RGD Reference Report - Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans. - Rat Genome Database

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Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans.

Authors: Ban, M  Booth, D  Heard, R  Stewart, G  Goris, A  Vandenbroeck, K  Dubois, B  Laaksonen, M  Ilonen, J  Alizadeh, M  Edan, G  Babron, MC  Brassat, D  Clanet, M  Cournu-Rebeix, I  Fontaine, B  Semana, G  Goedde, R  Epplen, J  Weber, A  Infante-Duarte, C  Zipp, F  Rajda, C  Bencsik, K  Vecsei, L  Heggarty, S  Graham, C  Hawkins, S  Liguori, M  Momigliano-Richiardi, P  Caputo, D  Grimaldi, LM  Leone, M  Massacesi, L  Milanese, C  Salvetti, M  Savettieri, G  Trojano, M  Bielecki, B  Mycko, MP  Selmaj, K  Santos, M  Maciel, P  Pereira, C  Silva, A  Silva, BM  Coraddu, F  Marrosu, MG  Akesson, E  Hillert, J  Datta, P  Oturai, A  Harbo, HF  Spurkland, A  Goertsches, R  Villoslada, P  Eraksoy, M  Hensiek, A  Compston, A  Setakis, E  Gray, J  Yeo, TW  Sawcer, S  Sawcer, Stephen 
Citation: Ban M, etal., J Neuroimmunol. 2006 Oct;179(1-2):108-16. Epub 2006 Aug 24.
RGD ID: 6482240
Pubmed: PMID:16934875   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jneuroim.2006.06.003   (Journal Full-text)

By combining all the data available from the Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES) project, we have been able to identify 17 microsatellite markers showing consistent evidence for apparent association. As might be expected five of these markers map within the Major Histocompatibility Complex (MHC) and are in LD with HLA-DRB1. Individual genotyping of the 12 non-MHC markers confirmed association for three of them--D11S1986, D19S552 and D20S894. Association mapping across the candidate genes implicated by these markers in 937 UK trio families revealed modestly associated haplotypes in JAG1 (p=0.019) on chromosome 20p12.2 and POU2AF1 (p=0.003) on chromosome 11q23.1.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
multiple sclerosis  IAGP 6482240 RGD 
multiple sclerosis  ISOJAG1 (Homo sapiens)6482240; 6482240 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Jag1  (jagged canonical Notch ligand 1)

Genes (Mus musculus)
Jag1  (jagged 1)

Genes (Homo sapiens)
JAG1  (jagged canonical Notch ligand 1)


Additional Information