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Gene: Mapk10 (mitogen-activated protein kinase 10) Mus musculus
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Symbol: Mapk10
Name: mitogen-activated protein kinase 10
Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-Jun N-terminal kinase 3; C230008H04Rik; JNK3; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; JNK3B1; JNK3B2; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; mitogen activated protein kinase 10; p493F12; p54bSAPK; SAPK(beta); SAPK/Erk/kinase 2; Serk2; stress-activated protein kinase JNK3
Orthologs:
Homo sapiens (human) : MAPK10 (mitogen-activated protein kinase 10)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mapk10 (mitogen activated protein kinase 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mapk10 (mitogen-activated protein kinase 10)
Pan paniscus (bonobo/pygmy chimpanzee) : MAPK10 (mitogen-activated protein kinase 10)
Canis lupus familiaris (dog) : MAPK10 (mitogen-activated protein kinase 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mapk10 (mitogen-activated protein kinase 10)
Sus scrofa (pig) : MAPK10 (mitogen-activated protein kinase 10)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm385102,908,547 - 103,212,604 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375103,336,967 - 103,640,353 (-)NCBIGRCm37mm9NCBIm37
MGSCv365103,152,671 - 103,451,379 (-)NCBImm8
Celera5100,221,882 - 100,523,871 (-)NCBICelera
Cytogenetic Map5 E5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Mapk10
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11285
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.