RGD Reference Report - Localization of rat genes in the nitric oxide signaling pathway: candidates for the pathogenesis of complex diseases. - Rat Genome Database

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Localization of rat genes in the nitric oxide signaling pathway: candidates for the pathogenesis of complex diseases.

Authors: Koike, G  Chiche, JD  Shiozawa, M  Simon, JS  Szpirer, J  Jacob, HJ  Szpirer, C  Bloch, KD 
Citation: Koike G, etal., Mamm Genome 1999 Jan;10(1):71-3
RGD ID: 61022
Web Url: http://link.springer-ny.com/link/service/journals/00335/bibs/10n1p71.html
Pubmed: PMID:9892738   (View Abstract at PubMed)

Nitric oxide (NO) has critical regulatory function in multiple cell types. In the vasculature, NO is a vasodilator but also modulates smooth muscle cell proliferation (Schmidt and Walter 1994) and apoptosis (Pollman et al. 1996). In the nervous system, NO serves as a neurotransmitter, whereas, in endocrine tissues, NO has important roles in the regulation of hormone release, such as insulin and renin (Schmidt and Walter 1994). Alterations in NO production and responsiveness could contribute to the pathogenesis of several complex human diseases, including hypertension, diabetes mellitus, and renal failure.



Objects referenced in this article
Gene Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 Rattus norvegicus

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