RGD Reference Report - Enhanced CCR5+/CCR3+ T helper cell ratio in patients with active cutaneous lupus erythematosus. - Rat Genome Database

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Enhanced CCR5+/CCR3+ T helper cell ratio in patients with active cutaneous lupus erythematosus.

Authors: Freutel, S  Gaffal, E  Zahn, S  Bieber, T  Tuting, T  Wenzel, J 
Citation: Freutel S, etal., Lupus. 2011 Oct;20(12):1300-4. Epub 2011 Aug 15.
RGD ID: 6892918
Pubmed: PMID:21844117   (View Abstract at PubMed)
DOI: DOI:10.1177/0961203311409267   (Journal Full-text)

Cutaneous lupus erythematosus (CLE) is characterized by enhanced interferon alpha (IFNalpha) levels in serum and in tissue. Since IFNalpha promotes a Th1-biased immune response, we hypothesized that a Th1-associated chemokine receptor profile should be a typical finding in patients with active CLE. Therefore, peripheral blood mononuclear cells were isolated from patients with different CLE subsets (n = 15), healthy controls (n = 13) and patients under immunotherapy with IFNalpha (n = 7). T helper cells were analysed by flow cytometry for the expression of the chemokines receptor CCR5, indicative for Th1 cells, and of CCR3, indicating Th2. In addition, intracellular levels of the type I IFN-inducible MxA protein were measured. Patients with widespread active CLE skin lesions had a significantly increased expression of CCR5, whereas expression of CCR3 was decreased when compared with healthy controls. MxA expression was significantly enhanced in all investigated CLE subtypes, with the highest levels in patients with widespread skin lesions. The enhanced CCR5/CCR3 ratio closely correlated with the MxA levels in peripheral lymphocytes and with disease activity. Our analyses revealed that active CLE is associated with a systemic type I IFN effect that appears to induce a shift towards a Th1-associated chemokine receptor profile. The CCR5/CCR3 T-helper cell ratio might therefore represent an indirect marker for the disease activity in CLE.

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Ccr3  (C-C motif chemokine receptor 3)

Genes (Mus musculus)
Ccr3  (chemokine (C-C motif) receptor 3)

Genes (Homo sapiens)
CCR3  (C-C motif chemokine receptor 3)

Additional Information