EN2 (engrailed homeobox 2) - Rat Genome Database

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Gene: EN2 (engrailed homeobox 2) Canis lupus familiaris
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Symbol: EN2
Name: engrailed homeobox 2
RGD ID: 12157074
Description: ENCODES a protein that exhibits sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN dopaminergic neuron differentiation (ortholog); embryonic brain development (ortholog); hindbrain development (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); Parkinsonism (ortholog); FOUND IN fibrillar center (ortholog); membrane (ortholog); nucleolus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homeobox protein engrailed-1; homeobox protein engrailed-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11618,358,100 - 18,365,827 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1618,992,467 - 18,999,003 (+)NCBI
ROS_Cfam_1.01620,088,528 - 20,095,217 (+)NCBI
ROS_Cfam_1.0 Ensembl1620,088,228 - 20,093,683 (+)Ensembl
UMICH_Zoey_3.11618,459,324 - 18,465,776 (+)NCBI
UNSW_CanFamBas_1.01619,039,243 - 19,045,664 (+)NCBI
UU_Cfam_GSD_1.01619,092,319 - 19,098,894 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
EN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11618,358,100 - 18,365,827 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1618,992,467 - 18,999,003 (+)NCBI
ROS_Cfam_1.01620,088,528 - 20,095,217 (+)NCBI
ROS_Cfam_1.0 Ensembl1620,088,228 - 20,093,683 (+)Ensembl
UMICH_Zoey_3.11618,459,324 - 18,465,776 (+)NCBI
UNSW_CanFamBas_1.01619,039,243 - 19,045,664 (+)NCBI
UU_Cfam_GSD_1.01619,092,319 - 19,098,894 (+)NCBI
EN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387155,458,129 - 155,464,831 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7155,458,129 - 155,464,831 (+)EnsemblGRCh38hg38GRCh38
GRCh377155,250,824 - 155,257,526 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367154,943,585 - 154,950,287 (+)NCBINCBI36hg18NCBI36
Build 347154,748,890 - 154,756,978NCBI
Celera7149,674,408 - 149,681,112 (+)NCBI
Cytogenetic Map7q36.3NCBI
HuRef7148,980,594 - 148,986,984 (+)NCBIHuRef
CHM1_17155,259,197 - 155,265,894 (+)NCBICHM1_1
T2T-CHM13v2.07156,638,709 - 156,645,413 (+)NCBI
CRA_TCAGchr7v27154,484,063 - 154,490,767 (+)NCBI
En2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39528,370,694 - 28,377,188 (+)NCBIGRCm39mm39
GRCm39 Ensembl528,370,692 - 28,377,164 (+)Ensembl
GRCm38528,165,696 - 28,172,190 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl528,165,694 - 28,172,166 (+)EnsemblGRCm38mm10GRCm38
MGSCv37528,492,236 - 28,498,706 (+)NCBIGRCm37mm9NCBIm37
MGSCv36528,497,267 - 28,502,960 (+)NCBImm8
Celera525,713,769 - 25,720,205 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map513.94NCBI
En2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.247,221,096 - 7,226,943 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl47,221,096 - 7,226,943 (-)Ensembl
Rnor_6.04438,668 - 444,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4438,668 - 444,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04433,481 - 439,321 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.442,469,889 - 2,475,729 (-)NCBIRGSC3.4rn4RGSC3.4
Celera43,053,145 - 3,059,092 (+)NCBICelera
Cytogenetic Map4q11NCBI
En2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554918,422,295 - 8,427,038 (+)NCBIChiLan1.0ChiLan1.0
EN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17158,770,353 - 158,780,666 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v07147,058,349 - 147,065,038 (+)NCBIMhudiblu_PPA_v0panPan3
En2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051183,110,229 - 3,116,402 (-)NCBI
SpeTri2.0NW_0049365279,787,174 - 9,791,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl182,781,977 - 2,788,824 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1182,781,977 - 2,788,441 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2182,988,192 - 2,993,905 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121123,590,840 - 123,596,381 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607219,753,357 - 19,760,188 (+)NCBIVero_WHO_p1.0
En2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248002,438,900 - 2,446,680 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248002,440,502 - 2,446,647 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00845023177   ⟹   ENSCAFP00845018176
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1620,088,228 - 20,093,683 (+)Ensembl
RefSeq Acc Id: XM_038452854   ⟹   XP_038308782
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1618,992,467 - 18,999,003 (+)NCBI
RefSeq Acc Id: XM_038497385   ⟹   XP_038353313
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11618,459,324 - 18,465,776 (+)NCBI
RefSeq Acc Id: XM_038559805   ⟹   XP_038415733
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01619,092,319 - 19,098,894 (+)NCBI
RefSeq Acc Id: XM_038623809   ⟹   XP_038479737
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01619,039,243 - 19,045,664 (+)NCBI
RefSeq Acc Id: XM_038689574   ⟹   XP_038545502
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01620,088,528 - 20,095,217 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_038353313   ⟸   XM_038497385
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038479737   ⟸   XM_038623809
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038545502   ⟸   XM_038689574
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038308782   ⟸   XM_038452854
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038415733   ⟸   XM_038559805
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845018176   ⟸   ENSCAFT00845023177


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00845013024 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00845018176 ENTREZGENE
  ENSCAFP00845018176.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845023177 ENTREZGENE
  ENSCAFT00845023177.1 UniProtKB/TrEMBL
NCBI Gene EN2 ENTREZGENE
UniProt A0A8I3RZT2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:51801 ENTREZGENE