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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3663
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk10
Name: mitogen activated protein kinase 10
Acc ID: CHEBI:4513
Term: dicoumarol
Definition: A hydroxycoumarin that is methane in which two hydrogens have each been substituted by a 4-hydroxycoumarin-3-yl group. Related to warfarin, it has been used as an anticoagulant.
Chemical ID: MESH:D001728
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk10decreases activityISORGD:7334416480464CTDDicumarol results in decreased activity of MAPK10 protein

PMID:10531305
Mapk10multiple interactionsISORGD:7334416480464CTDDicumarol inhibits the reaction [Anisomycin results in increased activity of MAPK10 protein] Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein] Dicumarol inhibits the reaction [TRAF2 protein results in increased activity of MAPK10 protein] NQO1 protein inhibits the reaction [Dicumarol results in decreased activity of MAPK10 protein]

PMID:10531305
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