Gucy1b1 (guanylate cyclase 1 soluble subunit beta 1) - Rat Genome Database

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Gene: Gucy1b1 (guanylate cyclase 1 soluble subunit beta 1) Rattus norvegicus
Analyze
Symbol: Gucy1b1
Name: guanylate cyclase 1 soluble subunit beta 1
RGD ID: 2769
Description: Enables Hsp90 protein binding activity; heme binding activity; and nitric oxide binding activity. Contributes to adenylate cyclase activity and cytidylate cyclase activity. Predicted to be involved in several processes, including cGMP biosynthetic process; cellular response to nitric oxide; and nitric oxide-cGMP-mediated signaling. Located in presynaptic active zone. Part of guanylate cyclase complex, soluble. Is active in glutamatergic synapse and presynaptic active zone cytoplasmic component. Biomarker of withdrawal disorder. Orthologous to human GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GCS-beta-1; GCS-beta-3; guanylate cyclase 1 soluble beta 3; guanylate cyclase 1 soluble subunit beta 3; guanylate cyclase 1, soluble, beta 3; Guanylate cyclase soluble beta 1 (GTP pyrophosphate - lyase); Guanylate cyclase soluble beta 1 (GTP pyrophosphate - lyase) see also D2Mgh17; guanylate cyclase soluble subunit beta-1; guanylate cyclase soluble subunit beta-3; guanylate cyclase, soluble, beta 1; Gucy1b3; MGC93604; SGC; soluble guanylate cyclase small subunit; soluble guanylyl cyclase beta 1 subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82169,646,897 - 169,697,060 (-)NCBIGRCr8
mRatBN7.22167,348,824 - 167,398,983 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2167,348,825 - 167,398,916 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2174,554,022 - 174,597,271 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02172,575,260 - 172,618,509 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02167,162,845 - 167,206,099 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02180,976,939 - 181,026,001 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2180,976,939 - 181,026,024 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02200,384,721 - 200,433,787 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,683,153 - 173,735,298 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12173,633,259 - 173,685,404 (-)NCBI
Celera2161,378,505 - 161,428,991 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3',5'-cyclic GMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
aconitine  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
apocynin  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
BQ 123  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cinaciguat  (EXP,ISO)
cisplatin  (ISO)
cocaine  (EXP)
cyanocob(III)alamin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diethyl malate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ferroheme b  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
glyphosate  (ISO)
GTP  (ISO)
heme b  (EXP,ISO)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
hydroxocobalamin  (ISO)
indinavir  (ISO)
ketamine  (EXP)
L-ascorbic acid  (EXP)
lamivudine  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
menadione  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
nitric oxide  (ISO)
nitroglycerin  (EXP,ISO)
nitroprusside  (EXP)
NONOate(1-)  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
phenobarbital  (ISO)
potassium hexacyanoferrate(3-)  (ISO)
propanal  (ISO)
protoporphyrin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
saquinavir  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
succimer  (ISO)
sunitinib  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)
zinc protoporphyrin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Beta-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial cells. Baltrons MA, etal., Neurobiol Dis 2002 Jul;10(2):139-49.
2. Reduced expression of NO-sensitive guanylyl cyclase in reactive astrocytes of Alzheimer disease, Creutzfeldt-Jakob disease, and multiple sclerosis brains. Baltrons MA, etal., Neurobiol Dis. 2004 Dec;17(3):462-72.
3. Nucleotidyl cyclase activity of soluble guanylyl cyclase alpha1beta1. Beste KY, etal., Biochemistry. 2012 Jan 10;51(1):194-204. doi: 10.1021/bi201259y. Epub 2011 Dec 13.
4. Synaptic localization of nitric oxide synthase and soluble guanylyl cyclase in the hippocampus. Burette A, etal., J Neurosci. 2002 Oct 15;22(20):8961-70.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Localization of rat genes in the nitric oxide signaling pathway: candidates for the pathogenesis of complex diseases. Koike G, etal., Mamm Genome 1999 Jan;10(1):71-3
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Molecular cloning of a cDNA coding for 70 kilodalton subunit of soluble guanylate cyclase from rat lung. Nakane M, etal., Biochem Biophys Res Commun 1988 Dec 30;157(3):1139-47.
11. Mapping of heme-binding domains in soluble guanylyl cyclase beta1 subunit. Namiki S, etal., Biochem Biophys Res Commun 2001 Nov 9;288(4):798-804.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Regional distribution of protein and activity of the nitric oxide receptor, soluble guanylyl cyclase, in rat brain suggests multiple mechanisms of regulation. Nedvetsky PI, etal., Brain Res 2002 Sep 20;950(1-2):148-54.
14. Interaction between the 90-kDa heat shock protein and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding. Papapetropoulos A, etal., Mol Pharmacol. 2005 Oct;68(4):1133-41. Epub 2005 Jul 15.
15. Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdrawal is related to the degree of abstinence. Peregud DI, etal., Bull Exp Biol Med. 2012 Oct;153(6):835-8. doi: 10.1007/s10517-012-1838-x.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes. Russwurm M, etal., J Biol Chem 2001 Nov 30;276(48):44647-52.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. Winger JA, etal., J Biol Chem. 2007 Jan 12;282(2):897-907. Epub 2006 Nov 10.
Additional References at PubMed
PMID:20623   PMID:1298936   PMID:14749300   PMID:14754757   PMID:15201957   PMID:15489334   PMID:15813955   PMID:16331987   PMID:16547975   PMID:18408126   PMID:18474600   PMID:19141686  
PMID:19433313   PMID:19461654   PMID:19466990   PMID:20009348   PMID:20353168   PMID:21164076   PMID:22806360   PMID:23505436   PMID:25413364   PMID:30485489   PMID:35089807  


Genomics

Comparative Map Data
Gucy1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82169,646,897 - 169,697,060 (-)NCBIGRCr8
mRatBN7.22167,348,824 - 167,398,983 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2167,348,825 - 167,398,916 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2174,554,022 - 174,597,271 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02172,575,260 - 172,618,509 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02167,162,845 - 167,206,099 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02180,976,939 - 181,026,001 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2180,976,939 - 181,026,024 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02200,384,721 - 200,433,787 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,683,153 - 173,735,298 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12173,633,259 - 173,685,404 (-)NCBI
Celera2161,378,505 - 161,428,991 (-)NCBICelera
Cytogenetic Map2q34NCBI
GUCY1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384155,759,021 - 155,807,811 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4155,758,992 - 155,807,811 (+)EnsemblGRCh38hg38GRCh38
GRCh374156,680,173 - 156,728,963 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364156,888,572 - 156,947,506 (+)NCBINCBI36Build 36hg18NCBI36
Build 344157,037,819 - 157,085,661NCBI
Celera4154,011,736 - 154,060,401 (+)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4152,419,159 - 152,467,730 (+)NCBIHuRef
CHM1_14156,657,845 - 156,706,460 (+)NCBICHM1_1
T2T-CHM13v2.04159,091,817 - 159,140,607 (+)NCBIT2T-CHM13v2.0
Gucy1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39381,939,311 - 81,982,018 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl381,939,313 - 81,981,996 (-)EnsemblGRCm39 Ensembl
GRCm38382,032,004 - 82,074,711 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl382,032,006 - 82,074,689 (-)EnsemblGRCm38mm10GRCm38
MGSCv37381,835,926 - 81,878,633 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36382,117,933 - 82,160,612 (-)NCBIMGSCv36mm8
Celera382,056,852 - 82,099,541 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map335.97NCBI
Gucy1b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547111,303,242 - 11,351,190 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547111,303,478 - 11,349,512 (-)NCBIChiLan1.0ChiLan1.0
GUCY1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23153,670,796 - 153,719,476 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14154,026,397 - 154,075,072 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04148,124,643 - 148,173,315 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14159,942,017 - 159,990,511 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4159,942,017 - 159,990,511 (+)Ensemblpanpan1.1panPan2
GUCY1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11553,266,243 - 53,312,109 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1553,265,350 - 53,312,111 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1553,601,513 - 53,647,751 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01553,972,715 - 54,019,854 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1553,972,653 - 54,020,379 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11553,226,121 - 53,272,692 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01553,335,788 - 53,382,060 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01553,649,434 - 53,695,985 (+)NCBIUU_Cfam_GSD_1.0
Gucy1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530137,076,967 - 37,119,457 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365762,427,416 - 2,470,072 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365762,427,451 - 2,469,946 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCY1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl844,544,179 - 44,604,687 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1844,544,364 - 44,604,690 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2846,747,661 - 46,765,506 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GUCY1B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17102,332,711 - 102,381,250 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7102,332,719 - 102,381,251 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603781,990,521 - 82,039,073 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gucy1b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248482,462,104 - 2,508,983 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248482,462,240 - 2,508,197 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gucy1b1
232 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:116
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000064930
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147686913168355276Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat

Markers in Region
D2Mgh17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22167,399,056 - 167,399,325 (+)MAPPERmRatBN7.2
Rnor_6.02181,026,142 - 181,026,410NCBIRnor6.0
Rnor_5.02200,433,928 - 200,434,196UniSTSRnor5.0
RGSC_v3.42173,735,438 - 173,735,708RGDRGSC3.4
RGSC_v3.42173,735,439 - 173,735,707UniSTSRGSC3.4
RGSC_v3.12173,685,544 - 173,685,814RGD
Celera2161,429,132 - 161,429,400UniSTS
Cytogenetic Map2q31-q33UniSTS
RH133401  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22167,349,052 - 167,349,235 (+)MAPPERmRatBN7.2
Rnor_6.02180,977,168 - 180,977,350NCBIRnor6.0
Rnor_5.02200,384,950 - 200,385,132UniSTSRnor5.0
RGSC_v3.42173,683,382 - 173,683,564UniSTSRGSC3.4
Celera2161,378,734 - 161,378,916UniSTS
Cytogenetic Map2q31-q33UniSTS
RH142298  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22167,349,040 - 167,349,202 (+)MAPPERmRatBN7.2
Rnor_6.02180,977,156 - 180,977,317NCBIRnor6.0
Rnor_5.02200,384,938 - 200,385,099UniSTSRnor5.0
RGSC_v3.42173,683,370 - 173,683,531UniSTSRGSC3.4
Celera2161,378,722 - 161,378,883UniSTS
Cytogenetic Map2q31-q33UniSTS
RH140703  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22167,367,758 - 167,368,715 (+)MAPPERmRatBN7.2
Rnor_6.02180,994,847 - 180,995,803NCBIRnor6.0
Rnor_5.02200,402,633 - 200,403,589UniSTSRnor5.0
RGSC_v3.42173,704,144 - 173,705,100UniSTSRGSC3.4
Celera2161,397,850 - 161,398,806UniSTS
RH 3.4 Map21074.5UniSTS
Cytogenetic Map2q31-q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 7 7 11 7 64 28 31 11
Low 1 17 50 34 8 34 8 11 10 7 10 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000064930   ⟹   ENSRNOP00000062785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2167,348,825 - 167,398,916 (-)Ensembl
Rnor_6.0 Ensembl2180,976,939 - 181,026,024 (-)Ensembl
RefSeq Acc Id: NM_012769   ⟹   NP_036901
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82169,646,897 - 169,696,987 (-)NCBI
mRatBN7.22167,348,824 - 167,398,916 (-)NCBI
Rnor_6.02180,976,939 - 181,026,001 (-)NCBI
Rnor_5.02200,384,721 - 200,433,787 (-)NCBI
RGSC_v3.42173,683,153 - 173,735,298 (-)RGD
Celera2161,378,505 - 161,428,991 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101764   ⟹   XP_038957692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82169,646,897 - 169,695,065 (-)NCBI
mRatBN7.22167,348,824 - 167,396,971 (-)NCBI
RefSeq Acc Id: XM_039101765   ⟹   XP_038957693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82169,664,759 - 169,697,060 (-)NCBI
mRatBN7.22167,366,734 - 167,398,983 (-)NCBI
RefSeq Acc Id: NP_036901   ⟸   NM_012769
- UniProtKB: Q8CH88 (UniProtKB/Swiss-Prot),   P20595 (UniProtKB/Swiss-Prot),   A6J5T8 (UniProtKB/TrEMBL),   Q80WY4 (UniProtKB/TrEMBL),   Q80WY5 (UniProtKB/TrEMBL),   Q8CH85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062785   ⟸   ENSRNOT00000064930
RefSeq Acc Id: XP_038957692   ⟸   XM_039101764
- Peptide Label: isoform X1
- UniProtKB: Q80WY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957693   ⟸   XM_039101765
- Peptide Label: isoform X2
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20595-F1-model_v2 AlphaFold P20595 1-619 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691391
Promoter ID:EPDNEW_R1916
Type:multiple initiation site
Name:Gucy1b3_1
Description:guanylate cyclase 1 soluble subunit beta 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02181,025,986 - 181,026,046EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2769 AgrOrtholog
BioCyc Gene G2FUF-52686 BioCyc
Ensembl Genes ENSRNOG00000012060 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055001317 UniProtKB/Swiss-Prot
  ENSRNOG00060007224 UniProtKB/Swiss-Prot
  ENSRNOG00065030848 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000064930 ENTREZGENE
  ENSRNOT00000064930.3 UniProtKB/Swiss-Prot
  ENSRNOT00055002177 UniProtKB/Swiss-Prot
  ENSRNOT00060011888 UniProtKB/Swiss-Prot
  ENSRNOT00065053182 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.450.260 UniProtKB/Swiss-Prot
  3.30.70.1230 UniProtKB/Swiss-Prot
  3.90.1520.10 UniProtKB/Swiss-Prot
  6.10.250.780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  H-NOX domain UniProtKB/TrEMBL
  Haem NO binding associated domain UniProtKB/TrEMBL
  Nucleotide cyclase UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7104600 IMAGE-MGC_LOAD
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  H-NOX_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heme_NO-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOB_dom_associated UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOB_dom_associated_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NO_sig/Golgi_transp_ligand-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93604 IMAGE-MGC_LOAD
NCBI Gene 25202 ENTREZGENE
PANTHER GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gucy1b1 PhenoGen
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012060 RatGTEx
  ENSRNOG00055001317 RatGTEx
  ENSRNOG00060007224 RatGTEx
  ENSRNOG00065030848 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Ligand-binding domain in the NO signalling and Golgi transport UniProtKB/TrEMBL
  Nucleotide cyclase UniProtKB/TrEMBL
  SSF111126 UniProtKB/Swiss-Prot
  SSF55073 UniProtKB/Swiss-Prot
TIGR TC215565
UniProt A6J5T8 ENTREZGENE, UniProtKB/TrEMBL
  GCYB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q80WY4 ENTREZGENE, UniProtKB/TrEMBL
  Q80WY5 ENTREZGENE, UniProtKB/TrEMBL
  Q8CH85 ENTREZGENE, UniProtKB/TrEMBL
  Q8CH88 ENTREZGENE
UniProt Secondary Q8CH88 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-22 Gucy1b1  guanylate cyclase 1 soluble subunit beta 1  Gucy1b3  guanylate cyclase 1 soluble subunit beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-29 Gucy1b3  guanylate cyclase 1 soluble subunit beta 3  Gucy1b3  guanylate cyclase 1, soluble, beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gucy1b3  guanylate cyclase 1, soluble, beta 3      Symbol and Name status set to approved 70586 APPROVED
2001-06-12 Gucy1b1  Guanylate cyclase, soluble, beta 1, (GTP pyrophosphate - lyase)      Symbol and Name withdrawn 62408 WITHDRAWN
2001-06-12 Gucy1b3  Guanylate cyclase 1, soluble, beta 3      Symbol and Name updated to reflect Human and Mouse nomenclature 62408 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function subunit of soluble guanylate cyclase, forms a heterodimer with Gucy1a3 that converts GTP to cGMP 68796
gene_mapping maps to the same position as D2Mit12 and D1Mit19 on rat chr 2 61022
gene_process functions as the receptor for nitric oxide and nitrovasodilator drugs 68796