LOC103231478 (myosin-6) - Rat Genome Database

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Pathways
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Gene: LOC103231478 (myosin-6) Chlorocebus sabaeus
Analyze
Symbol: LOC103231478 (Ensembl: MYH6)
Name: myosin-6 (Ensembl:myosin heavy chain 6)
RGD ID: 18562865
Description: ENCODES a protein that exhibits ATP binding (ortholog); calcium-dependent ATPase activity (ortholog); identical protein binding (ortholog); INVOLVED IN actin filament-based movement (ortholog); adult heart development (ortholog); cardiac muscle cell development (ortholog); ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); arrhythmogenic right ventricular dysplasia 9 (ortholog); atrial fibrillation (ortholog); FOUND IN muscle myosin complex (ortholog); myofibril (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MYH6; myosin heavy chain 6
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,753,251 - 23,780,822 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,753,309 - 23,778,107 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236674616 - 9,178 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
atrial fibrillation  (ISO)
atrial heart septal defect  (ISO)
atrial heart septal defect 3  (ISO)
atrioventricular block  (ISO)
autosomal dominant hyaline body myopathy  (ISO)
Brain-Lung-Thyroid Syndrome  (ISO)
Brugada syndrome  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
diastolic heart failure  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1EE  (ISO)
dilated cardiomyopathy 1H  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
distal myopathy  (ISO)
distal myopathy 1  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
heart disease  (ISO)
hemiplegia  (ISO)
hyaline body myopathy  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypertrophic cardiomyopathy 14  (ISO)
hypoplastic left heart syndrome  (ISO)
hypothyroidism  (ISO)
Left Ventricular Hypertrophy  (ISO)
left ventricular noncompaction  (ISO)
Left Ventricular Noncompaction 1  (ISO)
long QT syndrome  (ISO)
lysinuric protein intolerance  (ISO)
migraine  (ISO)
myocardial infarction  (ISO)
restrictive cardiomyopathy  (ISO)
scapuloperoneal myopathy  (ISO)
sick sinus syndrome  (ISO)
Sick Sinus Syndrome 3  (ISO)
Specific Granule Deficiency  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Unexpected Nocturnal Death Syndrome  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Tachycardia  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
LOC103231478
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,753,251 - 23,780,822 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,753,309 - 23,778,107 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236674616 - 9,178 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MYH6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,381,987 - 23,408,273 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,381,982 - 23,408,273 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,851,196 - 23,877,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,921,039 - 22,947,322 (-)NCBINCBI36Build 36hg18NCBI36
Build 341422,921,037 - 22,947,324NCBI
Celera143,713,910 - 3,740,182 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,967,617 - 3,993,925 (-)NCBIHuRef
CHM1_11423,849,871 - 23,876,158 (-)NCBICHM1_1
T2T-CHM13v2.01417,583,003 - 17,609,277 (-)NCBIT2T-CHM13v2.0
Myh6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,179,378 - 55,205,553 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,179,378 - 55,204,384 (-)EnsemblGRCm39 Ensembl
GRCm381454,941,921 - 54,968,017 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,941,921 - 54,966,927 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,560,758 - 55,585,444 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,896,133 - 53,920,780 (-)NCBIMGSCv36mm8
Celera1452,747,958 - 52,772,529 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.01NCBI
Myh6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,388,102 - 32,413,663 (-)NCBIGRCr8
mRatBN7.21528,418,120 - 28,442,316 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,417,616 - 28,441,720 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,263,773 - 30,287,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,410,975 - 31,434,710 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,653,709 - 29,677,297 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,605,653 - 33,629,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,605,654 - 33,629,699 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,492,599 - 37,516,786 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,044,506 - 33,068,098 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,060,206 - 33,083,798 (-)NCBI
Celera1527,995,918 - 28,019,393 (-)NCBICelera
Cytogenetic Map15p13NCBI
MYH6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,812,710 - 24,838,412 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,029,200 - 24,055,952 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,200,616 - 4,226,193 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,294,965 - 22,321,331 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,294,965 - 22,321,331 (-)Ensemblpanpan1.1panPan2
MYH6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.083,737,187 - 3,762,594 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,736,980 - 3,815,024 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,428,743 - 3,454,127 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,490,222 - 3,516,723 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,752,224 - 3,778,743 (-)NCBIUU_Cfam_GSD_1.0
LOC100736765
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,676,791 - 75,704,644 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,677,666 - 75,704,486 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2781,036,392 - 81,061,144 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 24 20
Low 12 14 40
Below cutoff 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000014060   ⟹   ENSCSAP00000012042
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2923,753,309 - 23,778,107 (-)Ensembl
RefSeq Acc Id: XM_037996162   ⟹   XP_037852090
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236674616 - 9,178 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037852090 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000012042.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000012042   ⟸   ENSCSAT00000014060
RefSeq Acc Id: XP_037852090   ⟸   XM_037996162


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015987 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014060.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/TrEMBL
  1.20.5.340 UniProtKB/TrEMBL
  1.20.5.370 UniProtKB/TrEMBL
  1.20.5.4820 UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/TrEMBL
  2.30.30.360 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  6.10.250.2420 UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  Myosin_S1_N UniProtKB/TrEMBL
  Myosin_tail UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  XRCC4-like_C UniProtKB/TrEMBL
NCBI Gene MYH6 ENTREZGENE
PANTHER MYOSIN HEAVY CHAIN, NON-MUSCLE UniProtKB/TrEMBL
  MYOSIN-6 UniProtKB/TrEMBL
Pfam Myosin_head UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  Myosin_tail_1 UniProtKB/TrEMBL
PRINTS MYOSINHEAVY UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/TrEMBL
SMART MYSc UniProtKB/TrEMBL
Superfamily-SCOP Myosin rod fragments UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  Tropomyosin UniProtKB/TrEMBL
UniProt A0A0D9RTV3_CHLSB UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-08 LOC103231478  myosin-6  MYH6  myosin heavy chain 6  Symbol and/or name change 5135510 APPROVED