Ptpn6 (protein tyrosine phosphatase, non-receptor type 6)

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Gene: Ptpn6 (protein tyrosine phosphatase, non-receptor type 6) Rattus norvegicus

Analyze

Symbol:

Ptpn6

Name:

protein tyrosine phosphatase, non-receptor type 6

RGD ID:

620660

Description:

Enables cytokine receptor binding activity and natural killer cell lectin-like receptor binding activity. Involved in cellular response to macrophage colony-stimulating factor stimulus and response to axon injury. Located in apical dendrite. Orthologous to human PTPN6 (protein tyrosine phosphatase non-receptor type 6); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MGC124580; protein-tyrosine phosphatase SHP-1; Ptph6; SH2 phosphatase 1; Shp-1; tyrosine-protein phosphatase non-receptor type 6

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	157,526,034 - 157,550,783 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	157,526,035 - 157,550,984 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	163,754,524 - 163,773,000 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	159,537,429 - 159,555,906 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	158,178,993 - 158,197,490 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	157,239,141 - 157,263,890 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	157,239,142 - 157,263,890 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	224,256,737 - 224,281,486 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	160,843,699 - 160,868,856 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	161,088,634 - 161,113,792 (-)	NCBI
Celera	4	146,264,696 - 146,289,049 (-)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

anogenital venereal wart (ISO)

autism spectrum disorder (ISO)

calcinosis (ISO)

cervical cancer (ISO)

developmental and epileptic encephalopathy 21 (ISO)

genetic disease (ISO)

heart valve disease (ISO)

Hyperphosphatemic Familial Tumoral Calcinosis 1 (ISO)

Klippel-Feil syndrome 3 (ISO)

lymphoproliferative syndrome 2 (ISO)

Neurodevelopmental Disorders (ISO)

peroxisome biogenesis disorder 2B (ISO)

respiratory allergy (ISO)

Temtamy syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,4-diaminotoluene (ISO)

2,6-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

acrylamide (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

all-trans-retinol (EXP)

ammonium chloride (EXP)

anthranilic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

caffeine (ISO)

capillarisin (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

chloroprene (ISO)

cisplatin (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

Cuprizon (EXP)

curcumin (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

digitoxin (ISO)

diuron (ISO)

elemental selenium (ISO)

emodin (ISO)

endosulfan (EXP)

ethanol (EXP,ISO)

flavonoids (EXP)

fonofos (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

lead diacetate (ISO)

lidocaine (EXP)

lipopolysaccharide (ISO)

methoxyacetic acid (EXP)

methoxychlor (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

parathion (ISO)

PD123319 (EXP)

pirinixic acid (ISO)

potassium dichromate (ISO)

raloxifene (ISO)

rotenone (ISO)

selenium atom (ISO)

silicon dioxide (EXP,ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (EXP)

sodium chloride (ISO)

sodium stibogluconate (ISO)

Soman (EXP)

terbufos (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thapsigargin (EXP)

titanium dioxide (ISO)

Tributyltin oxide (EXP,ISO)

trichloroethene (EXP)

trimethyltin (ISO)

valproic acid (ISO)

valsartan (EXP)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell receptor signaling pathway (IEA,ISO)

cell differentiation (IBA,ISO,ISS)

cellular response to macrophage colony-stimulating factor stimulus (IEP)

cellular response to organic substance (IEA)

dephosphorylation (IEA)

epididymis development (IEA,ISO)

hematopoietic progenitor cell differentiation (IEA,ISO)

intracellular signal transduction (IBA,ISO)

MAPK cascade (IEA,ISO)

megakaryocyte development (IEA,ISO)

mitotic cell cycle (IBA)

natural killer cell mediated cytotoxicity (IEA,ISO)

negative regulation of humoral immune response mediated by circulating immunoglobulin (IEA,ISO)

negative regulation of inflammatory response to wounding (IEA,ISO)

negative regulation of interleukin-6 production (IEA,ISO)

negative regulation of MAPK cascade (IEA,ISO)

negative regulation of mast cell activation involved in immune response (IEA,ISO)

negative regulation of peptidyl-tyrosine phosphorylation (IEA,ISO)

negative regulation of T cell proliferation (IEA,ISO)

negative regulation of T cell receptor signaling pathway (IEA,ISO)

negative regulation of tumor necrosis factor production (IEA,ISO)

platelet aggregation (IEA,ISO)

platelet formation (IEA,ISO)

positive regulation of cell adhesion mediated by integrin (IEA,ISO)

positive regulation of cell population proliferation (IEA,ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO)

protein dephosphorylation (TAS)

regulation of B cell differentiation (IEA,ISO)

regulation of ERK1 and ERK2 cascade (IEA,ISO,ISS)

regulation of G1/S transition of mitotic cell cycle (IEA,ISO)

regulation of release of sequestered calcium ion into cytosol (IEA,ISO)

response to axon injury (IEP)

T cell proliferation (IEA,ISO)

T cell receptor signaling pathway (IEA,ISO)

Cellular Component

alpha-beta T cell receptor complex (IEA,ISO)

apical dendrite (IDA)

cell-cell junction (IEA,ISO)

cytoplasm (IBA,IEA,ISO)

nucleolus (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (ISO)

protein-containing complex (ISO)

Molecular Function

cell adhesion molecule binding (IEA,ISO)

cytokine receptor binding (IPI)

natural killer cell lectin-like receptor binding (IPI)

non-membrane spanning protein tyrosine phosphatase activity (IBA)

phosphorylation-dependent protein binding (IEA,ISO)

phosphotyrosine residue binding (IBA,IEA,ISO)

protein binding (IPI,ISO)

protein kinase binding (IEA,ISO)

protein tyrosine phosphatase activity (IEA,ISO,TAS)

SH2 domain binding (IEA,ISO)

SH3 domain binding (IEA,ISO)

transmembrane receptor protein tyrosine phosphatase activity (IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

angiotensin II signaling pathway via AT2 receptor (ISO)

B cell receptor signaling pathway (IEA)

epidermal growth factor/neuregulin signaling pathway (ISO)

erythropoietin signaling pathway (ISO)

interleukin-4 signaling pathway (ISO)

Jak-Stat signaling pathway (IEA,ISO)

Leishmaniasis pathway (IEA)

T cell receptor signaling pathway (IEA)

vascular endothelial growth factor signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways.	Alblas J, etal., Mol Cell Biol. 2005 Aug;25(16):7181-92. doi: 10.1128/MCB.25.16.7181-7192.2005.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	A novel role for protein tyrosine phosphatase shp1 in controlling glial activation in the normal and injured nervous system.	Horvat A, etal., J Neurosci 2001 Feb 1;21(3):865-74.
5.	AT2 receptors: functional relevance in cardiovascular disease.	Jones ES, etal., Pharmacol Ther. 2008 Dec;120(3):292-316. Epub 2008 Aug 31.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Angiotensin II blocks nicotine-mediated neuroprotection against beta-amyloid (1-42) via activation of the tyrosine phosphatase SHP-1.	Shaw S, etal., J Neurosci 2003 Dec 3;23(35):11224-8.
14.	Significance of SHP-1 and SHP-2 expression in human papillomavirus infected Condyloma acuminatum and cervical cancer.	Tao XH, etal., Pathol Oncol Res. 2008 Dec;14(4):365-71. doi: 10.1007/s12253-008-9065-5. Epub 2008 Jun 10.
15.	JAK/STAT signal transduction: regulators and implication in hematological malignancies.	Valentino L and Pierre J, Biochem Pharmacol. 2006 Mar 14;71(6):713-21. Epub 2006 Jan 19.
16.	The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity.	Westgaard IH, etal., J Exp Med 2003 Jun 2;197(11):1551-61.

Additional References at PubMed

PMID:1302222	PMID:6971254	PMID:8632004	PMID:8943354	PMID:9064344	PMID:9254656	PMID:9285411	PMID:10206955	PMID:10229828	PMID:10556798	PMID:10585470	PMID:10940933
PMID:11162587	PMID:11266449	PMID:11986327	PMID:12051764	PMID:12163025	PMID:12221292	PMID:12477932	PMID:14684844	PMID:15115663	PMID:15341919	PMID:16159885	PMID:16223786
PMID:16814162	PMID:17068200	PMID:17562706	PMID:17954568	PMID:18294464	PMID:18680145	PMID:18802077	PMID:19056867	PMID:19749791	PMID:19838216	PMID:19948503	PMID:20458337
PMID:21166153	PMID:22077594	PMID:22120166	PMID:22499584	PMID:23509158	PMID:23509253	PMID:23793062	PMID:24029230	PMID:24140598	PMID:24225419	PMID:25007834	PMID:25404734
PMID:25790452	PMID:27323684	PMID:29758384	PMID:31967332	PMID:33207073	PMID:33932446	PMID:34872449

Genomics

Comparative Map Data

Ptpn6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	157,526,034 - 157,550,783 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	157,526,035 - 157,550,984 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	163,754,524 - 163,773,000 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	159,537,429 - 159,555,906 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	158,178,993 - 158,197,490 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	157,239,141 - 157,263,890 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	157,239,142 - 157,263,890 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	224,256,737 - 224,281,486 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	160,843,699 - 160,868,856 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	161,088,634 - 161,113,792 (-)	NCBI
Celera	4	146,264,696 - 146,289,049 (-)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

PTPN6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	6,946,577 - 6,961,316 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	6,946,468 - 6,961,316 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	7,055,740 - 7,070,479 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	6,926,001 - 6,940,740 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	6,930,762 - 6,940,740	NCBI
Celera	12	8,674,361 - 8,691,497 (+)	NCBI		Celera
Cytogenetic Map	12	p13.31	NCBI
HuRef	12	6,911,844 - 6,928,943 (+)	NCBI		HuRef
CHM1_1	12	7,054,727 - 7,069,431 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	6,957,743 - 6,974,790 (+)	NCBI		T2T-CHM13v2.0

Ptpn6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	124,697,670 - 124,715,672 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	124,697,670 - 124,715,677 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	124,720,707 - 124,738,709 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	124,720,707 - 124,738,714 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	124,670,736 - 124,688,727 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	124,686,336 - 124,698,725 (-)	NCBI		MGSCv36	mm8
Celera	6	126,402,447 - 126,420,442 (-)	NCBI		Celera
Cytogenetic Map	6	F2	NCBI
cM Map	6	59.17	NCBI

Ptpn6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	4,525,954 - 4,547,177 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	4,525,954 - 4,547,177 (+)	NCBI	ChiLan1.0	ChiLan1.0

PTPN6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	12	12,506,872 - 12,524,068 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	7,075,879 - 7,093,041 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	6,991,099 - 7,008,830 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	6,991,099 - 7,008,830 (+)	Ensembl	panpan1.1		panPan2

PTPN6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	38,084,976 - 38,101,552 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	38,084,980 - 38,101,937 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	8,519,708 - 8,531,714 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	38,437,567 - 38,449,584 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	38,437,569 - 38,453,615 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	38,312,457 - 38,324,047 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	38,353,429 - 38,365,020 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	7,998,465 - 8,010,486 (+)	NCBI		UU_Cfam_GSD_1.0

Ptpn6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	102,196,659 - 102,217,158 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936709	864,197 - 884,610 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936709	864,206 - 884,630 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTPN6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	63,762,112 - 63,808,350 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	63,762,109 - 63,779,086 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	66,198,250 - 66,215,843 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PTPN6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	6,977,480 - 6,994,525 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	6,984,710 - 6,994,545 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	1,223,213 - 1,240,430 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ptpn6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624860	3,580,560 - 3,595,090 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624860	3,580,225 - 3,595,403 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ptpn6
72 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	41
Count of miRNA genes:	39
Interacting mature miRNAs:	41
Transcripts:	ENSRNOT00000065416
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	64528739	157573521	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	83428419	177635233	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	85379421	167139601	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	93308457	167139447	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	109866907	167139601	Rat
1331759	Hrtrt13	Heart rate QTL 13	3.54628		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	110275411	168266883	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	114627026	159627026	Rat
724535	Cm18	Cardiac mass QTL 18	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	4	118856416	163856416	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	119428175	157578333	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	123143783	168143783	Rat
631683	Bp116	Blood pressure QTL 116		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	124303370	169303370	Rat
6478778	Anxrr51	Anxiety related response QTL 51		0.25384	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	124778595	169778595	Rat
7411558	Bw133	Body weight QTL 133	13.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	125590636	170590636	Rat
61451	Ciaa4	CIA Autoantibody QTL 4	3.1		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	4	126395976	167139601	Rat
737978	Pia23	Pristane induced arthritis QTL 23	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	131730738	167139601	Rat
631511	Pia7	Pristane induced arthritis QTL 7	4.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	131730738	167139601	Rat
1549827	Scl46	Serum cholesterol level QTL 46	3.5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	4	132396220	177396220	Rat
724558	Plsm2	Polydactyly-luxate syndrome (PLS) morphotypes QTL 2		0.0003	hindlimb integrity trait (VT:0010563)	hind foot phalanges count (CMO:0001949)	4	132422778	177422778	Rat
61422	Cia13	Collagen induced arthritis QTL 13	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	132642577	167139601	Rat
2303623	Vencon2	Ventilatory control QTL 2	3.8		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	4	135204660	180204660	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	135699135	180699135	Rat
2293659	Bmd35	Bone mineral density QTL 35	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	4	137755016	181392681	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	138503169	173369699	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	138503169	173369699	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	138503169	179293946	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	144639524	182687754	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	144639524	182687754	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	145568712	182687754	Rat
634342	Cia24	Collagen induced arthritis QTL 24	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	146565735	175236377	Rat
12798525	Anxrr57	Anxiety related response QTL 57	3.21	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	147278504	167139601	Rat
1582237	Kidm34	Kidney mass QTL 34	4	0.0001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	4	148090542	168069246	Rat
61446	Coreg2	Compensatory renal growth QTL 2	3.5		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	4	148423102	157580971	Rat
1581574	Eae20	Experimental allergic encephalomyelitis QTL 20	7.8		nervous system integrity trait (VT:0010566)	percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)	4	153031106	158841762	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	155561574	182687754	Rat

Markers in Region

AI411273

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	157,526,457 - 157,526,963 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	157,239,565 - 157,240,070	NCBI	Rnor6.0
Rnor_5.0	4	224,257,161 - 224,257,666	UniSTS	Rnor5.0
RGSC_v3.4	4	160,844,123 - 160,844,628	UniSTS	RGSC3.4
Celera	4	146,265,120 - 146,265,625	UniSTS
RH 3.4 Map	4	1003.4	UniSTS
Cytogenetic Map	4	q42	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	1	50	41	19	41				28	19	11
Low		42	7				8	11	74	7	22		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053908	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC129138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF468653	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC099824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U77038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000065416 ⟹ ENSRNOP00000059867

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	157,526,035 - 157,550,783 (-)	Ensembl
Rnor_6.0 Ensembl	4	157,239,142 - 157,263,890 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000079947 ⟹ ENSRNOP00000071714

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	157,526,035 - 157,539,290 (-)	Ensembl
Rnor_6.0 Ensembl	4	157,239,269 - 157,252,565 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000082739 ⟹ ENSRNOP00000071320

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	157,526,035 - 157,539,458 (-)	Ensembl
Rnor_6.0 Ensembl	4	157,239,143 - 157,252,104 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102617 ⟹ ENSRNOP00000082659

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	157,526,036 - 157,550,617 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000117641 ⟹ ENSRNOP00000082194

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	157,526,036 - 157,550,984 (-)	Ensembl

RefSeq Acc Id:

NM_053908 ⟹ NP_446360

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	157,526,034 - 157,550,783 (-)	NCBI
Rnor_6.0	4	157,239,141 - 157,263,890 (-)	NCBI
Rnor_5.0	4	224,256,737 - 224,281,486 (-)	NCBI
RGSC_v3.4	4	160,843,699 - 160,868,856 (-)	RGD
Celera	4	146,264,696 - 146,289,049 (-)	RGD

Sequence:

show sequence

GAATTCGGCACGAGAGGGGCTTGGCTCAAAGTGCCATTGGTTTGACAGGCTGGATGAGGAGGAA
GTGGCCGAAACCGAAATATTCTTCCTGAAGGTCTGGATCCCCGAACAGCTGTGCCACTCGATTG
GCCCCGCCCCTGTCGCCCTTTGCCTGTGACTTCCCCCACTCCTCCAGGGAGATGCTGTCCCGCG
GGTGGTTTCACCGGGACCTCAGTGGGCCTGATGCCGAGACCCTGCTCAAGGGCCGGGGAGTCCC
TGGGAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACTTCTCCCTCTCAGTCAGGGTG
GATGACCAGGTGACTCATATTCGGATCCAGAACTCAGGGGACTTCTATGACCTGTATGGAGGGG
AGAAGTTTGCGACGTCGACAGAGCTGGTGGAGTATTACACTCAGCAGCAGGGCATCCTGCAGGA
CCGAGACGGCACCATCATCCACCTCAAGTACCCACTGAACTGCTCGGACCCCACCAGCGAGAGG
TGGTATCATGGTCACATGTCTGGAGGGCAGGCAGAGTCACTGCTGCAGGCCAAGGGCGAGCCCT
GGACATTTCTTGTGCGTGAGAGTCTCAGCCAACCTGGTGATTTTGTGCTCTCTGTGCTCAATGA
CCAGCCCAAGGCTGCCCCGGGTTCCCCGCTCAGGGTCACGCACATCAAGGTTATGTGTGAGGGT
GGACGATACACTGTGGGTGGCTCAGAGACATTCGACAGCCTCACAGACCTGGTGGAGCACTTCA
AGAAGACGGGGATTGAGGAGGCCTCAGGTGCCTTTGTCTACCTGAGGCAGCCTTACTATGCCAC
TCGGGTAAATGCAGCAGACATTGAGAACCGGGTCTTGGAACTGAACAAGAAGCAGGAGTCAGAG
GACACAGCCAAGGCCGGCTTCTGGGAGGAGTTTGAGAGTCTGCAAAAGCAAGAGGCAAAGAACT
TGCACCAGCGTCTGGAAGGGCAGCGGCCGGAGAACAAGAGCAAGAACCGCTACAAGAACATTCT
TCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGTGACAGTAACATCCCAGGGTCTGATTAC
ATCAATGCCAACTACGTTAAGAACCAGCTGCTAGGTCCGGATGAGAACTCTAAGACCTACATCG
CCAGTCAGGGCTGTCTGGACGCTACCGTCAATGACTTCTGGCAGATGGCTTGGCAGGAGAACAC
TCGTGTCATCGTCATGACTACCAGAGAGGTGGAGAAAGGCCGGAACAAATGTGTCCCATACTGG
CCTGAGGTGGGCACTCAGCGCGTCTATGGGCTCTACTCTGTGACCAACTGTAAAGAGCATGACA
CAGCAGAGTACAAACTTCGAACATTGCAGATCTCCCCACTGGACAATGGGGACCTGGTTCGGGA
GATATGGCACTACCAGTACCTGAGCTGGCCTGACCATGGGGTTCCCAGTGAGCCTGGAGGTGTC
CTCAGCTTTCTGGATCAGATCAACCAGCGGCAGGAAAGTTTGCCTCACGCGGGGCCCATCATTG
TGCATTGCAGCGCTGGCATCGGCCGCACCGGCACCATCATCGTCATTGATATGCTCATGGAGAG
CGTCTCCACCAAGGGGCTAGACTGTGACATTGACATCCAGAAGACCATCCAGATGGTACGGGCA
CAGCGCTCTGGCATGGTGCAGACAGAGGCACAGTACAAGTTTATTTATGTGGCCATCGCCCAGT
TCATCGAAACAACCAAGAAGAAACTGGAGATCATACAATCCCAGAGGGGCCAGGAGTCGGAGTA
TGGGAACATCACCTACCCTCCGGCTTTGAGGAGTGCCCACGCCAAAGCCTCCCGTACCTCGTCC
AAACACAAGGAGGAGGTGTACGAAAACGTGCATAGCAAGAACAAGAAGGAAGAGAAAGTAAAGA
AGCAGCGATCGGCAGACAAGGAGAAGAACAAAGGTTCTCTCAAGAGGAACATCAGCCTTACTCC
GTGCAGAGGCCTCCGCTGGGCAGACAGAGACCTGTAGTCCACACCACCCCCATCTTGTTGTAAT
TTAAGTGACCGTGGTCCTCTGAACCTGTATATGGCTCAGCAAGCCTCAGGGAGAGTCAGACCCT
TCTCTTCTTGTAAATAAAGCCCCTGGACAACTGTGTAAAAAAAAAAAAAAAAAAAAAACTCGAG

hide sequence

RefSeq Acc Id:

XM_039106947 ⟹ XP_038962875

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	157,526,036 - 157,538,992 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_446360	(Get FASTA)	NCBI Sequence Viewer
	XP_038962875	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD00262	(Get FASTA)	NCBI Sequence Viewer
	AAH99824	(Get FASTA)	NCBI Sequence Viewer
	AAL77056	(Get FASTA)	NCBI Sequence Viewer
	EDM01944	(Get FASTA)	NCBI Sequence Viewer
	EDM01945	(Get FASTA)	NCBI Sequence Viewer
	P81718	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446360 ⟸ NM_053908

- UniProtKB:

Q499N7 (UniProtKB/TrEMBL), A6ILJ4 (UniProtKB/TrEMBL), G3V9T9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLSRGWFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQNSGDFYD
LYGGEKFATSTELVEYYTQQQGILQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAESLLQA
KGEPWTFLVRESLSQPGDFVLSVLNDQPKAAPGSPLRVTHIKVMCEGGRYTVGGSETFDSLTDL
VEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQ
EAKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYVKNQLLGPDENS
KTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNKCVPYWPEVGTQRVYGLYSVTNC
KEHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHA
GPIIVHCSAGIGRTGTIIVIDMLMESVSTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYV
AIAQFIETTKKKLEIIQSQRGQESEYGNITYPPALRSAHAKASRTSSKHKEEVYENVHSKNKKE
EKVKKQRSADKEKNKGSLKRNISLTPCRGLRWADRDL

hide sequence

RefSeq Acc Id:

ENSRNOP00000071320 ⟸ ENSRNOT00000082739

RefSeq Acc Id:

ENSRNOP00000071714 ⟸ ENSRNOT00000079947

RefSeq Acc Id:

ENSRNOP00000059867 ⟸ ENSRNOT00000065416

RefSeq Acc Id:	XP_038962875 ⟸ XM_039106947
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZT59 (UniProtKB/TrEMBL), A6ILJ5 (UniProtKB/TrEMBL), A0A0G2K064 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000082659 ⟸ ENSRNOT00000102617

RefSeq Acc Id:

ENSRNOP00000082194 ⟸ ENSRNOT00000117641

Protein Domains

SH2 Tyrosine specific protein phosphatases Tyrosine-protein phosphatase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P81718-F1-model_v2	AlphaFold	P81718	1-613	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620660	AgrOrtholog
BioCyc Gene	G2FUF-43078	BioCyc
Ensembl Genes	ENSRNOG00000014294	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000059867	ENTREZGENE
	ENSRNOP00000059867.1	UniProtKB/TrEMBL
	ENSRNOP00000071320.2	UniProtKB/TrEMBL
	ENSRNOP00000071714.2	UniProtKB/TrEMBL
	ENSRNOP00000082194	ENTREZGENE
	ENSRNOP00000082194.1	UniProtKB/TrEMBL
	ENSRNOP00000082659.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000065416	ENTREZGENE
	ENSRNOT00000065416.4	UniProtKB/TrEMBL
	ENSRNOT00000079947.2	UniProtKB/TrEMBL
	ENSRNOT00000082739.2	UniProtKB/TrEMBL
	ENSRNOT00000102617.1	UniProtKB/TrEMBL
	ENSRNOT00000117641	ENTREZGENE
	ENSRNOT00000117641.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.90.190.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7932620	IMAGE-MGC_LOAD
InterPro	Prot-tyrosine_phosphatase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTPase_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_Pase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_Pase_cat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_Pase_non-rcpt_typ-6/11	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYR_PHOSPHATASE_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:116689	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:124580	IMAGE-MGC_LOAD
NCBI Gene	116689	ENTREZGENE
PANTHER	TYROSINE-PROTEIN PHOSPHATASE CORKSCREW	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Y_phosphatase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PTPN6	RGD
PhenoGen	Ptpn6	PhenoGen
PIRSF	Tyr-Ptase_nr_6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	PRTYPHPHTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYR_PHOSPHATASE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYR_PHOSPHATASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYR_PHOSPHATASE_PTP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	PTPc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTPc_motif	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52799	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55550	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K064	ENTREZGENE, UniProtKB/TrEMBL
	A0A0G2K163_RAT	UniProtKB/TrEMBL
	A0A8I5ZT59	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZTX8_RAT	UniProtKB/TrEMBL
	A6ILJ4	ENTREZGENE, UniProtKB/TrEMBL
	A6ILJ5	ENTREZGENE, UniProtKB/TrEMBL
	G3V9T9	ENTREZGENE, UniProtKB/TrEMBL
	P81718	ENTREZGENE, UniProtKB/Swiss-Prot
	Q499N7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Ptpn6	protein tyrosine phosphatase, non-receptor type 6	Ptph6		Symbol updated	1299863	APPROVED
2002-08-07	Ptph6	protein tyrosine phosphatase, non-receptor type 6			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)