Top1 (DNA topoisomerase I) - Rat Genome Database

Name: Top1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Top1 (DNA topoisomerase I) Rattus norvegicus

Analyze

Symbol:

Top1

Name:

DNA topoisomerase I

RGD ID:

621246

Description:

Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity and chromatin DNA binding activity. Involved in several processes, including cellular response to luteinizing hormone stimulus; nucleic acid metabolic process; and response to gamma radiation. Located in dense fibrillar component and fibrillar center. Orthologous to human TOP1 (DNA topoisomerase I); PARTICIPATES IN irinotecan pharmacodynamics pathway; irinotecan pharmacokinetics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Ab2-086; DNA topoisomerase 1; topoisomerase (DNA) I

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TOP1 (DNA topoisomerase I)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Top1 (topoisomerase (DNA) I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Top1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TOP1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TOP1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Top1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TOP1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TOP1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Top1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TOP1 (DNA topoisomerase I)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Top1 (topoisomerase (DNA) I)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	top1l (DNA topoisomerase I, like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	top1 (DNA topoisomerase I)	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Top1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TOP1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	top-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)

Related Pseudogenes:

Top1-ps1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	149,293,469 - 149,376,618 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	149,293,403 - 149,376,623 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	153,107,309 - 153,188,513 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	161,606,688 - 161,687,898 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	159,345,818 - 159,427,549 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	156,635,688 - 156,717,686 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	156,642,464 - 156,717,686 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	162,865,335 - 162,947,076 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	151,428,931 - 151,512,884 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	151,334,966 - 151,418,920 (+)	NCBI
Celera	3	147,968,261 - 148,049,789 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

disease of cellular proliferation (ISO)

Disease Progression (ISO)

focal epilepsy (ISO)

genetic disease (ISO)

Liver Neoplasms (ISO)

Recurrence (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-nitropyrene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

3'-deamino-3'-(3-cyanomorpholin-4-yl)doxorubicin (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

actinomycin D (ISO)

afimoxifene (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

anthra[1,9-cd]pyrazol-6(2H)-one (ISO)

anthracenes (ISO)

antirheumatic drug (ISO)

benzo[a]pyrene diol epoxide I (ISO)

berberine (ISO)

betulinic acid (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

Boswellic acid (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

camptothecin (EXP,ISO)

captafol (ISO)

chloroacetaldehyde (ISO)

choline (ISO)

cidofovir anhydrous (ISO)

ciprofloxacin (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

delphinidin (ISO)

dibenzo[a,l]pyrene (ISO)

dioxygen (ISO)

diuron (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

ethanol (ISO)

fenofibrate (EXP)

flavonoids (EXP,ISO)

fluoranthene (ISO)

folic acid (ISO)

fulvestrant (ISO)

graphene oxide (ISO)

hydrogen peroxide (ISO)

hydroxyurea (ISO)

ifosfamide (ISO)

indirubin (ISO)

inulin (ISO)

irinotecan (ISO)

L-methionine (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

luteolin (EXP)

menadione (ISO)

methimazole (EXP)

methotrexate (ISO)

miconazole (ISO)

moxifloxacin (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (EXP)

nevadensin (ISO)

Nitidine (ISO)

oleanolic acid (ISO)

oxaliplatin (EXP,ISO)

p-anisidine (ISO)

p-menthan-3-ol (ISO)

paclitaxel (ISO)

palbociclib (ISO)

palmatine (ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

pirinixic acid (ISO)

propiconazole (EXP)

raloxifene (ISO)

resveratrol (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

testosterone (EXP)

tetrahydropalmatine (ISO)

topotecan (EXP,ISO)

trichloroethene (EXP)

trichostatin A (ISO)

tungsten (ISO)

tunicamycin (ISO)

urethane (ISO)

ursolic acid (ISO)

valproic acid (ISO)

vitamin E (ISO)

vorinostat (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ regeneration (IEP)

cellular response to luteinizing hormone stimulus (IEP)

chromatin remodeling (IEA,ISO,ISS)

chromosome segregation (IBA)

circadian regulation of gene expression (IEA,ISO,ISS)

circadian rhythm (ISO)

DNA replication (IBA,IEA,ISO)

DNA topological change (IBA,IDA,IEA,ISO)

embryonic cleavage (IEA,ISO)

response to cAMP (IEP)

response to gamma radiation (IEP)

response to temperature stimulus (IEP)

response to xenobiotic stimulus (IEA,ISO)

rRNA transcription (IMP)

Cellular Component

chromosome (IEA)

cytoplasm (ISO)

dense fibrillar component (IDA)

fibrillar center (IDA,IEA,ISO)

male germ cell nucleus (IEA,ISO)

nuclear chromosome (IEA,ISO)

nucleolus (IBA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

P-body (IEA,ISO)

perikaryon (IEA,ISO)

protein-DNA complex (IEA,ISO)

Molecular Function

ATP binding (IEA,ISO)

chromatin binding (IEA,ISO)

chromatin DNA binding (IDA)

DNA binding (IDA,IEA,ISO)

DNA binding, bending (ISO)

DNA topoisomerase type I (single strand cut, ATP-independent) activity (IBA,IDA,IEA,ISO)

double-stranded DNA binding (ISO)

protein binding (ISO)

protein domain specific binding (IEA,ISO)

protein serine/threonine kinase activity (IEA,ISO)

protein-containing complex binding (IDA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA,ISO,ISS)

single-stranded DNA binding (IEA,ISO)

supercoiled DNA binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

irinotecan pharmacodynamics pathway (ISO)

irinotecan pharmacokinetics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The giant fibrillar center: a nucleolar structure enriched in upstream binding factor (UBF) that appears in transcriptionally more active sensory ganglia neurons.	Casafont I, etal., J Struct Biol. 2007 Sep;159(3):451-61. Epub 2007 May 25.
2.	Purified apolipoprotein B gene regulatory factor-3 is DNA topoisomerase I.	Chuang SS, etal., Eur J Biochem. 1999 Aug;263(3):773-81.
3.	DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate.	Crespi MD, etal., Mol Cell Endocrinol. 1987 Oct;53(3):221-6.
4.	Enzymes involved in DNA synthesis in the testes are regulated by temperature in vitro.	Fujisawa M, etal., Eur Urol. 1997;31(2):237-42.
5.	Role of DNA topoisomerase I in the transcription of supercoiled rRNA gene.	Garg LC, etal., Proc Natl Acad Sci U S A. 1987 May;84(10):3185-8.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
8.	Variations in DNA topoisomerase I activity after gamma irradiation of mature neurons.	Ivanov VA Neurosci Lett. 1988 Nov 22;94(1-2):99-103.
9.	DNA topoisomerase I from rat brain neurons.	Ivanov VA, etal., Biochim Biophys Acta. 1986 Mar 26;866(2-3):154-60.
10.	Down modulation of topoisomerase I affects DNA repair efficiency.	Mao Y and Muller MT, DNA Repair (Amst) 2003 Oct 7;2(10):1115-26.
11.	DNA topoisomerase I activity in regenerating liver of hypothyroid rats.	Merlo M, etal., Boll Soc Ital Biol Sper. 1998 Jan-Feb;74(1-2):9-14.
12.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
13.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
14.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
15.	GOA pipeline	RGD automated data pipeline
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	Association of DNA topoisomerase I and RNA polymerase I: a possible role for topoisomerase I in ribosomal gene transcription.	Rose KM, etal., Chromosoma. 1988;96(6):411-6.
18.	Comparison of biochemical properties of DNA-topoisomerase I from normal and regenerating liver.	Tournier MF, etal., Eur J Biochem. 1992 Nov 15;210(1):359-64.
19.	Immunohistochemical analyses of DNA topoisomerase II isoforms in developing rat cerebellum.	Tsutsui K, et al., J Comp Neurol. 2001 Mar 5;431(2):228-39.

Additional References at PubMed

PMID:7842491	PMID:8567649	PMID:8631793	PMID:8631794	PMID:8943335	PMID:9049244	PMID:9094096	PMID:9611241	PMID:10497031	PMID:11016921	PMID:11756244	PMID:12878161
PMID:14594810	PMID:14654701	PMID:16127745	PMID:16261531	PMID:16791210	PMID:17355975	PMID:22206666	PMID:22215678	PMID:22658674	PMID:22681889	PMID:22904072	PMID:23012366

Genomics

Comparative Map Data

Top1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	149,293,469 - 149,376,618 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	149,293,403 - 149,376,623 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	153,107,309 - 153,188,513 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	161,606,688 - 161,687,898 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	159,345,818 - 159,427,549 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	156,635,688 - 156,717,686 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	156,642,464 - 156,717,686 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	162,865,335 - 162,947,076 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	151,428,931 - 151,512,884 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	151,334,966 - 151,418,920 (+)	NCBI
Celera	3	147,968,261 - 148,049,789 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

TOP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	41,028,822 - 41,124,487 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	41,028,822 - 41,124,487 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	39,657,462 - 39,753,127 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	39,090,876 - 39,186,541 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	39,090,875 - 39,186,541	NCBI
Celera	20	36,368,028 - 36,463,696 (+)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI
HuRef	20	36,395,468 - 36,491,177 (+)	NCBI		HuRef
CHM1_1	20	39,561,887 - 39,657,539 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	42,760,511 - 42,856,164 (+)	NCBI		T2T-CHM13v2.0

Top1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	160,487,901 - 160,564,684 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	160,487,808 - 160,564,684 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	160,645,897 - 160,722,764 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	160,645,888 - 160,722,764 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	160,471,633 - 160,548,500 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	160,337,671 - 160,414,152 (+)	NCBI		MGSCv36	mm8
Celera	2	166,577,915 - 166,654,823 (+)	NCBI		Celera
Cytogenetic Map	2	H2	NCBI
cM Map	2	80.96	NCBI

Top1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	15,834,017 - 15,922,785 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	15,834,017 - 15,922,785 (-)	NCBI	ChiLan1.0	ChiLan1.0

TOP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	20	46,762,969 - 46,859,450 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	37,368,606 - 37,464,649 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	38,468,197 - 38,563,842 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	38,468,452 - 38,562,652 (+)	Ensembl	panpan1.1		panPan2

TOP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	29,075,267 - 29,166,733 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	29,075,492 - 29,165,864 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	28,720,984 - 28,812,380 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	29,781,234 - 29,872,485 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	29,781,498 - 29,872,296 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	29,049,969 - 29,141,401 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	29,153,861 - 29,245,250 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	29,650,217 - 29,741,420 (+)	NCBI		UU_Cfam_GSD_1.0

Top1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	178,026,161 - 178,108,033 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	641,423 - 723,518 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936561	641,451 - 723,323 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TOP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	43,710,290 - 43,799,700 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	43,710,270 - 43,799,700 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	49,135,554 - 49,193,582 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TOP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	22,655,085 - 22,751,082 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	22,651,995 - 22,751,102 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	71,467,009 - 71,562,443 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Top1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624919	1,668,440 - 1,756,629 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624919	1,668,712 - 1,756,624 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Top1
220 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	138
Count of miRNA genes:	119
Interacting mature miRNAs:	123
Transcripts:	ENSRNOT00000041390
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141339013	162184794	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141339236	155617360	Rat
2317883	Alcrsp26	Alcohol response QTL 26	1.8	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	3	145526770	169034231	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	145925360	166177555	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	145925360	166177555	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	145925360	166177555	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	145925360	166177555	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	145925360	166177555	Rat
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	145925360	166177555	Rat
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	145925360	166177555	Rat
1300113	Bp176	Blood pressure QTL 176	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	145956084	157309487	Rat
1598854	Memor10	Memory QTL 10	2		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	3	145956084	161299569	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	145956084	169034231	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	149040888	168026850	Rat

Markers in Region

D3Rat144

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	149,313,702 - 149,313,851 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	156,656,295 - 156,656,443	NCBI	Rnor6.0
Rnor_5.0	3	162,885,942 - 162,886,090	UniSTS	Rnor5.0
RGSC_v3.4	3	151,448,967 - 151,449,116	RGD	RGSC3.4
RGSC_v3.4	3	151,448,968 - 151,449,116	UniSTS	RGSC3.4
RGSC_v3.1	3	151,355,003 - 151,355,152	RGD
Celera	3	147,988,297 - 147,988,445	UniSTS
SHRSP x BN Map	3	75.5299	RGD
SHRSP x BN Map	3	75.5299	UniSTS
Cytogenetic Map	3	q42	UniSTS

D3Got129

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	149,374,167 - 149,374,425 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	156,716,449 - 156,716,706	NCBI	Rnor6.0
Rnor_5.0	3	162,945,839 - 162,946,096	UniSTS	Rnor5.0
RGSC_v3.4	3	151,511,646 - 151,511,904	RGD	RGSC3.4
RGSC_v3.4	3	151,511,647 - 151,511,904	UniSTS	RGSC3.4
RGSC_v3.1	3	151,417,683 - 151,417,940	RGD
Celera	3	148,048,552 - 148,048,809	UniSTS
RH 3.4 Map	3	1368.8	UniSTS
RH 3.4 Map	3	1368.8	RGD
RH 2.0 Map	3	923.1	RGD
Cytogenetic Map	3	q42	UniSTS

BF405031

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	149,343,945 - 149,344,113 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	156,686,229 - 156,686,396	NCBI	Rnor6.0
Rnor_5.0	3	162,915,621 - 162,915,788	UniSTS	Rnor5.0
RGSC_v3.4	3	151,481,427 - 151,481,594	UniSTS	RGSC3.4
Celera	3	148,018,332 - 148,018,499	UniSTS
RH 3.4 Map	3	1367.7	UniSTS
Cytogenetic Map	3	q42	UniSTS

BE115617

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	127,423,790 - 127,423,946 (+)	MAPPER	mRatBN7.2
mRatBN7.2	3	149,293,404 - 149,293,572 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	156,635,435 - 156,635,602	NCBI	Rnor6.0
Rnor_6.0	1	134,992,286 - 134,992,441	NCBI	Rnor6.0
Rnor_5.0	3	162,865,082 - 162,865,249	UniSTS	Rnor5.0
Rnor_5.0	1	136,015,943 - 136,016,098	UniSTS	Rnor5.0
RGSC_v3.4	1	128,843,970 - 128,844,125	UniSTS	RGSC3.4
RGSC_v3.4	3	151,428,678 - 151,428,845	UniSTS	RGSC3.4
Celera	3	147,968,008 - 147,968,175	UniSTS
Celera	1	119,553,296 - 119,553,451	UniSTS
Cytogenetic Map	3	q42	UniSTS
Cytogenetic Map	1	q31	UniSTS

BM389249

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	149,307,989 - 149,308,159 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	156,650,589 - 156,650,758	NCBI	Rnor6.0
Rnor_5.0	3	162,880,236 - 162,880,405	UniSTS	Rnor5.0
RGSC_v3.4	3	151,443,262 - 151,443,431	UniSTS	RGSC3.4
Celera	3	147,982,592 - 147,982,761	UniSTS
RH 3.4 Map	3	1364.0	UniSTS
Cytogenetic Map	3	q42	UniSTS

UniSTS:234589

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	149,297,204 - 149,297,432 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	156,639,536 - 156,639,763	NCBI	Rnor6.0
Rnor_5.0	3	162,869,183 - 162,869,410	UniSTS	Rnor5.0
RGSC_v3.4	3	151,432,478 - 151,432,705	UniSTS	RGSC3.4
Celera	3	147,971,808 - 147,972,035	UniSTS
Cytogenetic Map	3	q42	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	35	54	38	19	38	1	3	74	35	39	11	1
Low		8	3	3		3	7	8			2		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022615	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF140782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY325188	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000120	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000041390 ⟹ ENSRNOP00000040134

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	156,662,114 - 156,662,958 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000085354 ⟹ ENSRNOP00000072312

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	156,642,464 - 156,662,224 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000086260 ⟹ ENSRNOP00000072794

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	149,293,403 - 149,375,591 (+)	Ensembl
Rnor_6.0 Ensembl	3	156,662,120 - 156,717,686 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000113376 ⟹ ENSRNOP00000076575

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	149,293,451 - 149,376,623 (+)	Ensembl

RefSeq Acc Id:

NM_022615 ⟹ NP_072137

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	149,293,469 - 149,376,618 (+)	NCBI
Rnor_6.0	3	156,635,688 - 156,717,686 (+)	NCBI
Rnor_5.0	3	162,865,335 - 162,947,076 (+)	NCBI
RGSC_v3.4	3	151,428,931 - 151,512,884 (+)	RGD
Celera	3	147,968,261 - 148,049,789 (+)	RGD

Sequence:

show sequence

ATGAGCGGGGACCATCTCCACAACGACTCCCAGATCGAAGCGGATTTCCGATTGAATGATTCTC
ATAAACACAAAGATAAACACAAAGATCGAGAACACCGGCATAAGGAGCACAAGAAGGATAAGGA
TAAGGACCGGGAAAAGTCTAAACATAGCAACAGTGAACATAAAGATTCTGAAAAGAAACACAAA
GAGAAAGAGAAAACCAAACACAAAGATGGAAGCTCAGACAAACATAAAGACAAACATAAAGACA
GAGACAAGGAAAAACGAAAGGAGGAAAAGATTAGAGCTGCTGGGGATGCAAAAATAAAGAAGGA
GAAGGAAAATGGCTTCTCTAGTCCACCACGAATTAAAGACGAGCCTGAAGATGATGGCTATTTT
GCTCCTCCAAAAGAGGATATAAAGCCACTGAAGAGGCCTCGGGATGAAGATGATGCTGATTATA
AGCCTAAGAAAATTAAGACAGAAGATATCAAGAAGGAGAAGAAACGAAAACTAGAAGAAGAAGA
GGATGGCAAACTTAAAAAGCCCAAGAATAAAGATAAAGATAAAAAGGTTGCTGAGCCAGATAAT
AAGAAGAAGAAGGCGAAAAAGGAAGAGGAGCAGAAGTGGAAATGGTGGGAAGAAGAACGCTATC
CAGAAGGCATCAAGTGGAAATTCCTAGAACATAAAGGGCCTGTTTTCGCTCCACCGTATGAGCC
TCTGCCAGAGGGTGTCAAGTTTTACTATGATGGTAAAGTTATGAAGCTGAGTCCCAAAGCAGAA
GAAGTAGCTACATTCTTTGCAAAAATGCTTGACCATGAATATACTACTAAGGAAATATTCAGGA
AAAATTTCTTTAAAGACTGGAGAAAGGAAATGACTAATGATGAAAAAAATACGATTACCAACCT
AAGCAAATGCGACTTTACACAGATGAGCCAGTACTTCAAAGCTCAATCAGAAGCTCGGAAACAG
ATGAGCAAGGAAGAAAAATTGAAAATCAAAGAAGAAAATGAAAAATTATTGAAAGAATATGGCT
TTTGTGTAATGGATAATCATAGAGAGCGGATTGCCAACTTCAAGATAGAGCCTCCAGGGCTCTT
CCGAGGCCGTGGCAACCACCCCAAGATGGGTATGCTGAAGAGAAGGATCATGCCTGAGGACATC
ATCATCAACTGTAGCAAAGATGCCAAGGTTCCTTCTCCTCCTCCTGGACATAAATGGAAGGAAG
TTCGACATGATAACAAGGTTACTTGGCTGGTCTCCTGGACAGAGAATATCCAAGGTTCTATCAA
ATATATCATGCTGAATCCCAGTTCACGAATCAAGGGTGAGAAAGACTGGCAGAAGTATGAGACT
GCTCGGCGACTGAAGAAGTGTGTGGACAAGATCCGAAATCAGTATCGGGAAGACTGGAAGTCCA
AAGAAATGAAAGTTCGGCAGAGAGCTGTAGCACTGTACTTCATTGATAAGCTTGCTCTGAGAGC
AGGCAATGAGAAGGAAGAAGGAGAGACAGCAGACACTGTGGGTTGCTGTTCACTTAGAGTGGAA
CACATCAATCTACACCCAGAATTGGATGGTCAGGAGTACGTGGTGGAGTTTGACTTTCCTGGGA
AGGACTCAATCAGATACTACAACAAAGTCCCAGTTGAGAAACGAGTTTTTAAAAACTTACAACT
ATTTATGGAGAACAAGCAGCCTGAGGATGATCTTTTTGATCGACTTAATACTGGTATTCTAAAT
AAGCATCTTCAAGATCTCATGGAGGGCTTGACTGCCAAGGTGTTCCGTACCTACAATGCCTCCA
TCACGCTGCAGCAGCAGCTTAAAGAGCTCACAGCCCCTGATGAGAATGTACCAGCAAAGATTCT
ATCTTATAACCGTGCCAATCGCGCTGTTGCAATTCTTTGTAACCACCAGAGGGCGCCACCAAAG
ACCTTTGAGAAGTCAATGATGAACTTGCAGTCTAAGATTGATGCCAAGAAAGATCAGCTAGCAG
ATGCTCGAAAGGACCTGAAAAGCGCTAAGGCTGATGCCAAAGTCATGAAGGATGCAAAGACCAA
GAAGGTAGTAGAGTCAAAAAAGAAGGCTGTACAGAGATTAGAAGAGCAGCTGATGAAGCTGGAG
GTTCAAGCCACAGACCGAGAGGAGAACAAACAAATTGCCTTGGGGACCTCCAAACTCAATTACC
TGGACCCTAGGATCACAGTGGCTTGGTGCAAAAAATGGGGGGTCCCAATCGAGAAGATTTACAA
CAAAACCCAGAGAGAGAAGTTTGCTTGGGCCATTGATATGACTGATGAGGACTACGAGTTTTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_072137	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD30137	(Get FASTA)	NCBI Sequence Viewer
	AAP92589	(Get FASTA)	NCBI Sequence Viewer
	EDL96618	(Get FASTA)	NCBI Sequence Viewer
	Q9WUL0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_072137 ⟸ NM_022615

- UniProtKB:

Q9WUL0 (UniProtKB/Swiss-Prot), A6JWZ1 (UniProtKB/TrEMBL), A0A8I5Y067 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKDKDREKSKHSNSEHKDSEKKHK
EKEKTKHKDGSSDKHKDKHKDRDKEKRKEEKIRAAGDAKIKKEKENGFSSPPRIKDEPEDDGYF
APPKEDIKPLKRPRDEDDADYKPKKIKTEDIKKEKKRKLEEEEDGKLKKPKNKDKDKKVAEPDN
KKKKAKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPEGVKFYYDGKVMKLSPKAE
EVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNTITNLSKCDFTQMSQYFKAQSEARKQ
MSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDI
IINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYET
ARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVE
HINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILN
KHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPK
TFEKSMMNLQSKIDAKKDQLADARKDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLE
VQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF

hide sequence

RefSeq Acc Id:

ENSRNOP00000072312 ⟸ ENSRNOT00000085354

RefSeq Acc Id:

ENSRNOP00000040134 ⟸ ENSRNOT00000041390

RefSeq Acc Id:

ENSRNOP00000072794 ⟸ ENSRNOT00000086260

RefSeq Acc Id:

ENSRNOP00000076575 ⟸ ENSRNOT00000113376

Protein Domains

DNA topoisomerase I eukaryotic-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9WUL0-F1-model_v2	AlphaFold	Q9WUL0	1-767	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621246	AgrOrtholog
BioCyc Gene	G2FUF-46971	BioCyc
Ensembl Genes	ENSRNOG00000047611	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000072794.1	UniProtKB/TrEMBL
	ENSRNOP00000076575	ENTREZGENE
	ENSRNOP00000076575.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000086260.2	UniProtKB/TrEMBL
	ENSRNOT00000113376	ENTREZGENE
	ENSRNOT00000113376.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.41	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	1.10.132.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.170.11.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	DNA_brk_join_enz	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DNA_topo_DNA_db_N_dom1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DNA_topo_DNA_db_N_dom2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TopoI	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TopoI_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TopoI_C_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TopoI_cat_a-hlx-sub_euk	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TopoI_cat_a/b-sub_euk	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TopoI_cat_euk	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TopoI_DNA-bd_euk	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TopoI_DNA-bd_euk_N_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TopoI_euk	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64550	UniProtKB/Swiss-Prot
NCBI Gene	64550	ENTREZGENE
PANTHER	DNA TOPOISOMERASE 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DNA TOPOISOMERASE I	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Topo_C_assoc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Topoisom_I	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Topoisom_I_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	TOP1	RGD
PhenoGen	Top1	PhenoGen
PRINTS	EUTPISMRASEI	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	TOPOISOMERASE_I_EUK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	TOPEUc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Eukaryotic DNA topoisomerase I, dispensable insert domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56349	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56741	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K3V7_RAT	UniProtKB/TrEMBL
	A0A8I5Y067	ENTREZGENE, UniProtKB/TrEMBL
	A6JWZ1	ENTREZGENE, UniProtKB/TrEMBL
	Q9WUL0	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-08-16	Top1	DNA topoisomerase I	Top1	topoisomerase (DNA) I	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Top1	topoisomerase (DNA) I		DNA topoisomerase I	Name updated	1299863	APPROVED
2002-08-07	Top1	DNA topoisomerase I			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB