Jag1 (jagged 1) - Rat Genome Database

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Gene: Jag1 (jagged 1) Mus musculus
Analyze
Symbol: Jag1
Name: jagged 1
RGD ID: 735466
MGI Page MGI
Description: Enables Notch binding activity. Involved in several processes, including circulatory system development; nephron epithelium development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including ciliary body morphogenesis; negative regulation of cell differentiation; and positive regulation of cell differentiation. Located in adherens junction and apical plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study Alagille syndrome. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ABE; ABE2; Gena228; Gsfab; Gsfabe2; Headtu; Headturner; Htu; Oz; Ozz; protein jagged-1; Ser-1; Serra; Serrate-1; slalom
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392136,923,371 - 136,958,440 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2136,923,376 - 136,958,564 (-)EnsemblGRCm39 Ensembl
GRCm382137,081,451 - 137,116,520 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2137,081,456 - 137,116,644 (-)EnsemblGRCm38mm10GRCm38
MGSCv372136,907,194 - 136,942,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362136,772,899 - 136,807,772 (-)NCBIMGSCv36mm8
Celera2138,273,274 - 138,308,181 (-)NCBICelera
Cytogenetic Map2F3NCBI
cM Map267.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,4-benzoquinone  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
9-phenanthrol  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (ISO)
celastrol  (ISO)
chloropicrin  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
DAPT  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
enzacamene  (ISO)
enzalutamide  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
flavonoids  (ISO)
fluoxetine  (ISO)
formaldehyde  (ISO)
furan  (ISO)
gedunin  (ISO)
genistein  (EXP)
gentamycin  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hypochlorous acid  (EXP)
indometacin  (ISO)
L-ascorbic acid  (EXP)
leflunomide  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
mechlorethamine  (EXP)
menadione  (ISO)
mercury dichloride  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N(6)-dimethylallyladenine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
pinosylvin  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP)
sodium fluoride  (EXP)
succimer  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetracycline  (EXP)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trans-pinosylvin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (EXP)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zearalenone  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IMP)
animal organ regeneration  (ISO)
aorta morphogenesis  (IMP)
blood vessel remodeling  (IMP)
camera-type eye development  (IMP)
cardiac neural crest cell development involved in outflow tract morphogenesis  (IMP)
cardiac right ventricle morphogenesis  (IMP)
cardiac septum morphogenesis  (IMP)
cell communication  (IEA)
ciliary body morphogenesis  (IMP)
distal tubule development  (IEP)
endocardial cushion cell development  (IMP)
inhibition of neuroepithelial cell differentiation  (IMP)
inner ear auditory receptor cell differentiation  (IMP,ISO)
inner ear development  (IMP)
loop of Henle development  (IEP)
morphogenesis of an epithelial sheet  (IMP)
negative regulation of cell differentiation  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of cell-matrix adhesion  (ISO)
negative regulation of endothelial cell differentiation  (IDA)
negative regulation of fat cell differentiation  (IDA)
negative regulation of neuron differentiation  (IMP)
negative regulation of stem cell differentiation  (ISO)
nephron development  (IMP)
neuroendocrine cell differentiation  (IMP)
neuron differentiation  (IMP)
neuronal stem cell population maintenance  (ISO)
Notch signaling involved in heart development  (IMP,ISO)
Notch signaling pathway  (IDA,IGI,ISO,TAS)
podocyte development  (IMP)
positive regulation of cardiac epithelial to mesenchymal transition  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of myeloid cell differentiation  (IDA)
positive regulation of Notch signaling pathway  (IDA)
positive regulation of osteoblast differentiation  (IDA)
positive regulation of transcription by RNA polymerase II  (IMP,ISO)
pulmonary artery morphogenesis  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of epithelial cell proliferation  (IGI)
regulation of reproductive process  (IGI)
response to muramyl dipeptide  (IDA)
T cell mediated immunity  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal anterior eye segment morphology  (IAGP)
abnormal aorta morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal bile duct development  (IAGP)
abnormal bile duct morphology  (IAGP)
abnormal bile secretion  (IAGP)
abnormal biliary tract morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal cardiac epithelial to mesenchymal transition  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cholangiocyte morphology  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear hair cell morphology  (IAGP)
abnormal cochlear hair cell number  (IAGP)
abnormal cochlear outer hair cell morphology  (IAGP)
abnormal cochlear sensory epithelium morphology  (IAGP)
abnormal coronary vessel morphology  (IAGP)
abnormal crista ampullaris morphology  (IAGP)
abnormal eating behavior  (IAGP)
abnormal eye morphology  (IAGP)
abnormal feces composition  (IAGP)
abnormal glomerular capillary morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart valve morphology  (IAGP)
abnormal inner ear canal morphology  (IAGP)
abnormal iris morphology  (IAGP)
abnormal lateral semicircular canal morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal liver vasculature morphology  (IAGP)
abnormal nephron morphogenesis  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal palate morphology  (IAGP)
abnormal placement of pupils  (IAGP)
abnormal posterior semicircular canal morphology  (IAGP)
abnormal postnatal subventricular zone morphology  (IAGP)
abnormal primary palate development  (IAGP)
abnormal pulmonary trunk morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal rostral migratory stream morphology  (IAGP)
abnormal semicircular canal ampulla morphology  (IAGP)
abnormal semicircular canal morphology  (IAGP)
abnormal superior semicircular canal morphology  (IAGP)
abnormal utricular macula morphology  (IAGP)
abnormal vascular branching morphogenesis  (IAGP)
abnormal vascular development  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vestibular saccule morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent cochlear hair cells  (IAGP)
absent cochlear outer hair cells  (IAGP)
absent podocytes  (IAGP)
absent semicircular canals  (IAGP)
absent tunnel of Corti  (IAGP)
absent vestibular hair cells  (IAGP)
alopecia  (IAGP)
atrial septal defect  (IAGP)
bile duct proliferation  (IAGP)
calcified aortic valve  (IAGP)
cholestasis  (IAGP)
circling  (IAGP)
corneal opacity  (IAGP)
cyanosis  (IAGP)
decreased angiogenesis  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating serum albumin level  (IAGP)
decreased cochlear coiling  (IAGP)
decreased cochlear outer hair cell number  (IAGP)
decreased embryo size  (IAGP)
decreased nephron number  (IAGP)
decreased neuronal precursor cell number  (IAGP)
decreased palatal length  (IAGP)
decreased renal glomerulus number  (IAGP)
dilated bile duct  (IAGP)
dilated heart  (IAGP)
distended pericardium  (IAGP)
embryo tissue necrosis  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged heart right atrium  (IAGP)
enlarged pericardium  (IAGP)
fetal growth retardation  (IAGP)
head bobbing  (IAGP)
head shaking  (IAGP)
head tossing  (IEA)
heart right ventricle hypertrophy  (IAGP)
hemorrhage  (IAGP)
hepatic necrosis  (IAGP)
impaired balance  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating bilirubin level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating gamma-glutamyl transferase level  (IAGP)
increased circulating lactate dehydrogenase level  (IAGP)
increased cochlear inner hair cell number  (IAGP)
increased heart right ventricle size  (IAGP)
increased neuron number  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
intracranial hemorrhage  (IAGP)
iris coloboma  (IAGP)
irregularly shaped pupil  (IAGP)
jaundice  (IAGP)
kidney microaneurysm  (IAGP)
kinked neural tube  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lethality, incomplete penetrance  (IAGP)
lethargy  (IAGP)
liver hemorrhage  (IAGP)
malocclusion  (IAGP)
microphthalmia  (IAGP)
midface hypoplasia  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
overriding aortic valve  (IAGP)
pale yolk sac  (IAGP)
pallor  (IAGP)
patent ductus arteriosus  (IAGP)
pericardial edema  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
positive geotaxis  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
pulmonary artery stenosis  (IAGP)
pulmonary valve regurgitation  (IAGP)
pulmonary valve stenosis  (IAGP)
retroesophageal right subclavian artery  (IAGP)
short maxilla  (IAGP)
short snout  (IAGP)
slow postnatal weight gain  (IAGP)
small kidney  (IAGP)
small lens  (IAGP)
small utricle  (IAGP)
thick heart valve cusps  (IAGP)
thick ventricular wall  (IAGP)
ventricular hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans. Ban M, etal., J Neuroimmunol. 2006 Oct;179(1-2):108-16. Epub 2006 Aug 24.
2. Soluble Jagged-1 inhibits neointima formation by attenuating Notch-Herp2 signaling. Caolo V, etal., Arterioscler Thromb Vasc Biol. 2011 May;31(5):1059-65. Epub 2011 Feb 17.
3. The pattern of expression of Notch protein members in normal and pathological endometrium. Cobellis L, etal., J Anat. 2008 Aug 4.
4. Familial Tetralogy of Fallot caused by mutation in the jagged1 gene. Eldadah ZA, etal., Hum Mol Genet. 2001 Jan 15;10(2):163-9.
5. JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. Elyaman W, etal., J Immunol. 2007 Nov 1;179(9):5990-8.
6. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
7. Differential effects of targeting Notch receptors in a mouse model of liver cancer. Huntzicker EG, etal., Hepatology. 2015 Mar;61(3):942-52. doi: 10.1002/hep.27566. Epub 2015 Jan 28.
8. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Johnston SH, etal., Development 1997 Jun;124(11):2245-54.
9. Notch1, Jagged1, and HES5 are abundantly expressed in osteoarthritis. Karlsson C, etal., Cells Tissues Organs. 2008;188(3):287-98. Epub 2008 Mar 20.
10. Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells. Kijima M, etal., J Immunol. 2009 Mar 15;182(6):3566-72.
11. Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Kohler C, etal., Hepatology 2004 Apr;39(4):1056-65.
12. The expression profile of Jagged1 and Delta-like 4 in hepatocellular carcinoma. Kunanopparat A, etal., Asian Pac J Allergy Immunol. 2019 Jan 13. doi: 10.12932/AP-040818-0388.
13. Familial deafness, congenital heart defects, and posterior embryotoxon caused by cysteine substitution in the first epidermal-growth-factor-like domain of jagged 1. Le Caignec C, etal., Am J Hum Genet. 2002 Jul;71(1):180-6. Epub 2002 May 17.
14. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. MGD IEA MGD IEA
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Alagille syndrome and the Jagged1 gene. Piccoli DA and Spinner NB, Semin Liver Dis. 2001 Nov;21(4):525-34.
19. Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis. Piggott K, etal., Circulation. 2011 Jan 25;123(3):309-18. Epub 2011 Jan 10.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. Oxidative stress-induced apoptosis in two patients with Alagille syndrome. Radi E, etal., J Neurol Sci. 2011 Sep 15;308(1-2):49-56. Epub 2011 Jun 28.
23. Mouse MP Annotation Import Pipeline RGD automated import pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Proteomics comparison of cerebrospinal fluid of relapsing remitting and primary progressive multiple sclerosis. Stoop MP, etal., PLoS One. 2010 Aug 27;5(8):e12442.
27. Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway. Su Y, etal., J Gastrointest Surg. 2006 Nov;10(9):1230-41; discussion 1242.
28. Ozzy, a Jag1 vestibular mouse mutant, displays characteristics of Alagille syndrome. Vrijens K, etal., Neurobiol Dis. 2006 Oct;24(1):28-40. Epub 2006 Jul 26.
29. Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate. Wang SY, etal., Neuroscience. 2015 Aug 20;301:276-88. doi: 10.1016/j.neuroscience.2015.06.002. Epub 2015 Jun 8.
Additional References at PubMed
PMID:8889548   PMID:8923452   PMID:8955070   PMID:9108364   PMID:9207787   PMID:9207788   PMID:9207795   PMID:9272948   PMID:9315901   PMID:9463360   PMID:9690472   PMID:9716576  
PMID:9858718   PMID:9858728   PMID:9889000   PMID:10196361   PMID:10329626   PMID:10330372   PMID:10349636   PMID:10383933   PMID:10473135   PMID:10476967   PMID:10551863   PMID:10556292  
PMID:10615124   PMID:10679295   PMID:10837027   PMID:10837254   PMID:10842072   PMID:10878608   PMID:10906776   PMID:10958687   PMID:11042159   PMID:11044610   PMID:11067884   PMID:11076861  
PMID:11118901   PMID:11171333   PMID:11181574   PMID:11217851   PMID:11259677   PMID:11344305   PMID:11427524   PMID:11528388   PMID:11549580   PMID:11578869   PMID:11713346   PMID:11807030  
PMID:11841846   PMID:11861489   PMID:11934853   PMID:11937492   PMID:11944948   PMID:11960707   PMID:12010793   PMID:12122015   PMID:12167404   PMID:12175503   PMID:12194867   PMID:12242716  
PMID:12244550   PMID:12244551   PMID:12244553   PMID:12397111   PMID:12441287   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12617809   PMID:12642503   PMID:12697902   PMID:12787792  
PMID:12835383   PMID:12846471   PMID:12866128   PMID:12904583   PMID:12971992   PMID:14651921   PMID:14701881   PMID:14702043   PMID:14732396   PMID:14757642   PMID:14960276   PMID:14988227  
PMID:15060169   PMID:15064243   PMID:15068794   PMID:15149848   PMID:15161092   PMID:15215207   PMID:15226394   PMID:15242798   PMID:15465493   PMID:15465494   PMID:15486060   PMID:15489334  
PMID:15499562   PMID:15543141   PMID:15550486   PMID:15574878   PMID:15578515   PMID:15634680   PMID:15659488   PMID:15689374   PMID:15788413   PMID:15821257   PMID:15845452   PMID:15875024  
PMID:15882997   PMID:15905075   PMID:15939383   PMID:15979417   PMID:16000382   PMID:16061358   PMID:16141072   PMID:16141073   PMID:16163386   PMID:16169709   PMID:16226707   PMID:16245338  
PMID:16324690   PMID:16378597   PMID:16410827   PMID:16412699   PMID:16495313   PMID:16518823   PMID:16524929   PMID:16554359   PMID:16602821   PMID:16621624   PMID:16647886   PMID:16678147  
PMID:16736472   PMID:16867989   PMID:16908629   PMID:16914494   PMID:16973960   PMID:17015435   PMID:17021047   PMID:17035290   PMID:17141159   PMID:17196193   PMID:17229764   PMID:17257418  
PMID:17273555   PMID:17303760   PMID:17366661   PMID:17400206   PMID:17476283   PMID:17572911   PMID:17576802   PMID:17625108   PMID:17626181   PMID:17685488   PMID:17709399   PMID:17714700  
PMID:17823936   PMID:17880938   PMID:17890364   PMID:17960184   PMID:18093989   PMID:18157569   PMID:18159948   PMID:18184658   PMID:18214313   PMID:18226990   PMID:18245384   PMID:18287559  
PMID:18291358   PMID:18292500   PMID:18365007   PMID:18383037   PMID:18404215   PMID:18495817   PMID:18505817   PMID:18515089   PMID:18528438   PMID:18588871   PMID:18591437   PMID:18618131  
PMID:18632939   PMID:18688026   PMID:18694942   PMID:18832397   PMID:18848976   PMID:19011097   PMID:19026002   PMID:19050233   PMID:19100252   PMID:19147503   PMID:19185577   PMID:19191219  
PMID:19208348   PMID:19217325   PMID:19223466   PMID:19325125   PMID:19327148   PMID:19369401   PMID:19389353   PMID:19389370   PMID:19389377   PMID:19403103   PMID:19501082   PMID:19501159  
PMID:19502490   PMID:19509466   PMID:19524514   PMID:19590010   PMID:19598246   PMID:19667086   PMID:19686682   PMID:19723505   PMID:19734891   PMID:19748502   PMID:19783740   PMID:19855135  
PMID:19865483   PMID:19897741   PMID:19898483   PMID:19914171   PMID:19914235   PMID:19935714   PMID:20007915   PMID:20017954   PMID:20038814   PMID:20058045   PMID:20079214   PMID:20081190  
PMID:20154142   PMID:20230750   PMID:20335360   PMID:20388655   PMID:20510365   PMID:20558824   PMID:20568246   PMID:20602435   PMID:20627076   PMID:20628038   PMID:20652952   PMID:20720151  
PMID:20727173   PMID:20727876   PMID:20733081   PMID:20798046   PMID:20805985   PMID:20808958   PMID:20870935   PMID:20940224   PMID:21062863   PMID:21068062   PMID:21068310   PMID:21074523  
PMID:21118511   PMID:21124801   PMID:21145498   PMID:21156172   PMID:21156799   PMID:21216305   PMID:21238454   PMID:21252157   PMID:21267068   PMID:21295524   PMID:21302255   PMID:21311046  
PMID:21328691   PMID:21352545   PMID:21386911   PMID:21402699   PMID:21402740   PMID:21420948   PMID:21421844   PMID:21472479   PMID:21472480   PMID:21490058   PMID:21491542   PMID:21532573  
PMID:21562282   PMID:21632926   PMID:21633169   PMID:21680900   PMID:21693521   PMID:21712044   PMID:21731673   PMID:21750033   PMID:21779340   PMID:21791528   PMID:21793101   PMID:21839733  
PMID:21873635   PMID:21888903   PMID:21905163   PMID:21912175   PMID:21929743   PMID:21959220   PMID:22028443   PMID:22096075   PMID:22147907   PMID:22156581   PMID:22159122   PMID:22173065  
PMID:22235191   PMID:22274697   PMID:22275127   PMID:22292060   PMID:22390640   PMID:22432025   PMID:22452482   PMID:22464328   PMID:22504165   PMID:22652674   PMID:22675208   PMID:22675211  
PMID:22705977   PMID:22753939   PMID:22783020   PMID:22887872   PMID:22902740   PMID:22932389   PMID:22998557   PMID:22999937   PMID:23095891   PMID:23123965   PMID:23160044   PMID:23192966  
PMID:23197537   PMID:23213461   PMID:23223237   PMID:23226461   PMID:23267012   PMID:23314057   PMID:23329048   PMID:23362348   PMID:23362349   PMID:23371561   PMID:23386589   PMID:23467742  
PMID:23487309   PMID:23489689   PMID:23526493   PMID:23530123   PMID:23555292   PMID:23560082   PMID:23567106   PMID:23604320   PMID:23614009   PMID:23630352   PMID:23665443   PMID:23666531  
PMID:23676271   PMID:23699523   PMID:23754280   PMID:23761906   PMID:23806616   PMID:23813480   PMID:23833236   PMID:23863842   PMID:23980096   PMID:23988635   PMID:24012753   PMID:24015274  
PMID:24098521   PMID:24148613   PMID:24153254   PMID:24191040   PMID:24257627   PMID:24391519   PMID:24391948   PMID:24398584   PMID:24429522   PMID:24465223   PMID:24478388   PMID:24491691  
PMID:24530424   PMID:24550112   PMID:24552588   PMID:24598167   PMID:24647000   PMID:24651014   PMID:24667410   PMID:24673559   PMID:24706781   PMID:24711412   PMID:24715457   PMID:24859004  
PMID:24907271   PMID:24952961   PMID:24982181   PMID:24990151   PMID:25057208   PMID:25100656   PMID:25168025   PMID:25257302   PMID:25283993   PMID:25318679   PMID:25401743   PMID:25406395  
PMID:25446530   PMID:25499214   PMID:25535084   PMID:25535917   PMID:25564622   PMID:25624266   PMID:25641696   PMID:25691540   PMID:25715395   PMID:25725069   PMID:25767274   PMID:25778822  
PMID:25803581   PMID:25804736   PMID:25825216   PMID:25890330   PMID:25915623   PMID:25916881   PMID:25919081   PMID:26116661   PMID:26160903   PMID:26177727   PMID:26191142   PMID:26209882  
PMID:26213336   PMID:26228240   PMID:26235536   PMID:26238476   PMID:26249804   PMID:26253400   PMID:26276215   PMID:26286942   PMID:26324903   PMID:26465397   PMID:26479710   PMID:26491108  
PMID:26507745   PMID:26527653   PMID:26542370   PMID:26552887   PMID:26577899   PMID:26641715   PMID:26658320   PMID:26697723   PMID:26745185   PMID:26779814   PMID:26786414   PMID:26884396  
PMID:26939553   PMID:27036007   PMID:27050391   PMID:27056911   PMID:27129289   PMID:27246713   PMID:27354375   PMID:27407072   PMID:27416809   PMID:27510977   PMID:27531557   PMID:27559308  
PMID:27591083   PMID:27596755   PMID:27606604   PMID:27631609   PMID:27633988   PMID:27633993   PMID:27641601   PMID:27659682   PMID:27719760   PMID:27869648   PMID:27922003   PMID:27930960  
PMID:27939883   PMID:27966429   PMID:27974206   PMID:28027303   PMID:28036337   PMID:28045060   PMID:28051360   PMID:28089369   PMID:28139517   PMID:28192800   PMID:28277610   PMID:28402857  
PMID:28438836   PMID:28455376   PMID:28537242   PMID:28561022   PMID:28566723   PMID:28577314   PMID:28656980   PMID:28699891   PMID:28714968   PMID:28760814   PMID:28779009   PMID:28794157  
PMID:28838968   PMID:28848392   PMID:28863329   PMID:28924218   PMID:28952437   PMID:29031500   PMID:29093270   PMID:29113990   PMID:29126263   PMID:29140246   PMID:29141232   PMID:29162437  
PMID:29199954   PMID:29217079   PMID:29360039   PMID:29367466   PMID:29449451   PMID:29449453   PMID:29459093   PMID:29507213   PMID:29627423   PMID:29712641   PMID:29791855   PMID:29853617  
PMID:29879109   PMID:29891551   PMID:29956664   PMID:29961574   PMID:30010003   PMID:30046000   PMID:30059908   PMID:30065304   PMID:30067986   PMID:30075174   PMID:30168730   PMID:30179592  
PMID:30188892   PMID:30220568   PMID:30226866   PMID:30418664   PMID:30518531   PMID:30529759   PMID:30580328   PMID:30758286   PMID:30796970   PMID:30929920   PMID:30930165   PMID:30943054  
PMID:30991836   PMID:31071093   PMID:31076486   PMID:31112136   PMID:31142573   PMID:31202705   PMID:31220272   PMID:31273345   PMID:31323030   PMID:31345231   PMID:31373354   PMID:31412026  
PMID:31469182   PMID:31504280   PMID:31590629   PMID:31591643   PMID:31609444   PMID:31631837   PMID:31673056   PMID:31685872   PMID:31704879   PMID:31789590   PMID:31814023   PMID:31843520  
PMID:31896583   PMID:31896743   PMID:31913453   PMID:31988190   PMID:32043969   PMID:32059775   PMID:32065591   PMID:32141129   PMID:32147304   PMID:32161758   PMID:32176858   PMID:32324134  
PMID:32325033   PMID:32464196   PMID:32467237   PMID:32497091   PMID:32520726   PMID:32546759   PMID:32554463   PMID:32554809   PMID:32747435   PMID:32778568   PMID:32878924   PMID:33046710  
PMID:33113370   PMID:33127852   PMID:33268505   PMID:33378407   PMID:33454003   PMID:33505317   PMID:33635272   PMID:33830085   PMID:34032268   PMID:34189436   PMID:34233187   PMID:34252231  
PMID:34376651   PMID:34428401   PMID:34547456   PMID:34665379   PMID:34758082   PMID:34838591   PMID:34910918   PMID:34990407   PMID:35064244   PMID:35084365   PMID:35103284   PMID:35247391  
PMID:35263601   PMID:35297995   PMID:35337816   PMID:35349480   PMID:35781329   PMID:35815610   PMID:36044575  


Genomics

Comparative Map Data
Jag1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392136,923,371 - 136,958,440 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2136,923,376 - 136,958,564 (-)EnsemblGRCm39 Ensembl
GRCm382137,081,451 - 137,116,520 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2137,081,456 - 137,116,644 (-)EnsemblGRCm38mm10GRCm38
MGSCv372136,907,194 - 136,942,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362136,772,899 - 136,807,772 (-)NCBIMGSCv36mm8
Celera2138,273,274 - 138,308,181 (-)NCBICelera
Cytogenetic Map2F3NCBI
cM Map267.73NCBI
JAG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382010,637,684 - 10,673,999 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2010,637,684 - 10,673,999 (-)EnsemblGRCh38hg38GRCh38
GRCh372010,618,332 - 10,654,647 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362010,566,334 - 10,602,590 (-)NCBINCBI36Build 36hg18NCBI36
Build 342010,566,333 - 10,602,590NCBI
Celera2010,688,304 - 10,724,650 (-)NCBICelera
Cytogenetic Map20p12.2NCBI
HuRef2010,569,771 - 10,606,135 (-)NCBIHuRef
CHM1_12010,618,904 - 10,655,234 (-)NCBICHM1_1
T2T-CHM13v2.02010,680,698 - 10,717,017 (-)NCBIT2T-CHM13v2.0
Jag1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23124,406,794 - 124,442,220 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3124,406,794 - 124,442,209 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3128,293,948 - 128,329,348 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03136,870,930 - 136,906,325 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03134,556,899 - 134,592,326 (-)NCBIRnor_WKY
Rnor_6.03130,079,361 - 130,114,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3130,079,361 - 130,114,770 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03136,558,688 - 136,594,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43125,181,063 - 125,216,481 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13125,086,635 - 125,122,054 (-)NCBI
Celera3123,126,087 - 123,161,497 (-)NCBICelera
Cytogenetic Map3q36NCBI
Jag1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541520,490,414 - 20,527,917 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541520,490,414 - 20,526,068 (-)NCBIChiLan1.0ChiLan1.0
JAG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12010,582,094 - 10,618,383 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2010,582,094 - 10,618,383 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02010,582,234 - 10,618,507 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JAG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12411,656,926 - 11,693,146 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2411,657,416 - 11,692,199 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2411,476,448 - 11,510,591 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02412,068,191 - 12,103,901 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2412,068,190 - 12,103,063 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12411,675,811 - 11,709,929 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02411,775,152 - 11,810,791 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02412,117,643 - 12,153,536 (+)NCBIUU_Cfam_GSD_1.0
Jag1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640160,426,337 - 160,462,907 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364858,857,688 - 8,894,270 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1719,591,259 - 19,629,641 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11719,591,248 - 19,629,659 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21722,066,099 - 22,104,519 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JAG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,484,699 - 27,521,108 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,484,760 - 27,522,504 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607117,075,556 - 17,111,911 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jag1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474111,647,463 - 11,683,488 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474111,647,723 - 11,683,137 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir200bmmu-miR-200b-3pOncomiRDBexternal_infoNANA21224848
Mir200bmmu-miR-200b-3pOncomiRDBexternal_infoNANA21224847
Mir200ammu-miR-200a-3pOncomiRDBexternal_infoNANA21224848
Mir200ammu-miR-200a-3pOncomiRDBexternal_infoNANA21224847
Mir124a-2mmu-miR-124-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19287386
Mir200cmmu-miR-200c-3pOncomiRDBexternal_infoNANA21224848
Mir200cmmu-miR-200c-3pOncomiRDBexternal_infoNANA21224847

Predicted Target Of
Summary Value
Count of predictions:726
Count of miRNA genes:433
Interacting mature miRNAs:539
Transcripts:ENSMUST00000028735, ENSMUST00000133640
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111173704145173821Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106233580140233729Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111623386145623526Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111173704145173821Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111173704145173821Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111173704145173821Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122207146142532135Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123231973148700377Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111551028145551163Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110489658144489807Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107255676141255676Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
13207586Mwmlpt2_mMorris water maze latency to platform, training, 2 (mouse)2131616184139216184Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112212746146213005Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112212746146213005Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112212746146213005Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
13207590Mwmlpa2_mMorris water maze latency to platform, all, 2 (mouse)2131616184139616184Mouse

Markers in Region
Jag1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv372136,909,197 - 136,910,751UniSTSGRCm37
MGSCv372136,907,363 - 136,907,612UniSTSGRCm37
Celera2138,273,443 - 138,273,692UniSTS
Celera2138,275,277 - 138,276,831UniSTS
Cytogenetic Map2F3UniSTS
cM Map277.0UniSTS
AW490567  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382137,081,566 - 137,081,686UniSTSGRCm38
MGSCv372136,907,302 - 136,907,422UniSTSGRCm37
Celera2138,273,382 - 138,273,502UniSTS
Cytogenetic Map2F3UniSTS
cM Map277.0UniSTS
Whitehead/MRC_RH21661.25UniSTS
PMC31145P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382137,096,024 - 137,096,265UniSTSGRCm38
MGSCv372136,921,760 - 136,922,001UniSTSGRCm37
Celera2138,287,840 - 138,288,081UniSTS
Cytogenetic Map2F3UniSTS
cM Map277.0UniSTS
Jag1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F3UniSTS
Jag1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382137,081,627 - 137,081,876UniSTSGRCm38
MGSCv372136,907,363 - 136,907,612UniSTSGRCm37
Celera2138,273,443 - 138,273,692UniSTS
Cytogenetic Map2F3UniSTS
Jag1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F3UniSTS
Jag1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382137,083,461 - 137,085,015UniSTSGRCm38
MGSCv372136,909,197 - 136,910,751UniSTSGRCm37
Celera2138,275,277 - 138,276,831UniSTS
Cytogenetic Map2F3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000028735   ⟹   ENSMUSP00000028735
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2136,923,376 - 136,958,564 (-)Ensembl
GRCm38.p6 Ensembl2137,081,456 - 137,116,644 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133640
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2136,924,813 - 136,927,869 (-)Ensembl
GRCm38.p6 Ensembl2137,082,893 - 137,085,949 (-)Ensembl
RefSeq Acc Id: NM_013822   ⟹   NP_038850
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392136,923,371 - 136,958,440 (-)NCBI
GRCm382137,081,451 - 137,116,520 (-)ENTREZGENE
MGSCv372136,907,194 - 136,942,067 (-)RGD
Celera2138,273,267 - 138,308,370 (-)ENTREZGENE
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011239312   ⟹   XP_011237614
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392136,923,376 - 136,955,215 (-)NCBI
GRCm382137,081,456 - 137,113,297 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038850   ⟸   NM_013822
- Peptide Label: precursor
- UniProtKB: Q9QXX0 (UniProtKB/Swiss-Prot),   Q3UVN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011237614   ⟸   XM_011239312
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000028735   ⟸   ENSMUST00000028735
Protein Domains
DSL   EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QXX0-F1-model_v2 AlphaFold Q9QXX0 1-1218 view protein structure

Promoters
RGD ID:6831644
Promoter ID:MM_KWN:31937
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   MEF_B6
Transcripts:OTTMUST00000036967
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362136,911,534 - 136,912,034 (-)MPROMDB
RGD ID:6831643
Promoter ID:MM_KWN:31938
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000036966
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362136,941,926 - 136,943,072 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1095416 AgrOrtholog
Ensembl Genes ENSMUSG00000027276 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000028735 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028735 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jag1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jagged/Serrate UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_ligand_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16449 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1095416 ENTREZGENE
NCBI Gene 16449 ENTREZGENE
PANTHER PTHR24049:SF18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MNNL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB JAG1 RGD
PhenoGen Jag1 PhenoGen
PRINTS JAGGEDFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC_out UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt JAG1_MOUSE UniProtKB/Swiss-Prot
  Q3TS72_MOUSE UniProtKB/TrEMBL
  Q3UVN4 ENTREZGENE, UniProtKB/TrEMBL
  Q8C5M7_MOUSE UniProtKB/TrEMBL
  Q9QXX0 ENTREZGENE