Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) - Rat Genome Database

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Gene: Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) Mus musculus
Analyze
Symbol: Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
RGD ID: 733823
MGI Page MGI
Description: Enables microfilament motor activity. Involved in cardiac muscle contraction. Acts upstream of or within several processes, including adult heart development; muscle cell development; and regulation of heart contraction. Located in Z disc and stress fiber. Part of myosin complex. Is expressed in several structures, including brown fat; embryo mesenchyme; great vessel of heart; heart; and skeletal musculature. Used to study dilated cardiomyopathy; dilated cardiomyopathy 1EE; and hypertrophic cardiomyopathy 14. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6); PARTICIPATES IN dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; myocarditis pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A830009F23Rik; AA517445; alph; alpha cardiac MHC; alpha myosin; alpha-MHC; alphaMHC; cardiac myosin heavy chain alpha isoform; cardiomyopathy, hypertrophic 1; MGC118706; Myhc; Myhc-; Myhc-a; myHC-alpha; Myhca; myosin heavy chain 6; Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha); myosin heavy chain, cardiac muscle, adult; myosin-6
RGD Orthologs
Human
Rat
Bonobo
Dog
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,179,378 - 55,205,553 (-)NCBIGRCm39mm39
GRCm39 Ensembl1455,179,378 - 55,204,384 (-)Ensembl
GRCm381454,941,921 - 54,968,017 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,941,921 - 54,966,927 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,560,758 - 55,585,444 (-)NCBIGRCm37mm9NCBIm37
MGSCv361453,896,133 - 53,920,780 (-)NCBImm8
Celera1452,747,958 - 52,772,529 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-ethylhexan-1-ol  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3,7-dihydropurine-6-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsenous acid  (ISO)
astemizole  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
butanal  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
chromium(6+)  (EXP)
cocaine  (ISO)
curcumin  (EXP)
daunorubicin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
enalapril  (ISO)
flavonoids  (ISO)
fluoranthene  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
fructose  (EXP)
genistein  (EXP,ISO)
glyphosate  (ISO)
icariin  (EXP)
Indeno[1,2,3-cd]pyrene  (EXP)
isoprenaline  (EXP)
L-ascorbic acid  (EXP)
lead diacetate  (EXP)
lead nitrate  (ISO)
lipopolysaccharide  (EXP)
losartan  (ISO)
maraviroc  (EXP)
mercaptopurine  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methimazole  (ISO)
mitoxantrone  (ISO)
Monobutylphthalate  (EXP)
monocrotaline  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
nitric oxide  (ISO)
nitrofen  (ISO)
ozone  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenylephrine  (ISO)
Plantamajoside  (EXP)
prazosin  (ISO)
progesterone  (EXP,ISO)
purine-6-thiol  (ISO)
resveratrol  (EXP)
ribavirin  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP)
sodium nitrate  (EXP)
streptozocin  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP)
thalidomide  (EXP)
titanium dioxide  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal atrial thrombosis  (IAGP)
abnormal cardiac muscle contractility  (IAGP)
abnormal cardiac muscle relaxation  (IAGP)
abnormal cardiac muscle tissue morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal heart atrium morphology  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal heart ventricle pressure  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal P wave  (IAGP)
atrioventricular block  (IAGP)
calcified myocardium  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cardiac interstitial fibrosis  (IAGP)
cardiac muscle necrosis  (IAGP)
cardiomyopathy  (IAGP)
congestive heart failure  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiac output  (IAGP)
decreased cardiac stroke volume  (IAGP)
decreased left ventricle diastolic pressure  (IAGP)
decreased left ventricle systolic pressure  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased ventricle muscle contractility  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated heart  (IAGP)
dilated heart atrium  (IAGP)
dilated heart left ventricle  (IAGP)
disorganized myocardium  (IAGP)
dystrophic cardiac calcinosis  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged heart atrium  (IAGP)
enlarged myocardial fiber  (IAGP)
heart left ventricle hypertrophy  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased heart left ventricle size  (IAGP)
increased heart weight  (IAGP)
increased lung weight  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
irregular heartbeat  (IAGP)
liver inflammation  (IAGP)
liver vascular congestion  (IAGP)
lung inflammation  (IAGP)
myocardial fiber degeneration  (IAGP)
myocardial fiber disarray  (IAGP)
myocardium hypertrophy  (IAGP)
myocardium necrosis  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prolonged PR interval  (IAGP)
prolonged QT interval  (IAGP)
prolonged RR interval  (IAGP)
pulmonary vascular congestion  (IAGP)
thick ventricular wall  (IAGP)
thin ventricular wall  (IAGP)
References

References - curated
1. Bachmaier K, etal., Circulation. 1999 Apr 13;99(14):1885-91.
2. Bowles NE, etal., Am J Med Genet A. 2015 Dec;167A(12):2975-84. doi: 10.1002/ajmg.a.37297. Epub 2015 Aug 18.
3. Carniel E, etal., Circulation. 2005 Jul 5;112(1):54-9.
4. Ching YH, etal., Nat Genet. 2005 Apr;37(4):423-8. Epub 2005 Feb 27.
5. Geisterfer-Lowrance AA, etal., Science. 1996 May 3;272(5262):731-4.
6. Haefliger JA, etal., J Biol Chem 1992 Jan 25;267(3):2057-64.
7. Izumo S, etal., J Clin Invest. 1987 Mar;79(3):970-7.
8. Macallan DC and Griffin GE, Clin Sci (Lond). 1994 Nov;87(5):539-46.
9. Mercadier JJ, etal., J Am Coll Cardiol. 1987 May;9(5):1024-30.
10. MGD and Homologene mouse data transfer
11. MGD data from the GO Consortium
12. MGD IEA
13. Nakao K, etal., J Clin Invest. 1997 Nov 1;100(9):2362-70.
14. Niimura H, etal., Circulation. 2002 Jan 29;105(4):446-51.
15. OMIM Disease Annotation Pipeline
16. Patrizio M, etal., Br J Pharmacol. 2007 Sep;152(2):216-22. Epub 2007 Jun 25.
17. Pipeline to import KEGG annotations from KEGG into RGD
18. RGD automated import pipeline
19. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. RGD automated import pipeline for gene-chemical interactions
21. Sanganalmath SK, etal., J Cell Mol Med. 2008 Sep-Oct;12(5A):1728-38. Epub 2007 Dec 14.
22. Schuyler GT and Yarbrough LR, Basic Res Cardiol. 1990 Sep-Oct;85(5):481-94.
23. Xu YJ, etal., J Cell Mol Med. 2004 Jan-Mar;8(1):85-92.
Additional References at PubMed
PMID:1429837   PMID:1577481   PMID:1694848   PMID:1722208   PMID:1848043   PMID:1939265   PMID:2026617   PMID:2036722   PMID:2144212   PMID:2277065   PMID:2552320   PMID:2574857  
PMID:3864153   PMID:7628699   PMID:7919499   PMID:8007990   PMID:8077211   PMID:8449897   PMID:8482409   PMID:8541217   PMID:8620598   PMID:8791411   PMID:8833241   PMID:8878443  
PMID:8898372   PMID:9004034   PMID:9045856   PMID:9136932   PMID:9136933   PMID:9171826   PMID:9325265   PMID:9389458   PMID:9486664   PMID:9541509   PMID:9676193   PMID:9876177  
PMID:9884344   PMID:9887021   PMID:9927321   PMID:10021345   PMID:10066683   PMID:10074482   PMID:10086390   PMID:10231857   PMID:10330263   PMID:10349636   PMID:10446263   PMID:10562721  
PMID:10679931   PMID:10737774   PMID:10737799   PMID:10807864   PMID:11042159   PMID:11044609   PMID:11066038   PMID:11076861   PMID:11104788   PMID:11123229   PMID:11164852   PMID:11179057  
PMID:11217851   PMID:11230104   PMID:11238910   PMID:11245568   PMID:11572777   PMID:11708849   PMID:11827928   PMID:11934868   PMID:11950896   PMID:11956238   PMID:12122109   PMID:12466851  
PMID:12477932   PMID:12629673   PMID:12645927   PMID:12750067   PMID:12761855   PMID:12925456   PMID:14499647   PMID:14667415   PMID:15001446   PMID:15079858   PMID:15169892   PMID:15363409  
PMID:15364804   PMID:15767668   PMID:15843414   PMID:15901664   PMID:15902305   PMID:16141072   PMID:16141073   PMID:16314518   PMID:16332958   PMID:16374517   PMID:16395406   PMID:16554359  
PMID:16819597   PMID:16847256   PMID:16983074   PMID:17075052   PMID:17192267   PMID:17322895   PMID:17351073   PMID:17360443   PMID:17379774   PMID:17468400   PMID:17482496   PMID:17526730  
PMID:17556586   PMID:17575272   PMID:17766470   PMID:18281382   PMID:18316483   PMID:18328475   PMID:18362229   PMID:18480046   PMID:18628400   PMID:18755891   PMID:18787025   PMID:18816849  
PMID:19084512   PMID:19690384   PMID:19706423   PMID:19715700   PMID:19726871   PMID:19922871   PMID:20007915   PMID:20080568   PMID:20130022   PMID:20194497   PMID:20596014   PMID:20656787  
PMID:20739404   PMID:20811150   PMID:20923879   PMID:21041481   PMID:21056972   PMID:21126233   PMID:21145505   PMID:21267068   PMID:21289070   PMID:21402699   PMID:21436590   PMID:21447557  
PMID:21526716   PMID:21768366   PMID:21778428   PMID:21983003   PMID:21985497   PMID:22090424   PMID:22158707   PMID:22190261   PMID:22207710   PMID:22215809   PMID:22343712   PMID:22553207  
PMID:22589735   PMID:22673621   PMID:22735528   PMID:22966157   PMID:22982234   PMID:23063798   PMID:23313350   PMID:23369715   PMID:23426694   PMID:23542581   PMID:23580644   PMID:23595884  
PMID:23715556   PMID:23756156   PMID:23968980   PMID:24020834   PMID:24091702   PMID:24092743   PMID:24137001   PMID:24301466   PMID:24335256   PMID:24371138   PMID:24509080   PMID:24590285  
PMID:24650916   PMID:24680892   PMID:24829265   PMID:24840128   PMID:24858909   PMID:24876128   PMID:24938781   PMID:25035421   PMID:25119045   PMID:25318870   PMID:25677315   PMID:25787764  
PMID:25900833   PMID:26141530   PMID:26204265   PMID:26378152   PMID:26487682   PMID:26493106   PMID:26539991   PMID:26912705   PMID:26952936   PMID:26971467   PMID:27052172   PMID:27114035  
PMID:27150455   PMID:27166947   PMID:27266388   PMID:27606604   PMID:27725084   PMID:27766308   PMID:28009297   PMID:28089740   PMID:28159809   PMID:28172500   PMID:28327634   PMID:28346476  
PMID:28378742   PMID:28381556   PMID:28659827   PMID:28737171   PMID:28771943   PMID:29325795   PMID:29374072   PMID:29509905   PMID:29632206   PMID:29859889   PMID:30167506   PMID:30428088  
PMID:30700554   PMID:30898653   PMID:30932177   PMID:31185811   PMID:31286143   PMID:31424496   PMID:31513549   PMID:31581792   PMID:31688894   PMID:31857666   PMID:31983222   PMID:32179912  
PMID:32248761   PMID:33006313   PMID:33466825  


Genomics

Comparative Map Data
Myh6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,179,378 - 55,205,553 (-)NCBIGRCm39mm39
GRCm39 Ensembl1455,179,378 - 55,204,384 (-)Ensembl
GRCm381454,941,921 - 54,968,017 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,941,921 - 54,966,927 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,560,758 - 55,585,444 (-)NCBIGRCm37mm9NCBIm37
MGSCv361453,896,133 - 53,920,780 (-)NCBImm8
Celera1452,747,958 - 52,772,529 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.01NCBI
MYH6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1423,381,982 - 23,408,273 (-)EnsemblGRCh38hg38GRCh38
GRCh381423,381,987 - 23,408,273 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371423,851,196 - 23,877,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,921,039 - 22,947,322 (-)NCBINCBI36hg18NCBI36
Build 341422,921,037 - 22,947,324NCBI
Celera143,713,910 - 3,740,182 (-)NCBI
Cytogenetic Map14q11.2NCBI
HuRef143,967,617 - 3,993,925 (-)NCBIHuRef
CHM1_11423,849,871 - 23,876,158 (-)NCBICHM1_1
Myh6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21528,418,120 - 28,442,316 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1528,417,616 - 28,441,720 (-)Ensembl
Rnor_6.01533,605,653 - 33,629,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,605,654 - 33,629,699 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,492,599 - 37,516,786 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,044,506 - 33,068,098 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11533,060,206 - 33,083,798 (-)NCBI
Celera1527,995,918 - 28,019,393 (-)NCBICelera
Cytogenetic Map15p13NCBI
MYH6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11422,294,965 - 22,321,331 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,294,965 - 22,321,331 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0144,200,616 - 4,226,193 (-)NCBIMhudiblu_PPA_v0panPan3
MYH6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.083,737,187 - 3,762,594 (-)NCBI
UMICH_Zoey_3.183,428,743 - 3,454,127 (-)NCBI
UNSW_CanFamBas_1.083,490,222 - 3,516,723 (-)NCBI
UU_Cfam_GSD_1.083,752,224 - 3,778,743 (-)NCBI
LOC103231478
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,753,251 - 23,780,822 (-)NCBI
ChlSab1.1 Ensembl2923,753,309 - 23,778,107 (-)Ensembl
Vero_WHO_p1.0NW_0236674616 - 9,178 (-)NCBI

Position Markers
RH125576  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,954,064 - 54,954,247UniSTSGRCm38
MGSCv371455,572,901 - 55,573,084UniSTSGRCm37
Celera1452,760,047 - 52,760,230UniSTS
Cytogenetic Map14C3UniSTS
cM Map1420.0UniSTS
Myh6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,962,684 - 54,963,087UniSTSGRCm38
MGSCv371455,581,521 - 55,581,924UniSTSGRCm37
Celera1452,768,623 - 52,769,027UniSTS
Cytogenetic Map14C3UniSTS
cM Map1420.0UniSTS
Myh7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,973,074 - 54,973,351UniSTSGRCm38
GRCm381454,944,664 - 54,946,362UniSTSGRCm38
MGSCv371455,591,911 - 55,592,188UniSTSGRCm37
MGSCv371455,563,501 - 55,565,199UniSTSGRCm37
Celera1452,750,698 - 52,752,397UniSTS
Celera1452,779,005 - 52,779,282UniSTS
Cytogenetic Map14C3UniSTS
cM Map1420.0UniSTS
cM Map1420.0UniSTS
Myhca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C3UniSTS
cM Map1420.0UniSTS
Myhca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C3UniSTS
cM Map1420.0UniSTS
Myh6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420837405121032392Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142101238271648361Mouse
14746973Manh76_mmandible shape 76 (mouse)142256526056565260Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492582457942312Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142820000060900000Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142975953763759676Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143009779364097924Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143009779364097924Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143060000087700000Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143350000059200000Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143532384068548287Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143719272871192863Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4009986274099862Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144272496776725144Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144272496776725144Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144279982176799969Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144282839876828596Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144282839876828596Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4709779359725144Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144921797683218107Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145204453586044676Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145352385687524089Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145370000087700000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1021
Count of miRNA genes:531
Interacting mature miRNAs:619
Transcripts:ENSMUST00000081857, ENSMUST00000111456, ENSMUST00000124930, ENSMUST00000131892, ENSMUST00000134256, ENSMUST00000145322
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001164171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006518677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006518678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC157212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT025533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ023232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ023233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ023234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ023235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ023236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ023237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M38127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M62404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M76598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M76599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M76600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M76601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000081857   ⟹   ENSMUSP00000080538
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,179,378 - 55,204,098 (-)Ensembl
GRCm38.p6 Ensembl1454,941,921 - 54,966,641 (-)Ensembl
RefSeq Acc Id: ENSMUST00000111456   ⟹   ENSMUSP00000107083
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,202,727 - 55,204,384 (-)Ensembl
GRCm38.p6 Ensembl1454,965,270 - 54,966,927 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124930   ⟹   ENSMUSP00000115615
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,201,415 - 55,204,031 (-)Ensembl
GRCm38.p6 Ensembl1454,963,958 - 54,966,574 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131892
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,194,529 - 55,195,364 (-)Ensembl
GRCm38.p6 Ensembl1454,957,072 - 54,957,907 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226297   ⟹   ENSMUSP00000154634
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,179,383 - 55,204,062 (-)Ensembl
GRCm38.p6 Ensembl1454,941,926 - 54,966,605 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227905
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,181,426 - 55,182,250 (-)Ensembl
GRCm38.p6 Ensembl1454,943,969 - 54,944,793 (-)Ensembl
RefSeq Acc Id: ENSMUST00000228731   ⟹   ENSMUSP00000153961
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1455,179,385 - 55,181,968 (-)Ensembl
GRCm38.p6 Ensembl1454,941,928 - 54,944,511 (-)Ensembl
RefSeq Acc Id: NM_001164171   ⟹   NP_001157643
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391455,179,378 - 55,204,064 (-)NCBI
GRCm381454,941,921 - 54,966,607 (-)NCBI
MGSCv371455,560,758 - 55,585,444 (-)RGD
Celera1452,747,958 - 52,772,529 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_010856   ⟹   NP_034986
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391455,179,378 - 55,204,064 (-)NCBI
GRCm381454,941,921 - 54,966,607 (-)NCBI
MGSCv371455,560,758 - 55,585,444 (-)RGD
Celera1452,747,958 - 52,772,529 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006518677   ⟹   XP_006518740
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391455,179,380 - 55,204,102 (-)NCBI
GRCm381454,941,923 - 54,966,645 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006518678   ⟹   XP_006518741
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391455,179,380 - 55,205,552 (-)NCBI
GRCm381454,941,923 - 54,968,017 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036158503   ⟹   XP_036014396
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391455,179,382 - 55,205,553 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_034986   ⟸   NM_010856
- UniProtKB: Q02566 (UniProtKB/Swiss-Prot),   B2RQQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157643   ⟸   NM_001164171
- UniProtKB: Q02566 (UniProtKB/Swiss-Prot),   B2RQQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006518741   ⟸   XM_006518678
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006518740   ⟸   XM_006518677
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000107083   ⟸   ENSMUST00000111456
RefSeq Acc Id: ENSMUSP00000115615   ⟸   ENSMUST00000124930
RefSeq Acc Id: ENSMUSP00000080538   ⟸   ENSMUST00000081857
RefSeq Acc Id: ENSMUSP00000154634   ⟸   ENSMUST00000226297
RefSeq Acc Id: ENSMUSP00000153961   ⟸   ENSMUST00000228731
RefSeq Acc Id: XP_036014396   ⟸   XM_036158503
- Peptide Label: isoform X2
Protein Domains
IQ   Myosin motor   Myosin N-terminal SH3-like   Myosin_tail_1

Promoters
RGD ID:8682388
Promoter ID:EPDNEW_M19225
Type:initiation region
Name:Myh6_1
Description:Mus musculus myosin, heavy polypeptide 6, cardiac muscle, alpha, transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381454,966,576 - 54,966,636EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97255 AgrOrtholog
Ensembl Genes ENSMUSG00000040752 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000080538 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000107083 UniProtKB/TrEMBL
  ENSMUSP00000115615 UniProtKB/TrEMBL
  ENSMUSP00000153961 UniProtKB/TrEMBL
  ENSMUSP00000154634 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000081857 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000111456 UniProtKB/TrEMBL
  ENSMUST00000124930 UniProtKB/TrEMBL
  ENSMUST00000226297 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000228731 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_IQ_contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_S1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_tail UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17888 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97255 ENTREZGENE
NCBI Gene 17888 ENTREZGENE
Pfam Myosin_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_tail_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myh6 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MYSc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Myosin_S1_N UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2I3BPY4_MOUSE UniProtKB/TrEMBL
  B2RQQ1 ENTREZGENE, UniProtKB/TrEMBL
  B8JJH3_MOUSE UniProtKB/TrEMBL
  MYH6_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q1WNP4_MOUSE UniProtKB/TrEMBL
  Q2TAW4_MOUSE UniProtKB/TrEMBL
  Q3UQQ3_MOUSE UniProtKB/TrEMBL
  Q5BKR0_MOUSE UniProtKB/TrEMBL
  Q6P8P3_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q64258 UniProtKB/Swiss-Prot
  Q64738 UniProtKB/Swiss-Prot