Jag1 (jagged canonical Notch ligand 1) - Rat Genome Database

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Gene: Jag1 (jagged canonical Notch ligand 1) Rattus norvegicus
Symbol: Jag1
Name: jagged canonical Notch ligand 1
RGD ID: 2937
Description: Enables Notch binding activity and receptor ligand activity. Involved in several processes, including animal organ regeneration; inner ear auditory receptor cell differentiation; and positive regulation of cardiac epithelial to mesenchymal transition. Predicted to be located in adherens junction and apical plasma membrane. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; Alagille syndrome pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: jagged 1; protein jagged-1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83144,859,453 - 144,894,883 (-)NCBIGRCr8
mRatBN7.23124,406,783 - 124,442,220 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3124,406,794 - 124,442,209 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3128,293,948 - 128,329,348 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03136,870,930 - 136,906,325 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03134,556,899 - 134,592,326 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03130,079,361 - 130,114,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3130,079,361 - 130,114,770 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03136,558,688 - 136,594,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43125,181,063 - 125,216,481 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13125,086,635 - 125,122,054 (-)NCBI
Celera3123,126,087 - 123,161,497 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,4-benzoquinone  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
8-Br-cAMP  (ISO)
9-phenanthrol  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (EXP)
alpha-pinene  (ISO)
alpha-Zearalanol  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Butylparaben  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (EXP)
celastrol  (ISO)
chloropicrin  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (EXP)
endosulfan  (EXP)
Enterolactone  (ISO)
enzacamene  (EXP)
enzalutamide  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
Ethylenethiourea  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP)
formaldehyde  (ISO)
furan  (EXP)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycyrrhizinic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
mechlorethamine  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (ISO)
N(6)-dimethylallyladenine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
pinosylvin  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tebuconazole  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
animal organ regeneration  (IEP)
aorta morphogenesis  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
camera-type eye development  (ISO)
cardiac neural crest cell development involved in outflow tract morphogenesis  (IEA,ISO)
cardiac right ventricle morphogenesis  (IEA,ISO)
cardiac septum morphogenesis  (IEA,ISO)
cell fate determination  (NAS)
ciliary body morphogenesis  (IEA,ISO)
distal tubule development  (IEA,ISO)
endocardial cushion cell development  (IEA,ISO)
inhibition of neuroepithelial cell differentiation  (IEA,ISO)
inner ear auditory receptor cell differentiation  (IEA,IMP,ISO)
inner ear development  (ISO)
loop of Henle development  (IEA,ISO)
morphogenesis of an epithelial sheet  (IEA,ISO)
negative regulation of cell differentiation  (IDA)
negative regulation of cell migration  (IEA,ISO)
negative regulation of cell-cell adhesion  (IEA,ISO)
negative regulation of cell-matrix adhesion  (IEA,ISO)
negative regulation of endothelial cell differentiation  (IEA,ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of neuron differentiation  (IEA,ISO)
negative regulation of stem cell differentiation  (IEA,ISO)
nephron development  (ISO,ISS)
neuroendocrine cell differentiation  (IEA,ISO)
neuron differentiation  (ISO)
neuronal stem cell population maintenance  (IEA,ISO)
Notch signaling pathway  (IDA,IEA,IMP,ISO)
podocyte development  (IEA,ISO,ISS)
positive regulation of cardiac epithelial to mesenchymal transition  (IGI)
positive regulation of gene expression  (IGI)
positive regulation of myeloid cell differentiation  (IEA,ISO)
positive regulation of Notch signaling pathway  (IEA,ISO,ISS)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
pulmonary artery morphogenesis  (IEA,ISO)
pulmonary valve morphogenesis  (IEA,ISO)
regulation of cell population proliferation  (IMP)
regulation of epithelial cell proliferation  (IEA,ISO)
regulation of reproductive process  (IEA)
response to muramyl dipeptide  (IEA,ISO)
T cell mediated immunity  (IEA,ISO)
wound healing  (IEP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans. Ban M, etal., J Neuroimmunol. 2006 Oct;179(1-2):108-16. Epub 2006 Aug 24.
2. Soluble Jagged-1 inhibits neointima formation by attenuating Notch-Herp2 signaling. Caolo V, etal., Arterioscler Thromb Vasc Biol. 2011 May;31(5):1059-65. Epub 2011 Feb 17.
3. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. Chen AC, etal., J Biol Chem. 2010 Apr 9;285(15):11378-91. doi: 10.1074/jbc.M109.088815. Epub 2010 Feb 9.
4. The pattern of expression of Notch protein members in normal and pathological endometrium. Cobellis L, etal., J Anat. 2008 Aug 4.
5. Familial Tetralogy of Fallot caused by mutation in the jagged1 gene. Eldadah ZA, etal., Hum Mol Genet. 2001 Jan 15;10(2):163-9.
6. JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. Elyaman W, etal., J Immunol. 2007 Nov 1;179(9):5990-8.
7. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Differential effects of targeting Notch receptors in a mouse model of liver cancer. Huntzicker EG, etal., Hepatology. 2015 Mar;61(3):942-52. doi: 10.1002/hep.27566. Epub 2015 Jan 28.
10. Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands. Kakuda S and Haltiwanger RS, Dev Cell. 2017 Jan 23;40(2):193-201. doi: 10.1016/j.devcel.2016.12.013. Epub 2017 Jan 12.
11. Notch1, Jagged1, and HES5 are abundantly expressed in osteoarthritis. Karlsson C, etal., Cells Tissues Organs. 2008;188(3):287-98. Epub 2008 Mar 20.
12. Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells. Kijima M, etal., J Immunol. 2009 Mar 15;182(6):3566-72.
13. Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Kohler C, etal., Hepatology 2004 Apr;39(4):1056-65.
14. The expression profile of Jagged1 and Delta-like 4 in hepatocellular carcinoma. Kunanopparat A, etal., Asian Pac J Allergy Immunol. 2019 Jan 13. doi: 10.12932/AP-040818-0388.
15. Familial deafness, congenital heart defects, and posterior embryotoxon caused by cysteine substitution in the first epidermal-growth-factor-like domain of jagged 1. Le Caignec C, etal., Am J Hum Genet. 2002 Jul;71(1):180-6. Epub 2002 May 17.
16. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Li L, etal., Nat Genet. 1997 Jul;16(3):243-51.
17. Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Lindner V, etal., Am J Pathol. 2001 Sep;159(3):875-83. doi: 10.1016/S0002-9440(10)61763-4.
18. Jagged: a mammalian ligand that activates Notch1. Lindsell CE, etal., Cell 1995 Mar 24;80(6):909-17.
19. NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling. McBride KL, etal., Hum Mol Genet. 2008 Sep 15;17(18):2886-93. doi: 10.1093/hmg/ddn187. Epub 2008 Jun 30.
20. Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling. Meng H, etal., J Biol Chem. 2010 Jul 23;285(30):23047-55. doi: 10.1074/jbc.M110.144634. Epub 2010 May 14.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy. Miloudi K, etal., Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12. Oda T, etal., Genomics. 1997 Aug 1;43(3):376-9.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. Alagille syndrome and the Jagged1 gene. Piccoli DA and Spinner NB, Semin Liver Dis. 2001 Nov;21(4):525-34.
27. Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis. Piggott K, etal., Circulation. 2011 Jan 25;123(3):309-18. Epub 2011 Jan 10.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. Oxidative stress-induced apoptosis in two patients with Alagille syndrome. Radi E, etal., J Neurol Sci. 2011 Sep 15;308(1-2):49-56. Epub 2011 Jun 28.
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT. Riley MF, etal., Biochim Biophys Acta. 2011 Jan;1812(1):121-9. doi: 10.1016/j.bbadis.2010.10.002. Epub 2010 Oct 14.
35. Proteomics comparison of cerebrospinal fluid of relapsing remitting and primary progressive multiple sclerosis. Stoop MP, etal., PLoS One. 2010 Aug 27;5(8):e12442.
36. Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway. Su Y, etal., J Gastrointest Surg. 2006 Nov;10(9):1230-41; discussion 1242.
37. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
38. Notch4 and Jagged-1 induce microvessel differentiation of rat brain endothelial cells. Uyttendaele H, etal., Microvasc Res 2000 Sep;60(2):91-103.
39. Ozzy, a Jag1 vestibular mouse mutant, displays characteristics of Alagille syndrome. Vrijens K, etal., Neurobiol Dis. 2006 Oct;24(1):28-40. Epub 2006 Jul 26.
40. Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate. Wang SY, etal., Neuroscience. 2015 Aug 20;301:276-88. doi: 10.1016/j.neuroscience.2015.06.002. Epub 2015 Jun 8.
41. The expression levels of Notch-related signaling molecules in pulmonary microvascular endothelial cells in bleomycin-induced rat pulmonary fibrosis. Yin Q, etal., Physiol Res. 2017 May 4;66(2):305-315. doi: 10.33549/physiolres.933356. Epub 2016 Dec 16.
42. Notch signaling regulates the pattern of auditory hair cell differentiation in mammals. Zine A, etal., Development. 2000 Aug;127(15):3373-83.
Additional References at PubMed
PMID:8923452   PMID:8955070   PMID:9207787   PMID:9707552   PMID:10196361   PMID:10329626   PMID:10551863   PMID:10679295   PMID:10958687   PMID:11006133   PMID:11067884   PMID:11181574  
PMID:11427524   PMID:11861489   PMID:12107827   PMID:15060169   PMID:15064243   PMID:15574878   PMID:15821257   PMID:15845452   PMID:16000382   PMID:16378597   PMID:16413496   PMID:16495313  
PMID:16647886   PMID:17475842   PMID:17761753   PMID:18079106   PMID:18449946   PMID:18781453   PMID:19389353   PMID:19481073   PMID:19503073   PMID:19509466   PMID:19682396   PMID:20081190  
PMID:20437614   PMID:21156799   PMID:22465068   PMID:23046039   PMID:23086448   PMID:23232913   PMID:23331119   PMID:23595520   PMID:23676271   PMID:23775982   PMID:23806616   PMID:23980096  
PMID:24667410   PMID:24715457   PMID:24866722   PMID:24907271   PMID:25406395   PMID:25446530   PMID:25535084   PMID:25660475   PMID:26276215   PMID:28163178   PMID:28776666   PMID:30134210  
PMID:31585906   PMID:33049352   PMID:34269482   PMID:34755661  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83144,859,453 - 144,894,883 (-)NCBIGRCr8
mRatBN7.23124,406,783 - 124,442,220 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3124,406,794 - 124,442,209 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3128,293,948 - 128,329,348 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03136,870,930 - 136,906,325 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03134,556,899 - 134,592,326 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03130,079,361 - 130,114,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3130,079,361 - 130,114,770 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03136,558,688 - 136,594,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43125,181,063 - 125,216,481 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13125,086,635 - 125,122,054 (-)NCBI
Celera3123,126,087 - 123,161,497 (-)NCBICelera
Cytogenetic Map3q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382010,637,684 - 10,673,999 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2010,637,684 - 10,673,999 (-)EnsemblGRCh38hg38GRCh38
GRCh372010,618,332 - 10,654,647 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362010,566,334 - 10,602,590 (-)NCBINCBI36Build 36hg18NCBI36
Build 342010,566,333 - 10,602,590NCBI
Celera2010,688,304 - 10,724,650 (-)NCBICelera
Cytogenetic Map20p12.2NCBI
HuRef2010,569,771 - 10,606,135 (-)NCBIHuRef
CHM1_12010,618,904 - 10,655,234 (-)NCBICHM1_1
T2T-CHM13v2.02010,680,698 - 10,717,017 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392136,923,371 - 136,958,440 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2136,923,376 - 136,958,564 (-)EnsemblGRCm39 Ensembl
GRCm382137,081,451 - 137,116,520 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2137,081,456 - 137,116,644 (-)EnsemblGRCm38mm10GRCm38
MGSCv372136,907,194 - 136,942,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362136,772,899 - 136,807,772 (-)NCBIMGSCv36mm8
Celera2138,273,274 - 138,308,181 (-)NCBICelera
Cytogenetic Map2F3NCBI
cM Map267.73NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541520,490,414 - 20,527,917 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541520,490,414 - 20,526,068 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v22111,508,727 - 11,544,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12011,505,265 - 11,541,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02010,582,234 - 10,618,507 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12010,582,094 - 10,618,383 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2010,582,094 - 10,618,383 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12411,656,926 - 11,693,146 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2411,657,416 - 11,692,199 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2411,476,448 - 11,510,591 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02412,068,191 - 12,103,901 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2412,068,190 - 12,103,063 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12411,675,811 - 11,709,929 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02411,775,152 - 11,810,791 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02412,117,643 - 12,153,536 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640160,426,337 - 160,462,907 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364858,857,669 - 8,895,315 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364858,857,688 - 8,894,270 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1719,591,259 - 19,629,641 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11719,591,248 - 19,629,659 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21722,066,099 - 22,104,519 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1227,484,699 - 27,521,108 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,484,760 - 27,522,504 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607117,075,556 - 17,111,911 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474111,647,463 - 11,683,488 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474111,647,723 - 11,683,137 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Jag1
124 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:824
Count of miRNA genes:304
Interacting mature miRNAs:416
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23124,406,834 - 124,406,997 (+)MAPPERmRatBN7.2
Rnor_6.03130,079,402 - 130,079,564NCBIRnor6.0
Rnor_5.03136,558,729 - 136,558,891UniSTSRnor5.0
RGSC_v3.43125,181,104 - 125,181,266UniSTSRGSC3.4
Celera3123,126,128 - 123,126,290UniSTS
RH 3.4 Map31118.4UniSTS
Cytogenetic Map3q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23124,408,780 - 124,410,360 (+)MAPPERmRatBN7.2
Rnor_6.03130,081,348 - 130,082,927NCBIRnor6.0
Rnor_5.03136,560,675 - 136,562,254UniSTSRnor5.0
RGSC_v3.43125,183,050 - 125,184,629UniSTSRGSC3.4
Celera3123,128,068 - 123,129,647UniSTS
Cytogenetic Map3q36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 17 3 11 2 2 32 35 34 11 2
Low 2 26 54 41 8 41 6 9 42 7 6
Below cutoff


RefSeq Acc Id: ENSRNOT00000010638   ⟹   ENSRNOP00000010638
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3124,406,794 - 124,442,209 (-)Ensembl
Rnor_6.0 Ensembl3130,079,361 - 130,114,770 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094546   ⟹   ENSRNOP00000097522
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3124,406,794 - 124,442,209 (-)Ensembl
RefSeq Acc Id: NM_019147   ⟹   NP_062020
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr83144,859,453 - 144,894,883 (-)NCBI
mRatBN7.23124,406,783 - 124,442,220 (-)NCBI
Rnor_6.03130,079,361 - 130,114,781 (-)NCBI
Rnor_5.03136,558,688 - 136,594,108 (-)NCBI
RGSC_v3.43125,181,063 - 125,216,481 (-)RGD
Celera3123,126,087 - 123,161,497 (-)RGD
Protein Sequences
Protein RefSeqs NP_062020 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB06509 (Get FASTA)   NCBI Sequence Viewer  
  EDL80309 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010638
GenBank Protein Q63722 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062020   ⟸   NM_019147
- Peptide Label: precursor
- UniProtKB: Q63722 (UniProtKB/Swiss-Prot),   P70640 (UniProtKB/Swiss-Prot),   G3V710 (UniProtKB/TrEMBL),   A6HQK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010638   ⟸   ENSRNOT00000010638
RefSeq Acc Id: ENSRNOP00000097522   ⟸   ENSRNOT00000094546
Protein Domains
DSL   EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63722-F1-model_v2 AlphaFold Q63722 1-1219 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2937 AgrOrtholog
BioCyc Gene G2FUF-47707 BioCyc
Ensembl Genes ENSRNOG00000007443 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010638 ENTREZGENE
  ENSRNOT00000010638.8 UniProtKB/TrEMBL
  ENSRNOT00000094546.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jagged/Serrate UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_ligand_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29146 UniProtKB/Swiss-Prot
Pfam DL-JAG_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MNNL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Jag1 PhenoGen
  DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007443 RatGTEx
SMART DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC_out UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208615
  JAG1_RAT UniProtKB/Swiss-Prot
UniProt Secondary P70640 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Jag1  jagged canonical Notch ligand 1  Jag1  jagged 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Jag1  jagged 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds with Notch and helps in keeping mammalian cells in an undifferentiated state 69863