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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gucy1b1
Name: guanylate cyclase 1 soluble subunit beta 1
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gucy1b1decreases expressionEXP 6480464CTDlead acetate results in decreased expression of GUCY1B1 mRNA; lead acetate results in decreased expression of GUCY1B1 proteinPMID:11729227 PMID:16395254
Gucy1b1multiple interactionsEXP 6480464CTDAscorbic Acid inhibits the reaction [lead acetate results in decreased expression of GUCY1B1 protein]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [lead acetate results in decreased expression of GUCY1B1 protein]PMID:11729227 PMID:16395254
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