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Gene: Fdft1 (farnesyl diphosphate farnesyl transferase 1) Rattus norvegicus
Symbol: Fdft1
Name: farnesyl diphosphate farnesyl transferase 1
Description: Exhibits farnesyl-diphosphate farnesyltransferase activity. Involved in cholesterol biosynthetic process and farnesyl diphosphate metabolic process. Localizes to the intracellular membrane-bounded organelle. Used to study cataract. Orthologous to human FDFT1 (farnesyl-diphosphate farnesyltransferase 1); PARTICIPATES IN cholesterol biosynthetic pathway; alendronate pharmacodynamics pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: farnesyl diphosphate farnesyltransferase; farnesyl-diphosphate farnesyltransferase; FPP:FPP farnesyltransferase; MGC93486; SQS; squalene synthase; squalene synthetase; SS
Homo sapiens (human) : FDFT1 (farnesyl-diphosphate farnesyltransferase 1)  HGNC  Alliance
Mus musculus (house mouse) : Fdft1 (farnesyl diphosphate farnesyl transferase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fdft1 (farnesyl-diphosphate farnesyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FDFT1 (farnesyl-diphosphate farnesyltransferase 1)
Canis lupus familiaris (dog) : FDFT1 (farnesyl-diphosphate farnesyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fdft1 (farnesyl-diphosphate farnesyltransferase 1)
Sus scrofa (pig) : FDFT1 (farnesyl-diphosphate farnesyltransferase 1)
Chlorocebus sabaeus (African green monkey) : FDFT1 (farnesyl-diphosphate farnesyltransferase 1)
Heterocephalus glaber (naked mole-rat) : Fdft1 (farnesyl-diphosphate farnesyltransferase 1)
more info ...
Is Marker For: Strains:   SCR/Sscr  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01546,339,248 - 46,367,302 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,339,249 - 46,367,302 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01550,104,042 - 50,132,096 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,425,336 - 42,453,390 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11542,442,550 - 42,469,109 (-)NCBI
Celera1537,096,417 - 37,124,524 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Fdft1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61834
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.