Ptpn6 (protein tyrosine phosphatase, non-receptor type 6) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Ptpn6 (protein tyrosine phosphatase, non-receptor type 6) Rattus norvegicus
Analyze
Symbol: Ptpn6
Name: protein tyrosine phosphatase, non-receptor type 6
RGD ID: 620660
Description: Enables cytokine receptor binding activity and natural killer cell lectin-like receptor binding activity. Involved in cellular response to macrophage colony-stimulating factor stimulus and response to axon injury. Located in apical dendrite. Orthologous to human PTPN6 (protein tyrosine phosphatase non-receptor type 6); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC124580; protein-tyrosine phosphatase SHP-1; Ptph6; SH2 phosphatase 1; Shp-1; tyrosine-protein phosphatase non-receptor type 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,212,320 - 159,237,069 (-)NCBIGRCr8
mRatBN7.24157,526,034 - 157,550,783 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,526,035 - 157,550,984 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,754,524 - 163,773,000 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,537,429 - 159,555,906 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,178,993 - 158,197,490 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,239,141 - 157,263,890 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,239,142 - 157,263,890 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,256,737 - 224,281,486 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,843,699 - 160,868,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,088,634 - 161,113,792 (-)NCBI
Celera4146,264,696 - 146,289,049 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-diaminotoluene  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
anthranilic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
caffeine  (ISO)
capillarisin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
digitoxin  (ISO)
diuron  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
flavonoids  (EXP)
fonofos  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
lead diacetate  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
methoxyacetic acid  (EXP)
methoxychlor  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
PD123319  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
prostaglandin E2  (EXP)
raloxifene  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium stibogluconate  (ISO)
Soman  (EXP)
terbufos  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell receptor signaling pathway  (IEA,ISO)
CD27 signaling pathway  (IEA,ISO)
cell differentiation  (IBA,ISO,ISS)
cellular response to macrophage colony-stimulating factor stimulus  (IEP)
epididymis development  (IEA,ISO)
hematopoietic progenitor cell differentiation  (IEA,ISO)
intracellular signal transduction  (IBA,ISO)
MAPK cascade  (IEA,ISO)
megakaryocyte development  (IEA,ISO)
mitotic cell cycle  (IBA)
natural killer cell mediated cytotoxicity  (IEA,ISO)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of B cell receptor signaling pathway  (IEA,ISO)
negative regulation of humoral immune response mediated by circulating immunoglobulin  (IEA,ISO)
negative regulation of inflammatory response to wounding  (IEA,ISO)
negative regulation of innate immune response  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA,ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of MAPK cascade  (IEA,ISO)
negative regulation of mast cell activation involved in immune response  (IEA,ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
negative regulation of T cell proliferation  (IEA,ISO)
negative regulation of T cell receptor signaling pathway  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
peptidyl-tyrosine dephosphorylation  (IEA,ISO)
peptidyl-tyrosine phosphorylation  (IEA,ISO)
platelet aggregation  (IEA,ISO)
platelet formation  (IEA,ISO)
positive regulation of cell adhesion mediated by integrin  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
protein dephosphorylation  (IEA,ISO,ISS,TAS)
regulation of B cell differentiation  (IEA,ISO)
regulation of ERK1 and ERK2 cascade  (IEA,ISO,ISS)
regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
response to axon injury  (IEP)
T cell activation  (ISO)
T cell proliferation  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. Alblas J, etal., Mol Cell Biol. 2005 Aug;25(16):7181-92. doi: 10.1128/MCB.25.16.7181-7192.2005.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. A novel role for protein tyrosine phosphatase shp1 in controlling glial activation in the normal and injured nervous system. Horvat A, etal., J Neurosci 2001 Feb 1;21(3):865-74.
5. AT2 receptors: functional relevance in cardiovascular disease. Jones ES, etal., Pharmacol Ther. 2008 Dec;120(3):292-316. Epub 2008 Aug 31.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Angiotensin II blocks nicotine-mediated neuroprotection against beta-amyloid (1-42) via activation of the tyrosine phosphatase SHP-1. Shaw S, etal., J Neurosci 2003 Dec 3;23(35):11224-8.
14. Significance of SHP-1 and SHP-2 expression in human papillomavirus infected Condyloma acuminatum and cervical cancer. Tao XH, etal., Pathol Oncol Res. 2008 Dec;14(4):365-71. doi: 10.1007/s12253-008-9065-5. Epub 2008 Jun 10.
15. JAK/STAT signal transduction: regulators and implication in hematological malignancies. Valentino L and Pierre J, Biochem Pharmacol. 2006 Mar 14;71(6):713-21. Epub 2006 Jan 19.
16. The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity. Westgaard IH, etal., J Exp Med 2003 Jun 2;197(11):1551-61.
Additional References at PubMed
PMID:1302222   PMID:6971254   PMID:8632004   PMID:8943354   PMID:9064344   PMID:9254656   PMID:9285411   PMID:10206955   PMID:10229828   PMID:10556798   PMID:10585470   PMID:10940933  
PMID:11162587   PMID:11266449   PMID:11986327   PMID:12051764   PMID:12163025   PMID:12221292   PMID:12477932   PMID:14684844   PMID:15115663   PMID:15341919   PMID:16159885   PMID:16223786  
PMID:16814162   PMID:17068200   PMID:17562706   PMID:17954568   PMID:18294464   PMID:18680145   PMID:18802077   PMID:19056867   PMID:19749791   PMID:19838216   PMID:19948503   PMID:20458337  
PMID:21166153   PMID:22077594   PMID:22120166   PMID:22499584   PMID:23509158   PMID:23509253   PMID:23793062   PMID:24029230   PMID:24140598   PMID:24225419   PMID:25007834   PMID:25404734  
PMID:25790452   PMID:27323684   PMID:29758384   PMID:31967332   PMID:33207073   PMID:33932446   PMID:34872449  


Genomics

Comparative Map Data
Ptpn6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,212,320 - 159,237,069 (-)NCBIGRCr8
mRatBN7.24157,526,034 - 157,550,783 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,526,035 - 157,550,984 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,754,524 - 163,773,000 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,537,429 - 159,555,906 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,178,993 - 158,197,490 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,239,141 - 157,263,890 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,239,142 - 157,263,890 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,256,737 - 224,281,486 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,843,699 - 160,868,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,088,634 - 161,113,792 (-)NCBI
Celera4146,264,696 - 146,289,049 (-)NCBICelera
Cytogenetic Map4q42NCBI
PTPN6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,946,577 - 6,961,316 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,946,468 - 6,961,316 (+)EnsemblGRCh38hg38GRCh38
GRCh37127,055,740 - 7,070,479 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,926,001 - 6,940,740 (+)NCBINCBI36Build 36hg18NCBI36
Build 34126,930,762 - 6,940,740NCBI
Celera128,674,361 - 8,691,497 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,911,844 - 6,928,943 (+)NCBIHuRef
CHM1_1127,054,727 - 7,069,431 (+)NCBICHM1_1
T2T-CHM13v2.0126,957,743 - 6,974,790 (+)NCBIT2T-CHM13v2.0
Ptpn6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,697,670 - 124,715,672 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,697,670 - 124,715,677 (-)EnsemblGRCm39 Ensembl
GRCm386124,720,707 - 124,738,709 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,720,707 - 124,738,714 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,670,736 - 124,688,727 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,686,336 - 124,698,725 (-)NCBIMGSCv36mm8
Celera6126,402,447 - 126,420,442 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Ptpn6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,525,954 - 4,547,177 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,525,954 - 4,547,177 (+)NCBIChiLan1.0ChiLan1.0
PTPN6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,510,113 - 12,527,309 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,506,872 - 12,524,068 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,075,879 - 7,093,041 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,991,099 - 7,008,830 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,991,099 - 7,008,830 (+)Ensemblpanpan1.1panPan2
PTPN6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,084,976 - 38,101,552 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,084,980 - 38,101,937 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,519,708 - 8,531,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,437,567 - 38,449,584 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,437,569 - 38,453,615 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,312,457 - 38,324,047 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,353,429 - 38,365,020 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,998,465 - 8,010,486 (+)NCBIUU_Cfam_GSD_1.0
Ptpn6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,196,659 - 102,217,158 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709864,197 - 884,610 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936709864,206 - 884,630 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,762,112 - 63,808,350 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,762,109 - 63,779,086 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,198,250 - 66,215,843 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,977,480 - 6,994,525 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,984,710 - 6,994,545 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,223,213 - 1,240,430 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,580,560 - 3,595,090 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,580,225 - 3,595,403 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptpn6
86 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:39
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000065416
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat

Markers in Region
AI411273  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,526,457 - 157,526,963 (+)MAPPERmRatBN7.2
Rnor_6.04157,239,565 - 157,240,070NCBIRnor6.0
Rnor_5.04224,257,161 - 224,257,666UniSTSRnor5.0
RGSC_v3.44160,844,123 - 160,844,628UniSTSRGSC3.4
Celera4146,265,120 - 146,265,625UniSTS
RH 3.4 Map41003.4UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000065416   ⟹   ENSRNOP00000059867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,526,035 - 157,550,783 (-)Ensembl
Rnor_6.0 Ensembl4157,239,142 - 157,263,890 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079947   ⟹   ENSRNOP00000071714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,526,035 - 157,539,290 (-)Ensembl
Rnor_6.0 Ensembl4157,239,269 - 157,252,565 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082739   ⟹   ENSRNOP00000071320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,526,035 - 157,539,458 (-)Ensembl
Rnor_6.0 Ensembl4157,239,143 - 157,252,104 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102617   ⟹   ENSRNOP00000082659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,526,036 - 157,550,617 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117641   ⟹   ENSRNOP00000082194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,526,036 - 157,550,984 (-)Ensembl
RefSeq Acc Id: NM_053908   ⟹   NP_446360
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,212,320 - 159,237,069 (-)NCBI
mRatBN7.24157,526,034 - 157,550,783 (-)NCBI
Rnor_6.04157,239,141 - 157,263,890 (-)NCBI
Rnor_5.04224,256,737 - 224,281,486 (-)NCBI
RGSC_v3.44160,843,699 - 160,868,856 (-)RGD
Celera4146,264,696 - 146,289,049 (-)RGD
Sequence:
RefSeq Acc Id: XM_039106947   ⟹   XP_038962875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,212,322 - 159,225,297 (-)NCBI
mRatBN7.24157,526,036 - 157,538,992 (-)NCBI
RefSeq Acc Id: NP_446360   ⟸   NM_053908
- UniProtKB: Q499N7 (UniProtKB/TrEMBL),   A6ILJ4 (UniProtKB/TrEMBL),   G3V9T9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071320   ⟸   ENSRNOT00000082739
Ensembl Acc Id: ENSRNOP00000071714   ⟸   ENSRNOT00000079947
Ensembl Acc Id: ENSRNOP00000059867   ⟸   ENSRNOT00000065416
RefSeq Acc Id: XP_038962875   ⟸   XM_039106947
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZT59 (UniProtKB/TrEMBL),   A6ILJ5 (UniProtKB/TrEMBL),   A0A0G2K064 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082659   ⟸   ENSRNOT00000102617
Ensembl Acc Id: ENSRNOP00000082194   ⟸   ENSRNOT00000117641
Protein Domains
SH2   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P81718-F1-model_v2 AlphaFold P81718 1-613 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693393
Promoter ID:EPDNEW_R3911
Type:initiation region
Name:Ptpn6_1
Description:protein tyrosine phosphatase, non-receptor type 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04157,252,095 - 157,252,155EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620660 AgrOrtholog
BioCyc Gene G2FUF-43078 BioCyc
Ensembl Genes ENSRNOG00000014294 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065416.4 UniProtKB/TrEMBL
  ENSRNOT00000079947.2 UniProtKB/TrEMBL
  ENSRNOT00000082739.2 UniProtKB/TrEMBL
  ENSRNOT00000102617.1 UniProtKB/TrEMBL
  ENSRNOT00000117641.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7932620 IMAGE-MGC_LOAD
InterPro Non-rcpt_Tyr_Phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_non-rcpt_typ-6/11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:124580 IMAGE-MGC_LOAD
NCBI Gene 116689 ENTREZGENE
PANTHER TYROSINE-PROTEIN PHOSPHATASE CORKSCREW UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PTPN6 RGD
PhenoGen Ptpn6 PhenoGen
PIRSF Tyr-Ptase_nr_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014294 RatGTEx
SMART PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K064 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K163_RAT UniProtKB/TrEMBL
  A0A8I5ZT59 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZTX8_RAT UniProtKB/TrEMBL
  A6ILJ4 ENTREZGENE, UniProtKB/TrEMBL
  A6ILJ5 ENTREZGENE, UniProtKB/TrEMBL
  G3V9T9 ENTREZGENE, UniProtKB/TrEMBL
  P81718 ENTREZGENE, UniProtKB/Swiss-Prot
  Q499N7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Ptpn6  protein tyrosine phosphatase, non-receptor type 6  Ptph6    Symbol updated 1299863 APPROVED
2002-08-07 Ptph6  protein tyrosine phosphatase, non-receptor type 6      Symbol and Name status set to provisional 70820 PROVISIONAL