Wars1 (tryptophanyl-tRNA synthetase 1) - Rat Genome Database

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Gene: Wars1 (tryptophanyl-tRNA synthetase 1) Rattus norvegicus
Analyze
Symbol: Wars1
Name: tryptophanyl-tRNA synthetase 1
RGD ID: 1308278
Description: Predicted to enable several functions, including kinase inhibitor activity; protein homodimerization activity; and tryptophan-tRNA ligase activity. Predicted to be involved in several processes, including regulation of angiogenesis; regulation of macromolecule metabolic process; and tryptophanyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1); PARTICIPATES IN tryptophan metabolic pathway; aminoacyl-tRNA biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314442; trpRS; tryptophan--tRNA ligase; tryptophan--tRNA ligase, cytoplasmic; tryptophanyl-tRNA synthetase; tryptophanyl-tRNA synthetase, cytoplasmic; Wars
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,540,463 - 133,571,645 (-)NCBIGRCr8
GRCr8 Ensembl6133,539,744 - 133,571,645 (-)EnsemblGRCr8 Ensembl
mRatBN7.26127,776,088 - 127,807,273 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,776,090 - 127,807,269 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6127,899,086 - 127,930,096 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06128,194,132 - 128,225,140 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,553,503 - 127,584,499 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,771,026 - 132,802,262 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,771,021 - 132,802,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,941,102 - 141,972,312 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46133,200,866 - 133,232,048 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6125,326,985 - 125,358,157 (-)NCBICelera
RGSC_v3.16133,207,052 - 133,238,235 (-)NCBI
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dichlorobenzene  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
butan-1-ol  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chlorpromazine  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
estriol  (ISO)
estrone  (ISO)
ethyl methanesulfonate  (ISO)
fenpyroximate  (ISO)
FR900359  (ISO)
furfural  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
haloperidol  (ISO)
ibuprofen  (EXP)
ifosfamide  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
metformin  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
N(4)-hydroxycytidine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
Nonylphenol  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
piroxicam  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
Propiverine  (EXP)
pyrimidifen  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISO)
nucleus  (IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
aminoacyl-tRNA biosynthetic pathway  (IEA)
tryptophan metabolic pathway  (IEA,ISO)

External Pathway Database Links

KEGG Pathway Tryptophan metabolism

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8889548   PMID:11773625   PMID:11773626   PMID:12060739   PMID:15489334   PMID:19941862   PMID:20458337   PMID:21630459   PMID:22082260   PMID:22504299   PMID:22871113   PMID:23533145  
PMID:24625528   PMID:28369220   PMID:29476059   PMID:30053369  


Genomics

Comparative Map Data
Wars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,540,463 - 133,571,645 (-)NCBIGRCr8
GRCr8 Ensembl6133,539,744 - 133,571,645 (-)EnsemblGRCr8 Ensembl
mRatBN7.26127,776,088 - 127,807,273 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,776,090 - 127,807,269 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6127,899,086 - 127,930,096 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06128,194,132 - 128,225,140 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,553,503 - 127,584,499 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,771,026 - 132,802,262 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,771,021 - 132,802,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,941,102 - 141,972,312 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46133,200,866 - 133,232,048 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6125,326,985 - 125,358,157 (-)NCBICelera
RGSC_v3.16133,207,052 - 133,238,235 (-)NCBI
Cytogenetic Map6q32NCBI
WARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814100,333,790 - 100,376,327 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14100,333,790 - 100,376,805 (-)EnsemblGRCh38hg38GRCh38
GRCh3714100,800,127 - 100,842,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,869,878 - 99,912,433 (-)NCBINCBI36Build 36hg18NCBI36
Build 341499,869,877 - 99,911,680NCBI
Celera1480,854,751 - 80,897,310 (-)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1480,981,470 - 81,024,059 (-)NCBIHuRef
CHM1_114100,737,895 - 100,780,446 (-)NCBICHM1_1
T2T-CHM13v2.01494,566,811 - 94,609,425 (-)NCBIT2T-CHM13v2.0
Wars1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,825,956 - 108,860,095 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,825,956 - 108,860,100 (-)EnsemblGRCm39 Ensembl
GRCm3812108,860,030 - 108,894,175 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,860,030 - 108,894,174 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712110,098,240 - 110,132,384 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612109,307,841 - 109,341,004 (-)NCBIMGSCv36mm8
Celera12110,098,849 - 110,127,409 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.66NCBI
Wars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543821,414,815 - 21,445,042 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543821,414,878 - 21,445,417 (-)NCBIChiLan1.0ChiLan1.0
WARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215101,485,389 - 101,526,405 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114100,701,881 - 100,742,894 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01480,954,852 - 80,996,316 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114100,268,845 - 100,310,662 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14100,268,845 - 100,310,662 (-)Ensemblpanpan1.1panPan2
WARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,610,105 - 68,644,616 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl868,610,090 - 68,643,467 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,128,827 - 68,162,983 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0868,893,954 - 68,928,323 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl868,893,953 - 68,928,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1868,555,815 - 68,590,006 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,621,956 - 68,656,146 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,019,419 - 69,053,607 (-)NCBIUU_Cfam_GSD_1.0
Wars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,065,559 - 6,097,465 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366043,984,872 - 4,016,911 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366043,985,002 - 4,016,870 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7121,212,981 - 121,238,113 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17121,212,981 - 121,238,144 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27128,677,569 - 128,702,996 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12478,296,154 - 78,340,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2478,295,741 - 78,339,732 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605365,436,415 - 65,479,619 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247343,782,733 - 3,817,852 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247343,777,866 - 3,815,369 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wars1
2125 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:330
Count of miRNA genes:201
Interacting mature miRNAs:246
Transcripts:ENSRNOT00000006128, ENSRNOT00000050350
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
RH137812  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86133,552,774 - 133,553,036 (+)Marker Load Pipeline
mRatBN7.26127,788,401 - 127,788,663 (+)MAPPERmRatBN7.2
Rnor_6.06132,783,340 - 132,783,601NCBIRnor6.0
Rnor_5.06141,953,416 - 141,953,677UniSTSRnor5.0
RGSC_v3.46133,213,178 - 133,213,439UniSTSRGSC3.4
Celera6125,339,298 - 125,339,559UniSTS
RH 3.4 Map8618.0UniSTS
Cytogenetic Map6q32UniSTS
AU048745  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q32UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map13q26UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map2q11UniSTS
Cytogenetic Map1q54UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map13p13UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map10q31UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map3p13UniSTS
RH128353  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,776,201 - 127,776,415 (+)MAPPERmRatBN7.2
Rnor_6.06132,771,142 - 132,771,355NCBIRnor6.0
Rnor_5.06141,941,218 - 141,941,431UniSTSRnor5.0
RGSC_v3.46133,200,980 - 133,201,193UniSTSRGSC3.4
Celera6125,327,099 - 125,327,312UniSTS
RH 3.4 Map6788.2UniSTS
Cytogenetic Map6q32UniSTS
RH140754  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,777,238 - 127,777,388 (+)MAPPERmRatBN7.2
Rnor_6.06132,772,177 - 132,772,326NCBIRnor6.0
Rnor_5.06141,942,253 - 141,942,402UniSTSRnor5.0
RGSC_v3.46133,202,015 - 133,202,164UniSTSRGSC3.4
Celera6125,328,134 - 125,328,283UniSTS
RH 3.4 Map6788.2UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000006128   ⟹   ENSRNOP00000006128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,539,744 - 133,571,645 (-)Ensembl
mRatBN7.2 Ensembl6127,776,090 - 127,806,636 (-)Ensembl
Rnor_6.0 Ensembl6132,771,021 - 132,797,675 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000050350   ⟹   ENSRNOP00000049063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,540,463 - 133,571,645 (-)Ensembl
mRatBN7.2 Ensembl6127,776,090 - 127,806,636 (-)Ensembl
Rnor_6.0 Ensembl6132,771,028 - 132,802,210 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080163   ⟹   ENSRNOP00000073702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,542,580 - 133,571,641 (-)Ensembl
mRatBN7.2 Ensembl6127,778,207 - 127,807,269 (-)Ensembl
Rnor_6.0 Ensembl6132,773,145 - 132,802,206 (-)Ensembl
RefSeq Acc Id: NM_001013170   ⟹   NP_001013188
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,540,463 - 133,571,645 (-)NCBI
mRatBN7.26127,776,088 - 127,807,273 (-)NCBI
Rnor_6.06132,771,028 - 132,802,210 (-)NCBI
Rnor_5.06141,941,102 - 141,972,312 (-)NCBI
RGSC_v3.46133,200,866 - 133,232,048 (-)RGD
Celera6125,326,985 - 125,358,157 (-)RGD
Sequence:
RefSeq Acc Id: XM_039112403   ⟹   XP_038968331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,540,463 - 133,570,993 (-)NCBI
mRatBN7.26127,776,088 - 127,806,583 (-)NCBI
RefSeq Acc Id: XM_039112404   ⟹   XP_038968332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,540,463 - 133,571,600 (-)NCBI
mRatBN7.26127,776,088 - 127,806,976 (-)NCBI
RefSeq Acc Id: XM_063262011   ⟹   XP_063118081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,540,463 - 133,567,014 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001013188 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968331 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968332 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118081 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61752 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006128.3
  ENSRNOP00000049063
  ENSRNOP00000073702
GenBank Protein Q6P7B0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001013188   ⟸   NM_001013170
- UniProtKB: A6KBI0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006128   ⟸   ENSRNOT00000006128
Ensembl Acc Id: ENSRNOP00000073702   ⟸   ENSRNOT00000080163
Ensembl Acc Id: ENSRNOP00000049063   ⟸   ENSRNOT00000050350
RefSeq Acc Id: XP_038968332   ⟸   XM_039112404
- Peptide Label: isoform X1
- UniProtKB: F8WFH8 (UniProtKB/TrEMBL),   A6KBI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968331   ⟸   XM_039112403
- Peptide Label: isoform X1
- UniProtKB: F8WFH8 (UniProtKB/TrEMBL),   A6KBI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118081   ⟸   XM_063262011
- Peptide Label: isoform X2
- UniProtKB: A6KBI0 (UniProtKB/TrEMBL)
Protein Domains
WHEP-TRS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P7B0-F1-model_v2 AlphaFold Q6P7B0 1-481 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694824
Promoter ID:EPDNEW_R5348
Type:multiple initiation site
Name:Wars_1
Description:tryptophanyl-tRNA synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06132,802,222 - 132,802,282EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308278 AgrOrtholog
BioCyc Gene G2FUF-36272 BioCyc
BioCyc Pathway TRNA-CHARGING-PWY [tRNA charging] BioCyc
BioCyc Pathway Image TRNA-CHARGING-PWY BioCyc
Ensembl Genes ENSRNOG00000004359 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006128.6 UniProtKB/Swiss-Prot
  ENSRNOT00000050350 ENTREZGENE
  ENSRNOT00000080163 ENTREZGENE
Gene3D-CATH 3.40.50.620 UniProtKB/Swiss-Prot
  S15/NS1, RNA-binding UniProtKB/Swiss-Prot
  Tyrosyl-Transfer RNA Synthetase UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5600013 IMAGE-MGC_LOAD
InterPro aa-tRNA-synth_I_CS UniProtKB/Swiss-Prot
  aa-tRNA-synth_Ic UniProtKB/Swiss-Prot
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot
  S15_NS1_RNA-bd UniProtKB/Swiss-Prot
  Trp-tRNA-ligase UniProtKB/Swiss-Prot
  WHEP-TRS_dom UniProtKB/Swiss-Prot
MGC_CLONE MGC:72556 IMAGE-MGC_LOAD
NCBI Gene 314442 ENTREZGENE
PANTHER TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC UniProtKB/Swiss-Prot
  TRYPTOPHANYL-TRNA SYNTHETASE UniProtKB/Swiss-Prot
Pfam tRNA-synt_1b UniProtKB/Swiss-Prot
  WHEP-TRS UniProtKB/Swiss-Prot
PhenoGen Wars1 PhenoGen
PRINTS TRNASYNTHTRP UniProtKB/Swiss-Prot
PROSITE AA_TRNA_LIGASE_I UniProtKB/Swiss-Prot
  WHEP_TRS_1 UniProtKB/Swiss-Prot
  WHEP_TRS_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004359 RatGTEx
SMART WHEP-TRS UniProtKB/Swiss-Prot
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/Swiss-Prot
  SSF47060 UniProtKB/Swiss-Prot
UniProt A0A0G2K673_RAT UniProtKB/TrEMBL
  A6KBI0 ENTREZGENE, UniProtKB/TrEMBL
  F8WFH8 ENTREZGENE, UniProtKB/TrEMBL
  Q6P7B0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Wars1  tryptophanyl-tRNA synthetase 1  Wars  tryptophanyl-tRNA synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Wars  tryptophanyl-tRNA synthetase  Wars_predicted  tryptophanyl-tRNA synthetase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Wars_predicted  tryptophanyl-tRNA synthetase (predicted)      Symbol and Name status set to approved 70820 APPROVED