3 (junctional adhesion molecule 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	STX7 (syntaxin 7)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	JAM3 (junctional adhesion molecule 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Jam3 (junction adhesion molecule 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	jam3b (junctional adhesion molecule 3b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	jam3a (junctional adhesion molecule 3a)	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	jam3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	33,767,606 - 33,828,451 (-)	NCBI		GRCr8
mRatBN7.2	8	25,508,461 - 25,569,306 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	25,507,057 - 25,569,355 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	29,550,421 - 29,611,261 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	27,844,708 - 27,905,552 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	25,724,719 - 25,785,571 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	28,147,110 - 28,208,466 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	28,147,111 - 28,208,466 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	28,166,275 - 28,227,631 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	26,697,127 - 26,758,579 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	26,697,127 - 26,758,579 (-)	NCBI
Celera	8	26,995,820 - 27,056,659 (-)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Jam3	Rat	allergic contact dermatitis		ISO	RGD:1551450	7488919		RGD
Jam3	Rat	Carcinoma, Lewis Lung		ISO	RGD:1551450	7488936		RGD
Jam3	Rat	Choroidal Neovascularization	treatment	ISO	RGD:1551450	7488935		RGD
Jam3	Rat	Retinal Neovascularization		ISO	RGD:1551450	7488936		RGD
Jam3	Rat	sciatic neuropathy		IEP		7488944		RGD
Jam3	Rat	systemic scleroderma		ISO	RGD:1346212	7488937	protein:decreased expression:skin, endothelial cell	RGD
Jam3	Rat	systemic scleroderma		ISO	RGD:1346212	7488920	protein:increased expression:skin	RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Jam3	Rat	chromosome 11 partial duplication syndrome		ISO	RGD:1346212	8554872	ClinVar Annotator: match by term: Distal trisomy 11q	ClinVar	PMID:25741868
Jam3	Rat	genetic disease		ISO	RGD:1346212	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868\|PMID:28492532
Jam3	Rat	Hemorrhagic Destruction of the Brain, Subependymal Calcification, and Cataracts		ISO	RGD:1346212	8554872	ClinVar Annotator: match by term: Hemorrhagic destruction of the brain, subependymal calcification, and cataracts \| more ...	ClinVar	PMID:21109224\|PMID:23255084\|PMID:25741868\|PMID:25741869\|PMID:28492532\|PMID:32860008
Jam3	Rat	Isobutyryl-CoA Dehydrogenase Deficiency		ISO	RGD:1346212	8554872	ClinVar Annotator: match by term: Deficiency of isobutyryl-CoA dehydrogenase	ClinVar	PMID:16857760\|PMID:21109224\|PMID:23255084\|PMID:28492532
Jam3	Rat	Jacobsen Syndrome		ISO	RGD:1346212	8554872	ClinVar Annotator: match by term: Paris-Trousseau thrombocytopenia	ClinVar	PMID:32581362
Jam3	Rat	schizophrenia		ISO	RGD:1346212	8554872	ClinVar Annotator: match by term: Schizophrenia	ClinVar	PMID:21681106\|PMID:30208311

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Jam3	Rat	autism spectrum disorder		ISO	RGD:1346212	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:35663546

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Jam3	Rat	Hemorrhagic Destruction of the Brain, Subependymal Calcification, and Cataracts		ISO	RGD:1346212	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Jam3	Rat	1,1-dichloroethene	decreases expression	ISO	RGD:1551450	6480464	vinylidene chloride results in decreased expression of JAM3 mRNA	CTD	PMID:26682919
Jam3	Rat	1-naphthyl isothiocyanate	increases expression	EXP		6480464	1-Naphthylisothiocyanate results in increased expression of JAM3 mRNA	CTD	PMID:30723492
Jam3	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of JAM3 mRNA	CTD	PMID:21215274
Jam3	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of JAM3 mRNA	CTD	PMID:33387578
Jam3	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of JAM3 mRNA	CTD	PMID:34747641
Jam3	Rat	3,3',4,4',5-pentachlorobiphenyl	decreases expression	EXP		6480464	3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of JAM3 mRNA	CTD	PMID:23196670
Jam3	Rat	3,3',4,4'-tetrachlorobiphenyl	multiple interactions	ISO	RGD:1551450	6480464	3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of JAM3 mRNA]	CTD	PMID:19467301
Jam3	Rat	3-isobutyl-1-methyl-7H-xanthine	multiple interactions	ISO	RGD:1346212	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ...	CTD	PMID:28628672
Jam3	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:1551450	6480464	bisphenol S results in increased expression of JAM3 mRNA	CTD	PMID:30951980
Jam3	Rat	4-hydroxyphenyl retinamide	increases expression	ISO	RGD:1551450	6480464	Fenretinide results in increased expression of JAM3 mRNA	CTD	PMID:28973697
Jam3	Rat	6-propyl-2-thiouracil	decreases expression	EXP		6480464	Propylthiouracil results in decreased expression of JAM3 mRNA	CTD	PMID:24780913\|PMID:36843608
Jam3	Rat	acetamide	increases expression	EXP		6480464	acetamide results in increased expression of JAM3 mRNA	CTD	PMID:31881176
Jam3	Rat	acetohydrazide	decreases expression	ISO	RGD:1551450	6480464	acetylhydrazine results in decreased expression of JAM3 mRNA	CTD	PMID:15282401
Jam3	Rat	aconitine	decreases expression	EXP		6480464	Aconitine results in decreased expression of JAM3 protein	CTD	PMID:33236894
Jam3	Rat	acrylamide	increases expression	ISO	RGD:1346212	6480464	Acrylamide results in increased expression of JAM3 mRNA	CTD	PMID:32763439
Jam3	Rat	aflatoxin B1	increases expression	EXP		6480464	Aflatoxin B1 results in increased expression of JAM3 mRNA	CTD	PMID:23385219\|PMID:23630614\|PMID:25378103\|PMID:33354967
Jam3	Rat	aflatoxin B1	increases methylation	ISO	RGD:1346212	6480464	Aflatoxin B1 results in increased methylation of JAM3 intron	CTD	PMID:30157460
Jam3	Rat	anthracen-2-amine	increases expression	EXP		6480464	2-anthramine results in increased expression of JAM3 mRNA	CTD	PMID:23038007
Jam3	Rat	aristolochic acid A	decreases expression	ISO	RGD:1346212	6480464	aristolochic acid I results in decreased expression of JAM3 mRNA	CTD	PMID:33212167
Jam3	Rat	arsane	multiple interactions	ISO	RGD:1346212	6480464	[sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of JAM3 more ...	CTD	PMID:32525701
Jam3	Rat	arsenic atom	multiple interactions	ISO	RGD:1346212	6480464	[sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of JAM3 more ...	CTD	PMID:32525701
Jam3	Rat	Azoxymethane	multiple interactions	ISO	RGD:1551450	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of JAM3 more ...	CTD	PMID:29950665
Jam3	Rat	benzatropine	multiple interactions	ISO	RGD:1346212	6480464	[Cuprizone co-treated with Benztropine] results in decreased expression of JAM3 protein	CTD	PMID:34122009
Jam3	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1551450	6480464	Benzo(a)pyrene results in increased expression of JAM3 mRNA	CTD	PMID:22228805
Jam3	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:1346212	6480464	Benzo(a)pyrene results in increased methylation of JAM3 exon	CTD	PMID:27901495
Jam3	Rat	benzo[a]pyrene	decreases methylation	ISO	RGD:1551450	6480464	Benzo(a)pyrene results in decreased methylation of JAM3 exon; Benzo(a)pyrene results in decreased methylation of JAM3 more ...	CTD	PMID:27901495
Jam3	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:1346212	6480464	Benzo(a)pyrene affects the methylation of JAM3 promoter	CTD	PMID:27901495
Jam3	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1346212	6480464	Benzo(a)pyrene metabolite results in increased expression of JAM3 mRNA	CTD	PMID:26314263
Jam3	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1551450	6480464	Benzo(a)pyrene results in decreased expression of JAM3 mRNA	CTD	PMID:23735875
Jam3	Rat	benzo[e]pyrene	increases methylation	ISO	RGD:1346212	6480464	benzo(e)pyrene results in increased methylation of JAM3 intron	CTD	PMID:30157460
Jam3	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	RGD:1551450	6480464	Diethylhexyl Phthalate results in increased expression of JAM3 mRNA	CTD	PMID:33754040
Jam3	Rat	bisphenol A	affects expression	EXP		6480464	bisphenol A affects the expression of JAM3 mRNA	CTD	PMID:25181051
Jam3	Rat	bisphenol A	increases expression	ISO	RGD:1551450	6480464	bisphenol A results in increased expression of JAM3 mRNA	CTD	PMID:30951980
Jam3	Rat	bisphenol A	multiple interactions	ISO	RGD:1346212	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of JAM3 gene; [INS protein co-treated more ...	CTD	PMID:28628672\|PMID:31601247
Jam3	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of JAM3 gene	CTD	PMID:28505145
Jam3	Rat	bisphenol F	multiple interactions	ISO	RGD:1346212	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...	CTD	PMID:28628672
Jam3	Rat	bisphenol F	increases expression	ISO	RGD:1551450	6480464	bisphenol F results in increased expression of JAM3 mRNA	CTD	PMID:30951980
Jam3	Rat	cadmium dichloride	increases methylation	EXP		6480464	Cadmium Chloride results in increased methylation of JAM3 promoter	CTD	PMID:22457795
Jam3	Rat	cadmium dichloride	increases expression	ISO	RGD:1346212	6480464	Cadmium Chloride results in increased expression of JAM3 mRNA	CTD	PMID:25851441
Jam3	Rat	clobetasol	increases expression	ISO	RGD:1551450	6480464	Clobetasol results in increased expression of JAM3 mRNA	CTD	PMID:27462272
Jam3	Rat	cobalt dichloride	increases expression	ISO	RGD:1346212	6480464	cobaltous chloride results in increased expression of JAM3 mRNA	CTD	PMID:26314263
Jam3	Rat	Cuprizon	decreases expression	EXP		6480464	Cuprizone results in decreased expression of JAM3 mRNA	CTD	PMID:26577399
Jam3	Rat	Cuprizon	multiple interactions	ISO	RGD:1346212	6480464	[Cuprizone co-treated with Benztropine] results in decreased expression of JAM3 protein	CTD	PMID:34122009
Jam3	Rat	dexamethasone	increases expression	ISO	RGD:1346212	6480464	Dexamethasone results in increased expression of JAM3 mRNA	CTD	PMID:12782123
Jam3	Rat	dexamethasone	multiple interactions	ISO	RGD:1346212	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ...	CTD	PMID:28628672
Jam3	Rat	dextran sulfate	multiple interactions	ISO	RGD:1551450	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of JAM3 more ...	CTD	PMID:29950665
Jam3	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1346212	6480464	di-n-butylphosphoric acid affects the expression of JAM3 mRNA	CTD	PMID:37042841
Jam3	Rat	diethyl maleate	decreases expression	EXP		6480464	diethyl maleate results in decreased expression of JAM3 mRNA	CTD	PMID:21161181
Jam3	Rat	endosulfan	decreases expression	EXP		6480464	Endosulfan results in decreased expression of JAM3 mRNA	CTD	PMID:29391264
Jam3	Rat	endosulfan	increases expression	EXP		6480464	Endosulfan results in increased expression of JAM3 mRNA	CTD	PMID:31464424
Jam3	Rat	epoxiconazole	decreases expression	ISO	RGD:1551450	6480464	epoxiconazole results in decreased expression of JAM3 mRNA	CTD	PMID:35436446
Jam3	Rat	fipronil	increases expression	EXP		6480464	fipronil results in increased expression of JAM3 mRNA	CTD	PMID:31881178
Jam3	Rat	fonofos	increases methylation	ISO	RGD:1346212	6480464	Fonofos results in increased methylation of JAM3 promoter	CTD	PMID:22847954
Jam3	Rat	FR900359	decreases phosphorylation	ISO	RGD:1346212	6480464	FR900359 results in decreased phosphorylation of JAM3 protein	CTD	PMID:37730182
Jam3	Rat	fulvestrant	multiple interactions	ISO	RGD:1346212	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of JAM3 gene	CTD	PMID:31601247
Jam3	Rat	gemcitabine	decreases expression	ISO	RGD:1346212	6480464	Gemcitabine results in decreased expression of JAM3 mRNA	CTD	PMID:17039268
Jam3	Rat	Heliotrine	increases expression	EXP		6480464	heliotrine results in increased expression of JAM3 mRNA	CTD	PMID:32419051
Jam3	Rat	indometacin	multiple interactions	ISO	RGD:1346212	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ...	CTD	PMID:28628672
Jam3	Rat	Lasiocarpine	increases expression	EXP		6480464	lasiocarpine results in increased expression of JAM3 mRNA	CTD	PMID:32419051
Jam3	Rat	lead(0)	affects expression	ISO	RGD:1346212	6480464	Lead affects the expression of JAM3 mRNA	CTD	PMID:28903495
Jam3	Rat	methapyrilene	increases methylation	ISO	RGD:1346212	6480464	Methapyrilene results in increased methylation of JAM3 intron	CTD	PMID:30157460
Jam3	Rat	methylmercury(1+)	increases expression	ISO	RGD:1346212	6480464	methylmercury II results in increased expression of JAM3 mRNA	CTD	PMID:26314263
Jam3	Rat	N(4)-hydroxycytidine	decreases expression	ISO	RGD:1551450	6480464	N(4)-hydroxycytidine results in decreased expression of JAM3 mRNA	CTD	PMID:37748715
Jam3	Rat	Nor-9-carboxy-delta9-THC	multiple interactions	ISO	RGD:1346212	6480464	[Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which affects the methylation of JAM3 gene	CTD	PMID:30521419
Jam3	Rat	ochratoxin A	increases expression	ISO	RGD:1346212	6480464	ochratoxin A metabolite results in increased expression of JAM3 mRNA; ochratoxin A results in increased more ...	CTD	PMID:26314263
Jam3	Rat	oxaliplatin	increases expression	EXP		6480464	oxaliplatin results in increased expression of JAM3 mRNA	CTD	PMID:25729387
Jam3	Rat	oxaliplatin	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in increased expression of JAM3 mRNA	CTD	PMID:25729387
Jam3	Rat	ozone	increases expression	ISO	RGD:1346212	6480464	Ozone results in increased expression of JAM3 mRNA	CTD	PMID:31476115
Jam3	Rat	ozone	increases expression	EXP		6480464	Ozone results in increased expression of JAM3 mRNA	CTD	PMID:35737395
Jam3	Rat	paracetamol	affects expression	ISO	RGD:1551450	6480464	Acetaminophen affects the expression of JAM3 mRNA	CTD	PMID:17562736
Jam3	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of JAM3 mRNA	CTD	PMID:33387578
Jam3	Rat	parathion	increases methylation	ISO	RGD:1346212	6480464	Parathion results in increased methylation of JAM3 promoter	CTD	PMID:22847954
Jam3	Rat	perfluorohexanesulfonic acid	increases expression	ISO	RGD:1551450	6480464	perfluorohexanesulfonic acid results in increased expression of JAM3 mRNA	CTD	PMID:37995155
Jam3	Rat	perfluorooctanoic acid	decreases expression	ISO	RGD:1346212	6480464	perfluorooctanoic acid results in decreased expression of JAM3 mRNA	CTD	PMID:23146750
Jam3	Rat	senecionine	increases expression	EXP		6480464	senecionine results in increased expression of JAM3 mRNA	CTD	PMID:32419051
Jam3	Rat	sodium arsenate	multiple interactions	ISO	RGD:1346212	6480464	[sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of JAM3 more ...	CTD	PMID:32525701
Jam3	Rat	sodium arsenite	decreases methylation	ISO	RGD:1551450	6480464	sodium arsenite results in decreased methylation of JAM3 gene	CTD	PMID:32068019
Jam3	Rat	T-2 toxin	decreases expression	ISO	RGD:1346212	6480464	T-2 Toxin results in decreased expression of JAM3 mRNA	CTD	PMID:31863870
Jam3	Rat	tamoxifen	decreases expression	ISO	RGD:1551450	6480464	Tamoxifen results in decreased expression of JAM3 mRNA	CTD	PMID:17555576
Jam3	Rat	terbufos	increases methylation	ISO	RGD:1346212	6480464	terbufos results in increased methylation of JAM3 promoter	CTD	PMID:22847954
Jam3	Rat	tert-butyl hydroperoxide	increases expression	ISO	RGD:1551450	6480464	tert-Butylhydroperoxide results in increased expression of JAM3 mRNA	CTD	PMID:14729362
Jam3	Rat	tetrachloromethane	affects expression	ISO	RGD:1551450	6480464	Carbon Tetrachloride affects the expression of JAM3 mRNA	CTD	PMID:17484886
Jam3	Rat	thioacetamide	affects expression	EXP		6480464	Thioacetamide affects the expression of JAM3 mRNA	CTD	PMID:34492290
Jam3	Rat	titanium dioxide	multiple interactions	ISO	RGD:1551450	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of JAM3 more ...	CTD	PMID:29950665
Jam3	Rat	titanium dioxide	decreases methylation	ISO	RGD:1551450	6480464	titanium dioxide results in decreased methylation of JAM3 gene	CTD	PMID:35295148
Jam3	Rat	topotecan	increases expression	EXP		6480464	Topotecan results in increased expression of JAM3 mRNA	CTD	PMID:25729387
Jam3	Rat	topotecan	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in increased expression of JAM3 mRNA	CTD	PMID:25729387
Jam3	Rat	tributylstannane	increases expression	ISO	RGD:1346212	6480464	tributyltin results in increased expression of JAM3 mRNA	CTD	PMID:26314263
Jam3	Rat	Tributyltin oxide	increases expression	ISO	RGD:1346212	6480464	bis(tri-n-butyltin)oxide results in increased expression of JAM3 mRNA	CTD	PMID:26314263
Jam3	Rat	trichloroethene	increases expression	EXP		6480464	Trichloroethylene results in increased expression of JAM3 mRNA	CTD	PMID:33387578
Jam3	Rat	triclosan	decreases expression	ISO	RGD:1346212	6480464	Triclosan results in decreased expression of JAM3 mRNA	CTD	PMID:30510588
Jam3	Rat	trimellitic anhydride	decreases expression	ISO	RGD:1551450	6480464	trimellitic anhydride results in decreased expression of JAM3 mRNA	CTD	PMID:19042947
Jam3	Rat	triphenyl phosphate	affects expression	ISO	RGD:1346212	6480464	triphenyl phosphate affects the expression of JAM3 mRNA	CTD	PMID:37042841
Jam3	Rat	triptonide	increases expression	ISO	RGD:1551450	6480464	triptonide results in increased expression of JAM3 mRNA	CTD	PMID:33045310
Jam3	Rat	tunicamycin	increases expression	ISO	RGD:1551450	6480464	Tunicamycin results in increased expression of JAM3 mRNA	CTD	PMID:17127020
Jam3	Rat	urethane	increases expression	ISO	RGD:1346212	6480464	Urethane results in increased expression of JAM3 mRNA	CTD	PMID:28818685
Jam3	Rat	valproic acid	affects expression	ISO	RGD:1346212	6480464	Valproic Acid affects the expression of JAM3 mRNA	CTD	PMID:25979313
Jam3	Rat	vinclozolin	affects expression	EXP		6480464	vinclozolin affects the expression of JAM3 mRNA	CTD	PMID:23034163

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Jam3	Rat	adaptive immune response	acts_upstream_of_or_within	ISO	RGD:1551450	1624291	MGI:3055281 PMID:19342649	RGD	PMID:19342649
Jam3	Rat	adherens junction assembly	involved_in	ISO	RGD:1346212	1624291	PMID:19060272	RGD	PMID:19060272
Jam3	Rat	adherens junction assembly	involved_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	angiogenesis	involved_in	ISO	RGD:1346212	1624291	PMID:20592283	RGD	PMID:20592283
Jam3	Rat	angiogenesis	involved_in	ISO	RGD:1551450	1624291	PMID:15994945	RGD	PMID:15994945
Jam3	Rat	angiogenesis	involved_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	apical protein localization	involved_in	ISO	RGD:1346212	1624291	UniProtKB:P15311 PMID:19060272	RGD	PMID:19060272
Jam3	Rat	apical protein localization	involved_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	axon regeneration		IEP		7488944		RGD
Jam3	Rat	cell adhesion	involved_in	IEA	InterPro:IPR042974	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Jam3	Rat	cell adhesion	involved_in	IEA	UniProtKB-KW:KW-0130	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Jam3	Rat	cell adhesion	acts_upstream_of_or_within	ISO	RGD:1551450	1624291	MGI:1933820\|MGI:96607\|MGI:96611 PMID:16093349, PMID:19342649	RGD	PMID:16093349\|PMID:19342649
Jam3	Rat	cell differentiation	involved_in	IEA	UniProtKB-KW:KW-0221	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Jam3	Rat	cell migration	involved_in	IBA	MGI:1933825\|PANTHER:PTN002893677\|UniProtKB:Q9BX67	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Jam3	Rat	cell migration	acts_upstream_of_or_within	ISO	RGD:1551450	1624291	PMID:17099249	RGD	PMID:17099249
Jam3	Rat	cell-cell adhesion	involved_in	ISO	RGD:1346212	1624291	PMID:11823489, PMID:19740376, PMID:24357068	RGD	PMID:11823489\|PMID:19740376\|PMID:24357068
Jam3	Rat	cell-cell adhesion	involved_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	cell-cell adhesion	involved_in	IBA	MGI:1933825\|PANTHER:PTN002893677\|UniProtKB:Q9BX67	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Jam3	Rat	cell-cell adhesion	involved_in	ISO	RGD:1551450	1624291	PMID:24357068	RGD	PMID:24357068
Jam3	Rat	cell-matrix adhesion	acts_upstream_of_or_within	ISO	RGD:1551450	1624291	MGI:96610\|MGI:96612 PMID:17099249	RGD	PMID:17099249
Jam3	Rat	establishment of cell polarity	acts_upstream_of_or_within	ISO	RGD:1551450	1624291	PMID:17099249	RGD	PMID:17099249
Jam3	Rat	granulocyte migration	involved_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	granulocyte migration	involved_in	ISO	RGD:1346212	1624291	PMID:19060272	RGD	PMID:19060272
Jam3	Rat	hematopoietic stem cell migration to bone marrow	involved_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	hematopoietic stem cell migration to bone marrow	involved_in	ISO	RGD:1551450	1624291	PMID:24357068	RGD	PMID:24357068
Jam3	Rat	hematopoietic stem cell migration to bone marrow	involved_in	ISO	RGD:1346212	1624291	PMID:24357068	RGD	PMID:24357068
Jam3	Rat	heterotypic cell-cell adhesion	involved_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	heterotypic cell-cell adhesion	involved_in	ISO	RGD:1346212	1624291	PMID:12208882	RGD	PMID:12208882
Jam3	Rat	leukocyte migration involved in inflammatory response	acts_upstream_of_or_within	ISO	RGD:1551450	1624291	PMID:15879142	RGD	PMID:15879142
Jam3	Rat	myelination	acts_upstream_of_or_within	ISO	RGD:1551450	1624291	PMID:18048693	RGD	PMID:18048693
Jam3	Rat	myeloid progenitor cell differentiation	acts_upstream_of_or_within	ISO	RGD:1551450	1624291	PMID:19109565	RGD	PMID:19109565
Jam3	Rat	negative regulation of cell adhesion mediated by integrin	involved_in	ISO	RGD:1346212	1624291	PMID:19461049	RGD	PMID:19461049
Jam3	Rat	negative regulation of cell adhesion mediated by integrin	involved_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	negative regulation of integrin activation	involved_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	negative regulation of integrin activation	involved_in	ISO	RGD:1346212	1624291	PMID:19461049	RGD	PMID:19461049
Jam3	Rat	neutrophil homeostasis	acts_upstream_of_or_within	ISO	RGD:1551450	1624291	MGI:3055281 PMID:17455169	RGD	PMID:17455169
Jam3	Rat	positive regulation of membrane permeability	acts_upstream_of_or_within	ISO	RGD:1346212	1624291	PMID:31926946	RGD	PMID:31926946
Jam3	Rat	positive regulation of membrane permeability	acts_upstream_of_or_within	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	positive regulation of monocyte extravasation	acts_upstream_of_or_within	ISO	RGD:1346212	1624291	PMID:31926946	RGD	PMID:31926946
Jam3	Rat	positive regulation of monocyte extravasation	acts_upstream_of_or_within	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	protein localization to cell junction	involved_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	protein localization to cell junction	involved_in	ISO	RGD:1346212	1624291	UniProtKB:Q07157 PMID:19060272	RGD	PMID:19060272
Jam3	Rat	protein localization to cell surface	involved_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	protein localization to cell surface	involved_in	ISO	RGD:1346212	1624291	UniProtKB:P19022 PMID:19060272	RGD	PMID:19060272
Jam3	Rat	regulation of actin cytoskeleton organization by cell-cell adhesion	acts_upstream_of_or_within	ISO	RGD:1551450	1624291	MGI:3055281 PMID:15372036	RGD	PMID:15372036
Jam3	Rat	regulation of neutrophil chemotaxis	involved_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	regulation of neutrophil chemotaxis	involved_in	ISO	RGD:1346212	1624291	PMID:15194813	RGD	PMID:15194813
Jam3	Rat	spermatid development	acts_upstream_of_or_within	ISO	RGD:1551450	1624291	MGI:3055281 PMID:15372036	RGD	PMID:15372036
Jam3	Rat	spermatogenesis	acts_upstream_of_or_within	ISO	RGD:1551450	1624291	MGI:3055281 PMID:15372036	RGD	PMID:15372036
Jam3	Rat	spermatogenesis	involved_in	IEA	UniProtKB-KW:KW-0744	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Jam3	Rat	transmission of nerve impulse	acts_upstream_of_or_within	ISO	RGD:1551450	1624291	PMID:18048693	RGD	PMID:18048693

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Jam3	Rat	anchoring junction	located_in	IEA	UniProtKB-KW:KW-0965	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Jam3	Rat	anchoring junction	located_in	IEA	UniProtKB-SubCell:SL-0038	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Jam3	Rat	bicellular tight junction	located_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	bicellular tight junction	located_in	IEA	UniProtKB-SubCell:SL-0265	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Jam3	Rat	bicellular tight junction	located_in	ISO	RGD:1551450	1624291	PMID:17853450	RGD	PMID:17853450
Jam3	Rat	bicellular tight junction	located_in	IEA	UniProtKB-KW:KW-0796	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Jam3	Rat	bicellular tight junction	located_in	ISO	RGD:1346212	1624291	PMID:28196865	RGD	PMID:28196865
Jam3	Rat	bicellular tight junction	located_in	ISS	UniProtKB:Q9BX67	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Jam3	Rat	cell-cell contact zone	located_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	cell-cell contact zone	is_active_in	IBA	PANTHER:PTN002893677\|UniProtKB:Q9BX67	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Jam3	Rat	cell-cell contact zone	located_in	ISO	RGD:1346212	1624291	PMID:15994945	RGD	PMID:15994945
Jam3	Rat	cell-cell junction	located_in	ISO	RGD:1346212	1624291	PMID:19461049	RGD	PMID:19461049
Jam3	Rat	cell-cell junction	located_in	ISO	RGD:1551450	1624291	PMID:15372036, PMID:16093349, PMID:17099249, PMID:17853450	RGD	PMID:15372036\|PMID:16093349\|PMID:17099249\|PMID:17853450
Jam3	Rat	cell-cell junction	located_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	desmosome	located_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	desmosome	located_in	IEA	UniProtKB-SubCell:SL-0092	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Jam3	Rat	desmosome	located_in	ISO	RGD:1346212	1624291	PMID:15194813	RGD	PMID:15194813
Jam3	Rat	extracellular region	located_in	IEA	UniProtKB-KW:KW-0964	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Jam3	Rat	extracellular region	located_in	IEA	UniProtKB-SubCell:SL-0243	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Jam3	Rat	extracellular space	located_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	extracellular space	located_in	ISO	RGD:1346212	1624291	PMID:20592283	RGD	PMID:20592283
Jam3	Rat	filamentous actin	part_of	ISO	RGD:1346212	1624291	PMID:19060272	RGD	PMID:19060272
Jam3	Rat	filamentous actin	part_of	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	Golgi apparatus	located_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	Golgi apparatus	located_in	ISO	RGD:1346212\|UniProtKB:Q9BX67-1	1624291		RGD	GO_REF:0000052
Jam3	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Jam3	Rat	microvillus	located_in	ISO	RGD:1346212	1624291	PMID:19060272	RGD	PMID:19060272
Jam3	Rat	microvillus	located_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	paranodal junction	located_in	ISO	RGD:1551450	1624291	PMID:18048693, PMID:21097846	RGD	PMID:18048693\|PMID:21097846
Jam3	Rat	plasma membrane	is_active_in	IBA	PANTHER:PTN002893677\|UniProtKB:Q9BX67	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Jam3	Rat	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Jam3	Rat	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Jam3	Rat	plasma membrane	located_in	ISO	RGD:1346212	1624291	PMID:11590146, PMID:19461049	RGD	PMID:11590146\|PMID:19461049
Jam3	Rat	plasma membrane	located_in	ISS	UniProtKB:Q9BX67	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Jam3	Rat	plasma membrane	located_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	protein complex involved in cell adhesion	part_of	ISS	UniProtKB:Q9BX67	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Jam3	Rat	protein complex involved in cell adhesion	part_of	IBA	PANTHER:PTN002893677\|UniProtKB:Q9BX67	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Jam3	Rat	protein complex involved in cell adhesion	part_of	ISO	RGD:1346212	1624291	PMID:11590146	RGD	PMID:11590146
Jam3	Rat	protein complex involved in cell adhesion	part_of	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	Schmidt-Lanterman incisure	located_in	ISO	RGD:1551450	1624291	PMID:21097846	RGD	PMID:21097846
Jam3	Rat	tight junction	located_in	ISO	RGD:1346212	1624291	PMID:19060272	RGD	PMID:19060272
Jam3	Rat	tight junction	located_in	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Jam3	Rat	cell-cell adhesion mediator activity	enables	ISO	RGD:1346212	1624291	PMID:11823489, PMID:19740376	RGD	PMID:11823489\|PMID:19740376
Jam3	Rat	cell-cell adhesion mediator activity	enables	IBA	PANTHER:PTN002893677\|UniProtKB:Q9BX67	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Jam3	Rat	cell-cell adhesion mediator activity	enables	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	identical protein binding	enables	ISO	RGD:1551450	1624291	PR:Q9D8B7 PMID:16093349	RGD	PMID:16093349
Jam3	Rat	integrin binding	enables	IEA	UniProtKB:Q9BX67\|ensembl:ENSP00000299106	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Jam3	Rat	integrin binding	enables	IBA	MGI:1933825\|PANTHER:PTN002893677\|UniProtKB:Q9BX67	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Jam3	Rat	integrin binding	enables	ISO	RGD:1551450	1624291	PR:P05555\|PR:P11835 PMID:16093349	RGD	PMID:16093349
Jam3	Rat	integrin binding	enables	ISO	RGD:1346212	1624291	UniProtKB:P05106\|UniProtKB:P05107\|UniProtKB:P11215 PMID:12208882, PMID:15194813, PMID:19461049	RGD	PMID:12208882\|PMID:15194813\|PMID:19461049
Jam3	Rat	protein binding	enables	ISO	RGD:1346212	1624291	UniProtKB:P55196\|UniProtKB:P57087\|UniProtKB:Q6FHY5 PMID:11590146, PMID:11823489, PMID:19461049, PMID:21982860, PMID:32296183	RGD	PMID:11590146\|PMID:11823489\|PMID:19461049\|PMID:21982860\|PMID:32296183
Jam3	Rat	protein binding	enables	ISO	RGD:1551450	1624291	PR:P97792\|PR:Q8R5M8\|PR:Q99NH2\|PR:Q9JI59 PMID:16093349, PMID:16410001, PMID:18055550	RGD	PMID:16093349\|PMID:16410001\|PMID:18055550
Jam3	Rat	protein heterodimerization activity	enables	IEA	InterPro:IPR042974	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Jam3	Rat	protein homodimerization activity	enables	IEA	InterPro:IPR042974	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

Disease Annotations Click to see Annotation Detail View

allergic contact dermatitis (ISO)

autism spectrum disorder (ISO)

Carcinoma, Lewis Lung (ISO)

Choroidal Neovascularization (ISO)

chromosome 11 partial duplication syndrome (ISO)

genetic disease (ISO)

Hemorrhagic Destruction of the Brain, Subependymal Calcification, and Cataracts (ISO)

Isobutyryl-CoA Dehydrogenase Deficiency (ISO)

Jacobsen Syndrome (ISO)

Retinal Neovascularization (ISO)

schizophrenia (ISO)

sciatic neuropathy (IEP)

systemic scleroderma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acetohydrazide (ISO)

aconitine (EXP)

acrylamide (ISO)

aflatoxin B1 (EXP,ISO)

anthracen-2-amine (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

Azoxymethane (ISO)

benzatropine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (EXP,ISO)

clobetasol (ISO)

cobalt dichloride (ISO)

Cuprizon (EXP,ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

Dibutyl phosphate (ISO)

diethyl maleate (EXP)

endosulfan (EXP)

epoxiconazole (ISO)

fipronil (EXP)

fonofos (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gemcitabine (ISO)

Heliotrine (EXP)

indometacin (ISO)

Lasiocarpine (EXP)

lead(0) (ISO)

methapyrilene (ISO)

methylmercury(1+) (ISO)

N(4)-hydroxycytidine (ISO)

Nor-9-carboxy-delta9-THC (ISO)

ochratoxin A (ISO)

oxaliplatin (EXP)

ozone (EXP,ISO)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (ISO)

senecionine (EXP)

sodium arsenate (ISO)

sodium arsenite (ISO)

T-2 toxin (ISO)

tamoxifen (ISO)

terbufos (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

tributylstannane (ISO)

Tributyltin oxide (ISO)

trichloroethene (EXP)

triclosan (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (ISO)

adherens junction assembly (IEA,ISO)

angiogenesis (IEA,ISO)

apical protein localization (IEA,ISO)

axon regeneration (IEP)

cell adhesion (IEA,ISO)

cell differentiation (IEA)

cell migration (IBA,ISO)

cell-cell adhesion (IBA,IEA,ISO)

cell-matrix adhesion (ISO)

establishment of cell polarity (ISO)

granulocyte migration (IEA,ISO)

hematopoietic stem cell migration to bone marrow (IEA,ISO)

heterotypic cell-cell adhesion (IEA,ISO)

leukocyte migration involved in inflammatory response (ISO)

myelination (ISO)

myeloid progenitor cell differentiation (ISO)

negative regulation of cell adhesion mediated by integrin (IEA,ISO)

negative regulation of integrin activation (IEA,ISO)

neutrophil homeostasis (ISO)

positive regulation of membrane permeability (IEA,ISO)

positive regulation of monocyte extravasation (IEA,ISO)

protein localization to cell junction (IEA,ISO)

protein localization to cell surface (IEA,ISO)

regulation of actin cytoskeleton organization by cell-cell adhesion (ISO)

regulation of neutrophil chemotaxis (IEA,ISO)

spermatid development (ISO)

spermatogenesis (IEA,ISO)

transmission of nerve impulse (ISO)

Cellular Component

anchoring junction (IEA)

bicellular tight junction (IEA,ISO,ISS)

cell-cell contact zone (IBA,IEA,ISO)

cell-cell junction (IEA,ISO)

desmosome (IEA,ISO)

extracellular region (IEA)

extracellular space (IEA,ISO)

filamentous actin (IEA,ISO)

Golgi apparatus (IEA,ISO)

membrane (IEA)

microvillus (IEA,ISO)

paranodal junction (ISO)

plasma membrane (IBA,IEA,ISO,ISS)

protein complex involved in cell adhesion (IBA,IEA,ISO,ISS)

Schmidt-Lanterman incisure (ISO)

tight junction (IEA,ISO)

Molecular Function

cell-cell adhesion mediator activity (IBA,IEA,ISO)

identical protein binding (ISO)

integrin binding (IBA,IEA,ISO)

protein binding (ISO)

protein heterodimerization activity (IEA)

protein homodimerization activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats.	Avari P, etal., Brain Behav. 2012 Jul;2(4):402-14. doi: 10.1002/brb3.63.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Targeting of junctional adhesion molecule-C inhibits experimental choroidal neovascularization.	Hou X, etal., Invest Ophthalmol Vis Sci. 2012 Mar 21;53(3):1584-91. doi: 10.1167/iovs.11-9005. Print 2012 Mar.
4.	Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth.	Lamagna C, etal., Cancer Res. 2005 Jul 1;65(13):5703-10.
5.	Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation.	Ludwig RJ, etal., J Invest Dermatol. 2005 Nov;125(5):969-76.
6.	Differential expression of junctional adhesion molecules in different stages of systemic sclerosis.	Manetti M, etal., Arthritis Rheum. 2013 Jan;65(1):247-57. doi: 10.1002/art.37712.
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	The proadhesive phenotype of systemic sclerosis skin promotes myeloid cell adhesion via ICAM-1 and VCAM-1.	Rabquer BJ, etal., Rheumatology (Oxford). 2009 Jul;48(7):734-40. doi: 10.1093/rheumatology/kep091. Epub 2009 May 13.
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:11590146	PMID:11823489	PMID:12208882	PMID:15194813	PMID:15372036	PMID:15489334	PMID:15879142	PMID:16093349	PMID:17099249	PMID:17455169	PMID:17853450	PMID:18048693
PMID:19060272	PMID:19109565	PMID:19342649	PMID:19461049	PMID:19740376	PMID:20592283	PMID:21097846	PMID:22871113	PMID:24357068	PMID:28196865

Genomics

Comparative Map Data

Jam3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	33,767,606 - 33,828,451 (-)	NCBI		GRCr8
mRatBN7.2	8	25,508,461 - 25,569,306 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	25,507,057 - 25,569,355 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	29,550,421 - 29,611,261 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	27,844,708 - 27,905,552 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	25,724,719 - 25,785,571 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	28,147,110 - 28,208,466 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	28,147,111 - 28,208,466 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	28,166,275 - 28,227,631 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	26,697,127 - 26,758,579 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	26,697,127 - 26,758,579 (-)	NCBI
Celera	8	26,995,820 - 27,056,659 (-)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

JAM3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	134,069,072 - 134,152,001 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	134,069,071 - 134,152,001 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	133,938,967 - 134,021,896 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	133,444,030 - 133,526,861 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	133,444,029 - 133,526,858	NCBI
Celera	11	131,112,218 - 131,194,832 (+)	NCBI		Celera
Cytogenetic Map	11	q25	NCBI
HuRef	11	129,893,248 - 129,976,188 (+)	NCBI		HuRef
CHM1_1	11	133,826,755 - 133,908,474 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	134,112,013 - 134,194,140 (+)	NCBI		T2T-CHM13v2.0

Jam3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	27,008,680 - 27,066,739 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	27,008,680 - 27,066,717 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	27,097,384 - 27,155,421 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	27,097,384 - 27,155,421 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	26,904,969 - 26,962,965 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	26,846,830 - 26,904,826 (-)	NCBI		MGSCv36	mm8
Celera	9	24,355,390 - 24,413,352 (-)	NCBI		Celera
Cytogenetic Map	9	A4	NCBI
cM Map	9	12.27	NCBI

Jam3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	34,901,681 - 34,967,394 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	34,901,850 - 34,967,394 (+)	NCBI	ChiLan1.0	ChiLan1.0

JAM3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	134,787,560 - 134,878,062 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	135,892,480 - 135,977,406 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	128,916,024 - 129,006,497 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	132,783,580 - 132,864,657 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	132,783,580 - 132,864,657 (+)	Ensembl	panpan1.1		panPan2

JAM3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	1,082,619 - 1,165,188 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	1,084,560 - 1,165,121 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	1,202,269 - 1,285,185 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	1,038,590 - 1,121,616 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	1,038,594 - 1,121,627 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	1,071,730 - 1,155,064 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	1,072,117 - 1,155,128 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	1,109,856 - 1,192,622 (-)	NCBI		UU_Cfam_GSD_1.0

Jam3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	115,840,860 - 115,913,401 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936684	1,692,089 - 1,762,087 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936684	1,689,594 - 1,762,066 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JAM3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	60,613,400 - 60,738,924 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	60,629,245 - 60,738,979 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	67,205,386 - 67,284,770 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JAM3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	125,136,963 - 125,211,424 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666043	831,362 - 904,938 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Jam3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624812	8,643,921 - 8,707,351 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624812	8,644,002 - 8,707,257 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Jam3
124 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	612
Count of miRNA genes:	244
Interacting mature miRNAs:	301
Transcripts:	ENSRNOT00000012247
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1558646	Swd5	Spike wave discharge measurement QTL 5	3.45	0.00036	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	8	14906751	59906751	Rat
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	9712463	41866876	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	8736635	53736635	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	19331152	93965294	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	2097640	47097640	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	4705810	49705810	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	7670578	52670578	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	22662330	67662330	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	18984168	84531599	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	4705810	49705810	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	9712220	53356647	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	2097640	47097640	Rat
1354595	Despr4	Despair related QTL 4	2.16	0.0036	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	8	7688955	52688955	Rat
1354627	Despr14	Despair related QTL 14		0.0056	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	7688955	52688955	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	2097640	47097640	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	8736635	53736635	Rat
2317882	Alcrsp24	Alcohol response QTL 24	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	8	1	25902202	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	4705810	49705810	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	9712463	41866876	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	2097640	47097640	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	16290444	61290444	Rat

Markers in Region

RH143914

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	25,508,834 - 25,508,991 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	28,147,484 - 28,147,640	NCBI	Rnor6.0
Rnor_5.0	8	28,166,649 - 28,166,805	UniSTS	Rnor5.0
RGSC_v3.4	8	26,697,501 - 26,697,657	UniSTS	RGSC3.4
Celera	8	26,996,194 - 26,996,350	UniSTS
RH 3.4 Map	8	220.2	UniSTS
Cytogenetic Map	8	q13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012247 ⟹ ENSRNOP00000012247

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	25,508,473 - 25,569,303 (-)	Ensembl
Rnor_6.0 Ensembl	8	28,147,111 - 28,208,466 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100354 ⟹ ENSRNOP00000087591

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	25,508,473 - 25,569,303 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100661 ⟹ ENSRNOP00000094560

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	25,508,473 - 25,569,306 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000101760 ⟹ ENSRNOP00000078492

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	25,507,057 - 25,569,355 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110398 ⟹ ENSRNOP00000088272

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	25,508,473 - 25,553,573 (-)	Ensembl

RefSeq Acc Id:

NM_001004269 ⟹ NP_001004269

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	33,767,606 - 33,828,451 (-)	NCBI
mRatBN7.2	8	25,508,461 - 25,569,306 (-)	NCBI
Rnor_6.0	8	28,147,110 - 28,208,466 (-)	NCBI
Rnor_5.0	8	28,166,275 - 28,227,631 (-)	NCBI
RGSC_v3.4	8	26,697,127 - 26,758,579 (-)	RGD
Celera	8	26,995,820 - 27,056,659 (-)	RGD

Sequence:

show sequence

CTCACATTCCCCTCGACATGGCGCTGAGCCGGCGGCTGCGACTTCGCCTGTGCGCGCGGCTACC
CGACTTCTTCCTGCTGCTGCTCTTCAGGGGCTGCGTGATAGAGGCAGTGAACCTCAAATCCAGC
AACCGCAACCCAGTGGTTCATGAATTTGAAAGTGTGGAATTGTCTTGTATCATTACGGACTCAC
AGACAAATGACCCTAGGATTGAATGGAAGAAAATTCAAGATGGCCAAACCACATATGTGTATTT
TGACAACAAGATTCAAGGAGACCTGGCCGGTCGCACAGATGTGTTTGGAAAAACTTCCCTGAGG
ATCTGGAACGTGACACGGTCAGACTCAGCCATCTATCGCTGTGAGGTTGTTGCTCTAAATGACC
GAAAAGAAGTTGATGAGCTTACCATTGAGTTAATTGTGCAAGTGAAGCCAGTGGCCCCTGTGTG
CAGAGTTCCAAAGGCTGTGCCTGTTGGCAAGGCAGCAACACTGCAATGCCAAGAGAGCGAGGGC
TATCCTCGGCCGTACTACAGCTGGTACCGCAATGATGTGCCACTGCCTACGGATTCCAGAGCCA
ATCCCAGGTTCCAGAATTCCTCCTTCCACGTGAACTCGGAGACAGGCACTCTGGTTTTCAGTGC
TGTGCACAAGGAAGACTCTGGGCAATATTACTGCATTGCTTCCAATGACGCAGGCGCAGCCCGG
TGTGAGGGGCAGGACATGGAAGTCTATGATTTGAACATTGCTGGGATTATTGGGGGAGTCCTGG
TTGTCCTTATTGTTCTTGCTGTGATCACAATGGGCATCTGCTGTGCGTACAGACGAGGCTGCTT
CATCAGCAGTAAACAGGATGGAGAAAGTTATAAAAGCCCAGGGAAGCATGAAGGCGTTAACTAC
ATCCGGACAAGTGAAGAGGGTGACTTCAGACACAAGTCATCCTTTGTTATCTGAGACCTGTTGG
CTGGGAGAGCACATACAAGCACCTGTGTGGGAAGCTGGTCACGGGCTGCGGGGACCCAGAGCAC
CCGACAGAGCTGGATGCGCAGAAGCATTTTGTTTTGGCCAAAGTTGATTCCTTCCTTCCTCTTT
AACAAGCCGCAAGAATAAAAGAAATCCTCCTGAGGACGGACGTAGACAGACTGTTGCTAGCCTG
ATCTTATGGGCATTAGGGTGGTCTCCAAGGCCCTTCTGGTCAGCTCTCCGGCAAAGGGCAGTTG
GGGCTGTTTAGCTGCCAGGACAACACTGGCCGAGAGAGGCTGAGGCGCTGGGCTGCAGCAGCAG
TGTGCCTGACGCCCGTGACAGTGCCCAGGAAGGTTTTCAGGCAGTGCCTTGCTCCCTGGACCCT
GACCCACCATGGTGCCTCTGTTGATTGGCCAGTATTATCATTTCTATCCTGGAGAATCTGTTTG
GATCAGCATTTTATAAAAACCCAAATCAGAAAGGTGAAACTGCTTGCTGGGAAGAGGGTTCTTG
CCTAAGGAACTCTCCTTCCAAAGAGTTGCCAGGAGTTAGGAGAACCTCTGTCTTAAGCTAAGTC
TGAAATGGTACTGAATTCTCCTTTTCTATTGGTCTTGCTTATTTTATAAAAATTTAACATTCTA
AATTTTTGCTAAAGATGTATTTTGATTATTGAAAATTTCTATATAAACTGTAAATATATTAGCA
TAGAGTGTTTTAAAACTTATTTTTTTAAGAGTTCAACTTAAGGTAGAAGGCTTGGGCTGCTAGT
GTTCAATTGGAAAGTACCAGTAATAAAGTCTTTTAAGGTTTTTCTTAAGGTTGAATATTCCTTT
GTTCAAAAGAAGTTTTAGCATTTTTTTCATAAGAAAACTTACTCTGTCTGACCACTGTTGCTTA
GGAAACCATTAAAGAATTCCAATTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001004269	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79429	(Get FASTA)	NCBI Sequence Viewer
	EDL83335	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012247
	ENSRNOP00000012247.4
GenBank Protein	Q68FQ2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001004269 ⟸ NM_001004269
- Peptide Label:	precursor
- UniProtKB:	Q68FQ2 (UniProtKB/Swiss-Prot), A6JYE0 (UniProtKB/TrEMBL), A0A8I6ANI6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALSRRLRLRLCARLPDFFLLLLFRGCVIEAVNLKSSNRNPVVHEFESVELSCIITDSQTNDPR IEWKKIQDGQTTYVYFDNKIQGDLAGRTDVFGKTSLRIWNVTRSDSAIYRCEVVALNDRKEVDE LTIELIVQVKPVAPVCRVPKAVPVGKAATLQCQESEGYPRPYYSWYRNDVPLPTDSRANPRFQN SSFHVNSETGTLVFSAVHKEDSGQYYCIASNDAGAARCEGQDMEVYDLNIAGIIGGVLVVLIVL AVITMGICCAYRRGCFISSKQDGESYKSPGKHEGVNYIRTSEEGDFRHKSSFVI hide sequence

Ensembl Acc Id:

ENSRNOP00000012247 ⟸ ENSRNOT00000012247

Ensembl Acc Id:

ENSRNOP00000094560 ⟸ ENSRNOT00000100661

Ensembl Acc Id:

ENSRNOP00000088272 ⟸ ENSRNOT00000110398

Ensembl Acc Id:

ENSRNOP00000078492 ⟸ ENSRNOT00000101760

Ensembl Acc Id:

ENSRNOP00000087591 ⟸ ENSRNOT00000100354

Protein Domains

Ig-like Ig-like C2-type Ig-like V-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q68FQ2-F1-model_v2	AlphaFold	Q68FQ2	1-310	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695820

Promoter ID:

EPDNEW_R6345

Type:

initiation region

Name:

Jam3_1

Description:

junctional adhesion molecule 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	28,208,462 - 28,208,522	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303248	AgrOrtholog
BioCyc Gene	G2FUF-31304	BioCyc
Ensembl Genes	ENSRNOG00000009149	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000012247	ENTREZGENE
	ENSRNOT00000012247.5	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7114667	IMAGE-MGC_LOAD
InterPro	Ig-like_dom	UniProtKB/Swiss-Prot
	Ig-like_dom_sf	UniProtKB/Swiss-Prot
	Ig-like_fold	UniProtKB/Swiss-Prot
	Ig_sub	UniProtKB/Swiss-Prot
	Ig_sub2	UniProtKB/Swiss-Prot
	Ig_V-set	UniProtKB/Swiss-Prot
	JAM-C	UniProtKB/Swiss-Prot
KEGG Report	rno:315509	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94974	IMAGE-MGC_LOAD
NCBI Gene	315509	ENTREZGENE
PANTHER	JUNCTIONAL ADHESION MOLECULE C	UniProtKB/Swiss-Prot
	PTHR44598	UniProtKB/Swiss-Prot
Pfam	Ig_3	UniProtKB/Swiss-Prot
	V-set	UniProtKB/Swiss-Prot
PhenoGen	Jam3	PhenoGen
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000009149	RatGTEx
SMART	IGc2	UniProtKB/Swiss-Prot
	IGv	UniProtKB/Swiss-Prot
	SM00409	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZL08_RAT	UniProtKB/TrEMBL
	A0A8I6AGV1_RAT	UniProtKB/TrEMBL
	A0A8I6AII5_RAT	UniProtKB/TrEMBL
	A0A8I6ANI6	ENTREZGENE, UniProtKB/TrEMBL
	A6JYE0	ENTREZGENE, UniProtKB/TrEMBL
	JAM3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Jam3	junctional adhesion molecule 3			Symbol and Name status set to approved	1299863	APPROVED
2005-09-30	Jam3				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM