EN2 (engrailed homeobox 2) - Rat Genome Database

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Gene: EN2 (engrailed homeobox 2) Sus scrofa
Analyze
Symbol: EN2
Name: engrailed homeobox 2
RGD ID: 14268236
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); RNA polymerase II cis-regulatory region sequence-specific DNA binding (inferred); INVOLVED IN dopaminergic neuron differentiation (ortholog); hindbrain development (ortholog); midbrain development (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN fibrillar center (inferred); nucleolus (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homeobox protein engrailed-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl182,782,831 - 2,788,165 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1182,781,977 - 2,788,441 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2182,988,192 - 2,993,905 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
fibrillar center  (IEA)
nucleolus  (IEA)
nucleoplasm  (IEA)
nucleus  (IBA,IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl182,782,831 - 2,788,165 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1182,781,977 - 2,788,441 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2182,988,192 - 2,993,905 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387155,458,129 - 155,464,831 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7155,458,129 - 155,464,831 (+)EnsemblGRCh38hg38GRCh38
GRCh377155,250,824 - 155,257,526 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367154,943,585 - 154,950,287 (+)NCBINCBI36Build 36hg18NCBI36
Build 347154,748,890 - 154,756,978NCBI
Celera7149,674,408 - 149,681,112 (+)NCBICelera
Cytogenetic Map7q36.3NCBI
HuRef7148,980,594 - 148,986,984 (+)NCBIHuRef
CHM1_17155,259,197 - 155,265,894 (+)NCBICHM1_1
T2T-CHM13v2.07156,638,709 - 156,645,413 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27154,484,063 - 154,490,767 (+)NCBI
En2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39528,370,694 - 28,377,195 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl528,370,692 - 28,377,164 (+)EnsemblGRCm39 Ensembl
GRCm38528,165,696 - 28,172,190 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl528,165,694 - 28,172,166 (+)EnsemblGRCm38mm10GRCm38
MGSCv37528,492,236 - 28,498,706 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36528,497,267 - 28,502,960 (+)NCBIMGSCv36mm8
Celera525,713,769 - 25,720,205 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map513.94NCBI
En2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr847,954,953 - 7,960,793 (-)NCBIGRCr8
mRatBN7.247,221,096 - 7,226,943 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl47,221,096 - 7,226,943 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx412,231,034 - 12,236,881 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.048,045,269 - 8,051,118 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.046,391,466 - 6,397,316 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04438,668 - 444,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4438,668 - 444,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04433,481 - 439,321 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.442,469,889 - 2,475,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera43,053,145 - 3,059,092 (+)NCBICelera
Cytogenetic Map4q11NCBI
En2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554918,422,295 - 8,427,038 (+)NCBIChiLan1.0ChiLan1.0
EN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26191,886,205 - 191,891,197 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1743,896,471 - 43,901,463 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07147,058,349 - 147,065,038 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17158,770,353 - 158,780,666 (+)NCBIpanpan1.1PanPan1.1panPan2
EN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11618,358,100 - 18,365,827 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1618,992,467 - 18,999,003 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01620,088,528 - 20,095,217 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1620,088,228 - 20,093,683 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11618,459,324 - 18,465,776 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01619,039,243 - 19,045,664 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01619,092,319 - 19,098,894 (+)NCBIUU_Cfam_GSD_1.0
En2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051183,110,229 - 3,116,402 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365279,787,174 - 9,791,422 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365279,787,174 - 9,791,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121123,590,840 - 123,596,381 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607219,753,357 - 19,760,188 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
En2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248002,438,900 - 2,446,680 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248002,440,502 - 2,446,647 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EN2
160 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

musculoskeletal system nervous system
High
Medium 2
Low 1
Below cutoff 2 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000047078   ⟹   ENSSSCP00000047826
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl182,782,831 - 2,788,165 (-)Ensembl
RefSeq Acc Id: XM_003134527   ⟹   XP_003134575
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1182,781,977 - 2,788,441 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003134575   ⟸   XM_003134527
- UniProtKB: A0A287AUN5 (UniProtKB/TrEMBL),   A0A8D1UFJ5 (UniProtKB/TrEMBL),   A0A8D0XZ05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000047826   ⟸   ENSSSCT00000047078
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000035324 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025029667 UniProtKB/TrEMBL
  ENSSSCG00030067465 UniProtKB/TrEMBL
  ENSSSCG00035034693 UniProtKB/TrEMBL
  ENSSSCG00045003801 UniProtKB/TrEMBL
  ENSSSCG00050064860 UniProtKB/TrEMBL
  ENSSSCG00055016420 UniProtKB/TrEMBL
  ENSSSCG00060001424 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000047078 ENTREZGENE
  ENSSSCT00000047078.3 UniProtKB/TrEMBL
  ENSSSCT00025040332.1 UniProtKB/TrEMBL
  ENSSSCT00030094323.1 UniProtKB/TrEMBL
  ENSSSCT00035045952.1 UniProtKB/TrEMBL
  ENSSSCT00045006300.1 UniProtKB/TrEMBL
  ENSSSCT00050088300.1 UniProtKB/TrEMBL
  ENSSSCT00055032388.1 UniProtKB/TrEMBL
  ENSSSCT00060001730.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-engrailed_C-terminal UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_engrailed UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
  Homoebox-engrailed_CS UniProtKB/TrEMBL
KEGG Report ssc:100512078 UniProtKB/TrEMBL
NCBI Gene EN2 ENTREZGENE
PANTHER HOMEOBOX PROTEIN ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX PROTEIN ENGRAILED-2 UniProtKB/TrEMBL
Pfam Engrail_1_C_sig UniProtKB/TrEMBL
  Homeodomain UniProtKB/TrEMBL
PRINTS ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX UniProtKB/TrEMBL
PROSITE ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A287AUN5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0XZ05 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1UFJ5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:87694 ENTREZGENE