Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-demecolcine | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | Demecolcine results in decreased expression of RIF1 mRNA | CTD | PMID:23649840 | 1,2-dimethylhydrazine | decreases expression | ISO | Rif1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of RIF1 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Rif1 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of RIF1 mRNA] | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | RIF1 (Homo sapiens) | 6480464 | Estradiol results in increased expression of RIF1 mRNA | CTD | PMID:23019147 and PMID:31614463 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Rif1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RIF1 mRNA | CTD | PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of RIF1 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RIF1 mRNA | CTD | PMID:32109520 | 2,6-di-tert-butyl-4-methylphenol | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | Butylated Hydroxytoluene results in increased expression of RIF1 mRNA | CTD | PMID:19000923 | 2-butoxyethanol | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | n-butoxyethanol results in increased expression of RIF1 mRNA | CTD | PMID:19812364 | 2-hydroxypropanoic acid | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of RIF1 mRNA | CTD | PMID:30851411 | 2-methylcholine | affects expression | ISO | RIF1 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of RIF1 mRNA | CTD | PMID:21179406 | 4,4'-sulfonyldiphenol | affects expression | ISO | RIF1 (Homo sapiens) | 6480464 | bisphenol S affects the expression of RIF1 protein | CTD | PMID:31945527 | 4-hydroxyphenyl retinamide | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | Fenretinide results in increased expression of RIF1 mRNA | CTD | PMID:28973697 | acrolein | multiple interactions | ISO | RIF1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of RIF1 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | acrylamide | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | Acrylamide results in increased expression of RIF1 protein | CTD | PMID:20025956 | aflatoxin B1 | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of RIF1 mRNA | CTD | PMID:19770486 | aflatoxin M1 | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | Aflatoxin M1 results in decreased expression of RIF1 mRNA | CTD | PMID:30928695 | all-trans-retinoic acid | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of RIF1 mRNA | CTD | PMID:15498508 and PMID:33167477 | alpha-pinene | multiple interactions | ISO | RIF1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of RIF1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of RIF1 mRNA | CTD | PMID:32699268 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of RIF1 mRNA | CTD | PMID:30779732 | anthracene-1,8,9-triol | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | Anthralin results in increased expression of RIF1 protein | CTD | PMID:20025956 | aristolochic acid A | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of RIF1 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | RIF1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to RIF1 mRNA] | CTD | PMID:32406909 | atrazine | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | Atrazine results in increased expression of RIF1 mRNA | CTD | PMID:27655631 | benzo[a]pyrene | increases methylation | ISO | RIF1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of RIF1 3' UTR | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | RIF1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of RIF1 intron | CTD | PMID:30157460 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 more ... | biochanin A | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | biochanin A results in decreased expression of RIF1 mRNA | CTD | PMID:12111696 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of RIF1 mRNA | CTD | PMID:30816183 | bisphenol A | increases methylation | ISO | RIF1 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of RIF1 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of RIF1 protein | CTD | PMID:31675489 and PMID:37567409 | bisphenol A | decreases expression | ISO | Rif1 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of RIF1 mRNA | CTD | PMID:33221593 | Bisphenol A diglycidyl ether | affects splicing | ISO | Rif1 (Mus musculus) | 6480464 | 2 and 2-bis(4-glycidyloxyphenyl)propane affects the splicing of RIF1 mRNA | CTD | PMID:36464114 | cadmium dichloride | decreases expression | ISO | Rif1 (Mus musculus) | 6480464 | Cadmium Chloride results in decreased expression of RIF1 mRNA | CTD | PMID:24982889 | caffeine | affects phosphorylation | ISO | RIF1 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of RIF1 protein | CTD | PMID:35688186 | chloroprene | increases expression | EXP | | 6480464 | Chloroprene results in increased expression of RIF1 mRNA | CTD | PMID:23125180 | chlorpyrifos | decreases expression | ISO | Rif1 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of RIF1 mRNA | CTD | PMID:37019170 | cholic acid | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | Cholic Acid results in increased expression of RIF1 protein | CTD | PMID:20025956 | cisplatin | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of RIF1 mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | ISO | RIF1 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of RIF1 mRNA | CTD | PMID:27392435 | clofibrate | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | Clofibrate results in increased expression of RIF1 protein | CTD | PMID:20025956 | cobalt dichloride | increases expression | ISO | RIF1 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of RIF1 mRNA | CTD | PMID:19376846 | coumarin | affects phosphorylation | ISO | RIF1 (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of RIF1 protein | CTD | PMID:35688186 | cyclosporin A | decreases expression | ISO | Rif1 (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of RIF1 mRNA | CTD | PMID:19770486 | decabromodiphenyl ether | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of RIF1 protein | CTD | PMID:31675489 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of RIF1 mRNA | CTD | PMID:21266533 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of RIF1 mRNA | CTD | PMID:25152437 | enzyme inhibitor | multiple interactions | ISO | RIF1 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RIF1 protein | CTD | PMID:23301498 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of RIF1 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Rif1 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of RIF1 mRNA] | CTD | PMID:22206623 | formaldehyde | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of RIF1 mRNA | CTD | PMID:20655997 | FR900359 | affects phosphorylation | ISO | RIF1 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of RIF1 protein | CTD | PMID:37730182 | hydrogen peroxide | affects expression | ISO | RIF1 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of RIF1 mRNA | CTD | PMID:21179406 | iron dichloride | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | ferrous chloride results in increased expression of RIF1 protein | CTD | PMID:20025956 | Mezerein | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | mezerein results in increased expression of RIF1 mRNA | CTD | PMID:19000923 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of RIF1 mRNA | CTD | PMID:25729387 | oxaliplatin | decreases expression | EXP | | 6480464 | oxaliplatin results in decreased expression of RIF1 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | RIF1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of RIF1 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | palytoxin | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | palytoxin results in increased expression of RIF1 protein | CTD | PMID:20025956 | paracetamol | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of RIF1 mRNA | CTD | PMID:21420995 | pentachlorophenol | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of RIF1 mRNA | CTD | PMID:23892564 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of RIF1 mRNA | CTD | PMID:27153767 | perfluorooctanoic acid | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | perfluorooctanoic acid results in increased expression of RIF1 protein | CTD | PMID:20025956 | phenobarbital | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of RIF1 mRNA | CTD | PMID:19000923 | phorbol 13-acetate 12-myristate | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | Tetradecanoylphorbol Acetate results in increased expression of RIF1 mRNA | CTD | PMID:19000923 | progesterone | increases expression | ISO | RIF1 (Homo sapiens) | 6480464 | Progesterone results in increased expression of RIF1 mRNA | CTD | PMID:18070364 | rac-lactic acid | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of RIF1 mRNA | CTD | PMID:30851411 | resveratrol | multiple interactions | ISO | RIF1 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of RIF1 mRNA | CTD | PMID:23557933 | saccharin | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | Saccharin results in increased expression of RIF1 mRNA | CTD | PMID:19000923 | SB 431542 | multiple interactions | ISO | RIF1 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of RIF1 protein | CTD | PMID:37664457 | silicon dioxide | decreases expression | ISO | Rif1 (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of RIF1 mRNA | CTD | PMID:19073995 | sodium arsenate | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of RIF1 mRNA | CTD | PMID:21795629 | succimer | multiple interactions | ISO | Rif1 (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RIF1 mRNA | CTD | PMID:21641980 | tamibarotene | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | tamibarotene results in decreased expression of RIF1 mRNA | CTD | PMID:15498508 | testosterone | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of RIF1 mRNA | CTD | PMID:33359661 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of RIF1 mRNA | CTD | PMID:31150632 | tetrachloromethane | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of RIF1 mRNA | CTD | PMID:31919559 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of RIF1 mRNA | CTD | PMID:23411599 | titanium dioxide | decreases expression | ISO | Rif1 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of RIF1 mRNA | CTD | PMID:29264374 | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of RIF1 mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of RIF1 mRNA | CTD | PMID:25729387 | torcetrapib | increases expression | ISO | RIF1 (Homo sapiens) | 6480464 | torcetrapib results in increased expression of RIF1 mRNA | CTD | PMID:23228038 | trichostatin A | increases expression | ISO | RIF1 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of RIF1 mRNA | CTD | PMID:24935251 | trichostatin A | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of RIF1 mRNA | CTD | PMID:28542535 | trimellitic anhydride | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of RIF1 mRNA | CTD | PMID:19042947 | triptonide | decreases expression | ISO | Rif1 (Mus musculus) | 6480464 | triptonide results in decreased expression of RIF1 mRNA | CTD | PMID:33045310 | troglitazone | decreases expression | ISO | Rif1 (Mus musculus) | 6480464 | troglitazone results in decreased expression of RIF1 mRNA | CTD | PMID:28973697 | tungsten | decreases expression | ISO | Rif1 (Mus musculus) | 6480464 | Tungsten results in decreased expression of RIF1 mRNA | CTD | PMID:30912803 | urethane | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | Urethane results in decreased expression of RIF1 mRNA | CTD | PMID:28818685 | valproic acid | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of RIF1 mRNA | CTD | PMID:23179753 and PMID:27188386 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of RIF1 mRNA | CTD | PMID:29427782 | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of RIF1 mRNA | CTD | PMID:29427782 | vincristine | decreases expression | ISO | RIF1 (Homo sapiens) | 6480464 | Vincristine results in decreased expression of RIF1 mRNA | CTD | PMID:23649840 | zinc dichloride | increases expression | ISO | Rif1 (Mus musculus) | 6480464 | zinc chloride results in increased expression of RIF1 mRNA | CTD | PMID:19000923 | |