Gucy1b1 (guanylate cyclase 1 soluble subunit beta 1)

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Gene: Gucy1b1 (guanylate cyclase 1 soluble subunit beta 1) Rattus norvegicus

Analyze

Symbol:

Gucy1b1

Name:

guanylate cyclase 1 soluble subunit beta 1

RGD ID:

2769

Description:

Enables Hsp90 protein binding activity; heme binding activity; and ion binding activity. Contributes to adenylate cyclase activity and cytidylate cyclase activity. Predicted to be involved in several processes, including cGMP biosynthetic process; cellular response to nitric oxide; and nitric oxide-cGMP-mediated signaling pathway. Located in presynaptic active zone. Part of guanylate cyclase complex, soluble. Is active in glutamatergic synapse and presynaptic active zone cytoplasmic component. Orthologous to human GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GCS-beta-1; GCS-beta-3; guanylate cyclase 1 soluble beta 3; guanylate cyclase 1 soluble subunit beta 3; guanylate cyclase 1, soluble, beta 3; Guanylate cyclase soluble beta 1 (GTP pyrophosphate - lyase); Guanylate cyclase soluble beta 1 (GTP pyrophosphate - lyase) see also D2Mgh17; guanylate cyclase soluble subunit beta-1; guanylate cyclase soluble subunit beta-3; guanylate cyclase, soluble, beta 1; Gucy1b3; MGC93604; SGC; soluble guanylate cyclase small subunit; soluble guanylyl cyclase beta 1 subunit

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gucy1b1 (guanylate cyclase 1, soluble, beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gucy1b1 (guanylate cyclase 1 soluble subunit beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gucy1b1 (guanylate cyclase 1 soluble subunit beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gucy1b1 (guanylate cyclase 1 soluble subunit beta 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DDHD2 (DDHD domain containing 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gucy1b1 (guanylate cyclase 1, soluble, beta 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Gycbeta100B	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gcy-34	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder)
Caenorhabditis elegans (roundworm):	gcy-36	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder)
Danio rerio (zebrafish):	gucy1b1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gucy1b1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	167,348,824 - 167,398,983 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	167,348,825 - 167,398,916 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	174,554,022 - 174,597,271 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	172,575,260 - 172,618,509 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	167,162,845 - 167,206,099 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	180,976,939 - 181,026,001 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	180,976,939 - 181,026,024 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	200,384,721 - 200,433,787 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	173,683,153 - 173,735,298 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	173,633,259 - 173,685,404 (-)	NCBI
Celera	2	161,378,505 - 161,428,991 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

genetic disease (ISO)

Sporadic Creutzfeldt-Jakob Disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3',5'-cyclic GMP (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

7H-xanthine (EXP)

9H-xanthine (EXP)

aconitine (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

apocynin (EXP)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

BQ 123 (EXP)

butanal (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

cinaciguat (EXP,ISO)

cisplatin (ISO)

cocaine (EXP)

cyanocob(III)alamin (ISO)

dexamethasone (ISO)

dibutyl phthalate (ISO)

diethyl malate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (ISO)

ferroheme b (EXP,ISO)

folic acid (ISO)

formaldehyde (ISO)

GTP (ISO)

heme b (EXP,ISO)

hydrogen peroxide (EXP)

hydroquinone (ISO)

hydroxocobalamin (ISO)

indinavir (ISO)

ketamine (EXP)

L-ascorbic acid (EXP)

lamivudine (ISO)

lead diacetate (EXP)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

menadione (EXP)

methotrexate (ISO)

methylmercury chloride (ISO)

mitoxantrone (ISO)

nitric oxide (ISO)

nitroglycerin (EXP,ISO)

nitroprusside (EXP)

NONOate(1-) (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

pentanal (ISO)

phenobarbital (ISO)

potassium hexacyanoferrate(3-) (ISO)

propanal (ISO)

protoporphyrin (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

saquinavir (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

succimer (ISO)

sunitinib (ISO)

titanium dioxide (ISO)

toluene (EXP)

topotecan (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vorinostat (ISO)

zidovudine (ISO)

zinc protoporphyrin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to nitric oxide (ISS)

cGMP biosynthetic process (IBA,ISO)

cGMP-mediated signaling (IBA,ISO)

nitric oxide-cGMP-mediated signaling pathway (ISO,ISS)

response to oxygen levels (IBA)

trans-synaptic signaling by nitric oxide, modulating synaptic transmission (ISO)

Cellular Component

cytosol (TAS)

glutamatergic synapse (IDA)

guanylate cyclase complex, soluble (IBA,IDA,ISO)

presynaptic active zone (IDA)

presynaptic active zone cytoplasmic component (IDA)

protein-containing complex (IDA)

Molecular Function

adenylate cyclase activity (IDA)

cytidylate cyclase activity (IDA)

GTP binding (IEA)

guanylate cyclase activity (IBA,ISO,TAS)

heme binding (IDA)

Hsp90 protein binding (IDA)

ion binding (IDA)

metal ion binding (IEA)

protein binding (IPI,ISO)

protein-containing complex binding (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

adenine phoshoribosyltransferase deficiency pathway (ISO)

adenosine monophosphate deaminase deficiency pathway (ISO)

adenylosuccinate lyase deficiency pathway (ISO)

AICA-ribosuria pathway (ISO)

azathioprine pharmacodynamics pathway (ISO)

Kelley-Seegmiller syndrome pathway (ISO)

Lesch-Nyhan syndrome pathway (ISO)

long term depression (IEA)

mercaptopurine pharmacodynamics pathway (ISO)

molybdenum cofactor deficiency pathway (ISO)

purine metabolic pathway (IEA,ISO)

purine nucleoside phosphorylase deficiency pathway (ISO)

tioguanine pharmacodynamics pathway (ISO)

xanthinuria type I pathway (ISO)

xanthinuria pathway (ISO)

xanthinuria type II pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Beta-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial cells.	Baltrons MA, etal., Neurobiol Dis 2002 Jul;10(2):139-49.
2.	Reduced expression of NO-sensitive guanylyl cyclase in reactive astrocytes of Alzheimer disease, Creutzfeldt-Jakob disease, and multiple sclerosis brains.	Baltrons MA, etal., Neurobiol Dis. 2004 Dec;17(3):462-72.
3.	Nucleotidyl cyclase activity of soluble guanylyl cyclase alpha1beta1.	Beste KY, etal., Biochemistry. 2012 Jan 10;51(1):194-204. doi: 10.1021/bi201259y. Epub 2011 Dec 13.
4.	Synaptic localization of nitric oxide synthase and soluble guanylyl cyclase in the hippocampus.	Burette A, etal., J Neurosci. 2002 Oct 15;22(20):8961-70.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
8.	Localization of rat genes in the nitric oxide signaling pathway: candidates for the pathogenesis of complex diseases.	Koike G, etal., Mamm Genome 1999 Jan;10(1):71-3
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	Molecular cloning of a cDNA coding for 70 kilodalton subunit of soluble guanylate cyclase from rat lung.	Nakane M, etal., Biochem Biophys Res Commun 1988 Dec 30;157(3):1139-47.
11.	Mapping of heme-binding domains in soluble guanylyl cyclase beta1 subunit.	Namiki S, etal., Biochem Biophys Res Commun 2001 Nov 9;288(4):798-804.
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	Regional distribution of protein and activity of the nitric oxide receptor, soluble guanylyl cyclase, in rat brain suggests multiple mechanisms of regulation.	Nedvetsky PI, etal., Brain Res 2002 Sep 20;950(1-2):148-54.
14.	Interaction between the 90-kDa heat shock protein and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding.	Papapetropoulos A, etal., Mol Pharmacol. 2005 Oct;68(4):1133-41. Epub 2005 Jul 15.
15.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
16.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
17.	GOA pipeline	RGD automated data pipeline
18.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
19.	Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes.	Russwurm M, etal., J Biol Chem 2001 Nov 30;276(48):44647-52.
20.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22.	Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs.	Winger JA, etal., J Biol Chem. 2007 Jan 12;282(2):897-907. Epub 2006 Nov 10.

Additional References at PubMed

PMID:20623	PMID:1298936	PMID:14749300	PMID:14754757	PMID:15201957	PMID:15489334	PMID:15813955	PMID:16331987	PMID:16547975	PMID:18408126	PMID:18474600	PMID:19141686
PMID:19433313	PMID:19461654	PMID:19466990	PMID:20009348	PMID:20353168	PMID:21164076	PMID:22806360	PMID:23505436	PMID:25413364	PMID:30485489	PMID:35089807

Genomics

Comparative Map Data

Gucy1b1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	167,348,824 - 167,398,983 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	167,348,825 - 167,398,916 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	174,554,022 - 174,597,271 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	172,575,260 - 172,618,509 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	167,162,845 - 167,206,099 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	180,976,939 - 181,026,001 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	180,976,939 - 181,026,024 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	200,384,721 - 200,433,787 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	173,683,153 - 173,735,298 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	173,633,259 - 173,685,404 (-)	NCBI
Celera	2	161,378,505 - 161,428,991 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

GUCY1B1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	155,759,021 - 155,807,811 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	4	155,758,992 - 155,807,811 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	156,680,173 - 156,728,963 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	156,888,572 - 156,947,506 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	157,037,819 - 157,085,661	NCBI
Celera	4	154,011,736 - 154,060,401 (+)	NCBI		Celera
Cytogenetic Map	4	q32.1	NCBI
HuRef	4	152,419,159 - 152,467,730 (+)	NCBI		HuRef
CHM1_1	4	156,657,845 - 156,706,460 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	159,091,817 - 159,140,607 (+)	NCBI		T2T-CHM13v2.0

Gucy1b1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	81,939,311 - 81,982,018 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	81,939,313 - 81,981,996 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	82,032,004 - 82,074,711 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	82,032,006 - 82,074,689 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	81,835,926 - 81,878,633 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	82,117,933 - 82,160,612 (-)	NCBI		MGSCv36	mm8
Celera	3	82,056,852 - 82,099,541 (-)	NCBI		Celera
Cytogenetic Map	3	E3	NCBI

Gucy1b1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955471	11,303,242 - 11,351,190 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955471	11,303,478 - 11,349,512 (-)	NCBI	ChiLan1.0	ChiLan1.0

GUCY1B1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	4	154,026,397 - 154,075,072 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	148,124,643 - 148,173,315 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	159,942,017 - 159,990,511 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	159,942,017 - 159,990,511 (+)	Ensembl	panpan1.1		panPan2

GUCY1B1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	53,266,243 - 53,312,109 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	53,265,350 - 53,312,111 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	53,601,513 - 53,647,751 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	53,972,715 - 54,019,854 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	53,972,653 - 54,020,379 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	53,226,121 - 53,272,692 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	53,335,788 - 53,382,060 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	53,649,434 - 53,695,985 (+)	NCBI		UU_Cfam_GSD_1.0

Gucy1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	37,076,967 - 37,119,457 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936576	2,427,416 - 2,470,072 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936576	2,427,451 - 2,469,946 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GUCY1B1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	44,544,179 - 44,604,687 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	44,544,364 - 44,604,690 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	46,747,661 - 46,765,506 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GUCY1B1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	102,332,711 - 102,381,250 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	102,332,719 - 102,381,251 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	81,990,521 - 82,039,073 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gucy1b1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624848	2,462,104 - 2,508,983 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624848	2,462,240 - 2,508,197 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gucy1b1
218 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	155
Count of miRNA genes:	116
Interacting mature miRNAs:	137
Transcripts:	ENSRNOT00000064930
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43154682	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	114837527	185876470	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	185876470	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
6907363	Bp357	Blood pressure QTL 357	4.1	0.002	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	129540907	174540907	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	133914684	202447032	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	135552573	202446871	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	136445150	202447032	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	136916935	189599348	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	136916935	213594495	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	141596551	202447032	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	143157029	210020885	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	143657411	190602963	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	143657411	190602963	Rat
6903312	Bw112	Body weight QTL 112	3.2	0.0013	body mass (VT:0001259)	body weight (CMO:0000012)	2	143657569	184114274	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	144599348	189599348	Rat
631520	Bp73	Blood pressure QTL 73		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147686913	168355276	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147798556	192798556	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	221167075	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150341585	189039377	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150341684	202446871	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150540301	202447032	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	150540301	202447032	Rat
12879845	Cm89	Cardiac mass QTL 89		0.008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	152413072	175950118	Rat
12879846	Cm90	Cardiac mass QTL 90		0.011	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	2	152413072	175950118	Rat
12879847	Am4	Aortic mass QTL 4		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	152413072	175950118	Rat
11565180	Kidm56	Kidney mass QTL 56		0.003	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	152413072	175950118	Rat
11565181	Bw176	Body weight QTL 176		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	2	152413072	175950118	Rat
2301415	Cm67	Cardiac mass QTL 67		0.003	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	152413072	175950118	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	152413072	185122374	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	152413072	185122374	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	152413072	185122374	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	152413072	185122374	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	152413072	185122374	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	157142078	192625452	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	157142078	211086598	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	157142209	202446871	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	160564068	205564068	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	161699179	222436696	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	162765032	207765032	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
1598838	Bp290	Blood pressure QTL 290	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166539266	211539266	Rat

Markers in Region

D2Mgh17

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	167,399,056 - 167,399,325 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	181,026,142 - 181,026,410	NCBI	Rnor6.0
Rnor_5.0	2	200,433,928 - 200,434,196	UniSTS	Rnor5.0
RGSC_v3.4	2	173,735,438 - 173,735,708	RGD	RGSC3.4
RGSC_v3.4	2	173,735,439 - 173,735,707	UniSTS	RGSC3.4
RGSC_v3.1	2	173,685,544 - 173,685,814	RGD
Celera	2	161,429,132 - 161,429,400	UniSTS
Cytogenetic Map	2	q31-q33	UniSTS

RH133401

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	167,349,052 - 167,349,235 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	180,977,168 - 180,977,350	NCBI	Rnor6.0
Rnor_5.0	2	200,384,950 - 200,385,132	UniSTS	Rnor5.0
RGSC_v3.4	2	173,683,382 - 173,683,564	UniSTS	RGSC3.4
Celera	2	161,378,734 - 161,378,916	UniSTS
Cytogenetic Map	2	q31-q33	UniSTS

RH142298

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	167,349,040 - 167,349,202 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	180,977,156 - 180,977,317	NCBI	Rnor6.0
Rnor_5.0	2	200,384,938 - 200,385,099	UniSTS	Rnor5.0
RGSC_v3.4	2	173,683,370 - 173,683,531	UniSTS	RGSC3.4
Celera	2	161,378,722 - 161,378,883	UniSTS
Cytogenetic Map	2	q31-q33	UniSTS

RH140703

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	167,367,758 - 167,368,715 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	180,994,847 - 180,995,803	NCBI	Rnor6.0
Rnor_5.0	2	200,402,633 - 200,403,589	UniSTS	Rnor5.0
RGSC_v3.4	2	173,704,144 - 173,705,100	UniSTS	RGSC3.4
Celera	2	161,397,850 - 161,398,806	UniSTS
RH 3.4 Map	2	1074.5	UniSTS
Cytogenetic Map	2	q31-q33	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	26	7	7	11	7			64	28	31	11
Low	1	17	50	34	8	34	8	11	10	7	10		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012769	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101765	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB098025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB098707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB099520	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB099521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF327644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081840	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M22562	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000064930 ⟹ ENSRNOP00000062785

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	167,348,825 - 167,398,916 (-)	Ensembl
Rnor_6.0 Ensembl	2	180,976,939 - 181,026,024 (-)	Ensembl

RefSeq Acc Id:

NM_012769 ⟹ NP_036901

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	167,348,824 - 167,398,916 (-)	NCBI
Rnor_6.0	2	180,976,939 - 181,026,001 (-)	NCBI
Rnor_5.0	2	200,384,721 - 200,433,787 (-)	NCBI
RGSC_v3.4	2	173,683,153 - 173,735,298 (-)	RGD
Celera	2	161,378,505 - 161,428,991 (-)	RGD

Sequence:

show sequence

TGCGCTGTCGCCGCTGTAGTCGCTGTCTGGGTCCCTTCCGCGGTACTCTTGCCTGGAGGCTGCC
TCCCAGGCTCCGGGAGCGGACACCATGTACGGTTTTGTGAACCATGCCCTGGAGCTGCTGGTGA
TCCGCAATTACGGTCCCGAGGTGTGGGAAGACATCAAAAAAGAGGCGCAGCTGGATGAAGAAGG
CCAGTTTCTTGTGAGAATAATCTACGATGATTCCAAAACCTATGACTTGGTGGCTGCTGCGAGC
AAAGTCCTCAACCTCAATGCTGGTGAAATCCTGCAGATGTTTGGGAAGATGTTTTTCGTCTTCT
GTCAAGAGTCTGGCTATGATACCATCTTGCGTGTCCTGGGATCTAATGTCAGGGAGTTTTTGCA
GAACCTCGACGCCCTGCACGACCACCTCGCCACCATCTACCCAGGGATGCGCGCACCTTCCTTC
CGGTGCACCGATGCAGAAAAAGGCAAAGGGCTCATTCTGCACTACTACTCGGAAAGAGAGGGGC
TTCAGGACATTGTGATCGGGATTATCAAGACTGTAGCTCAACAGATCCATGGCACTGAGATAGA
CATGAAGGTTATTCAGCAAAGAAGTGAAGAATGTGATCATACCCAATTTTTAATTGAAGAAAAA
GAATCAAAAGAAGAGGATTTTTATGAAGATCTGGACAGGTTTGAAGAGAACGGTACCCAGGACT
CCCGTATCAGCCCGTACACCTTCTGCAAAGCGTTTCCTTTTCACATCATATTTGACCGGGACCT
AGTAGTCACGCAGTGTGGAAATGCTATCTACAGAGTGCTCCCCCAGCTCCAGCCTGGGAAGTGC
AGCCTTCTGTCTGTCTTCTCTCTGGTCCGCCCTCATATTGACATCAGTTTCCACGGGATTCTTT
CACACATCAATACCGTCTTTGTACTGAGAAGCAAGGAAGGGTTGCTGGATGTTGAGAAACTTGA
ATGTGAGGATGAACTGACTGGGGCAGAGATTAGCTGCCTCCGTCTCAAAGGCCAAATGATCTAT
TTACCGGAAGCAGATAGCATCCTCTTCCTCTGTTCACCAAGTGTGATGAACTTGGATGACCTAA
CAAGAAGAGGCCTGTACCTGAGTGACATCCCTCTCCATGATGCTACACGAGACCTGGTCCTTTT
GGGAGAACAGTTCCGGGAGGAGTACAAACTGACACAAGAGCTGGAAATCCTCACAGACAGGCTG
CAGCTCACACTGAGGGCTTTGGAGGATGAGAAGAAAAAGACAGACACATTGCTATATTCTGTTC
TCCCTCCATCTGTTGCCAATGAGCTGAGACACAAGCGTCCAGTGCCGGCCAAAAGATACGACAA
TGTGACCATCCTCTTCAGTGGCATTGTGGGCTTCAACGCTTTCTGTAGCAAGCATGCATCTGGA
GAAGGGGCCATGAAGATTGTCAATCTACTCAACGACCTCTACACCAGATTCGACACACTGACTG
ATTCACGGAAAAACCCATTTGTTTACAAGGTGGAAACAGTTGGTGACAAGTATATGACAGTGAG
TGGTTTGCCAGAACCTTGTATCCACCATGCACGGTCCATTTGCCACCTGGCTTTAGACATGATG
GAAATTGCTGGTCAAGTTCAAGTAGATGGCGAATCTGTTCAGATAACCATCGGGATCCACACTG
GGGAGGTGGTGACAGGTGTGATTGGACAGCGGATGCCACGGTATTGTCTCTTCGGAAATACTGT
CAACCTCACAAGCAGGACAGAAACCACAGGAGAAAAGGGGAAGATAAACGTTTCCGAATATACA
TACAGGTGTCTCATGTCCCCAGAAAACTCGGATCCACAGTTCCACTTGGAGCACAGAGGTCCTG
TGTCCATGAAGGGCAAGAAGGAGCCAATGCAAGTCTGGTTTCTATCCAGGAAAAACACAGGCAC
AGAGGAAACAAACCAGGATGAAAACTGAATGGCAGCCTTTGTGGGGCAAAAAGAACTGTCAGCT
GGGCTCTGGTGACAGCCTAATGTGCGTCAAGCCAGGAGCACGCCTTCCCTGTGGATAACAATTT
CTACTTCCTGTTTTAGTGACCCAAGTCTTTCTCCTAGATACACAGATCTCACAGTACGGTTTAT
TTGGTGTTAGCCCTGCCTTTTGATTACTTTTAAAGTCTCAGTATATCTTCTAAGGTTTGGTTTT
TGAGGTGAATGATTTGAGCTTCATGTTTCTTAAATTCTGCTACAAGCGTTACCGAGACTGACAA
TCTAAAAGCGGTAGGCACCCTCTAGTTTAAGTTTGTTAAATCTGATGAAATGAGACTTAATAGT
GTCTGGCCATGCGTATATATGCCATGGCTTGGTAGATTTGTTTTATGCTCTGTGTATATGTGTA
TGTATGTATGTGTATATTTAAATGACTATAACATAAAACAAAGTTTATATCATGTTGGTGCATG
TCCTGCTAGAAACCATTTTATAAACAAGTGAATCTAAGTTTTAGAAAAAAAGGCAATTTATTTC
TAGACTTCTGAAGTAAGAACTAATATGCTGTATTAGGAAAAAAGAGTGACTATTTTGAAGTACG
TCAGTTCCCTTCTGGAACTCTAGGATACATATTTCTGTTATTACATTGGTTGCTCATTCAAATT
TCATGCCCTATTACAGCTTCTCTAACATCCATGTTGCCCTAATTTGTACTGAAGCCCTTGATAT
TGAGTGTTCTTGACCATTGTGGTTGTGATGGGGACTGAATTGCTTCACACTGAATGTTTACGTT
TGCTTACGCAAGTGTTAGTGGTTAAAATATGTCCAAGAGCAAGGCCAGGAATACATAGCTAGGA
CATTGCTATTAGAGCCCGCTTGGCCTAACTCCAGGCTTGAGTTTCTTTATTAGCTCAGAAGAAT
GTCAACTTACCCAAGGTATCATATTCAGAATATTCATAAAGCCATTTTAATTCTGAATGGACTG
CCTTCCTGCTGGAATATTTGGCCTATCATTCTTTAAATGTCTCCGATAAGTTATTGATATCTAT
CTTTATAAAATAGAATGAAACTGCTTTTCTGTAAAAATGTTTGTCTTTCATTTAGTATTTCATA
TCAGCACATCATTGTATGTATAAATGTTACATGTTAATTGTGGAAAAGAATCTACAATAAATTA
TTTTTACCACTTGTCTACAGTGCACTTTAATTTAATAAAGTGAAATTGACACCAAAAAAAAAAA
AAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039101764 ⟹ XP_038957692

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	167,348,824 - 167,396,971 (-)	NCBI

RefSeq Acc Id:

XM_039101765 ⟹ XP_038957693

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	167,366,734 - 167,398,983 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_036901	(Get FASTA)	NCBI Sequence Viewer
	XP_038957692	(Get FASTA)	NCBI Sequence Viewer
	XP_038957693	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41204	(Get FASTA)	NCBI Sequence Viewer
	AAH81840	(Get FASTA)	NCBI Sequence Viewer
	AAM67413	(Get FASTA)	NCBI Sequence Viewer
	BAC44989	(Get FASTA)	NCBI Sequence Viewer
	BAC53773	(Get FASTA)	NCBI Sequence Viewer
	BAC55086	(Get FASTA)	NCBI Sequence Viewer
	BAC55087	(Get FASTA)	NCBI Sequence Viewer
	EDM00850	(Get FASTA)	NCBI Sequence Viewer
	EDM00851	(Get FASTA)	NCBI Sequence Viewer
	P20595	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_036901 ⟸ NM_012769

- UniProtKB:

Q8CH88 (UniProtKB/Swiss-Prot), P20595 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAG
EILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKG
KGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRSEECDHTQFLIEEKESKEEDFY
EDLDRFEENGTQDSRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGKCSLLSVFSL
VRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGAEISCLRLKGQMIYLPEADSIL
FLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALE
DEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVN
LLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQV
DGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPE
NSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETNQDEN

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RefSeq Acc Id:

ENSRNOP00000062785 ⟸ ENSRNOT00000064930

RefSeq Acc Id:	XP_038957692 ⟸ XM_039101764
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038957693 ⟸ XM_039101765
- Peptide Label:	isoform X2

Protein Domains

Guanylate cyclase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P20595-F1-model_v2	AlphaFold	P20595	1-619	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691391

Promoter ID:

EPDNEW_R1916

Type:

multiple initiation site

Name:

Gucy1b3_1

Description:

guanylate cyclase 1 soluble subunit beta 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	181,025,986 - 181,026,046	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2769	AgrOrtholog
BioCyc Gene	G2FUF-52686	BioCyc
Ensembl Genes	ENSRNOG00000012060	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000062785	ENTREZGENE
	ENSRNOP00000062785.1	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000064930	ENTREZGENE
	ENSRNOT00000064930.3	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.450.260	UniProtKB/Swiss-Prot
	3.30.70.1230	UniProtKB/Swiss-Prot
	3.90.1520.10	UniProtKB/Swiss-Prot
	6.10.250.780	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7104600	IMAGE-MGC_LOAD
InterPro	A/G_cyclase	UniProtKB/Swiss-Prot
	A/G_cyclase_CS	UniProtKB/Swiss-Prot
	H-NOX_domain_sf	UniProtKB/Swiss-Prot
	Heme_NO-bd	UniProtKB/Swiss-Prot
	HNOB_dom_associated	UniProtKB/Swiss-Prot
	HNOB_dom_associated_sf	UniProtKB/Swiss-Prot
	NO_sig/Golgi_transp_ligand-bd	UniProtKB/Swiss-Prot
	Nucleotide_cyclase	UniProtKB/Swiss-Prot
KEGG Report	rno:25202	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93604	IMAGE-MGC_LOAD
NCBI Gene	25202	ENTREZGENE
PANTHER	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1	UniProtKB/Swiss-Prot
	GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2	UniProtKB/Swiss-Prot
Pfam	Guanylate_cyc	UniProtKB/Swiss-Prot
	HNOB	UniProtKB/Swiss-Prot
	HNOBA	UniProtKB/Swiss-Prot
PhenoGen	Gucy1b1	PhenoGen
PROSITE	GUANYLATE_CYCLASE_1	UniProtKB/Swiss-Prot
	GUANYLATE_CYCLASE_2	UniProtKB/Swiss-Prot
SMART	CYCc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF111126	UniProtKB/Swiss-Prot
	SSF55073	UniProtKB/Swiss-Prot
TIGR	TC215565
UniProt	GCYB1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q8CH88	ENTREZGENE
UniProt Secondary	Q8CH88	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-22	Gucy1b1	guanylate cyclase 1 soluble subunit beta 1	Gucy1b3	guanylate cyclase 1 soluble subunit beta 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-06-29	Gucy1b3	guanylate cyclase 1 soluble subunit beta 3	Gucy1b3	guanylate cyclase 1, soluble, beta 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Gucy1b3	guanylate cyclase 1, soluble, beta 3			Symbol and Name status set to approved	70586	APPROVED
2001-06-12	Gucy1b1	Guanylate cyclase, soluble, beta 1, (GTP pyrophosphate - lyase)			Symbol and Name withdrawn	62408	WITHDRAWN
2001-06-12	Gucy1b3	Guanylate cyclase 1, soluble, beta 3			Symbol and Name updated to reflect Human and Mouse nomenclature	62408	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_function	subunit of soluble guanylate cyclase, forms a heterodimer with Gucy1a3 that converts GTP to cGMP	68796
gene_mapping	maps to the same position as D2Mit12 and D1Mit19 on rat chr 2	61022
gene_process	functions as the receptor for nitric oxide and nitrovasodilator drugs	68796

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)