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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gucy1b1
Name: guanylate cyclase 1 soluble subunit beta 1
Acc ID: CHEBI:32234
Term: titanium dioxide
Definition: A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.
Chemical ID: MESH:C009495
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gucy1b1decreases expressionISOGucy1b1 (Mus musculus)6480464CTDtitanium dioxide results in decreased expression of GUCY1B1 mRNAPMID:23557971
Gucy1b1increases methylationISOGUCY1B1 (Homo sapiens)6480464CTDtitanium dioxide results in increased methylation of GUCY1B3 genePMID:34973136
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