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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gucy1b1
Name: guanylate cyclase 1 soluble subunit beta 1
Acc ID: CHEBI:26355
Term: heme b
Definition: A metalloprotoporphyrin in which the four pyrrole nitrogens of the protoporphyrin moiety are coordinated to iron. It is the most abundant of the heme compounds.
Chemical ID: MESH:D006418
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]], BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]], Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein], zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]], zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]

PMID:19466990
multiple interactionsISORGD:7318146480464CTDPolysorbates inhibits the reaction [Heme binds to GUCY1B1 protein]

PMID:22171090
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.