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Gene: En2 (engrailed homeobox 2) Rattus norvegicus
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Symbol: En2
Name: engrailed homeobox 2
Description: Predicted to have sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic brain development; negative regulation of neuron apoptotic process; and nervous system development. Localizes to the membrane and nucleus. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2); INTERACTS WITH bisphenol A; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: engrailed 2; homeobox protein engrailed-2; LOC499964; RGD1561842; similar to engrailed protein
Orthologs:
Homo sapiens (human) : EN2 (engrailed homeobox 2)  HGNC  Alliance
Mus musculus (house mouse) : En2 (engrailed 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : En2 (engrailed homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : EN2 (engrailed homeobox 2)
Canis lupus familiaris (dog) : EN2 (engrailed homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : En2 (engrailed homeobox 2)
Sus scrofa (pig) : EN2 (engrailed homeobox 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04438,668 - 444,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4438,668 - 444,501 (+)Ensembl
Rnor_5.04433,481 - 439,321 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.442,469,889 - 2,475,729 (-)NCBIRGSC3.4rn4RGSC3.4
Celera43,053,145 - 3,059,092 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on En2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1561842
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.