Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Top1 (DNA topoisomerase I) Rattus norvegicus
Analyze
Symbol: Top1
Name: DNA topoisomerase I
Description: Exhibits DNA topoisomerase type I activity and chromatin DNA binding activity. Involved in several processes, including cellular response to luteinizing hormone stimulus; nucleic acid metabolic process; and response to gamma radiation. Localizes to the dense fibrillar component and fibrillar center. Predicted to colocalize with the nuclear chromosome. Orthologous to human TOP1 (DNA topoisomerase I); PARTICIPATES IN irinotecan pharmacodynamics pathway; irinotecan pharmacokinetics pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Ab2-086; DNA topoisomerase 1; topoisomerase (DNA) I
Orthologs:
Homo sapiens (human) : TOP1 (DNA topoisomerase I)  HGNC  Alliance
Mus musculus (house mouse) : Top1 (topoisomerase (DNA) I)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top1 (DNA topoisomerase I)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP1 (DNA topoisomerase I)
Canis lupus familiaris (dog) : TOP1 (DNA topoisomerase I)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top1 (DNA topoisomerase I)
Sus scrofa (pig) : TOP1 (DNA topoisomerase I)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03156,635,688 - 156,717,686 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03162,865,335 - 162,947,076 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43151,428,931 - 151,512,884 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13151,334,966 - 151,418,920 (+)NCBI
Celera3147,968,261 - 148,049,789 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Top1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621246
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.