Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gucy1b1
Name: guanylate cyclase 1 soluble subunit beta 1
Acc ID: CHEBI:91215
Term: 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
Definition: A member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group.
Chemical ID: MESH:C095284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases degradationEXP 6480464CTD1H-(1, 2, 4)oxadiazolo(4, 3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein

PMID:19466990
multiple interactionsEXP 6480464CTD1H-(1, 2, 4)oxadiazolo(4, 3-a)quinoxalin-1-one inhibits the reaction [3-(2-(2, 2-dimethylpropylsulfanyl)pyridin-3-yl)-N-(3-hydroxycyclohexyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]], 1H-(1, 2, 4)oxadiazolo(4, 3-a)quinoxalin-1-one inhibits the reaction [3-(2-(4-chlorophenylsulfanyl)phenyl)-N-(4-dimethylaminobutyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]], 1H-(1, 2, 4)oxadiazolo(4, 3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]], 1H-(1, 2, 4)oxadiazolo(4, 3-a)quinoxalin-1-one promotes the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]], 1H-(1, 2, 4)oxadiazolo(4, 3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]

PMID:12495780, PMID:17050951, PMID:19466990
multiple interactionsISORGD:7318146480464CTD1H-(1, 2, 4)oxadiazolo(4, 3-a)quinoxalin-1-one affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]], 1H-(1, 2, 4)oxadiazolo(4, 3-a)quinoxalin-1-one inhibits the reaction [1, 1-diethyl-2-hydroxy-2-nitrosohydrazine results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]], 1H-(1, 2, 4)oxadiazolo(4, 3-a)quinoxalin-1-one promotes the reaction [dicyanocobinamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]], [BAY 58-2667 co-treated with 1H-(1, 2, 4)oxadiazolo(4, 3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]

PMID:11744065, PMID:22171090
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.