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Gene: Mapk10 (mitogen-activated protein kinase 10) Mus musculus
Symbol: Mapk10
Name: mitogen-activated protein kinase 10
Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-Jun N-terminal kinase 3; C230008H04Rik; JNK3; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; JNK3B1; JNK3B2; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; mitogen activated protein kinase 10; p493F12; p54bSAPK; SAPK(beta); SAPK/Erk/kinase 2; Serk2; stress-activated protein kinase JNK3
Homo sapiens (human) : MAPK10 (mitogen-activated protein kinase 10)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mapk10 (mitogen activated protein kinase 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mapk10 (mitogen-activated protein kinase 10)
Pan paniscus (bonobo/pygmy chimpanzee) : MAPK10 (mitogen-activated protein kinase 10)
Canis lupus familiaris (dog) : MAPK10 (mitogen-activated protein kinase 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mapk10 (mitogen-activated protein kinase 10)
Sus scrofa (pig) : MAPK10 (mitogen-activated protein kinase 10)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm385102,908,547 - 103,212,604 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375103,336,967 - 103,640,353 (-)NCBIGRCm37mm9NCBIm37
MGSCv365103,152,671 - 103,451,379 (-)NCBImm8
Celera5100,221,882 - 100,523,871 (-)NCBICelera
Cytogenetic Map5 E5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mapk10
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11285
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.