Mapk10 (mitogen activated protein kinase 10) - Rat Genome Database

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Gene: Mapk10 (mitogen activated protein kinase 10) Rattus norvegicus
Analyze
Symbol: Mapk10
Name: mitogen activated protein kinase 10
RGD ID: 3663
Description: Enables ATP binding activity and JUN kinase activity. Involved in several processes, including JUN phosphorylation; cellular hyperosmotic response; and neurotransmitter receptor transport to postsynaptic membrane. Located in several cellular components, including glutamatergic synapse; neuron projection; and perikaryon. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human MAPK10 (mitogen-activated protein kinase 10); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; FasL mediated signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 2-ethoxyethanol; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-Jun N-terminal kinase 3; Jnk3; MAP kinase 10; MAPK 10; mitogen-activated protein kinase 10; p54-beta; SAPb; SAPK-beta; SAPKC; Serk2; Stress activated protein kinase beta; stress-activated protein kinase JNK3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2146,497,662 - 6,790,109 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl146,497,707 - 6,786,201 (+)Ensembl
Rnor_6.0148,079,955 - 8,371,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,080,275 - 8,368,254 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0148,053,697 - 8,344,225 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4147,719,595 - 8,010,694 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1147,719,594 - 8,010,694 (+)NCBI
Celera146,636,411 - 6,919,118 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(R)-noradrenaline  (ISO)
1,2-dibromoethane  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
8-Br-cAMP  (ISO)
acetohydrazide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
carmustine  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
curcumin  (EXP)
cypermethrin  (ISO)
D-glucitol  (ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
dicoumarol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
genistein  (EXP,ISO)
glycidol  (ISO)
glyphosate  (EXP)
hydrogen peroxide  (EXP,ISO)
hypochlorous acid  (ISO)
L-serine  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
luteolin  (ISO)
LY294002  (ISO)
melatonin  (ISO)
menadione  (EXP,ISO)
mercury dibromide  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naringin  (ISO)
nickel atom  (ISO)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paraquat  (ISO)
pentanal  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
potassium chloride  (ISO)
potassium dichromate  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
reactive oxygen species  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
streptozocin  (ISO)
sulfates  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO,ISS)
glutamatergic synapse  (EXP,IDA,IMP)
mitochondrion  (ISO,ISS)
neuron projection  (IDA)
nucleus  (IBA,IDA)
perikaryon  (IDA)
plasma membrane  (ISO,ISS)
postsynaptic density  (ISO)

Molecular Function

References

References - curated
1. Bouman L, etal., Cell Death Differ. 2011 May;18(5):769-82. doi: 10.1038/cdd.2010.142. Epub 2010 Nov 26.
2. Butterfield L, etal., Biochem J. 1999 Mar 15;338 ( Pt 3):681-6.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. GOA data from the GO Consortium
5. Guzeloglu-Kayisli O, etal., Pediatr Int. 2008 Aug;50(4):474-6. doi: 10.1111/j.1442-200X.2008.02609.x.
6. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
7. KEGG
8. Kieran MW, etal., Oncogene. 1999 Nov 18;18(48):6647-57.
9. Kyriakis JM, etal., Nature 1994 May 12;369(6476):156-60.
10. McDonald PH, etal., Science. 2000 Nov 24;290(5496):1574-7.
11. Meeker R and Fernandes A, Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E475-86.
12. MGD data from the GO Consortium
13. Mori Y, etal., EMBO J. 2008 Jan 9;27(1):76-87. Epub 2007 Nov 29.
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline
16. Pan J, etal., Neuroscience. 2005;131(1):147-59.
17. Pipeline to import KEGG annotations from KEGG into RGD
18. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. RGD automated data pipeline
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Xu B, etal., Can J Physiol Pharmacol. 2010 Nov;88(11):1084-92. doi: 10.1139/y10-088.
24. Yang G, etal., Sci Signal. 2013 Jul 9;6(283):ra57. doi: 10.1126/scisignal.2003727.
25. Zhu X, etal., J Neurochem. 2001 Jan;76(2):435-41.
Additional References at PubMed
PMID:9349820   PMID:11726686   PMID:15699019   PMID:16737965   PMID:17114649   PMID:17161586   PMID:17724133   PMID:18307989   PMID:18513991   PMID:18703144   PMID:20421303   PMID:21468718  
PMID:21554942   PMID:22386689   PMID:22441692   PMID:22563476   PMID:25013167   PMID:25496994   PMID:25721670   PMID:26303065   PMID:27769787   PMID:28871032   PMID:29510185   PMID:32189007  
PMID:33307368  


Genomics

Comparative Map Data
Mapk10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2146,497,662 - 6,790,109 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl146,497,707 - 6,786,201 (+)Ensembl
Rnor_6.0148,079,955 - 8,371,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,080,275 - 8,368,254 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0148,053,697 - 8,344,225 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4147,719,595 - 8,010,694 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1147,719,594 - 8,010,694 (+)NCBI
Celera146,636,411 - 6,919,118 (+)NCBICelera
Cytogenetic Map14p22NCBI
MAPK10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl485,990,007 - 86,594,625 (-)EnsemblGRCh38hg38GRCh38
GRCh38486,010,405 - 86,594,625 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37486,931,558 - 87,374,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36487,156,656 - 87,593,307 (-)NCBINCBI36hg18NCBI36
Build 34487,294,810 - 87,632,922NCBI
Celera484,225,414 - 84,570,629 (-)NCBI
Cytogenetic Map4q21.3NCBI
HuRef482,680,152 - 83,118,708 (-)NCBIHuRef
CHM1_1486,912,970 - 87,350,773 (-)NCBICHM1_1
Mapk10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395103,056,413 - 103,360,470 (-)NCBIGRCm39mm39
GRCm39 Ensembl5103,055,814 - 103,359,200 (-)Ensembl
GRCm385102,908,547 - 103,212,604 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5102,907,948 - 103,211,334 (-)EnsemblGRCm38mm10GRCm38
MGSCv375103,336,967 - 103,640,353 (-)NCBIGRCm37mm9NCBIm37
MGSCv365103,152,671 - 103,451,379 (-)NCBImm8
Celera5100,221,882 - 100,523,871 (-)NCBICelera
Cytogenetic Map5E5NCBI
Mapk10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554743,624,679 - 3,772,458 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554743,451,656 - 3,772,405 (+)NCBIChiLan1.0ChiLan1.0
MAPK10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1489,056,754 - 89,392,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl489,059,579 - 89,392,196 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0478,326,129 - 78,756,794 (-)NCBIMhudiblu_PPA_v0panPan3
MAPK10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,584,437 - 9,889,118 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,575,492 - 9,884,325 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3232,059,481 - 32,299,296 (+)NCBI
ROS_Cfam_1.0329,607,730 - 9,912,898 (-)NCBI
UMICH_Zoey_3.1329,698,411 - 10,025,887 (-)NCBI
UNSW_CanFamBas_1.0329,545,360 - 9,851,058 (-)NCBI
UU_Cfam_GSD_1.03230,098,318 - 30,403,778 (+)NCBI
Mapk10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052852,447,490 - 2,761,815 (+)NCBI
SpeTri2.0NW_004936896228,908 - 539,836 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8132,249,635 - 132,776,820 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18132,445,818 - 132,751,575 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28141,972,691 - 142,138,440 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1734,394,600 - 34,725,658 (-)NCBI
ChlSab1.1 Ensembl734,399,544 - 34,564,212 (-)Ensembl
Vero_WHO_p1.0NW_02366603713,051,033 - 13,392,105 (-)NCBI
Mapk10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248722,460,308 - 2,830,569 (-)NCBI

Position Markers
BE120200  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2146,538,806 - 6,538,980 (+)MAPPERmRatBN7.2
Rnor_6.0148,121,221 - 8,121,394NCBIRnor6.0
Rnor_6.0147,465,940 - 7,466,113NCBIRnor6.0
Rnor_5.0148,094,676 - 8,094,849UniSTSRnor5.0
Rnor_5.0147,450,356 - 7,450,529UniSTSRnor5.0
RGSC_v3.4147,760,400 - 7,760,573UniSTSRGSC3.4
Celera146,677,520 - 6,677,693UniSTS
RH 3.4 Map14133.28UniSTS
Cytogenetic Map14p22UniSTS
RH131900  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2146,785,470 - 6,785,655 (+)MAPPERmRatBN7.2
Rnor_6.0148,368,052 - 8,368,236NCBIRnor6.0
Rnor_5.0148,340,189 - 8,340,373UniSTSRnor5.0
RGSC_v3.4148,010,975 - 8,011,159UniSTSRGSC3.4
Celera146,918,916 - 6,919,100UniSTS
RH 3.4 Map14130.59UniSTS
Cytogenetic Map14p22UniSTS
BF393702  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2146,710,741 - 6,710,832 (+)MAPPERmRatBN7.2
Rnor_6.0148,293,323 - 8,293,413NCBIRnor6.0
Rnor_5.0148,265,195 - 8,265,285UniSTSRnor5.0
RGSC_v3.4147,936,231 - 7,936,321UniSTSRGSC3.4
Celera146,846,313 - 6,846,403UniSTS
RH 3.4 Map14132.6UniSTS
Cytogenetic Map14p22UniSTS
RH137759  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2146,768,920 - 6,769,119 (+)MAPPERmRatBN7.2
Rnor_6.0148,351,502 - 8,351,700NCBIRnor6.0
Rnor_5.0148,323,639 - 8,323,837UniSTSRnor5.0
RGSC_v3.4147,994,425 - 7,994,623UniSTSRGSC3.4
Celera146,902,367 - 6,902,565UniSTS
RH 3.4 Map14152.09UniSTS
Cytogenetic Map14p22UniSTS
RH139507  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2146,778,328 - 6,778,547 (+)MAPPERmRatBN7.2
Rnor_6.0148,360,910 - 8,361,128NCBIRnor6.0
Rnor_5.0148,333,047 - 8,333,265UniSTSRnor5.0
RGSC_v3.4148,003,833 - 8,004,051UniSTSRGSC3.4
Celera146,911,774 - 6,911,992UniSTS
RH 3.4 Map14129.79UniSTS
Cytogenetic Map14p22UniSTS
RH140337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2146,778,318 - 6,778,555 (+)MAPPERmRatBN7.2
Rnor_6.0148,360,900 - 8,361,136NCBIRnor6.0
Rnor_5.0148,333,037 - 8,333,273UniSTSRnor5.0
RGSC_v3.4148,003,823 - 8,004,059UniSTSRGSC3.4
Celera146,911,764 - 6,912,000UniSTS
Cytogenetic Map14p22UniSTS
UniSTS:532281  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2146,784,818 - 6,785,639 (+)MAPPERmRatBN7.2
Rnor_6.0148,367,400 - 8,368,220NCBIRnor6.0
Rnor_5.0148,339,537 - 8,340,357UniSTSRnor5.0
Celera146,918,264 - 6,919,084UniSTS
Cytogenetic Map14p22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:71
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000065965
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 68 6
Low 3 23 26 10 18 10 6 7 6 14 28 10 6
Below cutoff 19 31 31 1 31 2 4 21 7 1 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS693293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ377224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ083521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ084081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L27128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000065965   ⟹   ENSRNOP00000060904
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl146,497,707 - 6,785,672 (+)Ensembl
Rnor_6.0 Ensembl148,080,275 - 8,368,254 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092395   ⟹   ENSRNOP00000075846
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl146,497,707 - 6,785,672 (+)Ensembl
Rnor_6.0 Ensembl148,080,565 - 8,367,771 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092466   ⟹   ENSRNOP00000075814
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl146,640,799 - 6,711,653 (+)Ensembl
Rnor_6.0 Ensembl148,223,474 - 8,294,234 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092542   ⟹   ENSRNOP00000075797
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl146,497,707 - 6,777,244 (+)Ensembl
Rnor_6.0 Ensembl148,080,277 - 8,359,963 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092719   ⟹   ENSRNOP00000075755
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl146,497,707 - 6,786,201 (+)Ensembl
Rnor_6.0 Ensembl148,182,383 - 8,367,519 (+)Ensembl
RefSeq Acc Id: NM_001270556   ⟹   NP_001257485
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2146,497,707 - 6,785,673 (+)NCBI
Rnor_6.0148,080,274 - 8,368,254 (+)NCBI
Rnor_5.0148,053,697 - 8,344,225 (+)NCBI
Celera146,636,411 - 6,919,118 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001318190   ⟹   NP_001305119
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2146,497,707 - 6,785,673 (+)NCBI
Rnor_6.0148,080,274 - 8,368,254 (+)NCBI
Celera146,636,411 - 6,919,118 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012806   ⟹   NP_036938
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2146,497,707 - 6,785,673 (+)NCBI
Rnor_6.0148,080,274 - 8,368,254 (+)NCBI
Rnor_5.0148,053,697 - 8,344,225 (+)NCBI
RGSC_v3.4147,719,595 - 8,010,694 (+)RGD
Celera146,636,411 - 6,919,118 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599083   ⟹   XP_017454572
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2146,497,664 - 6,790,109 (+)NCBI
Rnor_6.0148,080,148 - 8,371,508 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599084   ⟹   XP_017454573
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2146,497,662 - 6,790,109 (+)NCBI
Rnor_6.0148,080,147 - 8,371,508 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036938   ⟸   NM_012806
- Peptide Label: isoform 2
- UniProtKB: P49187 (UniProtKB/Swiss-Prot),   B0VXR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257485   ⟸   NM_001270556
- Peptide Label: isoform 1
- UniProtKB: A0A0U1RVI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001305119   ⟸   NM_001318190
- Peptide Label: isoform 1x
- Sequence:
RefSeq Acc Id: XP_017454573   ⟸   XM_017599084
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017454572   ⟸   XM_017599083
- Peptide Label: isoform X1
- UniProtKB: B0VXR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075846   ⟸   ENSRNOT00000092395
RefSeq Acc Id: ENSRNOP00000075755   ⟸   ENSRNOT00000092719
RefSeq Acc Id: ENSRNOP00000075797   ⟸   ENSRNOT00000092542
RefSeq Acc Id: ENSRNOP00000075814   ⟸   ENSRNOT00000092466
RefSeq Acc Id: ENSRNOP00000060904   ⟸   ENSRNOT00000065965
Protein Domains
Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699182
Promoter ID:EPDNEW_R9707
Type:multiple initiation site
Name:Mapk10_2
Description:mitogen activated protein kinase 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9708  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0148,080,275 - 8,080,335EPDNEW
RGD ID:13699187
Promoter ID:EPDNEW_R9708
Type:single initiation site
Name:Mapk10_1
Description:mitogen activated protein kinase 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9707  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0148,182,316 - 8,182,376EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3663 AgrOrtholog
Ensembl Genes ENSRNOG00000002079 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000060904 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000075755 UniProtKB/TrEMBL
  ENSRNOP00000075797 UniProtKB/TrEMBL
  ENSRNOP00000075814 UniProtKB/TrEMBL
  ENSRNOP00000075846 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000065965 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000092395 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000092466 UniProtKB/TrEMBL
  ENSRNOT00000092542 UniProtKB/TrEMBL
  ENSRNOT00000092719 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPK_JNK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25272 UniProtKB/Swiss-Prot
NCBI Gene 25272 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mapk10 PhenoGen
PRINTS JNKMAPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC235746
UniProt A0A0U1RRS7_RAT UniProtKB/TrEMBL
  A0A0U1RRU3_RAT UniProtKB/TrEMBL
  A0A0U1RVI2 ENTREZGENE, UniProtKB/TrEMBL
  B0VXR6 ENTREZGENE
  MK10_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B0VXR6 UniProtKB/Swiss-Prot
  D3ZQ33 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Mapk10  mitogen activated protein kinase 10  Serk2  Stress activated protein kinase beta  Symbol and Name updated 629477 APPROVED
2002-06-10 Serk2  Stress activated protein kinase beta      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation activated by cellular stress, sphingomyelinase and tumour necrosis factor (TNF)-alpha 729029