Myh6 (myosin heavy chain 6) - Rat Genome Database

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Gene: Myh6 (myosin heavy chain 6) Rattus norvegicus
Analyze
Symbol: Myh6
Name: myosin heavy chain 6
RGD ID: 62029
Description: Exhibits ATP binding activity; identical protein binding activity; and nucleoside-triphosphatase activity. Involved in several processes, including cellular response to 3,3',5-triiodo-L-thyronine; muscle contraction; and response to heat. Localizes to mitochondrion; muscle myosin complex; and myofibril. Biomarker of congestive heart failure; hypothyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6); PARTICIPATES IN dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; myocarditis pathway; INTERACTS WITH (R)-noradrenaline; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Myh7; myHC-alpha; MyHC-beta; MyHC-slow; Myhca; Myosin heavy chain 7; myosin heavy chain cardiac muscle adult; myosin heavy chain polypeptide 6 cardiac muscle adult; myosin heavy chain polypeptide 6 cardiac muscle alpha; myosin heavy chain, cardiac muscle alpha isoform; myosin heavy chain, polypeptide 6; myosin heavy chain, polypeptide 6, cardiac muscle, alpha; myosin, heavy chain 6, cardiac muscle, alpha; myosin, heavy polypeptide 6, cardiac muscle, alpha; myosin-6; Myosin-7
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21528,418,120 - 28,442,316 (-)NCBI
Rnor_6.0 Ensembl1533,605,654 - 33,629,699 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01533,605,653 - 33,629,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01537,492,599 - 37,516,786 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,044,506 - 33,068,098 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11533,060,206 - 33,083,798 (-)NCBI
Celera1527,995,918 - 28,019,393 (-)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-ethylhexan-1-ol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
butanal  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cocaine  (EXP)
curcumin  (ISO)
daunorubicin  (EXP,ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
doxorubicin  (EXP,ISO)
dronedarone  (EXP)
enalapril  (EXP)
flavonoids  (EXP)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fructose  (ISO)
genistein  (ISO)
glyphosate  (EXP)
icariin  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead nitrate  (EXP)
lipopolysaccharide  (ISO)
losartan  (EXP)
maraviroc  (ISO)
mercaptopurine  (EXP)
metformin  (EXP)
methamphetamine  (ISO)
methimazole  (EXP)
mitoxantrone  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
Plantamajoside  (ISO)
prazosin  (EXP)
progesterone  (EXP,ISO)
purine-6-thiol  (EXP)
resveratrol  (ISO)
ribavirin  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium nitrate  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
thalidomide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
mitochondrion  (IDA)
muscle myosin complex  (IDA)
myofibril  (IDA,ISO)
myosin complex  (IEA,ISO)
myosin filament  (IEA)
stress fiber  (IEA,ISO)
Z disc  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Bachmaier K, etal., Circulation. 1999 Apr 13;99(14):1885-91.
2. Bowles NE, etal., Am J Med Genet A. 2015 Dec;167A(12):2975-84. doi: 10.1002/ajmg.a.37297. Epub 2015 Aug 18.
3. Bunn RC, etal., Mol Biol Cell 1999 Apr;10(4):819-32.
4. Campbell KB, etal., Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1535-45.
5. Carniel E, etal., Circulation. 2005 Jul 5;112(1):54-9.
6. Ching YH, etal., Nat Genet. 2005 Apr;37(4):423-8. Epub 2005 Feb 27.
7. Chouchani ET, etal., Biochem J. 2010 Aug 15;430(1):49-59. doi: 10.1042/BJ20100633.
8. Dechesne CA, etal., J Cell Biol. 1987 Dec;105(6 Pt 2):3031-7.
9. Geisterfer-Lowrance AA, etal., Science. 1996 May 3;272(5262):731-4.
10. GOA data from the GO Consortium
11. Goldspink P, etal., J Cell Sci. 1997 Dec;110 ( Pt 23):2969-78.
12. Gupta M, etal., J Biol Chem. 2003 Nov 7;278(45):44935-48. Epub 2003 Aug 21.
13. Izumo S, etal., J Clin Invest. 1987 Mar;79(3):970-7.
14. Macallan DC and Griffin GE, Clin Sci (Lond). 1994 Nov;87(5):539-46.
15. Mahdavi V, etal., Eur Heart J 1984 Dec;5 Suppl F:181-91.
16. McNally EM, etal., Nucleic Acids Res 1989 Sep 25;17(18):7527-8.
17. Meehan J, etal., Basic Res Cardiol. 1999 Dec;94(6):481-8.
18. Mercadier JJ, etal., J Am Coll Cardiol. 1987 May;9(5):1024-30.
19. MGD data from the GO Consortium
20. Nakagawa Y, etal., Leg Med (Tokyo). 2012 Mar;14(2):63-8. doi: 10.1016/j.legalmed.2011.12.001. Epub 2012 Jan 28.
21. Nakao K, etal., J Clin Invest. 1997 Nov 1;100(9):2362-70.
22. NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Niimura H, etal., Circulation. 2002 Jan 29;105(4):446-51.
24. O'Neill L, etal., Cardioscience. 1991 Mar;2(1):1-5.
25. OMIM Disease Annotation Pipeline
26. Patrizio M, etal., Br J Pharmacol. 2007 Sep;152(2):216-22. Epub 2007 Jun 25.
27. Pipeline to import KEGG annotations from KEGG into RGD
28. Reiser PJ, etal., Electrophoresis. 2004 Feb;25(3):389-95.
29. RGD automated data pipeline
30. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. RGD automated import pipeline for gene-chemical interactions
32. Rundell VL, etal., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H896-903. Epub 2004 Oct 7.
33. Sanganalmath SK, etal., J Cell Mol Med. 2008 Sep-Oct;12(5A):1728-38. Epub 2007 Dec 14.
34. Schuyler GT and Yarbrough LR, Basic Res Cardiol. 1990 Sep-Oct;85(5):481-94.
35. Thompson RC, etal., FEBS Lett. 2012 Sep 21;586(19):3008-12. doi: 10.1016/j.febslet.2012.06.019. Epub 2012 Jun 21.
36. Wang B, etal., Can J Physiol Pharmacol. 2006 Aug-Sep;84(8-9):935-41.
37. Xu YJ, etal., J Cell Mol Med. 2004 Jan-Mar;8(1):85-92.
Additional References at PubMed
PMID:2614840   PMID:6585819   PMID:7045682   PMID:8482409   PMID:8878443   PMID:9045856   PMID:9541509   PMID:9884344   PMID:10066683   PMID:10074482   PMID:10231857   PMID:11708849  
PMID:12477932   PMID:15001446   PMID:15621050   PMID:16088376   PMID:16983074   PMID:17138609   PMID:17307996   PMID:17360443   PMID:17379774   PMID:17720185   PMID:17982008   PMID:18029400  
PMID:18429820   PMID:18631005   PMID:20833952   PMID:21126233   PMID:23382463   PMID:24137001   PMID:25865156   PMID:26342069   PMID:26945066   PMID:27018747   PMID:29293066   PMID:32987653  


Genomics

Comparative Map Data
Myh6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21528,418,120 - 28,442,316 (-)NCBI
Rnor_6.0 Ensembl1533,605,654 - 33,629,699 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01533,605,653 - 33,629,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01537,492,599 - 37,516,786 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,044,506 - 33,068,098 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11533,060,206 - 33,083,798 (-)NCBI
Celera1527,995,918 - 28,019,393 (-)NCBICelera
Cytogenetic Map15p13NCBI
MYH6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1423,381,982 - 23,408,273 (-)EnsemblGRCh38hg38GRCh38
GRCh381423,381,987 - 23,408,273 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371423,851,196 - 23,877,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,921,039 - 22,947,322 (-)NCBINCBI36hg18NCBI36
Build 341422,921,037 - 22,947,324NCBI
Celera143,713,910 - 3,740,182 (-)NCBI
Cytogenetic Map14q11.2NCBI
HuRef143,967,617 - 3,993,925 (-)NCBIHuRef
CHM1_11423,849,871 - 23,876,158 (-)NCBICHM1_1
Myh6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,179,378 - 55,205,553 (-)NCBIGRCm39mm39
GRCm39 Ensembl1455,179,378 - 55,204,384 (-)Ensembl
GRCm381454,941,921 - 54,968,017 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,941,921 - 54,966,927 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,560,758 - 55,585,444 (-)NCBIGRCm37mm9NCBIm37
MGSCv361453,896,133 - 53,920,780 (-)NCBImm8
Celera1452,747,958 - 52,772,529 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.01NCBI
MYH6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11422,294,965 - 22,321,331 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,294,965 - 22,321,331 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0144,200,616 - 4,226,193 (-)NCBIMhudiblu_PPA_v0panPan3
MYH6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.083,737,187 - 3,762,594 (-)NCBI
UMICH_Zoey_3.183,428,743 - 3,454,127 (-)NCBI
UNSW_CanFamBas_1.083,490,222 - 3,516,723 (-)NCBI
UU_Cfam_GSD_1.083,752,224 - 3,778,743 (-)NCBI
LOC103231478
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,753,251 - 23,780,822 (-)NCBI
ChlSab1.1 Ensembl2923,753,309 - 23,778,107 (-)Ensembl

Position Markers
BI283646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,418,153 - 28,418,682 (+)MAPPER
Rnor_6.01533,605,687 - 33,606,215NCBIRnor6.0
Rnor_5.01537,492,633 - 37,493,161UniSTSRnor5.0
RGSC_v3.41533,044,540 - 33,045,068UniSTSRGSC3.4
Celera1527,995,952 - 27,996,480UniSTS
Cytogenetic Map15p13UniSTS
BE107704  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,417,744 - 28,417,933 (+)MAPPER
Rnor_6.01533,605,278 - 33,605,466NCBIRnor6.0
Rnor_5.01537,492,224 - 37,492,412UniSTSRnor5.0
RGSC_v3.41533,044,131 - 33,044,319UniSTSRGSC3.4
Celera1527,995,543 - 27,995,731UniSTS
Cytogenetic Map15p13UniSTS
BE101980  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,431,450 - 28,431,605 (+)MAPPER
Rnor_6.01533,619,332 - 33,619,486NCBIRnor6.0
Rnor_5.01537,505,931 - 37,506,085UniSTSRnor5.0
RGSC_v3.41533,057,838 - 33,057,992UniSTSRGSC3.4
Celera1528,009,132 - 28,009,286UniSTS
Cytogenetic Map15p13UniSTS
RH138715  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,440,516 - 28,440,722 (+)MAPPER
Rnor_6.01533,628,389 - 33,628,594NCBIRnor6.0
Rnor_5.01537,514,988 - 37,515,193UniSTSRnor5.0
RGSC_v3.41533,066,895 - 33,067,100UniSTSRGSC3.4
Celera1528,018,190 - 28,018,395UniSTS
RH 3.4 Map15259.4UniSTS
Cytogenetic Map15p13UniSTS
MYH6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,438,630 - 28,439,034 (+)MAPPER
Rnor_6.01533,626,504 - 33,626,907NCBIRnor6.0
Rnor_5.01537,513,103 - 37,513,506UniSTSRnor5.0
RGSC_v3.41533,065,010 - 33,065,413UniSTSRGSC3.4
Celera1528,016,305 - 28,016,708UniSTS
Cytogenetic Map15p13UniSTS
Myh7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,449,124 - 28,449,397 (+)MAPPER
Rnor_6.01533,636,997 - 33,637,269NCBIRnor6.0
Rnor_5.01537,523,596 - 37,523,868UniSTSRnor5.0
Celera1528,026,798 - 28,027,070UniSTS
Cytogenetic Map15p13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15137708474Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15137708474Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15137708474Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15142844179Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15143521446Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15232787753535766Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15388113148881131Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151071919155719191Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151549236072568189Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151582824233657761Rat
9590272Scort14Serum corticosterone level QTL 142.780.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)151698090761980907Rat
8694427Bw163Body weight QTL 1634.820.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)151698090761980907Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151724964162249641Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151809320881255430Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151851391388036354Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152102134241082727Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152102134252831189Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152377896946825072Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1526381041106550657Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1526381041106550657Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1526381041106550657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152870974173709741Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)153321910189640841Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)153321910189640841Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)153321910189640841Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)153321910189640841Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)153321910189640841Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:71
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000023302
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 37
Medium 12 2 2 8 8 1 7 8 8
Low 1 30 16 15 16 3 16 13 20 3
Below cutoff 2 6 6 2 6 43 15 14

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023302   ⟹   ENSRNOP00000023301
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1533,605,654 - 33,629,699 (-)Ensembl
RefSeq Acc Id: NM_017239   ⟹   NP_058935
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21528,418,120 - 28,441,720 (-)NCBI
Rnor_6.01533,605,653 - 33,629,592 (-)NCBI
Rnor_5.01537,492,599 - 37,516,786 (-)NCBI
RGSC_v3.41533,044,506 - 33,068,098 (-)RGD
Celera1527,995,918 - 28,019,393 (-)RGD
Sequence:
RefSeq Acc Id: XM_017599641   ⟹   XP_017455130
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21528,418,120 - 28,441,339 (-)NCBI
Rnor_6.01533,605,653 - 33,629,730 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093219   ⟹   XP_038949147
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21528,418,126 - 28,442,316 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058935   ⟸   NM_017239
- Sequence:
RefSeq Acc Id: XP_017455130   ⟸   XM_017599641
- Peptide Label: isoform X2
- UniProtKB: G3V885 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023301   ⟸   ENSRNOT00000023302
RefSeq Acc Id: XP_038949147   ⟸   XM_039093219
- Peptide Label: isoform X1
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62029 AgrOrtholog
Ensembl Genes ENSRNOG00000025757 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023301 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023302 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_IQ_contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_S1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_tail UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29556 ENTREZGENE
Pfam Myosin_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_tail_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myh6 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MYSc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V885 ENTREZGENE, UniProtKB/TrEMBL
  MYH6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q63351 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Myh6  myosin heavy chain 6  Myh6  myosin, heavy chain 6, cardiac muscle, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Myh6  myosin, heavy chain 6, cardiac muscle, alpha  Myh6  myosin, heavy polypeptide 6, cardiac muscle, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Myh6  myosin, heavy polypeptide 6, cardiac muscle, alpha    myosin heavy chain, polypeptide 6  Name updated 1299863 APPROVED
2002-06-10 Myh6  myosin heavy chain, polypeptide 6      Name updated 70584 APPROVED
2002-02-27 Myh6  myosin heavy chain, polypeptide 6, cardiac muscle, alpha      Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the heart 729162