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Gene: Jag1 (jagged canonical Notch ligand 1) Rattus norvegicus
Symbol: Jag1
Name: jagged canonical Notch ligand 1
RGD ID: 2937
Description: Exhibits Notch binding activity and receptor ligand activity. Involved in several processes, including animal organ regeneration; inner ear auditory receptor cell differentiation; and positive regulation of cardiac epithelial to mesenchymal transition. Localizes to plasma membrane. Predicted to colocalize with membrane. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; Alagille syndrome pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
Also known as: jagged 1; protein jagged-1
Homo sapiens (human) : JAG1 (jagged canonical Notch ligand 1)  HGNC  Alliance
Mus musculus (house mouse) : Jag1 (jagged 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jag1 (jagged canonical Notch ligand 1)
Pan paniscus (bonobo/pygmy chimpanzee) : JAG1 (jagged canonical Notch ligand 1)
Canis lupus familiaris (dog) : JAG1 (jagged canonical Notch ligand 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jag1 (jagged canonical Notch ligand 1)
Sus scrofa (pig) : JAG1 (jagged canonical Notch ligand 1)
Chlorocebus sabaeus (African green monkey) : JAG1 (jagged canonical Notch ligand 1)
Heterocephalus glaber (naked mole-rat) : Jag1 (jagged canonical Notch ligand 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03130,079,361 - 130,114,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3130,079,361 - 130,114,770 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03136,558,688 - 136,594,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43125,181,063 - 125,216,481 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13125,086,635 - 125,122,054 (-)NCBI
Celera3123,126,087 - 123,161,497 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Jag1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2937
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.