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Gene: Abcc4 (ATP binding cassette subfamily C member 4) Rattus norvegicus
Symbol: Abcc4
Name: ATP binding cassette subfamily C member 4
Description: Predicted to have ATPase-coupled transmembrane transporter activity; efflux transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including bile acid signaling pathway; positive regulation of smooth muscle cell proliferation; and response to organonitrogen compound. Localizes to basolateral plasma membrane and external side of apical plasma membrane. Biomarker of cholestasis and extrahepatic cholestasis. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4); PARTICIPATES IN bile acid signaling pathway; azathioprine pharmacodynamics pathway; lamivudine pharmacokinetics pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: ABC-tranporter; ATP-binding cassette protein C4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; ATP-binding cassette, subfamily C (CFTR/MRP), member 4; LOC306166; Mrp4; multidrug resistance-associated protein 4; RGD1565953; similar to multidrug resistance-associated protein 4
Homo sapiens (human) : ABCC4 (ATP binding cassette subfamily C member 4)  HGNC  Alliance
Mus musculus (house mouse) : Abcc4 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Abcc4 (ATP binding cassette subfamily C member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ABCC4 (ATP binding cassette subfamily C member 4)
Canis lupus familiaris (dog) : ABCC4 (ATP binding cassette subfamily C member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abcc4 (ATP binding cassette subfamily C member 4)
Sus scrofa (pig) : LOC100738425 (multidrug resistance-associated protein 4)
Chlorocebus sabaeus (African green monkey) : ABCC4 (ATP binding cassette subfamily C member 4)
Heterocephalus glaber (naked mole-rat) : Abcc4 (ATP binding cassette subfamily C member 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.015103,695,415 - 103,927,980 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15103,696,557 - 103,927,592 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015107,127,408 - 107,356,997 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415103,384,848 - 103,611,238 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.115103,416,404 - 103,417,006 (-)NCBI
Celera1594,392,176 - 94,624,412 (-)NCBICelera
Cytogenetic Map15q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Abcc4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620266
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.