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Gene: Aph1a (aph-1 homolog A, gamma secretase subunit) Rattus norvegicus
Symbol: Aph1a
Name: aph-1 homolog A, gamma secretase subunit
RGD ID: 1311546
Description: Predicted to have endopeptidase activity. Predicted to be involved in several processes, including Notch receptor processing; amyloid-beta formation; and proteolysis. Localizes to cytoplasmic vesicle; integral component of presynaptic membrane; and mitochondrion. Orthologous to human APH1A (aph-1 homolog A, gamma-secretase subunit); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; Alzheimer's disease pathway; INTERACTS WITH acrylamide; bisphenol A; cocaine.
Type: protein-coding
Also known as: anterior pharynx defective 1 homolog A; anterior pharynx defective 1 homolog A (C. elegans); anterior pharynx defective 1a homolog; anterior pharynx defective 1a homolog (C. elegans); APH1A gamma secretase subunit; gamma-secretase subunit APH-1A; LOC365872; RGD1311546; similar to Aph1a-pending protein
Homo sapiens (human) : APH1A (aph-1 homolog A, gamma-secretase subunit)  HGNC  Alliance
Mus musculus (house mouse) : Aph1a (aph1 homolog A, gamma secretase subunit)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aph1a (aph-1 homolog A, gamma-secretase subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : APH1A (aph-1 homolog A, gamma-secretase subunit)
Canis lupus familiaris (dog) : APH1A (aph-1 homolog A, gamma-secretase subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aph1a (aph-1 homolog A, gamma-secretase subunit)
Sus scrofa (pig) : APH1A (aph-1 homolog A, gamma-secretase subunit)
Chlorocebus sabaeus (African green monkey) : APH1A (aph-1 homolog A, gamma-secretase subunit)
Heterocephalus glaber (naked mole-rat) : Aph1a (aph-1 homolog A, gamma-secretase subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02198,006,247 - 198,009,837 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,006,316 - 198,009,830 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,496,424 - 217,499,992 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,679,692 - 190,683,202 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12190,642,445 - 190,645,954 (+)NCBI
Celera2175,967,700 - 175,971,210 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Aph1a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1311546
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.