Ccr3 (C-C motif chemokine receptor 3) - Rat Genome Database

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Gene: Ccr3 (C-C motif chemokine receptor 3) Rattus norvegicus
Analyze
Symbol: Ccr3
Name: C-C motif chemokine receptor 3
RGD ID: 620593
Description: Predicted to have C-C chemokine binding activity and C-C chemokine receptor activity. Involved in ERK1 and ERK2 cascade; angioblast cell migration; and leukocyte chemotaxis. Localizes to endosome; extracellular space; and plasma membrane. Used to study asthma and myocardial infarction. Biomarker of rhinitis. Human ortholog(s) of this gene implicated in asthma; ovary epithelial cancer; and rhinitis. Orthologous to human CCR3 (C-C motif chemokine receptor 3); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; chemokine (C-C motif) receptor 3; chemokine (C-C) receptor 3; CKR3; Cmkbr3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28123,586,100 - 123,634,178 (+)NCBI
Rnor_6.0 Ensembl8133,029,625 - 133,040,997 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08133,026,539 - 133,040,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08132,180,887 - 132,190,686 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,759,943 - 128,769,341 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18128,779,679 - 128,789,067 (+)NCBI
Celera8122,724,521 - 122,733,919 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Al-Abdulhadi SA and Al-Rabia MW, Ann Saudi Med. 2010 Mar-Apr;30(2):115-22.
2. Allakhverdi Z, etal., Ann N Y Acad Sci. 2006 Oct;1082:62-73.
3. Andalib A, etal., Iran J Immunol. 2011 Mar;8(1):1-10.
4. Arrington ER, etal., Clin Nucl Med. 1992 May;17(5):371-4.
5. Balding CE, etal., Clin Exp Immunol. 2001 Aug;125(2):332-9.
6. Ben S, etal., Allergy. 2008 Sep;63(9):1164-76.
7. Bonaros N, etal., J Thorac Cardiovasc Surg. 2008 Oct;136(4):1044-53. Epub 2008 Jul 7.
8. Caproni M, etal., Clin Immunol. 2005 Mar;114(3):284-92.
9. Chuang CC, etal., Acta Trop. 2010 Mar;113(3):209-13. Epub 2009 Nov 1.
10. D'Avila H, etal., Infect Immun. 2007 Mar;75(3):1507-11. Epub 2006 Dec 11.
11. Fattouh R, etal., Am J Respir Crit Care Med. 2010 Aug 23.
12. Fortin M, etal., Cytokine. 2010 Aug 7.
13. Fortin M, etal., Oligonucleotides. 2006 Fall;16(3):203-12.
14. Francis JN, etal., Allergy. 2007 Jan;62(1):59-65.
15. Freutel S, etal., Lupus. 2011 Oct;20(12):1300-4. Epub 2011 Aug 15.
16. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
18. Goode EL, etal., Clin Cancer Res. 2010 Feb 1;16(3):995-1007. Epub 2010 Jan 26.
19. Habasque C, etal., Mol Hum Reprod 2002 May;8(5):419-25.
20. Han NR, etal., Life Sci. 2012 Jan 16;90(3-4):147-53. Epub 2011 Oct 29.
21. Hartl D, etal., J Immunol. 2008 Dec 1;181(11):8053-67.
22. Huan J, etal., J Immunol. 2004 Apr 1;172(7):4556-66.
23. Huaux F, etal., Am J Pathol. 2005 Dec;167(6):1485-96.
24. Huber J, etal., J Clin Endocrinol Metab. 2008 Aug;93(8):3215-21. Epub 2008 May 20.
25. Jung MY, etal., Oncol Rep. 2009 Nov;22(5):1141-7.
26. Kabashima H, etal., Cytokine. 2001 Oct 21;16(2):62-6.
27. Kato Y, etal., Int Arch Allergy Immunol. 2006;139(3):245-57. Epub 2006 Jan 30.
28. Kim SH, etal., Respir Med. 2010 May;104(5):626-32. Epub 2009 Dec 21.
29. Komai M, etal., J Pharmacol Sci. 2010 Feb;112(2):203-13. Epub 2010 Feb 4.
30. Komatsu N, etal., Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5307-13. Epub 2008 Jul 24.
31. Lamprecht P, etal., Arthritis Res Ther. 2003;5(1):R25-31. Epub 2002 Oct 24.
32. Lee JH, etal., J Allergy Clin Immunol. 2007 Nov;120(5):1110-7.
33. Li YM, etal., Chin Med Sci J. 2010 Sep;25(3):162-8.
34. Liclican EL, etal., Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6311-20. Epub 2010 Jul 7.
35. Manousou P, etal., Clin Exp Immunol. 2010 Nov;162(2):337-47.
36. Masterson JC, etal., Am J Pathol. 2011 Nov;179(5):2302-14. Epub 2011 Sep 23.
37. MGD data from the GO Consortium
38. Nakamura H, etal., Int Arch Allergy Immunol. 2007;142(4):329-34. Epub 2006 Nov 28.
39. NCBI rat LocusLink and RefSeq merged data July 26, 2002
40. Ohnuma A, etal., Exp Toxicol Pathol. 2009 Sep 15.
41. Ok IS, etal., Mediators Inflamm. 2009;2009:413270. Epub 2009 Aug 2.
42. Owen JL, etal., Cell Immunol. 2011;270(2):172-82. Epub 2011 May 10.
43. Pipeline to import KEGG annotations from KEGG into RGD
44. Potestio M, etal., Immunology. 2004 Oct;113(2):260-8.
45. RGD automated data pipeline
46. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. RGD automated import pipeline for gene-chemical interactions
48. Sterclova M, etal., Exp Lung Res. 2009 Aug;35(6):514-23.
49. Takeda A, etal., Nature. 2009 Jul 9;460(7252):225-30. Epub 2009 Jun 14.
50. TrehanPati N, etal., Hepatology. 2009 Mar;49(3):781-90.
51. Vassiliadis S, etal., JOP 2002 May;3(3):66-75.
52. Wainwright DA, etal., ASN Neuro. 2009 Dec 11;1(5):e00024.
53. Woo CH, etal., Biochem Biophys Res Commun. 2002 Nov 1;298(3):392-7.
Additional References at PubMed
PMID:7594543   PMID:9655467   PMID:11425309   PMID:12538707   PMID:16722399   PMID:22183343   PMID:28279120   PMID:31151084  


Genomics

Comparative Map Data
Ccr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28123,586,100 - 123,634,178 (+)NCBI
Rnor_6.0 Ensembl8133,029,625 - 133,040,997 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08133,026,539 - 133,040,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08132,180,887 - 132,190,686 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,759,943 - 128,769,341 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18128,779,679 - 128,789,067 (+)NCBI
Celera8122,724,521 - 122,733,919 (+)NCBICelera
Cytogenetic Map8q32NCBI
CCR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl346,163,604 - 46,266,706 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl346,130,890 - 46,266,706 (+)EnsemblGRCh38hg38GRCh38
GRCh38346,210,699 - 46,266,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37346,283,872 - 46,308,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,258,692 - 46,283,166 (+)NCBINCBI36hg18NCBI36
Build 34346,258,691 - 46,283,166NCBI
Celera346,221,217 - 46,245,543 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef346,327,575 - 46,351,905 (+)NCBIHuRef
CHM1_1346,233,878 - 46,258,185 (+)NCBICHM1_1
Ccr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,817,799 - 123,831,729 (+)NCBIGRCm39mm39
GRCm39 Ensembl9123,822,009 - 123,831,726 (+)Ensembl
GRCm389124,017,825 - 124,031,692 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,021,972 - 124,031,689 (+)EnsemblGRCm38mm10GRCm38
MGSCv379123,936,703 - 123,946,421 (+)NCBIGRCm37mm9NCBIm37
MGSCv369123,870,898 - 123,879,738 (+)NCBImm8
Celera9124,968,286 - 124,978,018 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
Ccr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,701,407 - 25,723,353 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,702,917 - 25,723,269 (-)NCBIChiLan1.0ChiLan1.0
CCR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1347,253,878 - 47,278,630 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,253,878 - 47,278,630 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0346,147,928 - 46,172,947 (+)NCBIMhudiblu_PPA_v0panPan3
CCR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,382,380 - 42,398,449 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,383,135 - 42,384,217 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,299,062 - 42,300,141 (-)NCBI
ROS_Cfam_1.02042,864,741 - 42,903,643 (-)NCBI
UMICH_Zoey_3.12042,106,665 - 42,107,744 (-)NCBI
UNSW_CanFamBas_1.02042,508,009 - 42,509,088 (-)NCBI
UU_Cfam_GSD_1.02042,789,121 - 42,790,200 (-)NCBI
Ccr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,674,516 - 200,675,950 (+)NCBI
SpeTri2.0NW_004936596223,660 - 224,739 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,251,959 - 29,376,346 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,251,950 - 29,286,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,348,402 - 32,450,254 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,648,410 - 7,698,523 (+)NCBI
ChlSab1.1 Ensembl227,697,068 - 7,698,135 (+)Ensembl
Ccr3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473074,768,668 - 74,769,749 (-)NCBI

Position Markers
PMC112554P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28123,631,159 - 123,632,084 (+)MAPPER
Rnor_6.08133,037,941 - 133,038,905NCBIRnor6.0
Rnor_5.08132,189,221 - 132,190,185UniSTSRnor5.0
RGSC_v3.48128,768,277 - 128,769,201UniSTSRGSC3.4
Celera8122,732,855 - 122,733,779UniSTS
Cytogenetic Map8q32UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102051964133307652Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8104682575133307652Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)8104682575133307652Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:24
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000008809
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11 2
Low 2 1 10 2 7 2 2 1 3 10
Below cutoff 1 10 27 19 1 19 8 8 21 10 14 1 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008809   ⟹   ENSRNOP00000008809
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8133,029,625 - 133,040,997 (+)Ensembl
RefSeq Acc Id: NM_053958   ⟹   NP_446410
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28123,622,826 - 123,632,224 (+)NCBI
Rnor_6.08133,029,607 - 133,039,045 (+)NCBI
Rnor_5.08132,180,887 - 132,190,686 (+)NCBI
RGSC_v3.48128,759,943 - 128,769,341 (+)RGD
Celera8122,724,521 - 122,733,919 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244178   ⟹   XP_006244240
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08133,026,539 - 133,040,999 (+)NCBI
Rnor_5.08132,180,887 - 132,190,686 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080707   ⟹   XP_038936635
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28123,586,101 - 123,634,178 (+)NCBI
RefSeq Acc Id: XM_039080708   ⟹   XP_038936636
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28123,586,100 - 123,634,178 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_446410   ⟸   NM_053958
- UniProtKB: O54814 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006244240   ⟸   XM_006244178
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000008809   ⟸   ENSRNOT00000008809
RefSeq Acc Id: XP_038936636   ⟸   XM_039080708
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038936635   ⟸   XM_039080707
- Peptide Label: isoform X1
Protein Domains
G_PROTEIN_RECEP_F1_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 132189670 132189671 C T snv LE/OrlBarth (UDEL), F344/NSlc (KyushuU), F344/Stm (KyushuU), F344/DuCrlCrlj (KyushuU), HTX/Kyo (KyushuU), F344/Jcl (KyushuU)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 133038390 133038391 C T snv SS/JrHsdMcwi (MCW), SBN/Ygl (MCW), LN/MavRrrc (RGD), SS/JrHsdMcwi (RGD), WN/N (MCW), SBN/Ygl (RGD), CDR, F344/NRrrc (MCW), LH/MavRrrc (RGD), MNS/Gib (RGD), SS/Jr (RGD), SR/JrHsd (MCW), SR/JrHsd (RGD)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 128768726 128768727 C T snv SS/JrHsdMcwi (MDC), F344/NHsd (ICAHN), HCR/1Mco (UMich), LH/MavRrrc (ICL), SBN/Ygl (ICL), SS/JrHsdMcwi (ICL), LCR/1Mco (UMich), SR/JrHsd (MCW), F344/NRrrc (KNAW), F344/NCrl (ICL), LCR/2Mco (UMich), WN/N (KNAW), SS/JrHsdMcwi (MCW), SR/JrHsd (ICL), SS/Jr (ICL), LN/MavRrrc (ICL), HCR/2Mco (UMich), MNS/Gib (ICL)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620593 AgrOrtholog
Ensembl Genes ENSRNOG00000006736 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008809 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008809 ENTREZGENE, UniProtKB/TrEMBL
InterPro Chemokine_CCR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117027 UniProtKB/Swiss-Prot
NCBI Gene 117027 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccr3 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHEMOKINER3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MXU9_RAT UniProtKB/TrEMBL
  CCR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O55169 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Ccr3  C-C motif chemokine receptor 3  Ccr3  chemokine (C-C motif) receptor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ccr3  chemokine (C-C motif) receptor 3  Cmkbr3  chemokine (C-C) receptor 3  Symbol and Name updated 1299863 APPROVED
2002-08-07 Cmkbr3  chemokine (C-C) receptor 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is absent from the testes 634762
gene_function a coreceptor for HIV virus 632390