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Gene: Lama2 (laminin subunit alpha 2) Rattus norvegicus
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Symbol: Lama2
Name: laminin subunit alpha 2
Description: Predicted to have extracellular matrix structural constituent. Involved in Schwann cell differentiation. Localizes to the basement membrane and dendritic spine. Biomarker of renovascular hypertension. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; dilated cardiomyopathy pathway; INTERACTS WITH (RS)-amphetamine; 17alpha-ethynylestradiol; atrazine.
Type: protein-coding
RefSeq Status: MODEL
Also known as: laminin subunit alpha-2; laminin, alpha 2; LOC309368
Orthologs:
Homo sapiens (human) : LAMA2 (laminin subunit alpha 2)  HGNC  Alliance
Mus musculus (house mouse) : Lama2 (laminin, alpha 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lama2 (laminin subunit alpha 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LAMA2 (laminin subunit alpha 2)
Canis lupus familiaris (dog) : LAMA2 (laminin subunit alpha 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lama2 (laminin subunit alpha 2)
Sus scrofa (pig) : LAMA2 (laminin subunit alpha 2)
more info ...
Allele / Splice: Lama2Tn(sb-T2/Bart3)2.2013Mcwi  
Genetic Models: F344-Lama2Tn(sb-T2/Bart3)2.2013Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0118,491,264 - 19,143,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0120,002,787 - 20,647,256 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4118,203,466 - 18,885,462 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1118,324,930 - 18,885,310 (+)NCBI
Celera116,078,601 - 16,724,118 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Lama2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308889
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.