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Gene: Gucy1b1 (guanylate cyclase 1 soluble subunit beta 1) Rattus norvegicus
Symbol: Gucy1b1
Name: guanylate cyclase 1 soluble subunit beta 1
Description: Exhibits several functions, including Hsp90 protein binding activity; heme binding activity; and protein heterodimerization activity. Contributes to adenylate cyclase activity and cytidylate cyclase activity. Predicted to be involved in several processes, including cGMP biosynthetic process; cellular response to nitric oxide; and nitric oxide-cGMP-mediated signaling pathway. Localizes to the glutamatergic synapse; guanylate cyclase complex, soluble; and presynaptic active zone cytoplasmic component. Orthologous to human GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: GCS-beta-1; GCS-beta-3; guanylate cyclase 1 soluble beta 3; guanylate cyclase 1 soluble subunit beta 3; guanylate cyclase 1, soluble, beta 3; Guanylate cyclase soluble beta 1 (GTP pyrophosphate - lyase); Guanylate cyclase soluble beta 1 (GTP pyrophosphate - lyase) see also D2Mgh17; guanylate cyclase soluble subunit beta-1; guanylate cyclase soluble subunit beta-3; guanylate cyclase, soluble, beta 1; Gucy1b3; MGC93604; SGC; soluble guanylate cyclase small subunit; soluble guanylyl cyclase beta 1 subunit
Homo sapiens (human) : GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1)  HGNC  Alliance
Mus musculus (house mouse) : Gucy1b1 (guanylate cyclase 1, soluble, beta 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gucy1b1 (guanylate cyclase 1 soluble subunit beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1)
Canis lupus familiaris (dog) : GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gucy1b1 (guanylate cyclase 1 soluble subunit beta 1)
Sus scrofa (pig) : GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02180,976,939 - 181,026,001 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02200,384,721 - 200,433,787 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,683,153 - 173,735,298 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12173,633,259 - 173,685,404 (-)NCBI
Celera2161,378,505 - 161,428,991 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gucy1b1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2769
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.