En2 (engrailed homeobox 2) - Rat Genome Database

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Gene: En2 (engrailed homeobox 2) Rattus norvegicus
Analyze
Symbol: En2
Name: engrailed homeobox 2
RGD ID: 1561842
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic brain development; negative regulation of neuron apoptotic process; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within nervous system development and positive regulation of transcription by RNA polymerase II. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A; DDT.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: engrailed 2; homeobox protein engrailed-2; LOC499964; RGD1561842; similar to engrailed protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr847,954,953 - 7,960,793 (-)NCBIGRCr8
mRatBN7.247,221,096 - 7,226,943 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl47,221,096 - 7,226,943 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx412,231,034 - 12,236,881 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.048,045,269 - 8,051,118 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.046,391,466 - 6,397,316 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04438,668 - 444,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4438,668 - 444,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04433,481 - 439,321 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.442,469,889 - 2,475,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera43,053,145 - 3,059,092 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
fibrillar center  (IEA,ISO)
nucleolus  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Association of Engrailed homeoproteins with vesicles presenting caveolae-like properties. Joliot A, etal., Development. 1997 May;124(10):1865-75.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Sgado P, etal., Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15242-7. Epub 2006 Oct 2.
Additional References at PubMed
PMID:7624797   PMID:9102311   PMID:11312297   PMID:15175251   PMID:15340832   PMID:15607945  


Genomics

Comparative Map Data
En2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr847,954,953 - 7,960,793 (-)NCBIGRCr8
mRatBN7.247,221,096 - 7,226,943 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl47,221,096 - 7,226,943 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx412,231,034 - 12,236,881 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.048,045,269 - 8,051,118 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.046,391,466 - 6,397,316 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04438,668 - 444,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4438,668 - 444,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04433,481 - 439,321 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.442,469,889 - 2,475,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera43,053,145 - 3,059,092 (+)NCBICelera
Cytogenetic Map4q11NCBI
EN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387155,458,129 - 155,464,831 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7155,458,129 - 155,464,831 (+)EnsemblGRCh38hg38GRCh38
GRCh377155,250,824 - 155,257,526 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367154,943,585 - 154,950,287 (+)NCBINCBI36Build 36hg18NCBI36
Build 347154,748,890 - 154,756,978NCBI
Celera7149,674,408 - 149,681,112 (+)NCBICelera
Cytogenetic Map7q36.3NCBI
HuRef7148,980,594 - 148,986,984 (+)NCBIHuRef
CHM1_17155,259,197 - 155,265,894 (+)NCBICHM1_1
T2T-CHM13v2.07156,638,709 - 156,645,413 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27154,484,063 - 154,490,767 (+)NCBI
En2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39528,370,694 - 28,377,195 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl528,370,692 - 28,377,164 (+)EnsemblGRCm39 Ensembl
GRCm38528,165,696 - 28,172,190 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl528,165,694 - 28,172,166 (+)EnsemblGRCm38mm10GRCm38
MGSCv37528,492,236 - 28,498,706 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36528,497,267 - 28,502,960 (+)NCBIMGSCv36mm8
Celera525,713,769 - 25,720,205 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map513.94NCBI
En2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554918,422,295 - 8,427,038 (+)NCBIChiLan1.0ChiLan1.0
EN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26191,886,205 - 191,891,197 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1743,896,471 - 43,901,463 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07147,058,349 - 147,065,038 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17158,770,353 - 158,780,666 (+)NCBIpanpan1.1PanPan1.1panPan2
EN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11618,358,100 - 18,365,827 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1618,992,467 - 18,999,003 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01620,088,528 - 20,095,217 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1620,088,228 - 20,093,683 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11618,459,324 - 18,465,776 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01619,039,243 - 19,045,664 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01619,092,319 - 19,098,894 (+)NCBIUU_Cfam_GSD_1.0
En2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051183,110,229 - 3,116,402 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365279,787,174 - 9,791,422 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365279,787,174 - 9,791,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl182,782,831 - 2,788,165 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1182,781,977 - 2,788,441 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2182,988,192 - 2,993,905 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121123,590,840 - 123,596,381 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607219,753,357 - 19,760,188 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
En2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248002,438,900 - 2,446,680 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248002,440,502 - 2,446,647 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in En2
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:139
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000008951
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat

Markers in Region
EN2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.247,222,931 - 7,223,078 (-)MAPPERmRatBN7.2
Rnor_6.04442,526 - 442,672NCBIRnor6.0
Rnor_5.04437,339 - 437,485UniSTSRnor5.0
RGSC_v3.442,471,725 - 2,471,871UniSTSRGSC3.4
Celera43,057,110 - 3,057,256UniSTS
Cytogenetic Map4q11UniSTS
UniSTS:238161  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.247,222,512 - 7,223,020 (-)MAPPERmRatBN7.2
Rnor_6.04442,584 - 443,091NCBIRnor6.0
Rnor_5.04437,397 - 437,904UniSTSRnor5.0
RGSC_v3.442,471,306 - 2,471,813UniSTSRGSC3.4
Celera43,057,168 - 3,057,675UniSTS
Cytogenetic Map4q11UniSTS
En2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.247,221,136 - 7,221,287 (-)MAPPERmRatBN7.2
Rnor_6.04444,317 - 444,467NCBIRnor6.0
Rnor_5.04439,130 - 439,280UniSTSRnor5.0
RGSC_v3.442,469,930 - 2,470,080UniSTSRGSC3.4
Celera43,058,901 - 3,059,051UniSTS
Cytogenetic Map4q11UniSTS
EN2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.247,222,985 - 7,223,101 (-)MAPPERmRatBN7.2
Rnor_6.04442,503 - 442,618NCBIRnor6.0
Rnor_5.04437,316 - 437,431UniSTSRnor5.0
RGSC_v3.442,471,779 - 2,471,894UniSTSRGSC3.4
Celera43,057,087 - 3,057,202UniSTS
Cytogenetic Map4q11UniSTS
EN2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.247,222,988 - 7,223,075 (-)MAPPERmRatBN7.2
Rnor_6.04442,529 - 442,615NCBIRnor6.0
Rnor_5.04437,342 - 437,428UniSTSRnor5.0
Celera43,057,113 - 3,057,199UniSTS
Cytogenetic Map4q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system appendage
High
Medium 37 16 3
Low 1 13 19 15
Below cutoff 7 10 3 3 2 2 16 12 2

Sequence


Ensembl Acc Id: ENSRNOT00000008951   ⟹   ENSRNOP00000008951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl47,221,096 - 7,226,943 (-)Ensembl
Rnor_6.0 Ensembl4438,668 - 444,501 (+)Ensembl
RefSeq Acc Id: NM_001109214   ⟹   NP_001102684
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr847,954,953 - 7,960,793 (-)NCBI
mRatBN7.247,221,096 - 7,226,943 (-)NCBI
Rnor_6.04438,668 - 444,508 (+)NCBI
Rnor_5.04433,481 - 439,321 (+)NCBI
RGSC_v3.442,469,889 - 2,475,729 (-)RGD
Celera43,053,145 - 3,059,092 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102684 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86414 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008951.3
RefSeq Acc Id: NP_001102684   ⟸   NM_001109214
- UniProtKB: D3Z8B1 (UniProtKB/TrEMBL),   A6KJL2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008951   ⟸   ENSRNOT00000008951
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z8B1-F1-model_v2 AlphaFold D3Z8B1 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561842 AgrOrtholog
BioCyc Gene G2FUF-46137 BioCyc
Ensembl Genes ENSRNOG00000006846 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008951.6 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox UniProtKB/TrEMBL
  Homeobox-engrailed UniProtKB/TrEMBL
  Homeobox-engrailed_C-terminal UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_region UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  Homoebox-engrailed_CS UniProtKB/TrEMBL
KEGG Report rno:499964 UniProtKB/TrEMBL
NCBI Gene 499964 ENTREZGENE
PANTHER HOMEOBOX PROTEIN ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX PROTEIN ENGRAILED-2 UniProtKB/TrEMBL
Pfam Engrail_1_C_sig UniProtKB/TrEMBL
  Homeobox UniProtKB/TrEMBL
PhenoGen En2 PhenoGen
PRINTS ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX UniProtKB/TrEMBL
PROSITE ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006846 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A6KJL2 ENTREZGENE, UniProtKB/TrEMBL
  D3Z8B1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-28 En2  engrailed homeobox 2  En2  engrailed 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 En2  engrailed 2  RGD1561842_predicted  similar to engrailed protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561842_predicted  similar to engrailed protein (predicted)  LOC499964  similar to engrailed protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499964  similar to engrailed protein      Symbol and Name status set to provisional 70820 PROVISIONAL