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Gene: Aph1a (aph-1 homolog A, gamma secretase subunit) Rattus norvegicus
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Symbol: Aph1a
Name: aph-1 homolog A, gamma secretase subunit
Description: Predicted to have endopeptidase activity. Predicted to be involved in several processes, including Notch receptor processing; amyloid-beta formation; and proteolysis. Localizes to the cytoplasm and integral component of presynaptic membrane. Orthologous to human APH1A (aph-1 homolog A, gamma-secretase subunit); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; Alzheimer's disease pathway; INTERACTS WITH acrylamide; bisphenol A; cocaine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: anterior pharynx defective 1 homolog A; anterior pharynx defective 1 homolog A (C. elegans); anterior pharynx defective 1a homolog; anterior pharynx defective 1a homolog (C. elegans); APH1A gamma secretase subunit; gamma-secretase subunit APH-1A; LOC365872; RGD1311546; similar to Aph1a-pending protein
Orthologs:
Homo sapiens (human) : APH1A (aph-1 homolog A, gamma-secretase subunit)  HGNC  Alliance
Mus musculus (house mouse) : Aph1a (aph1 homolog A, gamma secretase subunit)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aph1a (aph-1 homolog A, gamma-secretase subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : APH1A (aph-1 homolog A, gamma-secretase subunit)
Canis lupus familiaris (dog) : APH1A (aph-1 homolog A, gamma-secretase subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aph1a (aph-1 homolog A, gamma-secretase subunit)
Sus scrofa (pig) : APH1A (aph-1 homolog A, gamma-secretase subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02198,006,247 - 198,009,837 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02217,496,424 - 217,499,992 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,679,692 - 190,683,202 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12190,642,445 - 190,645,954 (+)NCBI
Celera2175,967,700 - 175,971,210 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Aph1a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1311546
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.